Cited by 104Cell Adhesion Molecules ResearchChemokine receptors and signalingBiochemical and Structural Characterization

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Adhesion Molecules in Inflammatory Diseases

Gonz??lez-Amaro, Roberto, D??az-Gonz??lez, Federico, S??nchez-Madrid, Francisco·1998·Drugs

DOI 10.2165/00003495-199856060-00003

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Abstract

Cell adhesion molecules (CAM) have a key role in the inflammatory response. Selectins, integrins and immunoglobulin (Ig) gene superfamily adhesion receptors mediate the different steps of the migration of leucocytes from the blood-stream towards inflammatory foci. The activation of endothelial cells (EC) upregulates the expression of several CAM and triggers the interaction of these cells with leucocytes. Selectins are involved in the initial interactions (tethering/rolling) of leucocytes with activated endothelium, whereas integrins and Ig superfamily CAM mediate the firm adhesion of these cells and their subsequent extravasation. During rolling, leucocytes are activated through the intracellular signals generated by CAM and chemokine receptors. Blockade of the function or expression of CAM has emerged as a new therapeutic target in inflammatory diseases. Different drugs are able to interfere with cell adhesion phenomena. In addition, new antiadhesion therapeutic approaches (blocking monoclonal antibodies, soluble receptors, synthetic peptides, peptidomimetics, etc.) are currently in development.

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Authors: Gonz??lez-Amaro, R., D??az-Gonz??lez, F., & S??nchez-Madrid, F.
Venue: Drugs
Publisher: Springer Science and Business Media LLC
Published: 1998
Volume: 56
Issue: 6
Pages: 977-988
ISSN: 0012-6667 (ISSN-L)
DOI: 10.2165/00003495-199856060-00003
OpenAlex: W2106562180
Cited by: 98
References: 125
Citations by year: 2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 3 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 5
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Locations: Drugs (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
Keywords: adhesion molecules, inflammation, selectins, integrins, immunoglobulin superfamily receptors, leukocyte migration, leukocyte-endothelium interaction, leukocyte rolling, leukocyte tethering, leukocyte transmigration, endothelial activation, chemokine receptors, anti-adhesion therapy, soluble receptor, peptidomimetics, monoclonal antibodies
MeSH terms: Anti-Inflammatory Agents, Cell Membrane, Humans, Inflammation, Leukocytes, Cell Adhesion Molecules, Up-Regulation, Receptors, Chemokine

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Adhesion Molecules in Inflammatory Diseases

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