Anti-Diabetic Effect of Trigonelline and Nicotinic Acid, on KK-Ay Mice

Yoshinari, O.; Igarashi, K.

doi:10.2174/092986710791299902

Cited by 92Natural Antidiabetic Agents StudiesBerberine and alkaloids researchDiabetes Treatment and Management

Anti-Diabetic Effect of Trigonelline and Nicotinic Acid, on KK-Ay Mice

Yoshinari, O., Igarashi, K.·2010·Current Medicinal Chemistry

DOI 10.2174/092986710791299902

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Abstract

Trigonelline (TRG) and nicotinic acid (NA), in which the former but not the latter improved the blood glucose level in the oral glucose tolerance test (OGTT) in Goto-Kakizaki (GK) rats were tested for anti-diabetic effects in mellitus models of KK-A(y) obese mice that had type 2 diabetes. Blood glucose level in OGTT carried out on day 22-23 was lowered after feeding in mice fed TRG and NA than that of the control mice not fed these compounds, indicating that both TRG and NA have sufficient activity to improve glucose tolerance in diabetes with obesity. The serum insulin levels at fasting showed significantly lower levels in mice fed TRG, and a lower tendency in mice fed NA, compared with the control mice. The triglyceride (TG) levels in the liver and adipose tissue in mice fed TRG and NA showed lower values or a lower tendency than those of the control mice, indicating that TRG and NA were also effective to improve the changes in lipid levels accompanied with diabetes. Higher values or a higher tendency of the glucokinase (GLK)/glucose-6-phosphatase (G6Pase) ratio in the liver and lower levels of the serum tumor necrosis factor (TNF)-alpha in the TRG- and NA-fed mice, compared to the control mice, suggested that the regulation of GLK and G6Pase, and TNF-alpha production by TRG and NA are closely related in suppressing the progression of diabetes in the KK-A(y) mice.

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Trigonelline can protect from metabolic dysfunction and improve glucose tolerance both in mice and humans.
“trigonelline can protect from metabolic dysfunction and improve glucose tolerance both in mice and humans62,63.”
From Trigonelline Is an NAD+ Precursor That Improves Muscle Function during Ageing and Is Reduced in Human Sarcopenia (2024) · cites this paper as [63]

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Płatkiewicz, J., Łapawa, A., Frankowski, R., Grześkowiak, T., Jeszka‐Skowron, M., Werner, J., & Zgoła‐Grześkowiak, A. (2025) · European Food Research and Technology · doi:10.1007/s00217-025-04661-w · Cited by 5 · see citing works
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Cation-exchange/hydrophilic interaction mixed-mode liquid chromatographic method for analyzing the trigonelline class of bioactives in coffee beans
Zhong, J., Zhao, L., Guo, Y., Li, Z., Ye, H., Guan, H., Xing, Z., & Wang, W. (2024) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2024.106011 · Cited by 5 · see citing works
Antidiabetic Potential of Trigonelline and 4-Hydroxyisoleucine in Fenugreek
Upaganlawar, A., Badole, S. L., & Bodhankar, S. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-397153-1.00006-8 · Cited by 5 · see citing works
SUMOylation Modulates CFTR Biogenesis: Is the Pathway Druggable?
Ahner, A., & Frizzell, R. A. (2015) · Current Drug Targets · doi:10.2174/1389450116666150531152236 · Cited by 5 · see citing works
High-performance thin-layer chromatographic determination of trigonelline content in various extracts and different varieties of some commercial coffees available in the Saudi Arabian market
Foudah, A. I., Alam, P., Abdel-Kader, M. S., et al. (2020) · Journal of Planar Chromatography – Modern TLC · doi:10.1007/s00764-019-00010-2 · Cited by 5 · see citing works
Effect of Phytochemicals on Diabetes‐Related Neurological Disorders
Mohammed, A., Pandey, K. B., & Rizvi, S. I. (2017) · doi:10.1002/9781119155195.ch13 · Cited by 5 · see citing works
Occurrence, harmful effects and analytical determination of Ochratoxin A in coffee
Nuhu, A. A. (2015) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2015.50121 · Cited by 4 · see citing works
“These chemical compounds include caffeine (Prediger, 2010), trigonelline (Dijk et al. , 2009; Yoshinari and Igarashi, 2010), chlorogenic acid (Moon et al. , 2009) and diterpenes (Sridevi et al. , 2011).”
Trigonella foenum-graecum and Its Bioactive Compounds Having Potential Antidiabetic Activity
Tabassum, H., & Ahmad, I. Z. (2021) · Springer eBooks · doi:10.1007/978-981-16-1197-1_19 · Cited by 4 · see citing works
Changes in the urinary metabolome accompanied alterations in body mass and composition in women with overweight – impact of high versus low protein breakfast
Correia, B. S. B., Dalgaard, L. B., Thams, L., Hansen, M., & Bertram, H. C. (2024) · Metabolomics · doi:10.1007/s11306-024-02156-5 · Cited by 3 · see citing works
“Studies on oral administration of trigonelline have also revealed beneficial effects on insulin resistance and glucose tolerance in both murine models (Yoshinari et al., 2009; Yoshinari & Igarashi, 2010) and humans (van Dijk et al., 2009).”
Background
Development of a Reversed-Phase High-Performance Thin-Layer Chromatography Method for the Simultaneous Determination of Trigonelline and Diosgenin Biomarkers inTrigonella foenum-graecumL. Seeds Grown in Variable Environment
Foudah, A. I., Alam, P., Alqarni, M. H., et al. (2019) · Journal of Planar Chromatography – Modern TLC · doi:10.1556/1006.2019.32.5.5 · Cited by 3 · see citing works
The Hepatoprotective Effect of Trigonelline in Diabetic Rat through Insulin-related IRS1-GLUT2 Pathway: A Biochemical, Molecular, Histopathological, and Immunohistochemical Study
Li, M., Li, S., Jiang, S., & Li, W.-H. (2024) · Pharmacognosy Magazine · doi:10.1177/09731296241247365 · Cited by 2 · see citing works
“Animal trials have illustrated that supplementing with TRIG can ameliorate glucose tolerance, augment insulin secretion, and mitigate insulin resistance in models of diabetes (Yoshinari & Igarashi, 2010).”
Chemical and pharmacological evidences for coffee as a modulator of type 2 diabetes and metabolic syndrome
Habtemariam, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102922-0.00021-3 · Cited by 2 · see citing works
Synergy Among Dietary Spices in Exerting Antidiabetic Influences
Pradeep, S. R., & Srinivasan, K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813822-9.00028-x · Cited by 2 · see citing works
LC/MS-QToF Profiling, Anti-Diabetic and Anti-Adipogenic potential of Divya MadhuKalp: A Novel Herbo-mineral FormulationPreprint
Balkrishna, A., Joshi, A. B., Das, S. K., Bisht, L., Sakat, S. S., Sharma, V., Sharma, N., Joshi, K., Verma, S., Sharma, V. K., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.15.950865 · Cited by 2 · see citing works
Low-grade green coffee with Bacillus amyloliquefaciens NY124 protease: extraction, purification, and functional synergy of chlorogenic acid and trigonelline
Im, A. E., Bharti, D., Lim, G., et al. (2025) · AMB Express · doi:10.1186/s13568-025-01920-7 · Cited by 1 · see citing works
“While CGA, malic acid, and trigonelline in coffee inhibit α-glucosidase enzyme (Yoshinari and Igarashi 2010), our study found trigonelline less effective than CGA.”
Effects of Pumpkin ( Cucurbita spp.) on Glycemic and Type 2 Diabetes–Related Metabolic Biomarkers: A Systematic Review of Controlled Clinical Trials
Ye, K., Cândido, F. G., RAMOS, J. D. S., et al. (2026) · Nutrition Reviews · doi:10.1093/nutrit/nuag027 · Cited by 1 · see citing works
Phytochemicals, Management of Diabetic Peripheral Neuropathy, Experimental Evidences
Saleh, H. (2017) · MOJ Anatomy & Physiology · doi:10.15406/mojap.2017.03.00106 · Cited by 1 · see citing works
“Trigonellafoenum (TF) It was reported a higher GLK/ glucose-6-phosphatase (G6Pase) ratio in the liver and lower levels of serum tumor necrosis factor alpha in TF-treated mice compared to controls [27].”
Background
Effect of Environmental Conditions on the Biomarker Trigonelline in Trigonella foenum-graecum L. seeds Using Validated HPTLC Method
Alqarni, M. H., Alam, P., Kharji, A. M. A., et al. (2019) · Current Pharmaceutical Analysis · doi:10.2174/1573412915666190304142047 · Cited by 1 · see citing works
Coffee, will it be Healthy Choice
Shanmugam, S. (2020) · IP Journal of Nutrition Metabolism and Health Science · doi:10.18231/j.ijnmhs.2020.010 · Cited by 1 · see citing works
Trigonelline: An Emerging Paradigm for Effective Therapy in Diabetes Mellitus
Walvekar, M. V., Jadhav, N. A., Daunde, J. A., Potphode, N. D., & Desai, S. S. (2023) · Journal of Endocrinology & Reproduction · doi:10.18311/jer/2023/29609 · Cited by 1 · see citing works
Exploring the ameliorating potentials of Phyllanthus fraternus methanolic leaf extract on hepatic and renal dysfunctions in diabetic rats
Glen, E., Nadro, M. S., Yaduma, W. G., et al. (2022) · African Journal of Biological Sciences · doi:10.33472/afjbs.4.4.2022.70-76
Bauhinia forficata, B. variegata
Gilbert, B., Alves, L. F., & Favoreto, R. D. F. (2022) · Editora FIOCRUZ eBooks · doi:10.7476/9786557081778.0004
Herbal Anti Diabetic A Review Efficacy and Mechanisms
Shinde, K., Waghmare, S., Nikam, N. V., et al. (2025) · International Journal of Advanced Research in Science Communication and Technology · doi:10.48175/ijarsct-23037
Trigonelline and its impact on insulin resistance: A detailed examination of its pharmacological benefits
Hebi, M., Ajebli, M., Mankour, Z., et al. (2026) · Scientific African · doi:10.1016/j.sciaf.2026.e03263

Authors: Yoshinari, O., & Igarashi, K.
Affiliations: Iwate University (JP)
Corresponding author: Igarashi, K.
ORCID: Igarashi, K.
Venue: Current Medicinal Chemistry
Publisher: Bentham Science Publishers Ltd.
Published: 2010-07-01
Volume: 17
Issue: 20
Pages: 2196-2202
ISSN: 0929-8673 (ISSN-L)
DOI: 10.2174/092986710791299902
OpenAlex: W1963493944
Cited by: 92
References: 0
Citations by year: 2026: 2 · 2025: 4 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 7 · 2012: 6
FWCI: 4.11
Type: journal article
Language: en
Open access: closed
Locations: Current Medicinal Chemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: trigonelline, nicotinic acid, type 2 diabetes, anti-diabetic effects, KK-Ay mice, glucose tolerance, blood glucose, serum insulin, triglycerides, glucokinase, glucose-6-phosphatase, TNF-α, obesity, liver
MeSH terms: Alkaloids, Animals, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Glucokinase, Glucose-6-Phosphatase, Hypoglycemic Agents, Insulin, Male, Mice, Obese, Niacin, Triglycerides, Tumor Necrosis Factor-alpha, Mice, Rats

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Anti-Diabetic Effect of Trigonelline and Nicotinic Acid, on KK-Ay Mice

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