CoChat
Sign Up
Cited by 130Exercise and Physiological ResponsesCardiovascular and exercise physiologyCardiovascular Effects of Exercise

The DOI matches its Crossref record; 103 of the 105 references it cites were found in a registry or an index.

Ultra-Endurance Exercise and Oxidative Damage: Implications for Cardiovascular Health

Knez, Wade L, Coombes, Jeff S, Jenkins, David G·2006·Sports Medicine
DOI 10.2165/00007256-200636050-00005
Open this paper in CoChat — free account

Abstract

At least 30 minutes of moderate-intensity physical activity accumulated on most, preferably all days is considered the minimum level necessary to reduce the risk of developing cardiovascular disease. Despite an unclear explanation, some epidemiological data paradoxically suggest that a very high volume of exercise is associated with a decrease in cardiovascular health. Although ultra-endurance exercise training has been shown to increase antioxidant defences (and therefore confer a protective effect against oxidative stress), an increase in oxidative stress may contribute to the development of atherosclerosis via oxidative modification of low-density lipoprotein (LDL). Research has also shown that ultra-endurance exercise is associated with acute cardiac dysfunction and injury, and these may also be related to an increase in free radical production. Longitudinal studies are needed to assess whether antioxidant defences are adequate to prevent LDL oxidation that may occur as a result of increased free radical production during very high volumes of exercise. In addition, this work will assist in understanding the accrued effect of repeated ultra-endurance exercise-induced myocardial damage.

Overview

Integrity signals

Registry

Crossref · 10.2165/00007256-200636050-00005

Cites

103 of 103 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 105 references

Research works printed but not linked: 9

  1. Lee, 1995, JAMA, 273, 1179, 10.1001/jama.1995.03520390039030 · DOI
  2. Niess, 1999, Exerc Immunol Rev, 5, 22
  3. Parks, 1986, Acta Physiol Scand Suppl, 548, 87
  4. Bousquet, 1996, Exerc Immunol Rev, 2, 35
  5. Gabriel, 1999, Exerc Immunol Rev, 5, 96
  6. Camhi, 1995, New Horiz, 3, 170
  7. Paffenbarger, 1978, Am J Epidemiol, 108, 12
  8. Radak, 2001, Exerc Immunol Rev, 7, 90
  9. Jenkins, 1993, Med Sci Sports Exerc, 25, 213

Cited by

Sorted by citations

See all 130

Related

Metadata

Authors
Knez, W. L., Coombes, J. S., & Jenkins, D. G.
Affiliations
The University of Queensland (AU)
Corresponding author
Knez, Wade L
ORCID
Venue
Sports Medicine
Publisher
Springer Science and Business Media LLC
Published
2006
Volume
36
Issue
5
Pages
429-441
ISSN
0112-1642 (ISSN-L)
DOI
10.2165/00007256-200636050-00005
OpenAlex
W2157959523
Cited by
130
References
105
Citations by year
2026: 2 · 2025: 2 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 3 · 2018: 8 · 2017: 10 · 2016: 4 · 2015: 3 · 2014: 13 · 2013: 10 · 2012: 6
FWCI
1.04
Type
journal article
Language
en
Open access
closed
Locations
  • Sports Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords
ultra-endurance exercise, oxidative stress, antioxidant defense, free radicals, LDL oxidation, atherosclerosis, exercise-induced myocardial injury, cardiovascular risk, exercise volume
MeSH terms
Antioxidants, Cardiovascular System, Energy Metabolism, Physical Exertion, Humans, Cholesterol, LDL, Physical Endurance, Physical Fitness, Queensland, Exercise, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review