The DOI matches its Crossref record; 124 of the 125 references it cites were found in a registry or an index.
Adhesion Molecules in Inflammatory Diseases
Abstract
Cell adhesion molecules (CAM) have a key role in the inflammatory response. Selectins, integrins and immunoglobulin (Ig) gene superfamily adhesion receptors mediate the different steps of the migration of leucocytes from the blood-stream towards inflammatory foci. The activation of endothelial cells (EC) upregulates the expression of several CAM and triggers the interaction of these cells with leucocytes. Selectins are involved in the initial interactions (tethering/rolling) of leucocytes with activated endothelium, whereas integrins and Ig superfamily CAM mediate the firm adhesion of these cells and their subsequent extravasation. During rolling, leucocytes are activated through the intracellular signals generated by CAM and chemokine receptors. Blockade of the function or expression of CAM has emerged as a new therapeutic target in inflammatory diseases. Different drugs are able to interfere with cell adhesion phenomena. In addition, new antiadhesion therapeutic approaches (blocking monoclonal antibodies, soluble receptors, synthetic peptides, peptidomimetics, etc.) are currently in development.
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“EC dysfunction has been shown to strongly affect arterial stiffness via cellular adhesion molecules (CAMs), matrix metalloproteinases (MMPs) and collagen molecules (COLs)67–71.”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [71]
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Cites
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Sayed, N., Huang, Y., Nguyen, K., Krejciova-Rajaniemi, Z., Grawe, A. P., Gao, T., Tibshirani, R., Hastie, T., Alpert, A., Cui, L., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00082-y · Cited by 572
Decreased alveolar oxygen induces lung inflammation
Madjdpour, C., Jewell, U. R., Kneller, S., Ziegler, U., Schwendener, R. A., Booy, C., Kläusli, L., Pasch, T., Schimmer, R. C., & Beck‐Schimmer, B. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00158.2002 · Cited by 201
Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury
Beck‐Schimmer, B., Schwendener, R. A., Pasch, T., Reyes, L., Booy, C., & Schimmer, R. C. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-61 · Cited by 190
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Metadata
- Authors
- Gonz??lez-Amaro, R., D??az-Gonz??lez, F., & S??nchez-Madrid, F.
- Venue
- Drugs
- Published
- 1998
- Volume
- 56
- Issue
- 6
- Pages
- 977-988
- ISSN
- 0012-6667 (ISSN-L)
- OpenAlex
- W2106562180
- Cited by
- 98
- References
- 125
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 3 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drugs (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Keywords
- adhesion molecules, inflammation, selectins, integrins, immunoglobulin superfamily receptors, leukocyte migration, leukocyte-endothelium interaction, leukocyte rolling, leukocyte tethering, leukocyte transmigration, endothelial activation, chemokine receptors, anti-adhesion therapy, soluble receptor, peptidomimetics, monoclonal antibodies
- MeSH terms
- Anti-Inflammatory Agents, Cell Membrane, Humans, Inflammation, Leukocytes, Cell Adhesion Molecules, Up-Regulation, Receptors, Chemokine
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