Pharmacokinetics of sulfamethoxazole with its hydroxy metabolites and N4-acetyl-, N1-glucuronide conjugates in healthy human volunteers
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NA-SMX accounts for approximately 44% of renally excreted metabolites, while parent SMX constitutes about 14% of drug-related material, and SMX-HA accounts for roughly 2% of urinary metabolites.
“NA-SMX accounts for approximately 44% of renally excreted metabolites, while the parent SMX constitutes about 14% of drug-related material, and SMX-HA accounts for roughly 2% of urinary metabolites.21,22”
From N-Acetyltransferase (NAT) 1 and NAT2 Enzyme Activities Drive Interindividual Variability in Sulfamethoxazole N-Acetylation (2025) · cites this paper as [22]
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Simultaneous determination of five antibiotics in urban wastewater using SPE-HPLC-MS/MS
Kosunen, P. H. (2015) · Jyväskylä University Digital Archive (University of Jyväskylä)
- Authors
- Vree, T. B., van der Ven, A. J. A. M., Koopmans, P. P., van Ewijk-Beneken Kolmer, E. W. J., & Verwey-van Wissen, C. P. W. G. M.
- Venue
- Clinical Drug Investigation
- Published
- 1995-01
- Volume
- 9
- Issue
- 1
- Pages
- 43-53
- ISSN
- 0114-2402 (ISSN-L)
- 1173-2563
- OpenAlex
- W2011053266
- Cited by
- 18
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2012: 1
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Clinical Drug Investigation (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
- Keywords
- sulfamethoxazole, pharmacokinetics, hydroxy metabolites, protein binding, renal clearance, urinary excretion, drug metabolism
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