Cited by 791Physical Activity and HealthCardiovascular and exercise physiologyExercise and Physiological Responses

Exercise is the real polypill.

Open access
Fiuza-Luces, Carmen, Garatachea, Nuria, Berger, Nathan A., Lucia, Alejandro·2013·Physiology

Abstract

The concept of a "polypill" is receiving growing attention to prevent cardiovascular disease. Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free intervention for which our genome has been haped over evolution. Compared with drugs, exercise is available at low cost and relatively free of adverse effects. We summarize epidemiological evidence on the preventive/therapeutic benefits of exercise and on the main biological mediators involved.

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Crossref · 10.1152/physiol.00019.2013

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538 of 538 references verified0 citation errors · 0 not checkable

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Authors
Fiuza-Luces, C., Garatachea, N., Berger, N. A., & Lucia, A.
Affiliations
  • Universidad Europea Madrid, Madrid, Spain;
  • Universidad de Zaragoza (ES)
  • Case Western Reserve University (US)
Venue
Physiology
Published
2013-09
Volume
28
Issue
5
Pages
330-358
ISSN
  • 0886-1714 (ISSN-L)
  • 1548-9213
  • 1548-9221
OpenAlex
W2117994923
Cited by
791
References
538
Citations by year
2026: 24 · 2025: 53 · 2024: 56 · 2023: 68 · 2022: 81 · 2021: 90 · 2020: 85 · 2019: 99 · 2018: 63 · 2017: 44 · 2016: 50 · 2015: 35 · 2014: 38 · 2013: 4
FWCI
4.67
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
National Cancer Institute (U54CA116867)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
physical activity, polypill, cardiovascular disease prevention, biological mediators, exercise epidemiology, cardiovascular risk reduction, adaptive evolution
MeSH terms
Age Factors, Aging, Animals, Cardiovascular Diseases, Drug Combinations, Humans, Physical Fitness, Risk Factors, Signal Transduction, Exercise, Oxidative Stress, Muscle, Skeletal, Polypharmacy, Risk Reduction Behavior, Sedentary Behavior

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