Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons
Abstract
The aim of this review was to assess critically the importance of the frequency, quantity and quality of retrograde menstruation and its relationship to peritoneal inflammation. The basis was the current evidence in women and in baboons supporting the Sampson hypothesis that retrograde menstruation is a key factor in the pathogenesis of endometriosis. It is not proven that retrograde menstruation is a universal phenomenon occurring similarly in women with and without endometriosis. A more thorough understanding of the physiological, cytological and immunological events in peritoneal fluid, peritoneum, endometrium and uterus during menstruation in women with and without endometriosis is critical in order to understand the pathogenesis of this enigmatic disease.
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Delay in diagnosis may have significant consequences in terms of disease progression.
“Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [13]
Endometriosis is more advanced in women whose diagnostic laparoscopy is delayed, supporting progression of disease over time.
“endometriosis is more advanced in women whose diagnostic laparoscopy is delayed, supporting progression of disease over time [13].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [13]
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- Authors
- D'Hooghe, T. M.
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-01-01
- Volume
- 8
- Issue
- 1
- Pages
- 84-88
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W2143537649
- Cited by
- 231
- References
- 45
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 17 · 2023: 13 · 2022: 8 · 2021: 8 · 2020: 12 · 2019: 14 · 2018: 1 · 2017: 9 · 2016: 15 · 2015: 9 · 2014: 15 · 2013: 19 · 2012: 13
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, retrograde menstruation, peritonitis, endometriosis pathogenesis, baboons, peritoneal fluid, menstrual physiology
- MeSH terms
- Animals, Disease Models, Animal, Endometriosis, Female, Humans, Menstruation Disturbances, Papio, Peritonitis, Prevalence
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