Advanced preclinical and clinical trials of natural products and related compounds from marine sources
Abstract
The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in anti-tumor, anti-inflammatory, analgesia, immuno-modulation, allergy and anti-viral assays. Although the case can and has been made that the nucleosides such as Ara-A and Ara-C are derived from knowledge gained from investigations of bioactive marine nucleosides, no drug directly from marine sources (whether isolated or by total synthesis) has yet made it to the commercial sector in any human disease. However, as shown in this review, there are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase III clinical trials in cancer, analgesia and allergy, with a very substantial number of other, quite different potential agents following in their wake, in these and in other diseases.
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The bio-active molecules impact has been evaluated against various cancer types in clinical trials.
“The bio-active molecules impact has been evaluated against various cancer types in clinical trials [41,42,43,44,45].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [44]
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The Possibility of an Infectious Etiology of Alzheimer Disease
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- Authors
- Newman, D. J., & Cragg, G. M.
- Affiliations
- Frederick National Laboratory for Cancer Research (US)
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2004-07-01
- Volume
- 11
- Issue
- 13
- Pages
- 1693-1713
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W1975604260
- Cited by
- 161
- References
- 0
- Citations by year
- 2024: 7 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 9 · 2016: 4 · 2015: 4 · 2014: 14 · 2013: 7 · 2012: 14
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
- Keywords
- marine natural products, marine-derived drugs, anticancer agents, anti-inflammatory agents, analgesics, allergy, antiviral agents, immunomodulation, nucleosides, ara-A, cytarabine, clinical trials, drug development
- MeSH terms
- Alzheimer Disease, Amino Acid Sequence, Anti-Inflammatory Agents, Antineoplastic Agents, Biological Products, Clinical Trials as Topic, DNA Polymerase I, Drug Evaluation, Preclinical, Humans, Molecular Sequence Data, Nucleosides, Seawater, Clinical Trials, Phase III as Topic
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