The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
Coumarins: Old Compounds with Novel Promising Therapeutic Perspectives
Open accessAbstract
Natural as well as synthetic coumarins have recently drawn much attention due to its broad pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti-tumor, anti-viral, anti-inflammatory and anti-oxidant effects, as well as anti-microbial and enzyme inhibition properties. The recognition of key structural features within coumarin family is crucial for the design and development of new analogues with improved activity and for the characterization of their mechanism of action and potential side effects. The different substituents in the coumarin nucleus strongly influence the biological activity of the resulting derivatives. Although some coumarins have been already characterized to evoke a particular biological activity, the challenge would be the design and synthesis of new derivatives with high specific activity for other pharmacological targets and define their mechanism of action to achieve new therapeutic drugs. The present review highlights the current progress in the development of coumarin scaffolds for drug discovery as novel anti-cancer agents. The major challenges about coumarins include the translation of current knowledge into new potential lead compounds and the repositioning of known compounds for the treatment of cancer.
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Cites
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Cited by
Kostova, I., Bhatia, S., Grigorov, P., Balkansky, S., S. Parmar, V., K. Prasad, A., & Saso, L. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711803414395 · Cited by 435
Molecular interplay between cdk4 and p21 dictates G0/G1 cell cycle arrest in prostate cancer cells
Gulappa, T., Reddy, R. S., Suman, S., Nyakeriga, A. M., & Damodaran, C. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.05.014 · Cited by 43
Metadata
- Authors
- Riveiro, M., De Kimpe, N., Moglioni, A., Vazquez, R., Monczor, F., Shayo, C., & Davio, C.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-05-01
- Volume
- 17
- Issue
- 13
- Pages
- 1325-1338
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2128531001
- Cited by
- 448
- References
- 72
- FWCI
- 12.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
