Cited by 213Advanced Glycation End Products researchPotato Plant ResearchGlycosylation and Glycoproteins Research

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The Road to Advanced Glycation End Products: A Mechanistic Perspective

Cho, S.-J., Roman, G., Yeboah, F., Konishi, Y.·2007·Current Medicinal Chemistry

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Abstract

Protein glycation is a slow natural process involving the chemical modification of the reactive amino and guanidine functions in amino acids by sugars and carbohydrates-derived reactive carbonyls. Its deleterious consequences are obvious in the case of long-lived proteins in aged people and are exacerbated by the high blood concentration of sugars in diabetic patients. The non-enzymatic glycation of proteins occurs through a wide range of concurrent processes comprising condensation, rearrangement, fragmentation, and oxidation reactions. Using a few well established intermediates such as Schiff base, Amadori product and reactive a-dicarbonyls as milestones and the results of in vitro glycation investigations, an overall detailed mechanistic analysis of protein glycation is presented for the first time. The pathways leading to several advanced glycation end products (AGEs) such as (carboxymethyl)lysine, pentosidine, and glucosepane are outlined, whereas other AGEs useful as potential biomarkers of glycation are only briefly mentioned. The current stage of the development of glycation inhibitors has been reviewed with an emphasis on their mechanism of action.

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Authors: Cho, S.-J., Roman, G., Yeboah, F., & Konishi, Y.
Affiliations: Biotechnology Research Institute (CA)
Corresponding author: Konishi, Y.
ORCID: Roman, G.
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2007-06-01
Volume: 14
Issue: 15
Pages: 1653-1671
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/092986707780830989
OpenAlex: W2112698509
Cited by: 213
References: 0
Citations by year: 2026: 4 · 2025: 15 · 2024: 13 · 2023: 21 · 2022: 13 · 2021: 16 · 2020: 6 · 2019: 12 · 2018: 10 · 2017: 11 · 2016: 17 · 2015: 5 · 2014: 7 · 2013: 16 · 2012: 14
FWCI: 5.06
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
NPARC (submittedVersion)
Funders: Diabetes Action Research and Education Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Keywords: advanced glycation end products, protein glycation, glycation, Schiff base, Amadori products, α-dicarbonyl compounds, carboxymethyllysine, pentosidine, glucosepane, glycation inhibitors, diabetes mellitus, aging, reactive carbonyl compounds
MeSH terms: Animals, Arabinose, Glucose, Humans, Proteins, Glycation End Products, Advanced, Oxidative Stress

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The Road to Advanced Glycation End Products: A Mechanistic Perspective

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