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Cited by 228Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsPolymer-Based Agricultural Enhancements

The DOI matches its Crossref record.

Thermosensitive Polymeric Hydrogels As Drug Delivery Systems

Gong, C., Qi, T., Wei, X., Qu, Y., Wu, Q., Luo, F., Qian, Z.·2012·Current Medicinal Chemistry
DOI 10.2174/0929867311302010009
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Abstract

Thermosensitive hydrogels are very important biomaterials used in drug delivery systems (DDSs), which gained increasing attention of researchers. Thermosensitive hydrogels have great potential in various applications, such as drug delivery, cell encapsulation, tissue engineering, and etc. Especially, injectable thermosensitive hydrogels with lower sol-gel transition temperature around physiological temperature have been extensively studied. By in vivo injection, the hydrogels formed non-flowing gel at body temperature. Upon incorporation of pharmaceutical agents, the hydrogel systems could act as sustained drug release depot in situ. Injectable thermosensitive hydrogel systems have a number of advantages, including simplicity of drug formulation, protective environment for drugs, prolonged and localized drug delivery, and ease of application. The objective of this review is to summarize fundamentals, applications, and recent advances of injectable thermosensitive hydrogel as DDSs, including chitosan and related derivatives, poly(N-isopropylacrylamide)-based (PNIPAAM) copolymers, poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) copolymers and its derivatives, and poly(ethylene glycol)/ biodegradable polyester copolymers. Keywords: Injectable, thermosensitive, hydrogel, phase transition, drug delivery, controlled release, chitosan, N-Isopropylacrylamide, pluronic, PEG, PLA, PLGA, PCL, PCLA, PHB

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Crossref · 10.2174/0929867311302010009

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Metadata

Authors
Gong, C., Qi, T., Wei, X., Qu, Y., Wu, Q., Luo, F., & Qian, Z.
Affiliations
Sichuan University (CN)
Corresponding author
  • Qi, T.
  • Wu, Q.
  • Qian, Z.
ORCID
Venue
Current Medicinal Chemistry
Publisher
Bentham Science Publishers Ltd.
Published
2012-12-01
Volume
20
Issue
1
Pages
79-94
ISSN
0929-8673 (ISSN-L)
DOI
10.2174/0929867311302010009
OpenAlex
W4241712141
Cited by
228
References
0
Citations by year
2026: 12 · 2025: 9 · 2024: 15 · 2023: 18 · 2022: 17 · 2021: 22 · 2020: 21 · 2019: 23 · 2018: 23 · 2017: 16 · 2016: 20 · 2015: 13 · 2014: 11 · 2013: 7
FWCI
4.56
Type
journal article
Language
en
Open access
closed
Locations
Current Medicinal Chemistry (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Polymer-Based Agricultural Enhancements
Keywords
thermosensitive hydrogel, injectable hydrogel, drug delivery systems, sol-gel transition, controlled drug release, chitosan, poly(N-isopropylacrylamide), poloxamer, polyethylene glycol, PLGA, PCL, polyhydroxybutyrate, cell encapsulation, tissue engineering

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