Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.

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Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity

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Studies on Calcium Dependence Reveal Multiple Modes of Action for Triptolide

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Triptolide Inhibits IL-12/IL-23 Expression in APCs via CCAAT/Enhancer-Binding Protein α

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Meta-Analysis of Tripterygium Wilfordii Hook F in the Immunosuppressive Treatment of IgA Nephropathy

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Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles

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Role of Triptolide as an Adjunct Chemotherapy for Ovarian Cancer

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Triptolide protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats: Implication for immunosuppressive therapy in Parkinson’s disease

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Alternative treatment strategies for neuropathic pain: Role of Indian medicinal plants and compounds of plant origin-A review

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Honeybee (Apis cerana) Foraging Responses to the Toxic Honey of Tripterygium hypoglaucum (Celastraceae): Changing Threshold of Nectar Acceptability

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Combination Therapy with Resveratrol and Celastrol Using Folic Acid‐Functionalized Exosomes Enhances the Therapeutic Efficacy of Sepsis

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Triptolide reverses the Taxol resistance of lung adenocarcinoma by inhibiting the NF-κB signaling pathway and the expression of NF-κB-regulated drug-resistant genes

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Triptolide-induced in vitro and in vivo cytotoxicity in human breast cancer stem cells and primary breast cancer cells

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N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury

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Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase

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Larvicidal, super hydrophobic and antibacterial properties of herbal nanoparticles from Acalypha indica for biomedical applications

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Triptolide-loaded nanoparticles targeting breast cancer in vivo with reduced toxicity

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Triptolide induces apoptosis of PMA-treated THP-1 cells through activation of caspases, inhibition of NF-κB and activation of MAPKs

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Triptolide Attenuates Endotoxin- and Staphylococcal Exotoxin-Induced T-Cell Proliferation and Production of Cytokines and Chemokines

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Tumor necrosis factor-? blocking agent as a treatment for nephrotic syndrome

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Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-κB signaling pathway

Yu, C., Shan, T., Feng, A., Li, Y., Zhu, W., Xie, Y., Li, N., & Li, J. (2011) · Fitoterapia · doi:10.1016/j.fitote.2011.02.011 · Cited by 39

(5R)-5-Hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation

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Dendritic cells as a pharmacological target of traditional Chinese medicine.

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Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Molecular Mechanism of Triptolide in the Treatment of Membranous Nephropathy

Zhang, P., Tang, J. Y., Yang, K., Zheng, Q. Y., Dong, Z. C., Geng, Y., Liu, Y., & Liu, W. J. (2022) · Drug Design Development and Therapy · doi:10.2147/dddt.s386031 · Cited by 37

Isolation and insecticidal activity of sesquiterpenes alkaloids from Tripterygium wilfordii Hook f.

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Triptolide attenuate the oxidative stress induced by LPS/D‐GalN in mice

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Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B

Wang, L., Zhang, L., Hou, Q., Zhu, X., Chen, Z., & Liu, Z. (2018) · Scientific Reports · doi:10.1038/s41598-018-29203-1 · Cited by 36

The effect of triptolide on CD4+ and CD8+ cells in Peyer's patch of SD rats with collagen induced arthritis

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Triptolide induces lysosomal-mediated programmed cell death in MCF-7 breast cancer cells

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The Effect of Triptolide on Apoptosis of Glioblastoma Multiforme (GBM) Cells

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Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation

Liu, Y., Chen, Y., Liu, F. Q., Lamb, J. R., & Tam, P. K. H. (2008) · Transplant International · doi:10.1111/j.1432-2277.2007.00630.x · Cited by 35

Herbal medicine in oral lichen planus

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Triptolide Synergistically Enhances Antitumor Activity of Oxaliplatin in Colon Carcinoma In Vitro and In Vivo

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(5 R)-5-Hydroxytriptolide Attenuated Collagen-Induced Arthritis in DBA/1 Mice via Suppressing Interferon-γ Production and Its Related Signaling

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Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells

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Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy

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Elevated serum IL-35 levels in rheumatoid arthritis are associated with disease activity

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Pharmacological Potential of Small Molecules for Treating Corneal Neovascularization

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Macropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer

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Triptolide prevents and attenuates neuropathic pain via inhibiting central immune response.

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The safe usage of herbal medicines: counterindications, cross-reactivity and toxicity

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Molecular Imaging in Traditional Chinese Medicine Therapy for Neurological Diseases

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Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells1

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Tripterygium wilfordii Inhibiting Angiogenesis for Rheumatoid Arthritis Treatment

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Network Pharmacology Integration and Experimental Verification to Elucidate the Molecular Mechanisms of Triptolide in Treating Membranous Nephropathy

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Novel nitric oxide-releasing derivatives of triptolide as antitumor and anti-inflammatory agents: Design, synthesis, biological evaluation, and nitric oxide release studies

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Geranylated Flavonoids from the Roots of Campylotropis hirtella and Their Immunosuppressive Activities

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Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells

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Triptolide potentiates lung cancer cells to cisplatin-induced apoptosis by selectively inhibiting the NER activity

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Novel Anti-Inflammatory and Neuroprotective Agents for Parkinsons Disease

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Complete Freund’s adjuvant–induced acute inflammatory pain could be attenuated by triptolide via inhibiting spinal glia activation in rats

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Triptolide, a Component of Chinese Herbal Medicine, Modulates the Functional Phenotype of Dendritic Cells

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Triptolide-Mediated Inhibition of Interferon Signaling Enhances Vesicular Stomatitis Virus-Based Oncolysis

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Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis

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Insights into emerging mechanisms of ferroptosis: new regulators for cancer therapeutics

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Inflammation aggravated the hepatotoxicity of triptolide by oxidative stress, lipid metabolism disorder, autophagy, and apoptosis in zebrafish

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The Pharmacological Effects and Mechanism of Tripterygium wilfordii Hook F in Central Nervous System Autoimmunity

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Triptolide inhibits donor-specific antibody production and attenuates mixed antibody-mediated renal allograft injury

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Triptonide inhibits the pathological functions of gastric cancer-associated fibroblasts

Wang, Z., Ma, D., Wang, C., Zhu, Z., Yang, Y.-Y., Zeng, F., Yuan, J., Liu, X., Gao, Y., Chen, Y., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.046 · Cited by 27

Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production

Wu, C.-X., Xia, Y., Wang, P., Lu, L., & Zhang, F. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.05.015 · Cited by 27

A renal-targeted triptolide aminoglycoside (TPAG) conjugate for lowering systemic toxicities of triptolide

Qi, B., Wang, X., Zhou, Y., Han, Q., He, L. T., Gong, T., Sun, X., Fu, Y. S., & Zhang, Z. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.04.008 · Cited by 27

Glycyrrhetinic Acid Accelerates the Clearance of Triptolide through P‐gp In Vitro

Li, Z., Yan, M., Cao, L.-J., Fang, P., Guo, Z., Hou, Z., & Zhang, B. (2017) · Phytotherapy Research · doi:10.1002/ptr.5831 · Cited by 27

Activity of triptolide against human mast cells harboring the kinase domain mutant KIT

Jin, Y., Chen, Q., Shi, X., Lu, Z., Cheng, C., Lai, Y., Zheng, Q., & Pan, J. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01159.x · Cited by 27

Intrathecal administration of triptolide, a T lymphocyte inhibitor, attenuates chronic constriction injury-induced neuropathic pain in rats

Hu, J., Li, C., & Wang, Y. (2011) · Brain Research · doi:10.1016/j.brainres.2011.11.051 · Cited by 26

Effect of Triptolide on T‐Cell Receptor Beta Variable Gene mRNA Expression in Rats With Collagen‐Induced Arthritis

Wang, J., Wang, A., Zeng, H., Liu, L., Jiang, W., Zhu, Y., & Xu, Y. (2012) · The Anatomical Record · doi:10.1002/ar.22479 · Cited by 26

Triptolide derivatives as potential multifunctional anti-Alzheimer agents: Synthesis and structure–activity relationship studies

Ning, C., Mo, L., Chen, X., Tu, W., Wu, J., Hou, S., & Xu, J. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.01.019 · Cited by 26

Plasma miR-126 expression correlates with risk and severity of psoriasis and its high level at baseline predicts worse response to Tripterygium wilfordii Hook F in combination with acitretin

Duan, Y., Zou, J., Mao, J., Guo, D., Wu, M., Xu, N., Zhou, J., Zhang, Y., Guo, W., & Jin, W. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108761 · Cited by 25

Alternative therapies: what role do they have in the management of lupus?

Chou, C.-T. (2010) · Lupus · doi:10.1177/0961203310379872 · Cited by 25

Therapeutic effects of triptolide on interleukin-10 gene-deficient mice with colitis

Wei, X., Gong, J., Zhu, J., Niu, L., Zhu, W., Li, N., & Li, J. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.08.019 · Cited by 25

The effectiveness of treatments for patients with SAPHO syndrome: a follow-up study of 24 cases from a single center and review of literature

Huang, H., Zhang, Z., Zhao, J., Hao, Y., & Zhou, W. (2020) · Clinical Rheumatology · doi:10.1007/s10067-020-05322-x · Cited by 25

Triptolide mitigates radiation-induced pneumonitis via inhibition of alveolar macrophages and related inflammatory molecules

Chen, C., Yang, S., Zhang, M., Zhang, Z., Zhang, S. B., Wu, B., Hong, J., Zhang, W., Lin, J., Okunieff, P., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16456 · Cited by 24

Comparison of protective effect of ordinary Cordyceps militaris and selenium-enriched Cordyceps militaris on triptolide-induced acute hepatotoxicity and the potential mechanisms

Wang, L., Huang, Q., Huang, Y., Xie, J., Qu, C. F., Chen, J., Zheng, L., Yi, T., Zeng, H., & Li, H.-L. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.05.016 · Cited by 23

Inflammatory setting, therapeutic strategies targeting some pro-inflammatory cytokines and pathways in mitigating ischemia/reperfusion-induced hepatic injury: a comprehensive review

Aboelez, M. O., Ezelarab, H. A. A., Alotaibi, G., & Abouzed, D. E. E. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03074-y · Cited by 24

Inhibitory effects of Triptolide on interferon‐γ‐induced human leucocyte antigen‐DR, intercellular adhesion molecule‐1, CD40 expression on retro‐ocular fibroblasts derived from patients with Graves’ ophthalmopathy

Yan, S., & Wang, Y. (2006) · Clinical and Experimental Ophthalmology · doi:10.1111/j.1442-9071.2006.01190.x · Cited by 24

Triptolide blocks the STAT3 signaling pathway through induction of protein tyrosine phosphatase SHP-1 in multiple myeloma cells

Kim, J.-H., & Park, B. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3122 · Cited by 23

Therapeutic applications and delivery systems for triptolide

Viegas, J. S. R., Praça, F. S. G., Kravicz, M., & Bentley, M. V. L. B. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00827-z · Cited by 23

T2 enhances in situ level of Foxp3+ regulatory cells and modulates inflammatory cytokines in Crohn's disease

Li, G., Ren, J., Wang, G., Gu, G., Hu, D., Ren, H., Hong, Z., Wu, X., Liu, S., & Li, J. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.12.014 · Cited by 23

Evaluation of the efficacy and safety of different Tripterygium preparations on collagen-induced arthritis in rats

Zhu, X., Zhang, J., Huo, R., Lin, J., Zhou, Z., Sun, Y., Wu, P., Li, H., Zhai, T., Shen, B., et al. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.10.021 · Cited by 23

The Application of Exosomes From Different Sources Loaded with Natural Small-Molecule Compounds in Disease

Zhang, L., Shi, C., Lan, Y., Zhang, X., Ji, X., Li, L., He, X., Tan, Y., Zhao, N., & Lu, C. C. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s542641 · Cited by 28

The Role of Natural Products in the Prevention and Treatment of Multiple Sclerosis

Shamsizadeh, A., Roohbakhsh, A., Ayoobi, F., & Moghaddam-Ahmadi, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805298-3.00025-6 · Cited by 22

New Therapeutic Horizon of Graves’ Hyperthyroidism: Treatment Regimens Based on Immunology and Ingredients From Traditional Chinese Medicine

He, Q., Dong, H., Gong, M., Guo, Y., Xia, Q., Gong, J., & Lu, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.862831 · Cited by 23

A systematic review of potential candidates of herbal medicine in treatment of chronic kidney disease

Borkar, P., Yadav, V., Tiwari, R., & Samarth, R. M. (2022) · Phytomedicine Plus · doi:10.1016/j.phyplu.2022.100361 · Cited by 23

Inhibitory effects of triptolide on titanium particle-induced osteolysis and receptor activator of nuclear factor-κB ligand-mediated osteoclast differentiation

Kim, J. A., Ihn, H. J., Park, J. Y., Lim, J., Hong, J. M., Kim, S. H., Kim, S., Shin, H., & Park, E. K. (2014) · International Orthopaedics · doi:10.1007/s00264-014-2596-3 · Cited by 22

Metabolite profiling and identification of triptolide in rats

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How useful is traditional herbal medicine for pulmonary fibrosis?

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