Cited by 130Exercise and Physiological ResponsesCardiovascular and exercise physiologyCardiovascular Effects of Exercise

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Ultra-Endurance Exercise and Oxidative Damage: Implications for Cardiovascular Health

Knez, Wade L, Coombes, Jeff S, Jenkins, David G·2006·Sports Medicine

DOI 10.2165/00007256-200636050-00005

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Abstract

At least 30 minutes of moderate-intensity physical activity accumulated on most, preferably all days is considered the minimum level necessary to reduce the risk of developing cardiovascular disease. Despite an unclear explanation, some epidemiological data paradoxically suggest that a very high volume of exercise is associated with a decrease in cardiovascular health. Although ultra-endurance exercise training has been shown to increase antioxidant defences (and therefore confer a protective effect against oxidative stress), an increase in oxidative stress may contribute to the development of atherosclerosis via oxidative modification of low-density lipoprotein (LDL). Research has also shown that ultra-endurance exercise is associated with acute cardiac dysfunction and injury, and these may also be related to an increase in free radical production. Longitudinal studies are needed to assess whether antioxidant defences are adequate to prevent LDL oxidation that may occur as a result of increased free radical production during very high volumes of exercise. In addition, this work will assist in understanding the accrued effect of repeated ultra-endurance exercise-induced myocardial damage.

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Authors: Knez, W. L., Coombes, J. S., & Jenkins, D. G.
Affiliations: The University of Queensland (AU)
Corresponding author: Knez, Wade L
ORCID: Coombes, Jeff S
Jenkins, David G
Venue: Sports Medicine
Publisher: Springer Science and Business Media LLC
Published: 2006
Volume: 36
Issue: 5
Pages: 429-441
ISSN: 0112-1642 (ISSN-L)
DOI: 10.2165/00007256-200636050-00005
OpenAlex: W2157959523
Cited by: 130
References: 105
Citations by year: 2026: 2 · 2025: 2 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 3 · 2018: 8 · 2017: 10 · 2016: 4 · 2015: 3 · 2014: 13 · 2013: 10 · 2012: 6
FWCI: 1.04
Type: journal article
Language: en
Open access: closed
Locations: Sports Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
Keywords: ultra-endurance exercise, oxidative stress, antioxidant defense, free radicals, LDL oxidation, atherosclerosis, exercise-induced myocardial injury, cardiovascular risk, exercise volume
MeSH terms: Antioxidants, Cardiovascular System, Energy Metabolism, Physical Exertion, Humans, Cholesterol, LDL, Physical Endurance, Physical Fitness, Queensland, Exercise, Oxidative Stress

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Ultra-Endurance Exercise and Oxidative Damage: Implications for Cardiovascular Health

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