Follow-up lipid tests and physician visits are associated with improved adherence to statin therapy
Abstract
Introduction and objective The National Cholesterol Education Program recommends regular physician follow-up and lipid testing to promote adherence with lipid-lowering medications. The objective of this study was to determine whether lipid tests and physician visits after treatment initiation are indeed associated with adherence to statin therapy.Subjects and methods A retrospective cohort study was conducted among 19 422 enrolees in a US managed care plan who initiated treatment with a statin between October 1999 and August 2001. Computerised pharmacy, medical and laboratory records were used to study the patterns and predictors of adherence with lipid-lowering therapy for up to 3 years. Adherence was assessed in 3-month intervals with patients considered 'adherent' if > or = 80% of days were covered by lipid-lowering therapy.Results In the first 3 months, 40% of patients had follow-up lipid tests and only 21% had dyslipidaemia visits (14% had both). Those receiving such care were substantially more likely to be adherent in subsequent intervals. Compared with those without follow-up, the relative odds of adherence were 1.42 and 1.27 for patients with one or more lipid test and one or more dyslipidaemia visit, respectively (95% confidence intervals [CI] 1.33, 1.50 and 1.16, 1.39). Patients who received a follow-up visit and lipid test were 45% more likely to be adherent (95% CI 1.34, 1.55). Similar associations were observed when lipid tests and dyslipidaemia visits occurred later in therapy.Conclusion Early and frequent follow-up by physicians--especially lipid testing--was associated with improved adherence to lipid-lowering therapy. A randomised prospective study is needed to determine whether this relationship is causal.
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Adherence to medication decreases as the number of doses per day increases.
“It is known that the adherence to medication decreases when the number of daily doses increases725, 726).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [726]
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- Authors
- Benner, J. S., Tierce, J. C., Ballantyne, C. M., Prasad, C., Bullano, M. F., Willey, V. J., Erbey, J., & Sugano, D. S.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Benner, Joshua S.
- Venue
- PharmacoEconomics
- Published
- 2004-11
- Volume
- 22
- Issue
- S3
- Pages
- 13-23
- ISSN
- 1170-7690 (ISSN-L)
- 1179-2027
- OpenAlex
- W2058622522
- Cited by
- 115
- References
- 37
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 8 · 2012: 5
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PharmacoEconomics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
- Keywords
- statin therapy, medication adherence, lipid testing, dyslipidemia, lipid-lowering therapy, managed care, National Cholesterol Education Program, secondary prevention
- MeSH terms
- Adolescent, Adult, Aged, Coronary Disease, Female, Humans, Hyperlipidemias, Lipids, Male, Middle Aged, Patient Compliance, Physician-Patient Relations, Practice Patterns, Physicians', Retrospective Studies, Risk Factors, Time Factors, United States, Cohort Studies, Multivariate Analysis, Hydroxymethylglutaryl-CoA Reductase Inhibitors
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