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Privileged Structures as Leads in Medicinal Chemistry
Abstract
Among the strategies that can lead to the discovery of new drugs, the identification and use of privileged structures, molecular fragments that are able to interact with more than one target, gained particular attention, in an attempt to find new drugs in a shorter time with respect to other strategies. These structures, that have been identified mainly by empirical observations, can target only a given protein family, or can be able to interact with more, unrelated targets. This review deals with structures not covered in recent papers on this topic, and emphasizes the importance of understanding the structure-target relationships, that confer the privileged status. Keywords: Privileged structures, drug discovery, carbohydrates, benzodiazepines, biphenyls, pyrrolinones
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Citations
Cited by
Natural products as sources of new drugs over the last 25 years
Newman, D. J., & Cragg, G. M. (2007) · Journal of Natural Products · doi:10.1021/np068054v · Cited by 5,517
Natural products as sources of new drugs over the 30 years from 1981 to 2010
Newman, D. J., & Cragg, G. M. (2012) · Journal of Natural Products · doi:10.1021/np200906s · Cited by 4,687
Privileged scaffolds for library design and drug discovery
Welsch, M. E., Snyder, S. A., & Stockwell, B. R. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.02.018 · Cited by 1,509
A Dual Lewis Base Activation Strategy for Enantioselective Carbene-Catalyzed Annulations
Izquierdo, J., Orue, A., & Scheidt, K. A. (2013) · Journal of the American Chemical Society · doi:10.1021/ja405833m · Cited by 332
Metadata
- Authors
- Costantino, L., & Barlocco, D.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2006-01-01
- Volume
- 13
- Issue
- 1
- Pages
- 65-85
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W4248232688
- Cited by
- 330
- References
- 0
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- closed
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