The DOI matches its Crossref record; 157 of the 161 references it cites were found in a registry or an index.
Mitochondrial Respiratory Complex I: Structure, Function and Implication in Human Diseases
Open accessAbstract
Mitochondria are ubiquitous organelles in eukaryotic cells whose primary function is to generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry point for most electrons into the respiratory chain, NADH:ubiquinone oxidoreductase, or complex I, is the largest and least understood component of the mitochondrial oxidative phosphorylation system. Substantial progress has been made in recent years in understanding its subunit composition, its assembly, the interaction among complex I and other respiratory components, and its role in oxidative stress and apoptosis. This review provides an updated overview of the structure of complex I, as well as its cellular functions, and discusses the implication of complex I dysfunction in various human diseases.
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“An undesired effect of the redox reactions occurring in mitochondria is the generation of reactive oxygen species [27].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [27]
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Chronic systemic pesticide exposure reproduces features of Parkinson's disease
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A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
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The sites and topology of mitochondrial superoxide production
Brand, M. D. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.01.003 · Cited by 1,217
Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease
Panth, N., Paudel, K. R., & Parajuli, K. (2016) · Advances in Medicine · doi:10.1155/2016/9152732 · Cited by 415
Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity
Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342
The Roles of ROS in Cancer Heterogeneity and Therapy
Júnior, P. L. D. S., Câmara, D. A. D., Porcacchia, A. S., Fonseca, P. M. M., Jorge, S. D., Araldi, R. P., & Ferreira, A. K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2467940 · Cited by 298
Jiang, L., Yin, X., Chen, Y., Chen, Y., Jiang, W., Zheng, H., Huang, F., Liu, B., Zhou, W., Qi, L., et al. (2020) · Theranostics · doi:10.7150/thno.43895 · Cited by 217
Metadata
- Authors
- Sharma, L., Lu, J., & Bai, Y.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-04-01
- Volume
- 16
- Issue
- 10
- Pages
- 1266-1277
- ISSN
- 0929-8673 (ISSN-L)
- PMC
- PMC4706149
- OpenAlex
- W2126962886
- Cited by
- 438
- References
- 161
- Citations by year
- 2026: 41 · 2025: 51 · 2024: 69 · 2023: 52 · 2022: 48 · 2021: 50 · 2020: 42 · 2019: 22 · 2018: 16 · 2017: 15 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 7 · 2012: 8
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG025223)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- mitochondrial complex I, complex I, mitochondrial respiratory chain, oxidative phosphorylation, complex I assembly, subunit composition, oxidative stress, apoptosis, complex I dysfunction, human disease
- MeSH terms
- Animals, Disease, Humans, Apoptosis, Reactive Oxygen Species, Electron Transport Complex I
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