Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy
Abstract
Photodynamic therapy (PDT) has been developed as an alternative modality for the management of neoplastic and nonneoplastic diseases. It is a minimally invasive treatment that involves the interaction of a non-toxic photosensitizer (PS), light and molecular oxygen to generate reactive oxygen species (ROS), resulting in the destruction of unwanted cells and tissues. Discovery and development of new PSs with optimized properties are much crucial for achieving a desirable therapeutic efficacy. This review describes the photochemical and photobiological mechanisms of PDT, and outlines the recent progress in discovery and development of natural products and their derivatives as phototherapeutic drugs. The potential limitations and future perspectives of PDT in clinical application are also presented and discussed.
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Many dyes, pigments, and aromatic hydrocarbons are effective photosensitizers because these molecules may reach a long-lived triplet state in high quantum yield.
“Many dyes, for example methylene blue, rose Bengal and eosin, pigments, for example chlorophyll, hematoporphyrin and flavins, and aromatic hydrocarbons are effective photosensitizers because these molecules may reach a long-lived triplet state in high quantum yield”
From Skin protection from solar ultraviolet radiation using natural compounds: a review (2024) · cites this paper as Xiao et al. 2018
Cited by
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Natural Photosensitizers in Antimicrobial Photodynamic Therapy
Polat, E., & Kang, K. (2021) · Biomedicines · doi:10.3390/biomedicines9060584 · Cited by 235 · see citing works
Skin protection from solar ultraviolet radiation using natural compounds: a review
Verma, A., Zanoletti, A., Kareem, K. Y., Adelodun, B., Kumar, P., Ajibade, F. O., Silva, L. F. O., Phillips, A. J., Kartheeswaran, T., Bontempi, E., et al. (2024) · Environmental Chemistry Letters · doi:10.1007/s10311-023-01649-4 · Cited by 102 · see citing works
- Authors
- Xiao, Q., Wu, J., Pang, X., Jiang, Y., Wang, P., Leung, A. W., Gao, L., Jiang, S., & Xu, C.
- Affiliations
- Chinese University of Hong Kong (HK)
- Sun Yat-sen University (CN)
- China Pharmaceutical University (CN)
- Corresponding author
- Xu, Chuanshan
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2018-03-15
- Volume
- 25
- Issue
- 7
- Pages
- 839-860
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2750468042
- Cited by
- 105
- References
- 0
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 25 · 2023: 12 · 2022: 7 · 2021: 19 · 2020: 9 · 2019: 7 · 2018: 2
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
- Keywords
- photodynamic therapy, photosensitizers, natural products, natural product derivatives, reactive oxygen species, photochemical mechanism, cancer therapy
- MeSH terms
- Biological Products, Humans, Neoplasms, Photochemotherapy, Molecular Structure, Photosensitizing Agents, Reactive Oxygen Species, Drug Discovery
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