Exercise is the real polypill.
Open accessAbstract
The concept of a "polypill" is receiving growing attention to prevent cardiovascular disease. Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free intervention for which our genome has been haped over evolution. Compared with drugs, exercise is available at low cost and relatively free of adverse effects. We summarize epidemiological evidence on the preventive/therapeutic benefits of exercise and on the main biological mediators involved.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AE is known to elicit comparatively few adverse side effects and is associated with improvements in the social, physical and affective well being of individuals with psychiatric disorders.
“Contrastingly, AE is known to elicit comparatively few adverse side effects and is associated with improvements in the social, physical and affective well being of individuals with psychiatric disorders (Fiuza-Luces et al., 2013).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Fiuza-Luces et al., 2013
Cites
2 retracted
Immunohistochemical detection of interleukin‐6 in human skeletal muscle fibers following exercise
Penkowa, M., Keller, C., Keller, P., Jauffred, S., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0311fje · Cited by 154 · see citing works
RetractedEffects of Eccentric Exercise on NF-κB Activation in Blood Mononuclear Cells
López, D. G., Cuevas, M. J., Almar, M., Lima‐Cabello, E., Fernández, J. A. D. P., & González‐Gallego, J. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04f6 · Cited by 59 · see citing works
RetractedHeart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Isolation of Putative Progenitor Endothelial Cells for Angiogenesis
Asahara, T., Murohara, T., Sullivan, A., Silver, M., van der Zee, R., Li, T., Witzenbichler, B., Schatteman, G., & Isner, J. M. (1997) · Science · doi:10.1126/science.275.5302.964 · Cited by 8,725 · see citing works
Lee, I.-M., Shiroma, E. J., Lobelo, F., Puska, P., Blair, S. N., & Katzmarzyk, P. T. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61031-9 · Cited by 8,215 · see citing works
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,669 · see citing works
Cholesterol Treatment Trialists' (CTT) Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)61350-5 · Cited by 6,550 · see citing works
Global physical activity levels: surveillance progress, pitfalls, and prospects
Hallal, P. C., Andersen, L. B., Bull, F. C., Guthold, R., Haskell, W., & Ekelund, U. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60646-1 · Cited by 5,711 · see citing works
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114 · see citing works
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013 · see citing works
Rovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120 · see citing works
Kodama, S. (2009) · JAMA · doi:10.1001/jama.2009.681 · Cited by 3,035 · see citing works
A Map of Recent Positive Selection in the Human Genome
Voight, B. F., Kudaravalli, S., Wen, X., & Pritchard, J. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040072 · Cited by 2,912 · see citing works
Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works
Exercise: a behavioral intervention to enhance brain health and plasticity
Cotman, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02143-4 · Cited by 2,739 · see citing works
Friedenstein, A. J., Chailakhjan, R. K., & Lalykina, K. S. (1970) · Cell Proliferation · doi:10.1111/j.1365-2184.1970.tb00347.x · Cited by 2,726 · see citing works
Cellular and Molecular Regulation of Muscle Regeneration
CHARGÉ, S. B. P., & Rudnicki, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00019.2003 · Cited by 2,691 · see citing works
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459 · see citing works
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388 · see citing works
Exercise builds brain health: key roles of growth factor cascades and inflammation
Cotman, C. W., Berchtold, N. C., & Christie, L.-A. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.011 · Cited by 2,268 · see citing works
Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works
Old, L. J. (1985) · Science · doi:10.1126/science.2413547 · Cited by 1,885 · see citing works
Exercise Training for Blood Pressure: A Systematic Review and Meta‐analysis
Cornelissen, V. A., & Smart, N. A. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.112.004473 · Cited by 1,683 · see citing works
Regulation of myostatin activity and muscle growth
Lee, S.-J., & McPherron, A. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151270098 · Cited by 1,616 · see citing works
Hydrogen peroxide sensing and signaling
Veal, E. A., Day, A. M., & Morgan, B. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.016 · Cited by 1,604 · see citing works
Antioxidants prevent health-promoting effects of physical exercise in humans
Ristow, M., Zarse, K., Oberbach, A., Klöting, N., Birringer, M., Kiehntopf, M., Stumvoll, M., Kahn, C. R., & Blüher, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903485106 · Cited by 1,582 · see citing works
A strategy to reduce cardiovascular disease by more than 80%
Wald, N., & Law, M. R. (2003) · BMJ · doi:10.1136/bmj.326.7404.1419 · Cited by 1,568 · see citing works
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460 · see citing works
Mechanisms involved in the therapeutic properties of mesenchymal stem cells
da Silva Meirelles, L., Fontes, A. M., Covas, D. T., & Caplan, A. I. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.002 · Cited by 1,436 · see citing works
Regular physical exercise and low-fat diet. Effects on progression of coronary artery disease.
Schuler, G. C., Hambrecht, R., Schlierf, G., Niebauer, J., Hauer, K. A., Neumann, J., Hoberg, E., Drinkmann, A., Bacher, F., & Grunze, M. F. (1992) · Circulation · doi:10.1161/01.cir.86.1.1 · Cited by 1,339 · see citing works
Oxidative stress and gene regulation
Allen, R. G., & Tresini, M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00242-7 · Cited by 1,297 · see citing works
AMPK and PPARδ Agonists Are Exercise Mimetics
Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.051 · Cited by 1,222 · see citing works
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
He, C., Bassik, M. C., Moresi, V., Sun, K., Wei, Y., Zou, Z., An, Z., Loh, J., Fisher, J., Sun, Q., et al. (2012) · Nature · doi:10.1038/nature10758 · Cited by 1,136 · see citing works
Why are MSCs therapeutic? New data: new insight
Caplan, A. I. (2008) · The Journal of Pathology · doi:10.1002/path.2469 · Cited by 1,115 · see citing works
Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095 · see citing works
Sympathovagal Balance: A Critical Appraisal
Eckberg, D. L. (1997) · Circulation · doi:10.1161/01.cir.96.9.3224 · Cited by 1,087 · see citing works
Exercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · see citing works
Effect of exercise training on endothelium‐derived nitric oxide function in humans
Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068197 · Cited by 1,040 · see citing works
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works
Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training
Gomez-Cabrera, M.-C., Domenech, E., & Viña, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.02.001 · Cited by 1,020 · see citing works
Neeper, S. A., Gómez‐Pinilla, F., Choi, J., & Cotman, C. W. (1996) · Brain Research · doi:10.1016/0006-8993(96)00273-9 · Cited by 1,015 · see citing works
Cornelissen, V. A., & Fagard, R. H. (2005) · Hypertension · doi:10.1161/01.hyp.0000184225.05629.51 · Cited by 1,005 · see citing works
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells
Dellavalle, A., Sampaolesi, M., Tonlorenzi, R., Tagliafico, E., Sacchetti, B., Perani, L., Innocenzi, A., Gálvez, B. G., Messina, G., Roberta Morosetti, A., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1542 · Cited by 1,001 · see citing works
Physical Activity and Reduced Risk of Cardiovascular Events: Potential Mediating Mechanisms
Mora, S., Cook, N., Buring, J. E., Ridker, P. M., & Lee, I.-M. (2007) · Circulation · doi:10.1161/circulationaha.107.729939 · Cited by 1,000 · see citing works
Rizos, E. C., Ntzani, E. E., Bika, E., Kostapanos, M. S., & Elisaf, M. S. (2012) · JAMA · doi:10.1001/2012.jama.11374 · Cited by 960 · see citing works
Nitric oxide in skeletal muscle
Kobzik, L., Reid, M. B., Bredt, D. S., & Stamler, J. S. (1994) · Nature · doi:10.1038/372546a0 · Cited by 955 · see citing works
Evidence for a release of brain-derived neurotrophic factor from the brain during exercise
Rasmussen, P., Brassard, P., Adser, H., Pedersen, M. V., Leick, L., Hart, E., Secher, N. H., Pedersen, B. K., & Pilegaard, H. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.048512 · Cited by 914 · see citing works
Myostatin Inhibits Myoblast Differentiation by Down-regulating MyoD Expression
Langley, B. C., Thomas, M., Bishop, A., Sharma, M., Gilmour, S., & Kambadur, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204291200 · Cited by 910 · see citing works
Dvořák, J., McCrory, P. R., Aubry, M., Molloy, M. J., & Engebretsen, L. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.059360 · Cited by 907 · see citing works
Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes · doi:10.2337/db05-1404 · Cited by 898 · see citing works
DeSouza, C. A., Shapiro, L. F., Clevenger, C. M., Dinenno, F. A., Monahan, K. D., Tanaka, H., & Seals, D. R. (2000) · Circulation · doi:10.1161/01.cir.102.12.1351 · Cited by 896 · cited 2× · see citing works
“In previously sedentary middleaged and older healthy men, regular aerobic exercise can prevent the age-associated loss in endothelium-dependent vasodilation (as assessed by vasodilatory response to acetylcholine) and restore this variable to levels similar to those of young adults (103).”
BackgroundResultHaskell, W. L., Alderman, E. L., Fair, J. M., Maron, D. J., Mackey, S. F., Superko, H. R., Williams, P. T., Johnstone, I. M., Champagne, M. A., & Krauss, R. M. (1994) · Circulation · doi:10.1161/01.cir.89.3.975 · Cited by 884 · see citing works
Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010) · Sports Medicine · doi:10.2165/11534530-000000000-00000 · Cited by 882 · see citing works
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.011 · Cited by 873 · cited 1× · see citing works
“Other potential roles of IL-6 are stimulation of muscle growth (7, 441) and angiogenesis (172).”
BackgroundVEGF is necessary for exercise‐induced adult hippocampal neurogenesis
Fabel, K., Fabel, K., Tam, B., Kaufer, D., Baiker, A., Simmons, N., Kuo, C. J., & Palmer, T. D. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03041.x · Cited by 861 · see citing works
Laufs, U., Werner, N., Link, A., Endres, M., Waßmann, S., Jürgens, K., Miche, E., Böhm, M., & Nickenig, G. (2003) · Circulation · doi:10.1161/01.cir.0000109141.48980.37 · Cited by 858 · see citing works
FERRIS, L. T., WILLIAMS, J. S., & SHEN, C.-L. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04c7 · Cited by 849 · see citing works
Gomez-Cabrera, M.-C., Domenech, E., Romagnoli, M., Arduini, A., Borras, C., Pallardo, F. V., Sastre, J., & Viña, J. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.1.142 · Cited by 844 · see citing works
Role of Myokines in Exercise and Metabolism
Pedersen, B. K., Åkerström, T. C. A., Nielsen, A. R., & Fischer, C. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00080.2007 · Cited by 841 · see citing works
Functional improvement of dystrophic muscle by myostatin blockade
Bogdanovich, S., Krag, T. O. B., Barton, E. R., Morris, L. D., Whittemore, L.-A., Ahima, R. S., & Khurana, T. S. (2002) · Nature · doi:10.1038/nature01154 · Cited by 831 · see citing works
Interleukin-6 in acute exercise and training: what is the biological relevance?
Fischer, C. P. (2026) · PubMed · doi:10.22029/eir.2006.1620 · Cited by 817 · see citing works
High impact running improves learning
Winter, B., Breitenstein, C., Mooren, F. C., Voelker, K., Fobker, M., Lechtermann, A., Krueger, K., Fromme, A., Korsukewitz, C., Flöel, A., et al. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.11.003 · Cited by 795 · see citing works
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size
Trendelenburg, A. U., Meyer, A., Rohner, D., Boyle, J., Hatakeyama, S., & Glass, D. J. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00105.2009 · Cited by 792 · see citing works
Oxidative Stress: Relationship with Exercise and Training
Finaud, J., Lac, G., & Filaire, E. (2006) · Sports Medicine · doi:10.2165/00007256-200636040-00004 · Cited by 771 · see citing works
Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs
Sampaolesi, M., Blot, S., D’Antona, G., Granger, N. P., Tonlorenzi, R., Innocenzi, A., Mognol, P., Thibaud, J. L., Gálvez, B. G., Barthélémy, I., et al. (2006) · Nature · doi:10.1038/nature05282 · Cited by 768 · see citing works
Interleukin-6 stimulates lipolysis and fat oxidation in humans
van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021687 · Cited by 767 · see citing works
Hambrecht, R., Walther, C., Möbius-Winkler, S., Gielen, S., Linke, A., Conradi, K., Erbs, S., Kluge, R., Kendziorra, K., Sabri, O., et al. (2004) · Circulation · doi:10.1161/01.cir.0000121360.31954.1f · Cited by 752 · see citing works
Assessing Identity, Phenotype, and Fate of Endothelial Progenitor Cells
Hirschi, K. K., Ingram, D. A., & Yöder, M. C. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.155960 · Cited by 746 · see citing works
Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
Gómez-Pinilla, F., Ying, Z., Roy, R. R., Molteni, R., & Edgerton, V. R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00152.2002 · Cited by 724 · see citing works
Matthews, V. B., Åström, M.-B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Åkerström, T., Yfanti, C., Broholm, C., Mortensen, O. H., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1364-1 · Cited by 722 · cited 2× · see citing works
“Several tissues, such as contracting muscles (111, 152, 293) or platelets (465), can express BDNF.”
BackgroundPhysical Activity and Coronary Heart Disease in Men: The Harvard Alumni Health Study
Sesso, H., Paffenbarger, R., & Lee, I. (2000) · Circulation · doi:10.1161/01.cir.102.9.975 · Cited by 719 · see citing works
Moore, S. C., Patel, A. V., Matthews, C. E., Berrington de Gonzalez, A., Park, Y., Katki, H. A., Linet, M. S., Weiderpass, E., Visvanathan, K., Helzlsouer, K. J., et al. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001335 · Cited by 693 · see citing works
Werner, N., Junk, S., Laufs, U., Link, A., Walenta, K. L. H., Böhm, M., & Nickenig, G. (2003) · Circulation Research · doi:10.1161/01.res.0000083812.30141.74 · Cited by 693 · see citing works
Tumor necrosis factor Characterization at the molecular, cellular and in vivo level
Fiers, W. C. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80803-b · Cited by 684 · see citing works
Myogenic specification of side population cells in skeletal muscle
Asakura, A., Seale, P., Girgis-Gabardo, A., & Rudnicki, M. A. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202092 · Cited by 681 · see citing works
Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running
Ostrowski, K., Rohde, T., Zacho, M., Asp, S., & Pedersen, B. K. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.949bp.x · Cited by 673 · see citing works
Exercise, oxidative stress and hormesis
Radak, Z., Chung, H. Y., Koltai, E., Taylor, A. W., & Goto, S. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.04.004 · Cited by 638 · see citing works
Rovere, M. T. L., Specchia, G., Mortara, A., & Schwartz, P. J. (1988) · Circulation · doi:10.1161/01.cir.78.4.816 · Cited by 631 · see citing works
SPARC, a matricellular protein: at the crossroads of cell–matrix communication
Brekken, R. A., & Sage, E. H. (2001) · Matrix Biology · doi:10.1016/s0945-053x(00)00133-5 · Cited by 587 · see citing works
Gonzalez-Cadavid, N. F., Taylor, W. E., Yarasheski, K., Sinha-Hikim, I., Ma, K., Ezzat, S., Shen, R., Lalani, R., Asa, S., Mamita, M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14938 · Cited by 571 · see citing works
Rebbapragada, A., Benchabane, H., Wrana, J. L., Celeste, A. J., & Attisano, L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7230-7242.2003 · Cited by 566 · see citing works
Effects of exercise, vitamin E, and ozone on pulmonary function and lipid peroxidation
Dillard, C. J., Litov, R. E., SAVIN, W. M., Dumelin, E. E., & Tappel, A. L. (1978) · Journal of Applied Physiology · doi:10.1152/jappl.1978.45.6.927 · Cited by 561 · see citing works
Kelley, G. A., & Kelley, K. S. (2000) · Hypertension · doi:10.1161/01.hyp.35.3.838 · Cited by 555 · see citing works
Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training
Fukai, T., Siegfried, M. R., Ushio‐Fukai, M., Cheng, Y. C., Kojda, G., & Harrison, D. G. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9551 · Cited by 552 · see citing works
Beat to beat variability in cardiovascular variables: Noise or music?
Appel, M. L., Berger, R. D., Saul, J. P., Smith, J. M., & Cohen, R. J. (1989) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(89)90408-7 · Cited by 551 · see citing works
Impact of Resistance Training on Blood Pressure and Other Cardiovascular Risk Factors
Cornelissen, V., Fagard, R. H., Coeckelberghs, E., & Vanhees, L. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.177071 · Cited by 550 · see citing works
Mechanisms of Vascular Aging: New Perspectives
Ungvari, Z. I., Kaley, G., de Cabo, R., Sonntag, W. E., & Csiszár, A. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq113 · Cited by 534 · see citing works
Exercise protects the cardiovascular system: effects beyond traditional risk factors
Joyner, M. J., & Green, D. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.179432 · Cited by 520 · see citing works
Crosby, J. R., Kaminski, W. E., Schatteman, G. C., Martin, P. J., Raines, E. W., Seifert, R. A., & Bowen‐Pope, D. F. (2000) · Circulation Research · doi:10.1161/01.res.87.9.728 · Cited by 519 · see citing works
Smad2 and 3 transcription factors control muscle mass in adulthood
Sartori, R., Milan, G., Patron, M., Mammucari, C., Blaauw, B., Abraham, R., & Sandri, M. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00104.2009 · Cited by 517 · see citing works
Mizuhara, H., O'Neill, E., Seki, N., Ogawa, T., Kusunoki, C., Otsuka, K., Satoh, S., Niwa, M., Senoh, H., & Fujiwara, H. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.5.1529 · Cited by 517 · see citing works
Keller, C., Steensberg, A., Pilegaard, H., Osada, T., Saltin, B., Pedersen, B. K., & Neufer, P. D. (2001) · The FASEB Journal · doi:10.1096/fj.01-0507fje · Cited by 514 · see citing works
Cardiovascular effects of marine omega-3 fatty acids
Saravanan, P., Davidson, N. C., Schmidt, E. B., & Calder, P. C. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60445-x · Cited by 510 · see citing works
IL-4 Acts as a Myoblast Recruitment Factor during Mammalian Muscle Growth
Horsley, V., Jansen, K. M., Mills, S. T., & Pavlath, G. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00319-2 · Cited by 508 · see citing works
Suppression of body fat accumulation in myostatin-deficient mice
McPherron, A. C., & Lee, S.-J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213562 · Cited by 505 · see citing works
Mechanisms of sudden cardiac death
Rubart, M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26381 · Cited by 503 · see citing works
Endurance training enhances BDNF release from the human brain
Seifert, T., Brassard, P., Wissenberg, M., Rasmussen, P., Nordby, P., Stallknecht, B., Adser, H., Jakobsen, A. H., Pilegaard, H., Nielsen, H. B., et al. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00525.2009 · Cited by 502 · see citing works
Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review
Powers, S. K., Ji, L. L., & Leeuwenburgh, C. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199907000-00011 · Cited by 501 · see citing works
Exercise-induced mitochondrial biogenesis begins before the increase in muscle PGC-1α expression.
Wright, D. C., Han, D.-H., Garcia-Roves, P. M., Geiger, P. C., Jones, T. E., & Holloszy, J. O. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606116200 · Cited by 488 · see citing works
A phase I/IItrial of MYO‐029 in adult subjects with muscular dystrophy
Wagner, K. R., Fleckenstein, J. L., Amato, A. A., Barohn, R. J., Bushby, K., Escolar, D. M., Flanigan, K. M., Pestronk, A., Tawil, R., Wolfe, G. I., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21338 · Cited by 481 · see citing works
McFarlane, C., Plummer, E., Thomas, M., Hennebry, A., Ashby, M. G., Ling, N., Smith, H., Sharma, M., & Kambadur, R. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20757 · Cited by 480 · see citing works
Louis, E., Raue, U., Yang, Y., Jemiolo, B., & Trappe, S. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00679.2007 · Cited by 478 · see citing works
Gómez‐Cabrera, M. C., Borrás, C., Pallardó, F. V., Sastre, J., Ji, L. L., & Viña, J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2004.080564 · Cited by 477 · see citing works
Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus
Kronenberg, G., Bick-Sander, A., Bunk, E., Wolf, C., Ehninger, D., & Kempermann, G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.016 · Cited by 477 · see citing works
Ortega, F. B., Lee, D.-C., Katzmarzyk, P. T., Ruiz, J. R., Sui, X., Church, T. S., & Blair, S. N. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs174 · Cited by 471 · see citing works
Oxidative stress and disuse muscle atrophy
Powers, S. K., Kavazis, A. N., & McClung, J. M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01202.2006 · Cited by 471 · see citing works
Berchtold, N. C., Chinn, G., Chou, M., Kesslak, J. P., & Cotman, C. W. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.026 · Cited by 471 · see citing works
Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice
Duman, C. H., Schlesinger, L., Russell, D. S., & Duman, R. S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.047 · Cited by 465 · see citing works
Navarro, A., Gómez, C., López-Cepero, J. M., & Boveris, A. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00208.2003 · Cited by 464 · see citing works
Ji, L. L., Gómez‐Cabrera, M. C., & Viña, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.061 · Cited by 445 · see citing works
Steensberg, A., Febbraio, M. A., Osada, T., Schjerling, P., van Hall, G., Saltin, B., & Pedersen, B. K. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00633.x · Cited by 444 · see citing works
Cornelissen, V. A., & Fagard, R. H. (2005) · Journal of Hypertension · doi:10.1097/00004872-200502000-00003 · Cited by 439 · see citing works
Lee, D.-C., Sui, X., Ortega, F. B., Kim, Y.-S., Church, T. S., Winett, R. A., Ekelund, U., Katzmarzyk, P. T., & Blair, S. N. (2010) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.066209 · Cited by 435 · see citing works
Nerve Sprouting and Sudden Cardiac Death
Cao, J., Chen, L. S., KenKnight, B. H., Ohara, T., Lee, M., Tsai, J., Lai, W. W., Karagueuzian, H. S., Wolf, P. L., Fishbein, M. C., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.7.816 · Cited by 433 · see citing works
Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise
Mahoney, D. J., Parise, G., Melov, S., Safdar, A., & Tarnopolsky, M. A. (2005) · The FASEB Journal · doi:10.1096/fj.04-3149fje · Cited by 418 · see citing works
FGF21 is an Akt‐regulated myokine
Izumiya, Y., Bina, H. A., Ouchi, N., Akasaki, Y., Kharitonenkov, A., & Walsh, K. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.10.021 · Cited by 415 · see citing works
Exercise and hormesis: oxidative stress-related adaptation for successful aging
Radak, Z. O., Chung, H. Y., & Goto, S. (2005) · Biogerontology · doi:10.1007/s10522-004-7386-7 · Cited by 413 · see citing works
IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle
Steensberg, A., Keller, C., Starkie, R. L., Osada, T., Febbraio, M. A., & Pedersen, B. K. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00255.2002 · Cited by 410 · see citing works
Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis
Seldin, M. M., Peterson, J. M., Byerly, M. S., Wei, Z., & Wong, G. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336834 · Cited by 406 · see citing works
Nitric oxide release is present from incubated skeletal muscle preparations
Balon, T. W., & Nadler, J. L. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.6.2519 · Cited by 406 · see citing works
Guo, T., Jou, W., Chanturiya, T., Portas, J., Gavrilova, O., & McPherron, A. C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004937 · Cited by 402 · see citing works
Is irisin a human exercise gene?
Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012) · Nature · doi:10.1038/nature11364 · Cited by 389 · see citing works
Strenuous endurance training in humans reduces oxidative stress following exhausting exercise
Miyazaki, H., Oh‐ishi, S., Ookawara, T., Kizaki, T., Toshinai, K., Ha, S., Haga, S., Ji, L. L., & Ohno, H. (2001) · European Journal of Applied Physiology · doi:10.1007/s004210000342 · Cited by 388 · see citing works
Muscle-Derived Neurotrophin-4 as an Activity-Dependent Trophic Signal for Adult Motor Neurons
Funakoshi, H., Belluardo, N., Arenas, E., Yamamoto, Y., Casabona, A., Persson, H., & Ibáñez, C. F. (1995) · Science · doi:10.1126/science.7770776 · Cited by 383 · see citing works
Russo-Neustadt, A. A., Beard, R., Huang, Y.-M., & Cotman, C. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00349-3 · Cited by 382 · see citing works
Improvements in heart rate variability with exercise therapy
Routledge, F. S., Campbell, T. S., McFetridge-Durdle, J. A., & Bacon, S. L. (2010) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(10)70395-0 · Cited by 381 · see citing works
Influence of exercise and fiber type on antioxidant enzyme activity in rat skeletal muscle
Powers, S. K., Criswell, D. S., Lawler, J., Ji, L. L., Martin, D., Herb, R. A., & Dudley, G. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.266.2.r375 · Cited by 379 · see citing works
Exercise, MAPK, and NF-κB signaling in skeletal muscle
Kramer, H. F., & Goodyear, L. J. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00085.2007 · Cited by 375 · see citing works
Niebauer, J., Hambrecht, R., Velich, T., Hauer, K., Marburger, C., Kälberer, B., Weiss, C., von Hodenberg, E., Schlierf, G., Schuler, G., et al. (1997) · Circulation · doi:10.1161/01.cir.96.8.2534 · Cited by 372 · see citing works
Cao, L., Liu, X., Lin, E.-J. D., Wang, C., Choi, E., Riban, V., Lin, B., & During, M. J. (2010) · Cell · doi:10.1016/j.cell.2010.05.029 · Cited by 369 · see citing works
Mechanisms of disuse muscle atrophy: role of oxidative stress
Powers, S. K., Kavazis, A. N., & DeRuisseau, K. C. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00469.2004 · Cited by 368 · see citing works
Adams, V., Lenk, K., Linke, A., Lenz, D., Erbs, S., Sandri, M., Tarnok, A., Gielen, S., Emmrich, F., Schuler, G., et al. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000124104.23702.a0 · Cited by 367 · see citing works
Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle
Gómez‐Pinilla, F., Ying, Z., Opazo, P., Roy, R. R., & Edgerton, V. R. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01484.x · Cited by 362 · see citing works
Oliff, H. S., Berchtold, N. C., Isackson, P., & Cotman, C. W. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00222-8 · Cited by 361 · see citing works
Carlson, C. J., Booth, F. W., & Gordon, S. E. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.2.r601 · Cited by 358 · see citing works
Timmons, J. A., Knudsen, S., Rankinen, T., Koch, L. G., Sarzynski, M., Jensen, T., Keller, P., Scheele, C., Vollaard, N. B. J., Nielsen, S., et al. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01295.2009 · Cited by 358 · see citing works
Rojas Vega, S., Strüder, H. K., Vera Wahrmann, B., Schmidt, A., Bloch, W., & Hollmann, W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.105 · Cited by 357 · see citing works
Irrcher, I., Ljubicic, V., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00267.2007 · Cited by 356 · see citing works
Physical activity and plasma interleukin-6 in humans - effect of intensity of exercise
Ostrowski, K., Schjerling, P., & Pedersen, B. K. (2000) · European Journal of Applied Physiology · doi:10.1007/s004210000312 · Cited by 355 · see citing works
Nieman, D. C., Davis, J. M., Henson, D. A., Walberg-Rankin, J., Shute, M., Dumke, C. L., Utter, A. C., Vinci, D. M., Carson, J. A., Brown, A., et al. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01130.2002 · Cited by 353 · see citing works
Molteni, R., Wu, A., Vaynman, S., Ying, Z., Barnard, R. J., & Gómez‐Pinilla, F. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.020 · Cited by 350 · see citing works
Contractile activity-induced oxidative stress: cellular origin and adaptive responses
McArdle, A., Pattwell, D. M., Vasilaki, A., Griffiths, R. D., & Jackson, M. J. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.3.c621 · Cited by 349 · see citing works
Aoi, W., Naito, Y., Takagi, T., Tanimura, Y., Takanami, Y., Kawai, Y., Sakuma, K., Hang, L. P., Mizushima, K., Hirai, Y., et al. (2013) · Gut · doi:10.1136/gutjnl-2011-300776 · Cited by 347 · see citing works
Decreased spontaneous heart rate variability in congestive heart failure
Casolo, G., Balli, E., Taddei, T., Amuhasi, J., & Gori, C. (1989) · The American Journal of Cardiology · doi:10.1016/0002-9149(89)90871-0 · Cited by 344 · see citing works
Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle
Powers, S. K., Talbert, E. E., & Adhihetty, P. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.201327 · Cited by 340 · see citing works
Ouchi, N., Oshima, Y., Ohashi, K., Higuchi, A., Ikegami, C., Izumiya, Y., & Walsh, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803440200 · Cited by 338 · see citing works
Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death
Chen, L. S. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00308-4 · Cited by 333 · see citing works
Stranahan, A. M., Lee, K. M., Martin, B., Maudsley, S. R., Golden, E. J., Cutler, R. G., & Mattson, M. P. (2009) · Hippocampus · doi:10.1002/hipo.20577 · Cited by 333 · see citing works
Increased secretion and expression of myostatin in skeletal muscle from extremely obese women
Hittel, D. S., Berggren, J. R., Shearer, J., Boyle, K., & Houmard, J. A. (2009) · Diabetes · doi:10.2337/db08-0943 · Cited by 324 · see citing works
Rehman, J., Li, J., Parvathaneni, L., Karlsson, G., Panchal, V. R., Temm, C. J., Mahenthiran, J., & March, K. L. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.02.049 · Cited by 322 · see citing works
Physical Activity, Energy Expenditure and Fitness: An Evolutionary Perspective
Cordain, L., Gotshall, R. W., Eaton, S. B., & Eaton, S. B. (1998) · International Journal of Sports Medicine · doi:10.1055/s-2007-971926 · Cited by 314 · see citing works
Schulz, K., Gold, S. M., Witte, J. A., Bartsch, K., Lang, U. E., Hellweg, R., Reer, R., Braumann, K.-M., & Heesen, C. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.06.009 · Cited by 313 · see citing works
Petersen, E. W., Carey, A. L., Sacchetti, M., Steinberg, G. R., Macaulay, S. L., Febbraio, M. A., & Pedersen, B. K. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00257.2004 · Cited by 311 · see citing works
Regulation of the transcription factors NF-κB and AP-1 by redox changes
Meyer, M., Pahl, H. L., & Baeuerle, P. A. (1994) · Chemico-Biological Interactions · doi:10.1016/0009-2797(94)90029-9 · Cited by 310 · see citing works
Reactive oxygen in skeletal muscle. II. Extracellular release of free radicals
Reid, M. B., Shoji, T., Moody, M. R., & Entman, M. L. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.1805 · Cited by 310 · see citing works
Zoladz, J. A., Pilc, A., Majerczak, J., Grandys, M., Zapart-Bukowska, J., & Duda, K. (2008) · PubMed · Cited by 309 · see citing works
Neural regulation of heart rate variability in endurance athletes and sedentary controls
Dixon, E. M., Kamath, M. V., McCartney, N., & Fallen, E. L. (1992) · Cardiovascular Research · doi:10.1093/cvr/26.7.713 · Cited by 307 · see citing works
Physical Activity and Mortality in Older Men With Diagnosed Coronary Heart Disease
Wannamethee, S. G., Shaper, A. G., & Walker, M. (2000) · Circulation · doi:10.1161/01.cir.102.12.1358 · Cited by 305 · see citing works
Liao, D., Carnethon, M. R., Evans, G. W., Cascio, W. E., & HEISS, G. M. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3524 · Cited by 304 · see citing works
Dynamics of the skeletal muscle secretome during myoblast differentiation
Henningsen, J., Rigbolt, K. T. G., Blagoev, B., Pedersen, B. K., & Kratchmarova, I. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.002113 · Cited by 303 · see citing works
Redox-Sensitive Kinases of the Nuclear Factor-κB Signaling Pathway
Pantano, C., Reynaert, N., van der Vliet, A., & Janssen-Heininger, Y. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1791 · Cited by 302 · see citing works
Shan, T., Liang, X., Bi, P., & Kuang, S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225755 · Cited by 301 · see citing works
Gold, S. M., Schulz, K., Hartmann, S., Mladek, M., Lang, U. E., Hellweg, R., Reer, R., Braumann, K.-M., & Heesen, C. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00121-8 · Cited by 300 · see citing works
Jensen, M. T., Suadicani, P., Hein, H. O., & Gyntelberg, F. (2013) · Heart · doi:10.1136/heartjnl-2012-303375 · Cited by 297 · see citing works
Skeletal muscle NAMPT is induced by exercise in humans
Costford, S. R., Bajpeyi, S., Pasarica, M., Albarado, D. C., Thomas, S. C., Xie, H., Church, T. S., Jubrias, S. A., Conley, K. E., & Smith, S. R. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00318.2009 · Cited by 297 · see citing works
Yarasheski, K. E., Bhasin, S., Sinha‐Hikim, I., Pak-Loduca, J., & González-Cadavid, N. F. (2002) · PubMed · Cited by 295 · see citing works
Leeuwenburgh, C., Fiebig, R., Chandwaney, R. H., & Ji, L. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.2.r439 · Cited by 289 · see citing works
AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise.
Kelly, M., Keller, C., Avilucea, P. R., Keller, P., Luo, Z., Xiang, X., Giralt, M., Hidalgo, J., Saha, A. K., Pedersen, B. K., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.188 · Cited by 289 · see citing works
Early and late effects of exercise and athletic training on neural mechanisms controlling heart rate
Furlan, R., Piazza, S., Dell’Orto, S., Gentile, E., Cerutti, S., Pagani, M., & Malliani, A. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.3.482 · Cited by 289 · see citing works
Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?
GREEN, D. J., O’Driscoll, G., Joyner, M. J., & Cable, N. T. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01028.2007 · Cited by 284 · see citing works
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats
Koltai, E., Szabo, Z., Atalay, M., Boldogh, I., Naito, H., Goto, S., Nyakas, C., & Radak, Z. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.11.002 · Cited by 283 · see citing works
Superoxide Dismutase and Catalase in Skeletal Muscle: Adaptive Response to Exercise
Higuchi, M., Cartier, L.-J., Chen, M., et al. (1985) · Journal of Gerontology · doi:10.1093/geronj/40.3.281 · Cited by 282 · see citing works
Amirouche, A., Durieux, A., Banzet, S., Koulmann, N., Bonnefoy, R., Mouret, C., Bigard, X. A., Peinnequin, A., & Freyssenet, D. G. (2008) · Endocrinology · doi:10.1210/en.2008-0959 · Cited by 282 · see citing works
Laukkanen, J. A., Kurl, S., Salonen, R. M., Rauramaa, R., & Salonen, J. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.06.013 · Cited by 282 · see citing works
Antioxidant enzyme systems in rat liver and skeletal muscle
Ji, L. L., Stratman, F. W., & Lardy, H. A. (1988) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(88)90623-6 · Cited by 280 · see citing works
Effects of Walking on Coronary Heart Disease in Elderly Men: The Honolulu Heart Program
Hakim, A. A., Curb, J. D., Petrovitch, H., Rodriguez, B. L., Yano, K., Ross, G. W., White, L. R., & Abbott, R. D. (1999) · Circulation · doi:10.1161/01.cir.100.1.9 · Cited by 277 · see citing works
Khassaf, M. B., McArdle, A., Esanu, C., Vasilaki, A., McArdle, F., Griffiths, R. D., Brodie, D. A., & Jackson, M. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.040303 · Cited by 273 · see citing works
Hiscock, N. J., Chan, S. M. H., Bisucci, T., Darby, I. A., & Febbraio, M. A. (2004) · The FASEB Journal · doi:10.1096/fj.03-1259fje · Cited by 273 · see citing works
Myostatin decreases with aerobic exercise and associates with insulin resistance
HITTEL, D. S., AXELSON, M., SARNA, N., SHEARER, J., HUFFMAN, K. M., & KRAUS, W. E. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181e0b9a8 · Cited by 271 · see citing works
Relationships between Transforming Growth Factor-β1, Myostatin, and Decorin
Zhu, J., Li, Y., Shen, W., Qiao, C., Ambrosio, F., Lavasani, M., Nozaki, M., Branca, M. F., & Huard, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704146200 · Cited by 270 · see citing works
Interleukin-15: a novel anabolic cytokine for skeletal muscle.
Quinn, L. S., Haugk, K. L., & Grabstein, K. H. (1995) · Endocrinology · doi:10.1210/endo.136.8.7628408 · Cited by 270 · see citing works
Zoladz, J. A., & Pilc, A. (2010) · PubMed · Cited by 268 · see citing works
Oversecretion of interleukin-15 from skeletal muscle reduces adiposity
Quinn, L. S., Anderson, B. G., Strait-Bodey, L., Stroud, A. M., & Argilés, J. M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90506.2008 · Cited by 267 · see citing works
Nielsen, A. R., Mounier, R., Plomgaard, P., Mortensen, O. H., Penkowa, M., Speerschneider, T., Pilegaard, H., & Pedersen, B. K. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.139618 · Cited by 266 · see citing works
Pattyn, N., Cornelissen, V. A., Eshghi, S. R. T., & Vanhees, L. (2013) · Sports Medicine · doi:10.1007/s40279-012-0003-z · Cited by 266 · see citing works
Kim, J.-S., Cross, J. M., & Bamman, M. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00464.2004 · Cited by 260 · see citing works
Exercise induces autophagy in peripheral tissues and in the brain
He, C., Sumpter, R., & Levine, B. (2012) · Autophagy · doi:10.4161/auto.21327 · Cited by 259 · see citing works
Muscle contractions induce interleukin‐6 mRNA production in rat skeletal muscles
Jonsdottir, I. H., Schjerling, P., Ostrowski, S. R., Asp, S., Richter, E. A., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00157.x · Cited by 251 · see citing works
Increased blood antioxidant systems of runners in response to training load
Robertson, J. D., Maughan, R., Duthie, G. G., & Morrice, P. C. (1991) · Clinical Science · doi:10.1042/cs0800611 · Cited by 251 · see citing works
Leeuwenburgh, C., Hollander, J., Leichtweis, S. B., Griffiths, M. A., Gore, M. T., & Ji, L. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.1.r363 · Cited by 250 · see citing works
Signaling Specificity of Interleukin-6 Action on Glucose and Lipid Metabolism in Skeletal Muscle
Al-Khalili, L., Bouzakri, K., Glund, S., Lönnqvist, F., Koistinen, H. A., & Krook, A. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0490 · Cited by 250 · see citing works
Steiner, S., Niessner, A., Ziegler, S., Richter, B., Seidinger, D., Pleiner, J., Penka, M., Wolzt, M., Huber, K., Wojta, J., et al. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.01.006 · Cited by 250 · see citing works
Selig, S. E., Carey, M., Menzies, D. G., PATTERSON, J., Geerling, R. H., Williams, A. D., Bamroongsuk, V., Toia, D., Krum, H., & Hare, D. L. (2004) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(03)00583-9 · Cited by 248 · see citing works
Tang, S. W., Chu, E., Hui, T. C. K., Helmeste, D. M., & Law, C. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.019 · Cited by 247 · see citing works
Reduced physical activity and risk of chronic disease: the biology behind the consequences
Booth, F. W., Laye, M. J., Lees, S. J., Rector, R. S., & Thyfault, J. P. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0606-5 · Cited by 239 · see citing works
Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function
Jackson, M. J. (2002) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(02)00018-3 · Cited by 238 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott, E., Storey, R. F., Deaton, C., Cuisset, T., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz425 · Cited by 7,166 · see citing works
Integrative Biology of Exercise
Hawley, J. A., Hargreaves, M., Joyner, M. J., & Zierath, J. R. (2014) · Cell · doi:10.1016/j.cell.2014.10.029 · Cited by 1,152 · see citing works
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Fiuza-Luces, C., Santos-Lozano, A., Joyner, M., Carrera-Bastos, P., Picazo, O., Zugaza, J. L., Izquierdo, M., Ruilope, L. M., & Lucia, A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0065-1 · Cited by 803 · see citing works
Self-citationMuscle, Bone, and Fat Crosstalk: The Biological Role of Myokines, Osteokines, and Adipokines
Kirk, B., Feehan, J., Lombardi, G., & Duque, G. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00599-y · Cited by 510 · see citing works
Klimentidis, Y. C., Raichlen, D. A., Bea, J., Garcia, D. O., Wineinger, N. E., Mandarino, L. J., Alexander, G. E., Chen, Z., & Going, S. B. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0120-3 · Cited by 403 · see citing works
Exercise Attenuates the Major Hallmarks of Aging
Garatachea, N., Pareja-Galeano, H., Sanchis-Gomar, F., Santos-Lozano, A., Fiuza-Luces, C., Morán, M., Emanuele, E., Joyner, M. J., & Lucia, A. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1623 · Cited by 413 · see citing works
Self-citationA Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease
Hampel, H., Caraci, F., Cuello, A. C., Caruso, G., Nisticò, R., Corbo, M., Baldacci, F., Toschi, N., Garaci, F., Chiesa, P. A., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00456 · Cited by 360 · see citing works
Self-citationKeating, S. E., Johnson, N. A., Mielke, G. I., & Coombes, J. S. (2017) · Obesity Reviews · doi:10.1111/obr.12536 · Cited by 344 · see citing works
Sultana, R. N., Sabag, A., Keating, S. E., & Johnson, N. A. (2019) · Sports Medicine · doi:10.1007/s40279-019-01167-w · Cited by 286 · see citing works
Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety
Kandola, A., Vancampfort, D., Herring, M., Rebar, A., Hallgren, M., Firth, J., & Stubbs, B. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0923-x · Cited by 291 · see citing works
Exercise sustains the hallmarks of health
Qiu, Y., Fernández-García, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otín, C., & Xiao, J. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.10.003 · Cited by 270 · see citing works
Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246 · see citing works
Exercise benefits in cardiovascular diseases: From mechanisms to clinical implementation
Valenzuela, P. L., Ruilope, L. M., Santos-Lozano, A., Wilhelm, M., Kränkel, N., Fiuza-Luces, C., & Lucia, A. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad170 · Cited by 237 · see citing works
Self-citation‘Adipaging’: ageing and obesity share biological hallmarks related to a dysfunctional adipose tissue
Pérez, L. M., Pareja‐Galeano, H., Sanchis‐Gomar, F., Emanuele, E., Lucia, A., & Gálvez, B. G. (2016) · The Journal of Physiology · doi:10.1113/jp271691 · Cited by 215 · see citing works
Self-citationTGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism
Takahashi, H., Alves, C. R. R., Stanford, K. I., Middelbeek, R. J. W., Nigro, P., Ryan, R. E., Xue, R., Sakaguchi, M., Lynes, M. D., So, K., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0030-7 · Cited by 204 · see citing works
Do Non-Responders to Exercise Exist—and If So, What Should We Do About Them?
Pickering, C., & Kiely, J. (2019) · Sports Medicine · doi:10.1007/s40279-018-01041-1 · Cited by 165 · see citing works
Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works
“Contrastingly, AE is known to elicit comparatively few adverse side effects and is associated with improvements in the social, physical and affective well being of individuals with psychiatric disorders (Fiuza-Luces et al., 2013).”
Zangger, G., Bricca, A., Liaghat, B., Juhl, C. B., Mortensen, S. R., Andersen, R. M., Damsted, C., Hamborg, T. G., Ried-Larsen, M., Tang, L. H., et al. (2023) · Journal of Medical Internet Research · doi:10.2196/46439 · Cited by 116 · see citing works
Cellular and molecular mechanisms of sarcopenia: The S100B perspective
Riuzzi, F., Sorci, G., Arcuri, C., Giambanco, I., Bellezza, I., Minelli, A., & Donato, R. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12363 · Cited by 114 · see citing works
Zhang, X., Devlin, H. M., Smith, B., Imperatore, G., Thomas, W., Lobelo, F., Ali, M. K., Norris, K., Gruss, S., Bardenheier, B., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0176436 · Cited by 110 · see citing works
Neuropathy and neural plasticity in the subcutaneous white adipose depot
Blaszkiewicz, M., Willows, J. W., Dubois, A. L., Waible, S., DiBello, K., Lyons, L. L., Johnson, C. P., Paradie, E., Banks, N., Motyl, K., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0221766 · Cited by 87 · see citing works
Role of the Cytokine-like Hormone Leptin in Muscle-bone Crosstalk with Aging
Hamrick, M. W. (2017) · Journal of Bone Metabolism · doi:10.11005/jbm.2017.24.1.1 · Cited by 77 · see citing works
Resistance exercise impacts lean muscle mass in women with polycystic ovary syndrome
KOGURE, G. S., MIRANDA-FURTADO, C. L., SILVA, R. C., MELO, A. S., FERRIANI, R. A., DE SÁ, M. F. S., & REIS, R. M. D. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000822 · Cited by 68 · see citing works
Zapata-Lamana, R., Lalanza, J. F., Losilla, J.-M., Parrado, E., & Capdevila, L. (2020) · PeerJ · doi:10.7717/peerj.8848 · Cited by 61 · see citing works
Acosta‐Manzano, P., Rodriguez‐Ayllon, M., Acosta, F. M., Niederseer, D., & Niebauer, J. (2020) · Obesity Reviews · doi:10.1111/obr.13007 · Cited by 59 · see citing works
Myokine/Adipokine response to “Aerobic” exercise: Is it just a matter of exercise load?
He, Z., Tian, Y., Valenzuela, P. L., Huang, C., Zhao, J., Hong, P., He, Z., Yin, S., & Lucia, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00691 · Cited by 59 · see citing works
Pablos, A., Nebot, V., Vañó-Vicent, V., Ceca, D., & Elvira, L. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2017-0348 · Cited by 38 · see citing works
Harder-Lauridsen, N. M., Nielsen, S. T., Mann, S. P., Lyngbæk, M. P., Benatti, F. B., Langkilde, A. R., Law, I., Wedell-Neergaard, A.-S., Thomsen, C., Møller, K., et al. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00846.2016 · Cited by 27 · see citing works
New Molecular Targets and Lifestyle Interventions to Delay Aging Sarcopenia
Sanchis-Gomar, F., Pareja-Galeano, H., Mayero, S., Perez-Quilis, C., & Lucia, A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00156 · Cited by 24 · see citing works
Martínez-Vizcaíno, V., Amaro-Gahete, F. J., Fernández-Rodríguez, R., Garrido-Miguel, M., Cavero-Redondo, I., & Pozuelo-Carrascosa, D. P. (2022) · Sports Medicine · doi:10.1007/s40279-021-01607-6 · Cited by 24 · see citing works
Fontana, A., Vieira, J. G., Vianna, J. M., Bichowska, M., Krzysztofik, M., Wilk, M., & Reis, V. M. (2023) · PLOS ONE · doi:10.1371/journal.pone.0288730 · Cited by 22 · see citing works
Overexpressing FSTL1 for heart repair
Sanchis-Gomar, F., Perez-Quilis, C., & Lucia, A. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.03.003 · Cited by 12 · see citing works
Self-citation
- Authors
- Fiuza-Luces, C., Garatachea, N., Berger, N. A., & Lucia, A.
- Affiliations
- Universidad Europea Madrid, Madrid, Spain;
- Universidad de Zaragoza (ES)
- Case Western Reserve University (US)
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2013-09
- Volume
- 28
- Issue
- 5
- Pages
- 330-358
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2117994923
- Cited by
- 791
- References
- 538
- Citations by year
- 2026: 24 · 2025: 53 · 2024: 56 · 2023: 68 · 2022: 81 · 2021: 90 · 2020: 85 · 2019: 99 · 2018: 63 · 2017: 44 · 2016: 50 · 2015: 35 · 2014: 38 · 2013: 4
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- Locations
- Physiology (publishedVersion)
- PubMed (publishedVersion)
- ABACUS. Repositorio de Producción Científica (Universidad Europea) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- National Cancer Institute (U54CA116867)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- physical activity, polypill, cardiovascular disease prevention, biological mediators, exercise epidemiology, cardiovascular risk reduction, adaptive evolution
- MeSH terms
- Age Factors, Aging, Animals, Cardiovascular Diseases, Drug Combinations, Humans, Physical Fitness, Risk Factors, Signal Transduction, Exercise, Oxidative Stress, Muscle, Skeletal, Polypharmacy, Risk Reduction Behavior, Sedentary Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review