Advanced Glycation End-Products: A Biological Consequence of Lifestyle Contributing to Cancer Disparity
Open accessAbstract
Low income, poor diet, obesity, and a lack of exercise are interrelated lifestyle factors that can profoundly alter our biologic make up to increase cancer risk, growth, and development. We recently reported a potential mechanistic link between carbohydrate-derived metabolites and cancer, which may provide a biologic consequence of lifestyle that can directly affect tumor biology. Advanced glycation end-products (AGE) are reactive metabolites produced as a by-product of sugar metabolism. Failure to remove these highly reactive metabolites can lead to protein damage, aberrant cell signaling, increased stress responses, and decreased genetic fidelity. Critically, AGE accumulation is also directly affected by our lifestyle choices and shows a race-specific, tumor-dependent pattern of accumulation in cancer patients. This review will discuss the contribution of AGEs to the cancer phenotype, with a particular emphasis on their biologic links with the socioeconomic and environmental risk factors that drive cancer disparity. Given the potential benefits of lifestyle changes and the potential biologic role of AGEs in promoting cancer, opportunities exist for collaborations affecting basic, translational, epidemiologic, and cancer prevention initiatives. Cancer Res; 75(10); 1925–9. ©2015 AACR.
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Higher levels of AGE cross-links are commonly detected in experimental animal models and autopsied tissue samples from people who are aging or have cancer, obesity, or diabetic complications.
“In fact, higher levels of AGE cross-links are commonly detected in experimental animal models and autopsied tissue samples from people who are aging or have cancer, obesity, or diabetic complications31–33.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [31]
Elevated amounts of AGEs are observed in tumor tissues in cancer.
“Elevated amounts of AGEs are observed in tumor tissues in cancer.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [31]
Increased AGEs and AGE-RAGE interactions provide a link to cancer initiation, progression, migration, and metastasis.
“Increased AGEs and AGE-RAGE interactions provide a link to cancer initiation, progression, migration, and metastasis31,86.”
From Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury (2021) · cites this paper as [31]
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Cites
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
Colotta, F., Allavena, P., Sica, A., Garlanda, C., & Mantovani, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp127 · Cited by 2,882 · see citing works
Advanced glycation end products in foods and a practical guide to their reduction in the diet
Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G. E., & Vlassara, H. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.03.018 · Cited by 1,289 · see citing works
Galland, L. (2010) · Nutrition in Clinical Practice · doi:10.1177/0884533610385703 · Cited by 686 · see citing works
Diet, nutrition and the prevention of cancer
Key, T. J., Schatzkin, A. G., Willett, W. C., Allen, N. E., Spencer, E. A., & Travis, R. C. (2004) · Public Health Nutrition · doi:10.1079/phn2003588 · Cited by 652 · see citing works
Ekelund, U., Ward, H. A., Norat, T., Luan, J., May, A. M., Weiderpass, E., Sharp, S. J., Overvad, K., Østergaard, J. N., Tjønneland, A., et al. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.100065 · Cited by 347 · cited 1× · see citing works
“• Recent data from the European Prospective Investigation into Cancer and Nutrition Study concludes that a sedentary lifestyle poses twice the risk of premature death as being overweight or obese (15).”
BackgroundExercise, inflammation and aging.
(2012) · Europe PMC (PubMed Central) · Cited by 345 · see citing works
Zenk, S. N., Lachance, L., Schulz, A. J., Mentz, G. B., Kannan, S., & Ridella, W. (2009) · American Journal of Health Promotion · doi:10.4278/ajhp.071204127 · Cited by 270 · see citing works
The receptor RAGE: Bridging inflammation and cancer
Riehl, A., Németh, J., Angel, P. E., & Heß, J. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-12 · Cited by 236 · see citing works
Guimarães, E. L. M., Empsen, C., Geerts, A. E., & van Grunsven, L. A. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.12.007 · Cited by 226 · see citing works
The road to advanced glycation end products: a mechanistic perspective
Cho, S.-J., Roman, G., Yeboah, F., & Konishi, Y. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707780830989 · Cited by 213 · see citing works
Ishiguro, H., Nakaigawa, N., Miyoshi, Y., Fujinami, K., Kubota, Y., & Uemura, H. (2005) · The Prostate · doi:10.1002/pros.20219 · Cited by 211 · see citing works
Powell, I. J., Dyson, G. E., Land, S. J., Ruterbusch, J. J., Bock, C. H., Lenk, S., Herawi, M., Everson, R., Giroux, C. N., Schwartz, A. G., et al. (2013) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-1238 · Cited by 162 · see citing works
Kellow, N. J., & Savige, G. S. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.220 · Cited by 149 · see citing works
Racial Differences in Oxidative Stress and Inflammation: In Vitro and In Vivo
Feairheller, D. L., Park, J., Sturgeon, K. M., Williamson, S. T., Diaz, K. M., Veerabhadrappa, P., & Brown, M. D. (2011) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2011.00264.x · Cited by 148 · see citing works
Reiner, A. P., Beleza, S. S., Franceschini, N., Auer, P. L., Robinson, J. G., Kooperberg, C. L., Peters, U., & Tang, H. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.07.023 · Cited by 127 · see citing works
Sharaf, H., Matou‐Nasri, S., Wang, Q., Rabhan, Z., Al‐Eidi, H., Abdulrahman, A. A., & Ahmed, N. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.12.009 · Cited by 122 · see citing works
Boor, P., Celec, P., Behuliak, M., Grančič, P., Kebis, A., Kukan, M., Prónayová, N., Liptaj, T., Ostendorf, T., & Šebeková, K. (2009) · Metabolism · doi:10.1016/j.metabol.2009.05.025 · Cited by 121 · see citing works
Association Between Acute-Phase Reactants and Advanced Glycation End Products in Type 2 Diabetes
Tan, K. C. B., Chow, W.-S., Tam, S., Bucala, R., & Betteridge, J. D. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.223 · Cited by 118 · see citing works
Jiao, L., Stolzenberg‐Solomon, R. Z., Zimmerman, T. P., Duan, Z., Chen, L., Kahle, L., Risch, A., Subar, A. F., Cross, A. J., Hollenbeck, A. R., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.098061 · Cited by 91 · see citing works
Morris, A. A., Zhao, L., Patel, R. S., Jones, D. P., Ahmed, Y. A., Stoyanova, N., Gibbons, G. H., Vaccarino, V., Din‐Dzietham, R., & Quyyumi, A. A. (2012) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2011.0117 · Cited by 90 · see citing works
Kinseth, M. A., Jia, Z., Rahmatpanah, F. B., Sawyers, A., Sutton, M., Wang‐Rodriguez, J., Mercola, D., & McGuire, K. L. (2013) · International Journal of Cancer · doi:10.1002/ijc.28326 · Cited by 87 · see citing works
Chandler, P. D., Scott, J. B., Drake, B. F., Ng, K., Manson, J. E., Rifai, N., Chan, A. T., Bennett, G. G., Hollis, B. W., Giovannucci, E. L., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0338-t · Cited by 84 · see citing works
Biological determinants of health disparities in prostate cancer
Martin, D. N., Starks, A. M., & Ambs, S. (2013) · Current Opinion in Oncology · doi:10.1097/cco.0b013e32835eb5d1 · Cited by 78 · see citing works
Reams, R., Agrawal, D., Davis, M. B., et al. (2009) · Infectious Agents and Cancer · doi:10.1186/1750-9378-4-s1-s3 · Cited by 63 · see citing works
Rose, A. E., Satagopan, J. M., Oddoux, C., et al. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-70 · Cited by 59 · see citing works
9. Cancers attributable to inadequate physical exercise in the UK in 2010
Parkin, D. M. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.482 · Cited by 58 · see citing works
Wright, K., Thomas, M. M., Betik, A. C., et al. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.11.006 · Cited by 57 · see citing works
Advanced Glycation and ROS: A Link between Diabetes and Heart Failure
Armando Rojas, R., Mercadal, E., Figueroa, H., & Morales, M. A. (2008) · Current Vascular Pharmacology · doi:10.2174/157016108783331312 · Cited by 53 · see citing works
Rodríguez, M., Gronau, J. H., Breit, C., Zhang, Y. Z., Minamidate, A., Caley, M. P., McCarthy, A., Cox, T. R., Erler, J. T., Gaughan, L., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4485 · Cited by 49 · see citing works
AGE Metabolites: A Biomarker Linked to Cancer Disparity?
Foster, D., Spruill, L., Walter, K. R., Nogueira, L. M., Fedarovich, H., Turner, R. Y., Ahmed, M., Salley, J. D., Ford, M. E., Findlay, V. J., et al. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-14-0564 · Cited by 46 · see citing works
Self-citationYoshikawa, T., Miyazaki, A., & Fujimoto, S. (2009) · PubMed · Cited by 42 · see citing works
Park, N.-J., & Kang, D.-H. (2013) · Oncology nursing forum · doi:10.1188/13.onf.40-05ap · Cited by 41 · see citing works
Obesity in US Children and Adults
Sauaia, A., & Byers, T. (2012) · JAMA · doi:10.1001/jama.2012.4726 · Cited by 4 · see citing works
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Rungratanawanich, W., Qu, Y., Wang, X., Essa, M. M., & Song, B.-J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00561-7 · Cited by 411 · see citing works
Dietary advanced glycation end products and their relevance for human health
Nowotny, K., Schröter, D., Schreiner, M., & Grune, T. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.005 · Cited by 255 · see citing works
Role of advanced glycation end products in carcinogenesis and their therapeutic implications
Schröter, D., & Höhn, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190130145549 · Cited by 126 · see citing works
- Authors
- Turner, D. P.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Turner, David P.
- ORCID
- Turner, David P.
- Venue
- Cancer Research
- Published
- 2015-05-13
- Volume
- 75
- Issue
- 10
- Pages
- 1925-1929
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC4433613
- OpenAlex
- W1987603842
- Cited by
- 109
- References
- 33
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 13 · 2023: 6 · 2022: 10 · 2021: 16 · 2020: 10 · 2019: 11 · 2018: 9 · 2017: 13 · 2016: 7 · 2015: 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R21CA176135, P20CA157071)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- advanced glycation end products, cancer disparities, lifestyle factors, socioeconomic risk factors, obesity, diet, physical inactivity, carbohydrate metabolism, protein damage, signal transduction, tumor biology, racial differences in cancer, cancer prevention
- MeSH terms
- Animals, Humans, Life Style, Neoplasms, Obesity, Glycation End Products, Advanced, Oxidative Stress, Diet, Western
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