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The Genetics of Artemisinin Content in Artemisia annua L. and the Breeding of High Yielding Cultivars
Abstract
Artemisinin, the endoperoxide sesquiterpene lactone produced by the Chinese medicinal herb Artemisia annua, is very difficult to synthesise. Moreover, its production by mean of cell, tissue or organ cultures is very low. Presently, only its extraction from cultivated plants is viable. A large variation in artemisinin content has been observed in the leaves of plants from different origins. The genetic basis of this variation has been assessed and evidence for a quantitative inheritance of the artemisinin concentration presented. Additive genetic components were predominant, resulting in a high narrow-sense heritability estimate. Thus, goods results can be expected from mass selection for the breeding of lines of Artemisia annua rich in artemisinin. Yet, dominance variance is also present in the total genetic variability, indicating that crosses between selected genotypes should generate progenies with particularly high artemisinin content. As a matter of fact, selection and crossing, in wild populations, of genotypes with high artemisinin concentration resulted in hybrid lines containing up to 1.4 % artemisinin (on dry leaves basis).
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“Due to the heterozygous nature of A. annua , however, not all published plant lines are stable over generations; even the transgenic varieties developed in the same laboratory have varying artemisinin content (Delabays et al. 2001).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Delabays et al. 2001
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Sesquiterpenoids Lactones: Benefits to Plants and People
Chadwick, M., Trewin, H., Gawthrop, F., & Wagstaff, C. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140612780 · Cited by 698
“[83] found it was stored in the highest levels in the upper leaves.”
Green extraction of natural products. Origins, current status, and future challenges
Chemat, F., Vian, M. A., Fabiano‐Tixier, A., Strube, J., Uhlenbrock, L., Gunjević, V., & Cravotto, G. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.05.037 · Cited by 652
Bringing medicinal plants into cultivation: opportunities and challenges for biotechnology
Canter, P. H., Thomas, H., & Ernst, E. K. (2005) · Trends in biotechnology · doi:10.1016/j.tibtech.2005.02.002 · Cited by 550
Graham, I. A., Besser, K., Blumer, S., Branigan, C. A., Czechowski, T., Elias, L., Guterman, I., Harvey, D., Isaac, P. G., Khan, A. M., et al. (2010) · Science · doi:10.1126/science.1182612 · Cited by 348
Efferth, T. (2007) · Planta Medica · doi:10.1055/s-2007-967138 · Cited by 275
Metadata
- Authors
- Delabays, N., Simonnet, X., & Gaudin, M.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2001-12-01
- Volume
- 8
- Issue
- 15
- Pages
- 1795-1801
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2134009021
- Cited by
- 178
- References
- 0
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 5 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 9 · 2018: 14 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 10 · 2013: 17 · 2012: 10
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetics and Plant Breeding
- Physical Sciences › Chemistry › Organic Chemistry › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- artemisinin, Artemisia annua, artemisinin content, polygenic inheritance, narrow-sense heritability, additive genetic variance, dominance variance, mass selection, plant breeding, high-yielding varieties, genetic variation, hybrid lines
- MeSH terms
- Antimalarials, Cloning, Molecular, Crosses, Genetic, Sesquiterpenes, Artemisia, Artemisinins
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