The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Vascular calcifications as a marker of increased cardiovascular risk: A meta-analysis
Open accessAbstract
BACKGROUND: Several imaging techniques may reveal calcification of the arterial wall or cardiac valves. Many studies indicate that the risk for cardiovascular disease is increased when calcification is present. Recent meta-analyses on coronary calcification and cardiovascular risk may be confounded by indication. Therefore, this meta-analysis was performed with extensive subgroup analysis to assess the overall cardiovascular risk of finding calcification in any arterial wall or cardiac valve when using different imaging techniques. METHODS AND RESULTS: A meta-analysis of prospective studies reporting calcifications and cardiovascular end-points was performed. Thirty articles were selected. The overall odds ratios (95% confidence interval [CI]) for calcifications versus no calcifications in 218,080 subjects after a mean follow-up of 10.1 years amounted to 4.62 (CI 2.24 to 9.53) for all cause mortality, 3.94 (CI 2.39 to 6.50) for cardiovascular mortality, 3.74 (CI 2.56 to 5.45) for coronary events, 2.21 (CI 1.81 to 2.69) for stroke, and 3.41 (CI 2.71 to 4.30) for any cardiovascular event. Heterogeneity was largely explained by length of follow up and sort of imaging technique. Subgroup analysis of patients with end stage renal disease revealed a much higher odds ratio for any event of 6.22 (CI 2.73 to 14.14). CONCLUSION: The presence of calcification in any arterial wall is associated with a 3-4-fold higher risk for mortality and cardiovascular events. Interpretation of the pooled estimates has to be done with caution because of heterogeneity across studies.
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Cites
Systematic Reviews in Health Care : Meta-Analysis in Context
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Arterial Calcifications, Arterial Stiffness, and Cardiovascular Risk in End-Stage Renal Disease
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Long-Term Prognosis Associated With Coronary Calcification
Budoff, M. J., Shaw, L. J., Liu, S. T., Weinstein, S. R., Tseng, P. H., Flores, F. R., Callister, T. Q., Raggi, P., Berman, D. S., & Mosler, T. P. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.079 · Cited by 1,342
A Randomized Trial of Intensive Lipid-Lowering Therapy in Calcific Aortic Stenosis
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Cited by
Vascular calcification: Mechanisms of vascular smooth muscle cell calcification
Leopold, J. A. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.10.021 · Cited by 468
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production
Ceneri, N., Zhao, L., Young, B. D., Healy, A., Coskun, S., Vasavada, H., Yarovinsky, T. O., Ike, K., Pardi, R., Qin, L., et al. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.308507 · Cited by 124
Burton, D. G. A., Matsubara, H., & Ikeda, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.07.005 · Cited by 121
Advancements in the application of deep learning for coronary artery calcification
Tang, K.-X., Wu, Y.-L., Shan, S.-K., & Yuan, L.-Q. (2025) · Meta-Radiology · doi:10.1016/j.metrad.2025.100134 · Cited by 2
Metadata
- Authors
- Rennenberg, R., Kessels, Schurgers, Engelshoven, V., de Leeuw, P., & Kroon
- Venue
- Vascular Health and Risk Management
- Publisher
- Informa UK Limited
- Published
- 2009-01
- Volume
- 5
- Issue
- 1
- Pages
- 185
- ISSN
- 1176-6344 (ISSN-L)
- 1178-2048
- OpenAlex
- W1713906157
- Cited by
- 469
- References
- 42
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Rennenberg, R., Kessels, Schurgers, Engelshoven, V., de Leeuw, P., & Kroon. (2009). Vascular calcifications as a marker of increased cardiovascular risk: A meta-analysis. Vascular Health and Risk Management. https://doi.org/10.2147/vhrm.s4822
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