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Cited by 162Advanced Glycation End Products researchPotato Plant ResearchGenetics, Aging, and Longevity in Model Organisms

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Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology

Nedić, O., Rattan, S. I. S., Grune, T., Trougakos, I. P.·2013·Free Radical Research
DOI 10.3109/10715762.2013.806798
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Abstract

Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the Maillard chemical process of non- enzymatic glycation of free amino groups of proteins, lipids and nucleic acids. This chemical modification of biomolecules is triggered by endogeneous hyperglycaemic or oxidative stress-related processes. Additionally, AGEs can derive from exogenous, mostly diet-related, sources. Considering that AGE accumulation in tissues correlates with ageing and is a hallmark in several age-related diseases it is not surprising that the role of AGEs in ageing and pathology has become increasingly evident. The receptor for AGEs (RAGE) is a single transmembrane protein being expressed in a wide variety of human cells. RAGE binds a broad repertoire of extracellular ligands and mediates responses to stress conditions by activating multiple signal transduction pathways being mostly responsible for acute and/or chronic inflammation. RAGE activation has been implicated in ageing as well as in a number of age-related diseases, including atherosclerosis, neurodegeneration, arthritis, stoke, diabetes and cancer. Here we present a synopsis of findings that relate to AGEs-reported implication in cell signalling pathways and ageing, as well as in pathology. Potential implications and opportunities for translational research and the development of new therapies are also discussed.

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  • A major difficulty in detection of glycoxidation products for standardized clinical research is their structural complexity and heterogeneity, deriving from various formation mechanisms.

    “One major difficulty in detection of glycoxidation products for standardized clinical research is their structural complexity and heterogeneity, deriving from various formation mechanisms [154,155].”

    From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [155]

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Research works printed but not linked: 127

  1. Ulrich P, 2001, Recent Prog Horm Res, 56, 1, 10.1210/rp.56.1.1 · DOI
  2. Takeuchi M, 2009, J. Alzheimers Dis, 16, 845, 10.3233/JAD-2009-0974 · DOI
  3. Uribarri J, 2005, Ann N Y Acad Sci, 1043, 461, 10.1196/annals.1333.052 · DOI
  4. Semba RD, 2012, Eur J Clin Nutr, 66, 3, 10.1038/ejcn.2011.139 · DOI
  5. Hipkiss AR, 2012, Biogerontology, 13, 633, 10.1007/s10522-012-9401-8 · DOI
  6. Bryland A, 2010, Intensive Care Med, 36, 1213, 10.1007/s00134-010-1873-x · DOI
  7. Schmidt AM, 1992, J Biol Chem., 267, 14987, 10.1016/S0021-9258(18)42137-0 · DOI
  8. Basta G, 2008, Atherosclerosis, 196, 9, 10.1016/j.atherosclerosis.2007.07.025 · DOI
  9. Sparvero LJ, 2009, J Translat Med, 7, 17, 10.1186/1479-5876-7-17 · DOI
  10. Riehl A, 2009, Cell Commun Signal, 7, 12, 10.1186/1478-811X-7-12 · DOI
  11. Li J, 1997, J Biol Chem, 272, 16498, 10.1074/jbc.272.26.16498 · DOI · Paper page
  12. Brett J, 1993, Am J Pathol, 143, 1699
  13. Sakaguchi M, 2011, PLoS One, 6, 23132, 10.1371/journal.pone.0023132 · DOI
  14. Hu P, 2012, Int J Mol Med, 29, 613, 10.3892/ijmm.2012.891 · DOI
  15. Xiang Y, 2011, Cell Biochem Funct, 29, 149, 10.1002/cbf.1736 · DOI
  16. Liu Y, 2010, Atherosclerosis, 208, 34, 10.1016/j.atherosclerosis.2009.06.007 · DOI
  17. Alikhani M, 2007, Am J Physiol Cell Physiol, 292, C850, 10.1152/ajpcell.00356.2006 · DOI
  18. Yamagishi S, 2002, Biochem Biophys Res Commun, 290, 973, 10.1006/bbrc.2001.6312 · DOI
  19. Fukami K, 2004, Kidney Int., 66, 2137, 10.1111/j.1523-1755.2004.66004.x · DOI
  20. Cai W, 2012, Proc Natl Acad Sci USA, 109, 15888, 10.1073/pnas.1205847109 · DOI
  21. Molinari J, 2008, Biogerontology, 9, 177, 10.1007/s10522-008-9129-7 · DOI
  22. Bansal S, 2012, Mol Cell Biochem, 361, 289, 10.1007/s11010-011-1114-9 · DOI
  23. Wautier MP, 2001, Am J Physiol Endocrinol Metab, 280, E685, 10.1152/ajpendo.2001.280.5.E685 · DOI
  24. Coughlan MT, 2009, J Am Soc Nephrol, 20, 742, 10.1681/ASN.2008050514 · DOI
  25. Cai W, 2008, Am J Physiol Cell Physiol, 294, C145, 10.1152/ajpcell.00350.2007 · DOI
  26. Nagai R, 2007, Biochim Biophys Acta, 1772, 1192, 10.1016/j.bbadis.2007.09.001 · DOI
  27. Pluddemann A, 2007, Methods, 43, 207, 10.1016/j.ymeth.2007.06.004 · DOI
  28. Saito A, 2005, Nephrology, 10, S26, 10.1111/j.1440-1797.2005.00453.x · DOI
  29. Rojas A, 2013, Cell Signal, 25, 609, 10.1016/j.cellsig.2012.11.022 · DOI
  30. Ohe K, 2010, J Biochem, 147, 651, 10.1093/jb/mvp207 · DOI
  31. 10.1096/fj.08-109033 · DOI
  32. 10.1007/s11739-009-0300-1 · DOI
  33. Lertwittayapon T, 2012, Genet Mol Res, 11, 1712, 10.4238/2012.June.29.3 · DOI
  34. Markaki M, 2011, Biogerontology, 12, 377, 10.1007/s10522-011-9324-9 · DOI
  35. Rattan SI, 2012, Biogerontology, 13, 83, 10.1007/s10522-011-9354-3 · DOI
  36. 10.1515/BC.2008.030 · DOI
  37. Trougakos IP, 2009, Adv Cancer Res, 104, 171, 10.1016/S0065-230X(09)04009-3 · DOI
  38. Rattan SI, 2010, Adv Exp Med Biol, 694, 1, 10.1007/978-1-4419-7002-2_1 · DOI
  39. Hubbard VM, 2012, Biogerontology, 13, 21, 10.1007/s10522-011-9331-x · DOI
  40. Li SY, 2005, Aging Cell, 4, 57, 10.1111/j.1474-9728.2005.00146.x · DOI
  41. Jacobson J, 2010, Aging Cell, 9, 466, 10.1111/j.1474-9726.2010.00573.x · DOI
  42. Grimm S, 2010, Free Radic Res, 44, 1013, 10.3109/10715762.2010.495127 · DOI
  43. Grimm S, 2012, Free Radic Biol Med, 52, 1011, 10.1016/j.freeradbiomed.2011.12.021 · DOI
  44. Stolzing A, 2006, Free Radic Biol Med, 40, 1017, 10.1016/j.freeradbiomed.2005.10.061 · DOI
  45. Stratford FL, 2006, FEBS Lett, 580, 3989, 10.1016/j.febslet.2006.06.029 · DOI
  46. Demir I, 2001, Jpn Heart J, 42, 607, 10.1536/jhj.42.607 · DOI
  47. Vetter SW, 2011, Clin Chim Acta, 412, 2105, 10.1016/j.cca.2011.07.022 · DOI
  48. Sell DR, 2012, Gerontology, 58, 227, 10.1159/000334668 · DOI
  49. Virella G, 2003, J Lipid Res, 44, 487, 10.1194/jlr.M200370-JLR200 · DOI
  50. Vytásek R, 2010, BMC Musculoskelet Disord, 11, 83, 10.1186/1471-2474-11-83 · DOI
  51. Greenwald SE, 2007, J Pathol, 211, 157, 10.1002/path.2101 · DOI
  52. Ando K, 1999, Biochem Biophys Res Commun, 258, 123, 10.1006/bbrc.1999.0606 · DOI
  53. Kimura T, 1996, Neurosci Lett, 208, 53, 10.1016/0304-3940(96)12537-4 · DOI
  54. Kumar PA, 2007, Biochem J, 408, 251, 10.1042/BJ20070989 · DOI
  55. Kueper T, 2007, J Biol Chem, 282, 23427, 10.1074/jbc.M701586200 · DOI
  56. Haus JM, 2007, J Appl Physiol, 103, 2068, 10.1152/japplphysiol.00670.2007 · DOI
  57. Semba RD, 2010, Eur J Appl Physiol, 108, 191, 10.1007/s00421-009-1192-5 · DOI
  58. Hein G, 2003, Rheumatology, 42, 1242, 10.1093/rheumatology/keg324 · DOI
  59. Hein GE, 2006, Clin Chim Acta, 371, 32, 10.1016/j.cca.2006.03.017 · DOI
  60. Odetti P, 2005, Ann N Y Acad Sci, 1043, 710, 10.1196/annals.1333.082 · DOI
  61. Tang SY, 2007, Bone, 40, 1144, 10.1016/j.bone.2006.12.056 · DOI
  62. Aso Y, 2000, Acta Diabetol, 37, 87, 10.1007/s005920070025 · DOI
  63. Bansal S, 2013, Clin Biochem, 46, 109, 10.1016/j.clinbiochem.2012.10.019 · DOI
  64. Beisswenger PJ, 1995, Diabetes, 44, 824, 10.2337/diab.44.7.824 · DOI
  65. Kiuchi K, 2001, Heart, 85, 87, 10.1136/heart.85.1.87 · DOI
  66. Yamagishi S, 2011, Exp Gerontol, 46, 217, 10.1016/j.exger.2010.11.007 · DOI
  67. Schinzel R, 2001, Nephron, 87, 295, 10.1159/000045934 · DOI
  68. Sebeková K, 2001, Kidney Int Suppl, 78, S58, 10.1046/j.1523-1755.2001.59780058.x · DOI
  69. Stam F, 2006, Nephrol Dial Transplant, 21, 677, 10.1093/ndt/gfi309 · DOI
  70. Misciagna G, 2007, Curr Pharm Des, 13, 3688, 10.2174/138161207783018545 · DOI
  71. Kanauchi M, 2001, Diabetes Care, 24, 1620, 10.2337/diacare.24.9.1620 · DOI
  72. McNulty M, 2007, Am J Hypertens, 20, 242, 10.1016/j.amjhyper.2006.08.009 · DOI
  73. 10.1172/JCI115014 · DOI
  74. Bucala R, 1995, J Biol Chem, 270, 10828, 10.1074/jbc.270.18.10828 · DOI
  75. Hofnagel O, 2007, Biochim Biophys Acta, 1771, 1117, 10.1016/j.bbalip.2007.06.003 · DOI
  76. 10.2337/diabetes.52.9.2381 · DOI
  77. Sakaguchi T, 2003, J Clin Invest, 111, 959, 10.1172/JCI200317115 · DOI
  78. Torreggiani M, 2009, Am J Pathol, 175, 1722, 10.2353/ajpath.2009.090138 · DOI
  79. Schulz JB, 2000, Eur J Biochem, 267, 4904, 10.1046/j.1432-1327.2000.01595.x · DOI
  80. Li J, 2012, J Neurol Sci, 317, 1, 10.1016/j.jns.2012.02.018 · DOI
  81. Cai Z, 2011, Neuromol Med, 13, 223, 10.1007/s12017-011-8155-9 · DOI · Paper page
  82. Laffont I, 2002, Biochim Biophys Acta, 1583, 99, 10.1016/S1388-1981(02)00188-9 · DOI
  83. Candore G, 2010, Rejuv Res, 13, 301, 10.1089/rej.2009.0993 · DOI
  84. Seneff S, 2011, Eur J Intern Med, 22, 134, 10.1016/j.ejim.2010.12.017 · DOI
  85. Salminen A, 2009, Progress Neurobiol, 87, 181, 10.1016/j.pneurobio.2009.01.001 · DOI
  86. Cho S, 2012, Curr Pharmaceut Des, 18, 3721, 10.2174/138161212802002760 · DOI
  87. Rojas A, 2010, Carcinogenesis, 31, 334, 10.1093/carcin/bgp322 · DOI
  88. Sesti F, 2012, In Vivo, 26, 395
  89. Hanahan D, 2011, Cell, 144, 646, 10.1016/j.cell.2011.02.013 · DOI · Paper page
  90. Greenhough A, 2009, Carcinogenesis, 30, 377, 10.1093/carcin/bgp014 · DOI · Paper page
  91. Takino J, 2012, World J Gastroenterol, 18, 1781, 10.3748/wjg.v18.i15.1781 · DOI · Paper page
  92. Kang R, 2010, Cell Death Differ, 17, 666, 10.1038/cdd.2009.149 · DOI
  93. 10.1080/07357900701560521 · DOI
  94. Gebhardt C, 2008, J Exp Med, 205, 275, 10.1084/jem.20070679 · DOI
  95. Turovskaya O, 2008, Carcinogenesis, 29, 2035, 10.1093/carcin/bgn188 · DOI
  96. Stav D, 2007, Int J Biol Markers, 22, 108, 10.1177/172460080702200204 · DOI
  97. Kodavanti UP, 2011, Environm Health Perspect, 119, 312, 10.1289/ehp.1002386 · DOI · Paper page
  98. Giordano D, 1996, J Invest Med, 44, 200a
  99. Campos C, 2011, Inh Toxicol, 23, 148, 10.3109/08958378.2011.554460 · DOI
  100. Tessier FJ, 2012, Amino Acids, 42, 1119, 10.1007/s00726-010-0776-z · DOI
  101. Koschinsky T, 1997, Proc. Natl Acad. Sci. USA, 94, 6474, 10.1073/pnas.94.12.6474 · DOI · Paper page
  102. Šebeková K, 2008, Ann N Y Acad Sci., 1126, 177, 10.1196/annals.1433.049 · DOI
  103. Vlassara H, 2002, Proc Natl Acad Sci USA, 99, 15596, 10.1073/pnas.242407999 · DOI · Paper page
  104. Cai W, 2004, Circulation, 110, 285, 10.1161/01.CIR.0000135587.92455.0D · DOI · Paper page
  105. Yang CW, 1994, Proc Natl Acad Sci USA, 91, 9436, 10.1073/pnas.91.20.9436 · DOI
  106. Vlassara H, 1994, Proc Natl Acad Sci USA, 91, 11704, 10.1073/pnas.91.24.11704 · DOI
  107. Zheng F, 2002, Diab Metab Res Rev, 18, 224, 10.1002/dmrr.283 · DOI
  108. Lin RY, 2003, Atherosclerosis, 168, 213, 10.1016/S0021-9150(03)00050-9 · DOI
  109. Sandu O, 2005, Diabetes, 54, 2314, 10.2337/diabetes.54.8.2314 · DOI
  110. Susic D, 2007, Biochem Soc Trans, 35, 853, 10.1042/BST0350853 · DOI
  111. Ueda S, 2006, Mol Med, 12, 180, 10.2119/2005-00034.Ueda · DOI
  112. Iacobini C, 2004, FASEB J, 18, 1773, 10.1096/fj.04-2031fje · DOI
  113. Iacobini C, 2005, Am J Physiol Renal Physiol, 289, F611, 10.1152/ajprenal.00435.2004 · DOI
  114. 10.1159/000075627 · DOI
  115. Coughlan MT, 2007, Kidney Int Suppl, 106, S54, 10.1038/sj.ki.5002387 · DOI
  116. Padival S, 2006, Ophthalmic Res, 38, 294, 10.1159/000095773 · DOI
  117. Adrover M, 2008, Bioorg Med Chem, 16, 5557, 10.1016/j.bmc.2008.04.002 · DOI
  118. Waanders F, 2008, Nephrol Dial Transplant., 23, 518, 10.1093/ndt/gfm589 · DOI
  119. 10.1021/jf9007168 · DOI
  120. Karachalias N, 2010, Diabetologia, 53, 1506, 10.1007/s00125-010-1722-z · DOI
  121. Stirban A, 2006, Diabetes Care, 29, 2064, 10.2337/dc06-0531 · DOI
  122. Alkhalaf A, 2012, PLoS One, 7, 40427, 10.1371/journal.pone.0040427 · DOI
  123. Nagai R, 2013, Amino Acids
  124. 10.2337/db09-1766 · DOI
  125. Deane R, 2012, J Clin Invest, 122, 1377, 10.1172/JCI58642 · DOI · Paper page
  126. 10.2174/138945007782151298 · DOI
  127. Steele M, 2007, Exp Gerontol, 42, 28, 10.1016/j.exger.2006.06.002 · DOI

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Metadata

Authors
Nedić, O., Rattan, S. I. S., Grune, T., & Trougakos, I. P.
Affiliations
  • University of Belgrade (RS)
  • Aarhus University (DK)
  • Friedrich Schiller University Jena (DE)
  • National and Kapodistrian University of Athens (GR)
Corresponding author
Trougakos, I. P.
ORCID
Venue
Free Radical Research
Publisher
Informa UK Limited
Published
2013-05-21
Volume
47
Issue
sup1
Pages
28-38
ISSN
  • 1029-2470 (ISSN-L)
  • 1071-5762
DOI
10.3109/10715762.2013.806798
OpenAlex
W1973520713
Cited by
162
References
11
Citations by year
2026: 5 · 2025: 5 · 2024: 6 · 2023: 10 · 2022: 9 · 2021: 16 · 2020: 12 · 2019: 16 · 2018: 12 · 2017: 21 · 2016: 13 · 2015: 15 · 2014: 15 · 2013: 7
FWCI
1.65
Type
journal article
Language
en
Open access
closed
Locations
  • Free Radical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords
advanced glycation end products, receptor for advanced glycation end products, RAGE, Maillard reaction, glycation, oxidative stress, hyperglycemia, signal transduction, inflammation, aging, age-related diseases, atherosclerosis, neurodegeneration, arthritis, diabetes mellitus, cancer
MeSH terms
Aging, Humans, Inflammation, Ligands, Signal Transduction, Glycation End Products, Advanced, Oxidative Stress, Atherosclerosis

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