Mitochondrial Respiratory Complex I: Structure, Function and Implication in Human Diseases

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Parkinson's Disease Brain Mitochondrial Complex I Has Oxidatively Damaged Subunits and Is Functionally Impaired and Misassembled

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Structure of the Hydrophilic Domain of Respiratory Complex I from Thermus thermophilus

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AIF deficiency compromises oxidative phosphorylation

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Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport Chain

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Targeting programmed cell death in neurodegenerative diseases

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Complex I Is the Major Site of Mitochondrial Superoxide Production by Paraquat

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Mitochondria as all‐round players of the calcium game

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Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase

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The respiratory‐chain NADH dehydrogenase (complex I) of mitochondria

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Bovine Complex I Is a Complex of 45 Different Subunits

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Respiratory Complex III Is Required to Maintain Complex I in Mammalian Mitochondria

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Mitochondrial DNA mutations in human disease

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Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

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NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor

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The nuclear encoded subunits of complex I from bovine heart mitochondria

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Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

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Studies on the Electron Transfer System

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URF6, Last Unidentified Reading Frame of Human mtDNA, Codes for an NADH Dehydrogenase Subunit

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Three-dimensional structure of bovine NADH:ubiquinone oxidoreductase (complex I) at 22 å in ice

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Mitochondrial DNA transmission of the mitochondrial defect in Parkinson's disease

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The production of reactive oxygen species by complex I

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Conservation of sequences of subunits of mitochondrial complex I and their relationships with other proteins

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The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron–sulfur cluster N2

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Complex I Binding by a Virally Encoded RNA Regulates Mitochondria-Induced Cell Death

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A molecular chaperone for mitochondrial complex I assembly is mutated in a progressive encephalopathy

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Clinical and molecular findings in children with complex I deficiency

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Analysis of the Assembly Profiles for Mitochondrial- and Nuclear-DNA-Encoded Subunits into Complex I

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GRIM-19, a Cell Death Regulatory Gene Product, Is a Subunit of Bovine Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I)

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A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

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Dominant cell death induction by extramitochondrially targeted apoptosis‐inducing factor

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Cytochrome c Oxidase Is Required for the Assembly/Stability of Respiratory Complex I in Mouse Fibroblasts

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Mitochondrial DNA Alterations in Cancer

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Defective Oxidative Phosphorylation in Thyroid Oncocytic Carcinoma Is Associated with Pathogenic Mitochondrial DNA Mutations Affecting Complexes I and III

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Assembly of mitochondrial complex I and defects in disease

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Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hürthle cell) tumours of the thyroid

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Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

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GRIM-19, a Cell Death Regulatory Protein, Is Essential for Assembly and Function of Mitochondrial Complex I

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Oxidative stress and cell death

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Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease

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NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency

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The mtDNA‐encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme

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Mitochondrial oversight of cellular Ca2+ signaling

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Mutations of the mitochondrial ND1 gene as a cause of MELAS

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De novo mutations in the mitochondrial ND3 gene as a cause of infantile mitochondrial encephalopathy and complex I deficiency

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Mutation of C20orf7 Disrupts Complex I Assembly and Causes Lethal Neonatal Mitochondrial Disease

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Mitochondrial dysfunction in Parkinson's disease

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Resolution of the Membrane Domain of Bovine Complex I into Subcomplexes: Implications for the Structural Organization of the Enzyme

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The mitochondrial complex i inhibitor annonacin is toxic to mesencephalic dopaminergic neurons by impairment of energy metabolism

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Mutant NDUFV2 subunit of mitochondrial complex I causes early onset hypertrophic cardiomyopathy and encephalopathy

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Mitochondrial acyl carrier protein is involved in lipoic acid synthesis in Saccharomyces cerevisiae

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C6ORF66 Is an Assembly Factor of Mitochondrial Complex I

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A New Metabolic Link

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Definition of the Nuclear Encoded Protein Composition of Bovine Heart Mitochondrial Complex I

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Localization of the Site of Oxygen Radical Generation inside the Complex I of Heart and Nonsynaptic Brain Mammalian Mitochondria

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The mitochondrial respiratory chain is a modulator of apoptosis

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Mitochondrial defects and anesthetic sensitivity

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Identification of Mitochondrial Complex I Assembly Intermediates by Tracing Tagged NDUFS3 Demonstrates the Entry Point of Mitochondrial Subunits

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Novel Role for Mitochondria: Protein Kinase Cθ-Dependent Oxidative Signaling Organelles in Activation-Induced T-Cell Death

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The reduction of NADH

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An Assembled Complex IV Maintains the Stability and Activity of Complex I in Mammalian Mitochondria

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