The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Combination Therapy in Alzheimer???s Disease: A Review of Current Evidence
Abstract
Treating dementia has become a major challenge in clinical practice. Presently, acetylcholinesterase inhibitors are the first-line drugs in the treatment of Alzheimer's disease (AD). These options are now complemented by memantine, which is approved for the treatment of moderate-to-severe AD. Altogether, a minimum of six agent classes already exist, all of which are approved for clinical use and are either already being tested or ready for phase III clinical trials for the treatment of AD. These include cholinesterase inhibitors, blockers of the NMDA receptor, antioxidants or blockers of oxidative deamination (including Gingko biloba), anti-inflammatory agents, neurotrophic factors (including hormone replacement therapy and drugs acting on insulin signal transduction) and antiamyloid agents (including cholesterol-lowering therapy). These approaches hold promise for disease modification and have a potential to be used as combination therapy for cognitive enhancement. Presently, only nine clinical studies have been published that have investigated the effects of a combination regimen on cognitive performance or AD. Among those, one study was conducted in elderly cognitively intact persons; the others involved patients with AD. Only five of the treatment studies followed a randomised, controlled design. Not all studies favoured the superior efficacy of combination therapy over monotherapy. Some studies, however, showed some evidence for synergistic combination effects of symptomatic therapy, including delay or prevention of disease progression in AD patients. In addition, six studies investigated the effects of AChE inhibitor in combination with antipsychotic or antidepressant therapy on behavioural aspects of AD symptomatology. In four of those studies there were indications that combination therapy had greater efficacy over monotherapy. The treatment of AD patients requires optimised options for all stages of illness based on the available drugs. There is a great need for further well designed studies on combination therapy in AD.
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“It should be noted that AChE inhibitors could be part of any combination therapy against AD [100].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [100]
In the citing paper
“Antioxidants such as tocopherol, selegiline, and ascorbic acid (vitamin C) were examined as a possible preventive therapy for AD, and they show delayed functional deterioration in AD patients [100].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [100]
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1 retracted
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Cited by
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Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
Cavalli, A., Bolognesi, M. L., Minarini, A., Rosini, M., Tumiatti, V., Recanatini, M., & Melchiorre, C. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm7009364 · Cited by 1,152
Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review
El-Saber Batiha, G., Magdy Beshbishy, A., G. Wasef, L., Elewa, Y. H. A., A. Al-Sagan, A., Abd El-Hack, M. E., Taha, A. E., M. Abd-Elhakim, Y., & Prasad Devkota, H. (2020) · Nutrients · doi:10.3390/nu12030872 · Cited by 931
Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Chougule, M. B., Shoyele, S. A., & Alexander, A. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.011 · Cited by 630
The Alzheimer’s Disease Clinical Spectrum
Atri, A. (2019) · Medical Clinics of North America · doi:10.1016/j.mcna.2018.10.009 · Cited by 623
Treatment Combinations for Alzheimer’s Disease: Current and Future Pharmacotherapy Options
Cummings, J. L., Tong, G., & Ballard, C. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-180766 · Cited by 588
Metadata
- Authors
- Schmitt, B., Bernhardt, T., Moeller, H.-J., Heuser, I., & Fr??lich, L.
- Affiliations
- Heidelberg University (DE)
- Ludwig-Maximilians-Universität München (DE)
- Humboldt-Universität zu Berlin (DE)
- ORCID
- Heuser, Isabella
- Venue
- CNS Drugs
- Published
- 2004
- Volume
- 18
- Issue
- 13
- Pages
- 827-844
- ISSN
- 1172-7047 (ISSN-L)
- OpenAlex
- W2135793938
- Cited by
- 182
- References
- 130
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 11 · 2022: 5 · 2021: 9 · 2020: 10 · 2019: 18 · 2018: 15 · 2017: 9 · 2016: 9 · 2015: 11 · 2014: 15 · 2013: 5 · 2012: 12
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- CNS Drugs (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, combination therapy, acetylcholinesterase inhibitors, memantine, NMDA receptor antagonists, antioxidants, Ginkgo biloba, anti-inflammatory agents, neurotrophic factors, hormone replacement therapy, insulin signaling, cholesterol-lowering therapy, disease modification, cognitive enhancement, behavioural symptoms, dementia treatment
- MeSH terms
- Alzheimer Disease, Animals, Anti-Inflammatory Agents, Antioxidants, Cholinesterase Inhibitors, Cognition, Combined Modality Therapy, Drug Therapy, Combination, Female, Humans, Male, Estrogen Replacement Therapy
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