Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis
Open accessAbstract
PURPOSE : This study aimed to investigate the effect of intraperitoneal administration of activin on the occurrence of endometriosis using a mouse model of endometriosis. METHODS : A mouse model of endometriosis was prepared by intraperitoneally administering endometrial tissue and blood collected from donor mice to C57BL/6J 7-8- week-old recipient mice. A total of 400 μg of activin A was intraperitoneally administered to model mice in the activin group for 5 days. Intraperitoneal endometriotic lesions were confirmed macroscopically and IL-6 and TNF-α levels in washed ascites were measured by ELISA. RESULTS : Endometriotic lesions were observed in all mice. In the activin group, the maximum diameter of endometriotic lesions was significantly larger than that in control group (4.7?1.3 vs 2.9?0.9 mm, p?0.01). The total area of the lesion was also significantly higher in the activin group than in the control group (21.1?9.9 vs 8.8?5.4 mm2,p?0.01). Furthermore, IL-6 and TNF-α levels in ascites were significantly higher in the activin group than in the control group (IL-6 : 85.8?15.3 vs 75.1?19.3 pg/ml, p?0.05 ; TNF-α : 629.8?15.4 vs 605.9?11.4 pg/ml, p?0.05). CONCLUSION : Activin promotes occurrence of endometriosis. Inflammatory cytokines are also elevated by activin administration,suggesting that they may contribute to progression of endometriosis J. Med. Invest. 66 : 123-127, February, 2019
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Giving activin to mice promotes endometriotic lesion growth.
“Women with endometriosis demonstrate higher levels of activin than unaffected controls (Cahill & Hull, 2000; Reis et al., 2012; Rombauts et al., 2006) and giving activin to mice promotes endometriotic lesion growth (Kasai et al., 2019).”
From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Kasai et al., 2019
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Endometriosis and polycystic ovary syndrome are diametric disorders
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“Women with endometriosis demonstrate higher levels of activin than unaffected controls (Cahill & Hull, 2000; Reis et al., 2012; Rombauts et al., 2006) and giving activin to mice promotes endometriotic lesion growth (Kasai et al., 2019).”
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- Authors
- Kasai, K., Kato, T., Kadota, Y., Erdenebayar, O., Keyama, K., Kawakita, T., Yoshida, K., Kuwahara, A., Matsuzaki, T., & Irahara, M.
- Affiliations
- Tokushima University (JP)
- ORCID
- Venue
- The Journal of Medical Investigation
- Published
- 2019-02-15
- Volume
- 66
- Issue
- 1.2
- Pages
- 123-127
- ISSN
- 1343-1420 (ISSN-L)
- 1349-6867
- OpenAlex
- W2941439294
- Cited by
- 9
- References
- 27
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- The Journal of Medical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Plant and fungal interactions
- Keywords
- activin A, endometriosis, endometriotic lesions, intraperitoneal administration, mouse model of endometriosis, interleukin-6, TNF-α, inflammatory cytokines, ascites, lesion progression
- MeSH terms
- Animals, Disease Models, Animal, Endometriosis, Female, Injections, Intraperitoneal, Mice, Inbred C57BL, Tumor Necrosis Factor-alpha, Interleukin-6, Activins, Mice
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