Circulating endothelial progenitor cells as biomarkers for prediction of cardiovascular outcomes
Abstract
Experimental studies suggest that bone marrow-derived endothelial progenitor cells (EPCs) play an important role in the maintenance of endothelial integrity and hemostasis. The number of circulating EPC has been shown to be inversely correlated with cardiovascular risk factors and vascular function and to predict cardiovascular events independent of both traditional and non-traditional risk factors. Thus, EPCs provide a clinical advantage over the use of other biomarkers as their measurement is directly associated with endothelial function, and available evidence suggests that they are consistently and significantly associated with a spectrum of cardiovascular complications, such as acute coronary syndromes and coronary artery disease. However, many issues in the field of EPC isolation and identification, particularly in regards to the effective and unequivocal molecular characterization of these cells still remain unresolved. In addition, simple EPC counts do not adequately describe cardiovascular disease risk. This limitation is attributable to variation in the definition of EPCs, the number of existing cardiovascular risk factors in different patients as well as a difference in the interaction between EPCs and other hematopoietic progenitor, inflammatory cells or platelets.
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Circulating angiogenic progenitor cell levels are inversely associated with CVD risk.
“whose levels are inversely associated with CVD risk 171”
From Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation (2023) · cites this paper as [171]
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- Authors
- Bakogiannis, C., Tousoulis, D., Androulakis, E., Briasoulis, A., Papageorgiou, N., Vogiatzi, G., Kampoli, A.-M., Charakida, M., Siasos, G., Latsios, G., Antoniades, C., & Stefanadis, C.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Universitätsklinikum des Saarlandes (DE)
- Corresponding author
- Vogiatzi, G.
- Siasos, G.
- Latsios, G.
- Antoniades, C.
- Stefanadis, C.
- ORCID
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-04-01
- Volume
- 19
- Issue
- 16
- Pages
- 2597-2604
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2144145279
- Cited by
- 71
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 11 · 2016: 9 · 2015: 7 · 2014: 13 · 2013: 5 · 2012: 1
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- endothelial progenitor cells, biomarkers, cardiovascular risk prediction, endothelial function, acute coronary syndrome, coronary artery disease, cardiovascular risk factors, platelets, inflammatory cells
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Risk Factors, Stem Cells, Biomarkers, Endothelial Cells
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