Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Polat, Ece; Kang, Kyungsu

doi:10.3390/biomedicines9060584

Cited by 235Photodynamic Therapy Research StudiesAntimicrobial agents and applicationsBacterial biofilms and quorum sensing

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Open access

Polat, Ece, Kang, Kyungsu·2021·Biomedicines

DOI 10.3390/biomedicines9060584PMC PMC8224061

Open this paper in CoChat — free account Open PDF

Abstract

Health problems and reduced treatment effectiveness due to antimicrobial resistance have become important global problems and are important factors that negatively affect life expectancy. Antimicrobial photodynamic therapy (APDT) is constantly evolving and can minimize this antimicrobial resistance problem. Reactive oxygen species produced when nontoxic photosensitizers are exposed to light are the main functional components of APDT responsible for microbial destruction; therefore, APDT has a broad spectrum of target pathogens, such as bacteria, fungi, and viruses. Various photosensitizers, including natural extracts, compounds, and their synthetic derivatives, are being investigated. The main limitations, such as weak antimicrobial activity against Gram-negative bacteria, solubility, specificity, and cost, encourage the exploration of new photosensitizer candidates. Many additional methods, such as cell surface engineering, cotreatment with membrane-damaging agents, nanotechnology, computational simulation, and sonodynamic therapy, are also being investigated to develop novel APDT methods with improved properties. In this review, we summarize APDT research, focusing on natural photosensitizers used in in vitro and in vivo experimental models. In addition, we describe the limitations observed for natural photosensitizers and the methods developed to counter those limitations with emerging technologies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/biomedicines9060584

Cites

180 of 180 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Natural photosensitizers demonstrate advantages over synthetic compounds including lower toxicity to healthy tissues, tissue specificity, broad spectrum of target pathogens, lower incidence of side effects, reduced dark toxicity, and potential to overcome antimicrobial resistance.
“Natural PSs, as opposed to synthetic compounds, demonstrate several advantages including lower toxicity to healthy tissues, tissue specificity, a broad spectrum of target pathogens, a lower incidence of side effects, reduced dark toxicity, and the potential to overcome antimicrobial resistance [132,136].”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [136]
The Introduction and Conclusions (pages not provided) describe tissue specificity, broad pathogen coverage, and potential to overcome antimicrobial resistance as features of APDT. Section 6 compares natural and synthetic photosensitizers, but does not establish that natural ones have lower toxicity to healthy tissue, fewer side effects, or less dark toxicity than synthetic ones. The claim incorrectly presents APDT-wide properties as comparative advantages of natural photosensitizers. (LLM, conf=0.86)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies
Pang, Z., Raudonis, R., Glick, B. R., Lin, T., & Cheng, Z. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.11.013 · Cited by 2,375 · see citing works
Photodynamic therapy – mechanisms, photosensitizers and combinations
Kwiatkowski, S., Knap, B., Przystupski, D., Saczko, J., Kędzierska, E., Knap-Czop, K., Kotlińska, J., Michel, O., Kotowski, K., & Kulbacka, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.07.049 · Cited by 2,173 · cited 3× · see citing works
“Nanoscale PS delivery systems increase treatment efficiency by minimizing the side effects of conventional APDT [22,165].”
Background
New photosensitizers for photodynamic therapy
Abrahamse, H., & Hamblin, M. R. (2016) · Biochemical Journal · doi:10.1042/bj20150942 · Cited by 2,049 · see citing works
Photodynamic therapy: a new antimicrobial approach to infectious disease?
Hamblin, M. R., & Hasan, T. G. (2004) · Photochemical & Photobiological Sciences · doi:10.1039/b311900a · Cited by 2,040 · see citing works
Supramolecular photosensitizers rejuvenate photodynamic therapy
Li, X., Lee, S., & Yoon, J. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00594f · Cited by 1,117 · see citing works
Photosensitizers for Photodynamic Therapy
Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,088 · see citing works
Antimicrobial photodynamic therapy – what we know and what we don’t
Cieplik, F., Deng, D., Crielaard, W., Buchalla, W., Hellwig, E., Al-Ahmad, A., & Maisch, T. (2018) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2018.1467876 · Cited by 902 · see citing works
Bactericidal Activity of Curcumin I Is Associated with Damaging of Bacterial Membrane
Tyagi, P., Singh, M., Kumari, H., Kumari, A., & Mukhopadhyay, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121313 · Cited by 694 · see citing works
Antimicrobial Photodynamic Therapy to Control Clinically Relevant Biofilm Infections
Hu, X., Huang, Y., Wang, Y., Wang, X., & Hamblin, M. R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01299 · Cited by 508 · see citing works
Type I and Type II mechanisms of antimicrobial photodynamic therapy: An in vitro study on gram‐negative and gram‐positive bacteria
Huang, L., Yi, X., Koide, Y., Zhiyentayev, T., Tanaka, M., & Hamblin, M. R. (2012) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22045 · Cited by 397 · see citing works
An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy
Mesquita, M. Q., Dias, C. J., Gamelas, S. R. D., Fardilha, M., Neves, M. G. P. M. S., & Faustino, M. A. F. (2018) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720170800 · Cited by 381 · see citing works
Synthetic Chlorins, Possible Surrogates for Chlorophylls, Prepared by Derivatization of Porphyrins
Taniguchi, M., & Lindsey, J. S. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00696 · Cited by 319 · see citing works
Antimicrobial resistance: one world, one fight!
participants, F. T. W. H.-A. I. R. F., Harbarth, S., Balkhy, H. H., Goossens, H., Jarlier, V., Kluytmans, J. A. J. W., Laxminarayan, R., Saam, M., van Belkum, A., & Pittet, D. (2015) · Antimicrobial Resistance and Infection Control · doi:10.1186/s13756-015-0091-2 · Cited by 261 · see citing works
All you need is light
Denis, T. G. S., Dai, T., Izikson, L., Astrakas, C., Anderson, R. R., Hamblin, M. R., & Tegos, G. P. (2011) · Virulence · doi:10.4161/viru.2.6.17889 · Cited by 241 · see citing works
Antimicrobial use of reactive oxygen therapy: current insights
Memar, M. Y., Ghotaslou, R., Samiei, M., & Adibkia, K. (2018) · Infection and Drug Resistance · doi:10.2147/idr.s142397 · Cited by 233 · see citing works
Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate
Wiegell, S. R., & Wulf, H. C. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.12.033 · Cited by 216 · see citing works
Advances in antimicrobial photodynamic inactivation at the nanoscale
Kashef, N., Huang, Y., & Hamblin, M. R. (2017) · Nanophotonics · doi:10.1515/nanoph-2016-0189 · Cited by 209 · see citing works
Understanding antibiotic resistance via outer membrane permeability
Ghai, I., & Ghai, S. (2018) · Infection and Drug Resistance · doi:10.2147/idr.s156995 · Cited by 207 · see citing works
Bodipy–Anthracene Dyads as Triplet Photosensitizers: Effect of Chromophore Orientation on Triplet-State Formation Efficiency and Application in Triplet–Triplet Annihilation Upconversion
Wang, Z., & Zhao, J. (2017) · Organic Letters · doi:10.1021/acs.orglett.7b02047 · Cited by 205 · see citing works
Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy
Klausen, M., Üçüncü, M., & Bradley, M. (2020) · Molecules · doi:10.3390/molecules25225239 · Cited by 200 · see citing works
Cholesterol-Assisted Bacterial Cell Surface Engineering for Photodynamic Inactivation of Gram-Positive and Gram-Negative Bacteria
Jia, H., Zhu, Y., Chen, Z., & Wu, F. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b02562 · Cited by 180 · see citing works
De NovoSynthesis of Gem-Dialkyl Chlorophyll Analogues for Probing and Emulating Our Green World
Lindsey, J. S. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00065 · Cited by 165 · see citing works
Conjugated Photosensitizers for Imaging and PDT in Cancer Research
Simões, J. C. S., Sarpaki, S., Papadimitroulas, P., Therrien, B., & Loudos, G. K. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00047 · Cited by 156 · see citing works
Helicobacter pylori in patients can be killed by visible light
Ganz, R. A., Viveiros, J. D., Ahmad, A., et al. (2005) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20161 · Cited by 139 · see citing works
Antibacterial Photosensitization-Based Treatment for Food Safety
Lukšiené, Ž., & Brovko, L. (2013) · Food Engineering Reviews · doi:10.1007/s12393-013-9070-7 · Cited by 132 · see citing works
Antimicrobial photodynamic and wound healing activity of curcumin encapsulated in silica nanoparticles
Mirzahosseinipour, M., Khorsandi, K., Hosseinzadeh, R., et al. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.101639 · Cited by 131 · see citing works
Effects of curcumin-based photodynamic treatment on the storage quality of fresh-cut apples
Tao, R., Zhang, F., Tang, Q., et al. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.08.042 · Cited by 127 · see citing works
Bacteriochlorins and their metal complexes as NIR-absorbing photosensitizers: properties, mechanisms, and applications
Pucelik, B., Sułek, A., & Dąbrowski, J. M. (2020) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2020.213340 · Cited by 127 · see citing works
Enhanced antibacterial and antibiofilm functions of the curcumin-mediated photodynamic inactivation against Listeria monocytogenes
Huang, J., Chen, B., Li, H., Zeng, Q., Wang, J. J., Liu, H., Pan, Y., & Zhao, Y. (2019) · Food Control · doi:10.1016/j.foodcont.2019.106886 · Cited by 126 · see citing works
Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy
Liu, Y., Ma, K., Jiao, T., Xing, R., Shen, G., & Yan, X. (2017) · Scientific Reports · doi:10.1038/srep42978 · Cited by 121 · see citing works
Antimicrobial Activity of Apple Cider Vinegar against Escherichia Coli, Staphylococcus Aureus and Candida Albicans; Downregulating Cytokine and Microbial Protein Expression
Yagnik, D., Serafin, V., & J. Shah, A. (2018) · Scientific Reports · doi:10.1038/s41598-017-18618-x · Cited by 117 · see citing works
Oxygen-Independent Antimicrobial Photoinactivation: Type III Photochemical Mechanism?
Hamblin, M. R., & Abrahamse, H. (2020) · Antibiotics · doi:10.3390/antibiotics9020053 · Cited by 117 · see citing works
Antimicrobial Photodynamic Therapy in the Control of COVID-19
Almeida, A., Faustino, M. A. F., & Neves, M. G. P. M. S. (2020) · Antibiotics · doi:10.3390/antibiotics9060320 · Cited by 112 · see citing works
The Breaking and Mending of meso-Tetraarylporphyrins: Transmuting the Pyrrolic Building Blocks
Brückner, C. (2016) · Accounts of Chemical Research · doi:10.1021/acs.accounts.6b00043 · Cited by 106 · see citing works
Antimicrobial susceptibility of Staphylococcus aureus and Staphylococcus pseudintermedius isolated from various animals.
Rubin, J. E., Ball, K. R., & Chirino‐Trejo, M. (2011) · PubMed · Cited by 105 · see citing works
Discovery and Development of Natural Products and their Derivatives as Photosensitizers for Photodynamic Therapy
Xiao, Q., Wu, J., Pang, X., Jiang, Y., Wang, P., Leung, A. W., Gao, L., Jiang, S., & Xu, C. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867324666170823143137 · Cited by 105 · see citing works
A combination of photodynamic therapy and antimicrobial compounds to treat skin and mucosal infections: a systematic review
Pérez-Laguna, V., Gilaberte, Y., Millán-Lou, M. I., Agut, M., Nonell, S., Rezusta, A., & Hamblin, M. R. (2019) · Photochemical & Photobiological Sciences · doi:10.1039/c8pp00534f · Cited by 105 · see citing works
Lignin–Bimetallic Nanoconjugate Doped pH-Responsive Hydrogels for Laser-Assisted Antimicrobial Photodynamic Therapy
Chandna, S., Thakur, N. S., Kaur, R., et al. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00695 · Cited by 105 · see citing works
Eradication of planktonic Vibrio parahaemolyticus and its sessile biofilm by curcumin-mediated photodynamic inactivation
Chen, B., Huang, J., Li, H., Zeng, Q., Wang, J. J., Liu, H., Pan, Y., & Zhao, Y. (2020) · Food Control · doi:10.1016/j.foodcont.2020.107181 · Cited by 104 · see citing works
Antimicrobial Photodynamic therapy enhanced by the peptide aurein 1.2
de Freitas, L. M., Lorenzón, E. N., Santos‐Filho, N. A., Zago, L. H. D. P., Uliana, M. P., de Oliveira, K. T., Cilli, E. M., & Fontana, C. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-22687-x · Cited by 101 · see citing works
Curcumin induced photodynamic therapy mediated suppression of quorum sensing pathway of Pseudomonas aeruginosa: An approach to inhibit biofilm in vitro
Abdulrahman, H., Misba, L., Ahmad, S., & Khan, A. U. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.101645 · Cited by 100 · see citing works
The photoactivity of natural products – An overlooked potential of phytomedicines?
Siewert, B., & Stuppner, H. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152985 · Cited by 96 · see citing works
Conjugating biomaterials with photosensitizes: advancers and perspectives for photodynamic antimicrobial chemotherapy
Maldonado-Carmona, N., Ouk, T., Calvete, M. J. F., Pereira, M. M., Villandier, N., & Leroy‐Lhez, S. (2020) · Photochemical & Photobiological Sciences · doi:10.1039/c9pp00398c · Cited by 96 · see citing works
Sonodynamic inactivation of Gram-positive and Gram-negative bacteria using a Rose Bengal–antimicrobial peptide conjugate
Costley, D., Nesbitt, H., Ternan, N. G., Dooley, J. S. G., Huang, Y., Hamblin, M. R., McHale, A. P., & Callan, J. F. (2016) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2016.09.034 · Cited by 88 · see citing works
Antibacterial effect of 460 nm light-emitting diode in combination with riboflavin against Listeria monocytogenes on smoked salmon
Josewin, S. W., Ghate, V. S., Kim, M.-J., & Yuk, H. (2017) · Food Control · doi:10.1016/j.foodcont.2017.08.017 · Cited by 88 · see citing works
Antibacterial photodynamic therapy with curcumin and Curcuma xanthorrhiza extract against Streptococcus mutans
Lee, H.-J., Kang, S., Jeong, S.-H., Chung, K.-H., & Kim, B. (2017) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2017.09.003 · Cited by 88 · see citing works
Antimicrobial Photodynamic Therapy Mediated by Curcumin-Loaded Polymeric Nanoparticles in a Murine Model of Oral Candidiasis
Sakima, V. T., Barbugli, P. A., Cerri, P. S., Chorilli, M., Carmello, J. C., Pavarina, A. C., & Mima, E. G. D. O. (2018) · Molecules · doi:10.3390/molecules23082075 · Cited by 88 · see citing works
Photodamage on Staphylococcus aureus by natural extract from Tetragonia tetragonoides (Pall.) Kuntze: Clean method of extraction, characterization and photophysical studies
Campanholi, K. D. S. S., Jaski, J. M., Júnior, R. C. D. S., et al. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111763 · Cited by 84 · see citing works
Photodynamic antimicrobial chemotherapy for Staphylococcus aureus and multidrug-resistant bacterial burn infection in vitro and in vivo
Mai, B., Gao, Y., Li, M., Wang, X., Zhang, K., Liu, Q., Xu, C., & Wang, P. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s138185 · Cited by 83 · see citing works
Back to the roots: photodynamic inactivation of bacteria based on water-soluble curcumin bound to polyvinylpyrrolidone as a photosensitizer
Winter, S., Tortik, N., Kubin, A., et al. (2013) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp50095k · Cited by 72 · see citing works
Secondary Plant Products Causing Photosensitization in Grazing Herbivores: Their Structure, Activity and Regulation
Quinn, J. C., Kessell, A., & Weston, L. A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011441 · Cited by 71 · see citing works
Exploring the Applications of the Photoprotective Properties of Anthocyanins in Biological Systems
Oliveira, H., Correia, P., Pereira, A. R., Araújo, P., Mateus, N. F. D. C. B., de Freitas, V. A. P., Oliveira, J., & Fernandes, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207464 · Cited by 71 · see citing works
The Chlorophyll Catabolite Pheophorbide a as a Photosensitizer for the Photodynamic Therapy
Xodo, L. E., Rapozzi, V., Zacchigna, M., et al. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712799034879 · Cited by 69 · see citing works
Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: A randomized, single-blind, split-face study
Song, B. H., Lee, D. H., Kim, B. C., et al. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2014.05.047 · Cited by 65 · see citing works
Photodynamic antibacterial and antibiofilm activity of RLP068/Cl against Staphylococcus aureus and Pseudomonas aeruginosa forming biofilms on prosthetic material
Vassena, C., Fenu, S., Giuliani, F., et al. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.03.012 · Cited by 65 · see citing works
Poly(carboxylic acid)-Cyclodextrin/Anionic Porphyrin Finished Fabrics as Photosensitizer Releasers for Antimicrobial Photodynamic Therapy
Castriciano, M. A., Zagami, R., Casaletto, M. P., et al. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.6b01752 · Cited by 65 · see citing works
Advances in aPDT based on the combination of a porphyrinic formulation with potassium iodide: Effectiveness on bacteria and fungi planktonic/biofilm forms and viruses
Vieira, C., dos Santos, A. R., Mesquita, M. Q., et al. (2019) · Journal of Porphyrins and Phthalocyanines · doi:10.1142/s1088424619500408 · Cited by 65 · see citing works
Inclusion of 5-[4-(1-Dodecanoylpyridinium)]-10,15,20-triphenylporphine in Supramolecular Aggregates of Cationic Amphiphilic Cyclodextrins: Physicochemical Characterization of the Complexes and Strengthening of the Antimicrobial Photosensitizing Activity
Ferro, S., Jori, G., Sortino, S., et al. (2009) · Biomacromolecules · doi:10.1021/bm900533r · Cited by 64 · see citing works
Curcumin and Photobiomodulation in Chronic Viral Hepatitis and Hepatocellular Carcinoma
Ailioaie, L. M., & Litscher, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197150 · Cited by 61 · see citing works
Ultrasonic activation and chemical modification of photosensitizers enhances the effects of photodynamic therapy against Enterococcus faecalis root-canal isolates
Tennert, C., Drews, A., Walther, V., et al. (2015) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2015.02.002 · Cited by 60 · see citing works
Photodynamic therapy of Curcuma longa extract stimulated with blue light against Aggregatibacter actinomycetemcomitans
Saitawee, D., Teerakapong, A., Morales, N. P., et al. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.03.001 · Cited by 60 · see citing works
Oral Decontamination of Orthodontic Patients Using Photodynamic Therapy Mediated by Blue-Light Irradiation and Curcumin Associated with Sodium Dodecyl Sulfate
Panhóca, V. H., Florez, F. L. E., Corrêa, T. Q., et al. (2016) · Photomedicine and Laser Surgery · doi:10.1089/pho.2015.4080 · Cited by 58 · see citing works
Avoiding ventilator-associated pneumonia: Curcumin-functionalized endotracheal tube and photodynamic action
Zangirolami, A. C., Dias, L. D., Blanco, K. C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006759117 · Cited by 58 · see citing works
Effects of the photosensitizer curcumin in inactivating foodborne pathogens on chicken skin
Gao, J., & Matthews, K. R. (2019) · Food Control · doi:10.1016/j.foodcont.2019.106959 · Cited by 57 · see citing works
Photodynamic inactivation of Listeria innocua biofilms with food-grade photosensitizers: a curcumin-rich extract of Curcuma longa vs commercial curcumin
Bonifacio, D. S., Martins, C. F., David, B., et al. (2018) · Journal of Applied Microbiology · doi:10.1111/jam.13767 · Cited by 56 · see citing works
Evaluation of hypocrellin A-loaded lipase sensitive polymer micelles for intervening methicillin-resistant Staphylococcus Aureus antibiotic-resistant bacterial infection
Guo, L.-Y., Yan, S., Tao, X., Yang, Q., Li, Q., Wang, T., Yu, S., & Chen, S. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110230 · Cited by 56 · see citing works
Parietin: an efficient photo-screening pigment in vivo with good photosensitizing and photodynamic antibacterial effects in vitro
Comini, L. R., Vieyra, F. E. M., Mignone, R. A., Páez, P. L., Mugas, M. L., Konigheim, B. S., Cabrera, J. L., Montoya, S. C. N., & Borsarelli, C. D. (2016) · Photochemical & Photobiological Sciences · doi:10.1039/c6pp00334f · Cited by 55 · see citing works
Antimicrobial sonodynamic and photodynamic therapies against Candida albicans
Alves, F., Pavarina, A. C., Mima, E. G. D. O., McHale, A. P., & Callan, J. F. (2018) · Biofouling · doi:10.1080/08927014.2018.1439935 · Cited by 54 · see citing works
Inactivation of multidrug resistant (MDR)- and extensively drug resistant (XDR)-Mycobacterium tuberculosis by photodynamic therapy
Sung, N., Back, S., Jung, J.-H., Kim, K., Kim, J.-K., Lee, J. H., Ra, Y., Yang, H. C., Lim, C., Cho, S., et al. (2013) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2013.09.001 · Cited by 53 · see citing works
Antimicrobial action of photodynamic therapy in root canals using LED curing light, curcumin and carbopol gel
Oda, D. F., Duarte, M. A. H., de Andrade, F. B., et al. (2019) · International Endodontic Journal · doi:10.1111/iej.13092 · Cited by 53 · see citing works
Antimicrobial blue light photoinactivation of Pseudomonas aeruginosa: Quorum sensing signaling molecules, biofilm formation and pathogenicity
Fila, G., Krychowiak‐Masnicka, M., Rychłowski, M., et al. (2018) · Journal of Biophotonics · doi:10.1002/jbio.201800079 · Cited by 52 · see citing works
Porphyrins and other pyrrolic macrocycles in cycloaddition reactions
Tomé, A. C., Neves, M. G. P. M. S., & Cavaleiro, J. A. S. (2009) · Journal of Porphyrins and Phthalocyanines · doi:10.1142/s1088424609000619 · Cited by 52 · see citing works
Screening for antibacterial activity of some Turkish plants against fish pathogens: a possible alternative in the treatment of bacterial infections
Türker, H., & Yıldırım, A. B. (2015) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2015.1006445 · Cited by 51 · see citing works
Hypericin inclusion complexes encapsulated in liposomes for antimicrobial photodynamic therapy
Plenagl, N., Seitz, B. S., Duse, L., et al. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118666 · Cited by 51 · see citing works
Hospital and Community Ampicillin-Resistant Enterococcus faecium Are Evolutionarily Closely Linked but Have Diversified through Niche Adaptation
de Regt, M. J. A., van Schaik, W., van Luit‐Asbroek, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030319 · Cited by 50 · see citing works
Bactericidal Effect of Photodynamic Therapy, Alone or in Combination with Mupirocin or Linezolid, on Staphylococcus aureus
Pérez-Laguna, V., Pérez-Artiaga, L., Lampaya-Pérez, V., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01002 · Cited by 50 · see citing works
Singlet oxygen photosensitisation by the fluorescent protein Pp2FbFP L30M, a novel derivative of Pseudomonas putida flavin-binding Pp2FbFP
Torra, J., Burgos‐Caminal, A., Endres, S., et al. (2014) · Photochemical & Photobiological Sciences · doi:10.1039/c4pp00338a · Cited by 48 · see citing works
Photodynamic Inactivation of Herpes Simplex Viruses
Monjo, A. L.-A., Pringle, E. S., Thornbury, M., Duguay, B. A., Monro, S. M. A., Hetu, M., Knight, D., Cameron, C. G., McFarland, S. A., & McCormick, C. (2018) · Viruses · doi:10.3390/v10100532 · Cited by 47 · see citing works
Save the crop: Photodynamic Inactivation of plant pathogens I: bacteria
Glueck, M., Hamminger, C., Fefer, M., Liu, J., & Plaetzer, K. (2019) · Photochemical & Photobiological Sciences · doi:10.1039/c9pp00128j · Cited by 47 · see citing works
The effects of aloe emodin-mediated antimicrobial photodynamic therapy on drug-sensitive and resistant Candida albicans
Ma, W., Liu, C., Li, J., et al. (2020) · Photochemical & Photobiological Sciences · doi:10.1039/c9pp00352e · Cited by 47 · see citing works
Pheophorbide a, a compound isolated from the leaves of Arrabidaea chica, induces photodynamic inactivation of Trypanosoma cruzi
Miranda, N., Gerola, A. P., Novello, C. R., et al. (2017) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2017.05.004 · Cited by 45 · see citing works
Efficient photosensitizers with aggregation-induced emission characteristics for lysosome- and Gram-positive bacteria-targeted photodynamic therapy
Zhuang, J., Yang, H., Li, Y., Wang, B., Li, N., & Zhao, N. (2020) · Chemical Communications · doi:10.1039/d0cc00394h · Cited by 45 · see citing works
In vitro antimicrobial photodynamic therapy using tetra-cationic porphyrins against multidrug-resistant bacteria isolated from canine otitis
Seeger, M. G., Ries, A. S., Gressler, L. T., Botton, S. D. Á., Iglesias, B. A., & Cargnelutti, J. F. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101982 · Cited by 45 · see citing works
Electroporation enhances antimicrobial photodynamic therapy mediated by the hydrophobic photosensitizer, hypericin
Melo, W., Lee, A. N., Perussi, J. R., et al. (2013) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2013.08.001 · Cited by 44 · see citing works
Antimicrobial Biophotonic Treatment of Ampicillin-Resistant Pseudomonas aeruginosa with Hypericin and Ampicillin Cotreatment Followed by Orange Light
Alam, S., Le, T., Park, J.-S., Kwon, H., & Kang, K. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11120641 · Cited by 44 · see citing works
Self-citation
Progressive cationic functionalization of chlorin derivatives for antimicrobial photodynamic inactivation and related vancomycin conjugates
Huang, L., Wang, M., Huang, Y., El‐Hussein, A., Wolf, L. M., Chiang, L. Y., & Hamblin, M. R. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00389g · Cited by 43 · see citing works
Photodynamic Antifungal Activity of Hypocrellin A Against Candida albicans
Yang, Y., Wang, C., Zhuge, Y., Zhang, J., Xu, K., Zhang, Q., Zhang, H., Chen, H., Chu, M., & Jia, C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01810 · Cited by 43 · see citing works
Dual wavelength irradiation antimicrobial photodynamic therapy using indocyanine green and metformin doped with nano-curcumin as an efficient adjunctive endodontic treatment modality
Pourhajibagher, M., Plotino, G., Chiniforush, N., & Bahador, A. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.101628 · Cited by 43 · see citing works
Comparison of efficacy of aminolaevulinic acid photodynamic therapy vs. adapalene gel plus oral doxycycline for treatment of moderate acne vulgaris–A simple, blind, randomized, and controlled trial
Nicklas, C., Rubio, R., Cárdenas, C., et al. (2018) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12413 · Cited by 42 · see citing works
3,3′-Diindolylmethane Improves Intestinal Permeability Dysfunction in Cultured Human Intestinal Cells and the Model Animal Caenorhabditis elegans
Kim, J. Y., Le, T. A. N., Lee, S. Y., Song, D., Hong, S.-C., Hyun, K., Lee, J. W., Pan, C., & Kang, K. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b03039 · Cited by 42 · see citing works
Self-citation
Antimicrobial photodynamic therapy on Staphylococcus aureus and Escherichia coli using malachite green encapsulated mesoporous silica nanoparticles: an in vitro study
Parasuraman, P., Busi, S., B, S. L. S., Sharan, A., Alyousef, A. A., Dosary, M. S. A., Arshad, M., & Syed, A. (2019) · PeerJ · doi:10.7717/peerj.7454 · Cited by 42 · see citing works
In vitro antimicrobial effect of curcumin-based photodynamic therapy on Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans.
Pan, H., Wang, D., & Zhang, F.-Q. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.102055 · Cited by 42 · see citing works
Synthesis and antimicrobial photodynamic activities of axially {4-[(1E)-3-oxo-3-(2-thienyl)prop-1-en-1-yl]phenoxy} groups substituted silicon phthalocyanine, subphthalocyanine on Gram-positive and Gram-negative bacteria
Bıyıklıoğlu, Z., Öztürk, İ., Arslan, T., et al. (2019) · Dyes and Pigments · doi:10.1016/j.dyepig.2019.03.010 · Cited by 41 · see citing works
Phototoxic effect of hypericin alone and in combination with acetylcysteine on Staphylococcus aureus biofilms
Kashef, N., Karami, S., & Djavid, G. E. (2015) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2015.04.001 · Cited by 40 · see citing works
Plant extracts as natural photosensitizers in photodynamic therapy: in vitro activity against human mammary adenocarcinoma MCF-7 cells
Villacorta, R. B., Roque, K. F. J., Tapang, G. A., & Jacinto, S. D. (2017) · Asian Pacific Journal of Tropical Biomedicine · doi:10.1016/j.apjtb.2017.01.025 · Cited by 40 · see citing works
Photodynamic inactivation of selected bovine viruses by isomeric cationic tetra-platinated porphyrins
Basso, G. B., Cargnelutti, J. F., de Oliveira, A. L. J., et al. (2019) · Journal of Porphyrins and Phthalocyanines · doi:10.1142/s1088424619500767 · Cited by 40 · see citing works
Photodynamically Active Electrospun Fibers for Antibiotic-Free Infection Control
Contreras, A., Raxworthy, M. J., Wood, S., et al. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00543 · Cited by 40 · see citing works
"Antimicrobial photodynamic therapy (aPDT) with curcumin and LED, as an enhancement to scaling and root planing in the treatment of residual pockets in diabetic patients: a randomized and controlled split-mouth clinical trial".
Ivanaga, C., Miessi, D., Nuernberg, M. A. A., Cláudio, M. M., Garcia, V., & Theodoro, L. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.07.005 · Cited by 39 · see citing works
Photodithazine-mediated antimicrobial photodynamic therapy against fluconazole-resistant Candida albicans in vivo
Alves, F., Carmello, J. C., Mima, E. G. D. O., Costa, C. A. D. S., Bagnato, V. S., & Pavarina, A. C. (2018) · Medical Mycology · doi:10.1093/mmy/myy083 · Cited by 38 · see citing works
Synergistic effect of carboxypterin and methylene blue applied to antimicrobial photodynamic therapy against mature biofilm of Klebsiella pneumoniae
Tosato, M. G., Schilardi, P. L., de Mele, M. F. L., et al. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03522 · Cited by 38 · see citing works
Antimicrobial photodynamic therapy against Propionibacterium acnes biofilms using hypericin (Hypericum perforatum) photosensitizer: in vitro study
Barroso, R. A., Navarro, R. S., Tim, C. R., et al. (2020) · Lasers in Medical Science · doi:10.1007/s10103-020-03163-3 · Cited by 38 · see citing works
Nanotechnology, Light and Chemical Action: an Effective Combination to Kill Cancer Cells
Deda, D. K., & Araki, K. (2015) · Journal of the Brazilian Chemical Society · doi:10.5935/0103-5053.20150316 · Cited by 37 · see citing works
Bacterial Viability After Antimicrobial Photodynamic Therapy with Curcumin on Multiresistant Staphylococcus Aureus
Freitas, M. A., Pereira, A. H., Pinto, J. G., Casas, A. G., & Ferreira–Strixino, J. (2019) · Future Microbiology · doi:10.2217/fmb-2019-0042 · Cited by 36 · see citing works
Topical antimicrobial photodynamic therapy improves angiogenesis in wounds of diabetic mice
Sahu, K., Sharma, M., Dube, A., et al. (2015) · Lasers in Medical Science · doi:10.1007/s10103-015-1784-8 · Cited by 35 · see citing works
Antifungal photodynamic activities of phthalocyanine derivatives on Candida albicans
Öztürk, İ., Tunçel, A., Yurt, F., Bıyıklıoğlu, Z., Ince, M., & Ocakoğlu, K. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101715 · Cited by 35 · see citing works
Natural photosensitizers in photodynamic therapy: In vitro activity against monolayers and spheroids of human colorectal adenocarcinoma SW480 cells
Cogno, I. S., Gilardi, P., Comini, L. R., Montoya, S. C. N., Cabrera, J. L., & Rivarola, V. A. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101852 · Cited by 35 · see citing works
Progress of photodynamic therapy applications in the treatment of musculoskeletal sarcoma (Review)
Zhang, X., Liu, T., Li, Z., & Zhang, X. (2014) · Oncology Letters · doi:10.3892/ol.2014.2332 · Cited by 34 · see citing works
Antimicrobial photodynamic efficacy of selected natural photosensitizers against food pathogens: Impacts and interrelationship of process parameters
Le, D. T., Phasupan, P., & Nguyen, L. T. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.102024 · Cited by 34 · see citing works
Farm-to-Tap Water Treatment: Naturally-Sourced Photosensitizers for Enhanced Solar Disinfection of Drinking Water
Ryberg, E. C., Knight, J., & Kim, J. (2020) · ACS ES&T Engineering · doi:10.1021/acsestengg.0c00067 · Cited by 34 · see citing works
Triphenylphosphonium cation: A valuable functional group for antimicrobial photodynamic therapy
Bresolí‐Obach, R., Gispert, I., Peña, D. G., Boga, S., Gulías, Ò., Agut, M., Vázquez, M. E., & Nonell, S. (2018) · Journal of Biophotonics · doi:10.1002/jbio.201800054 · Cited by 33 · see citing works
Genetically Encoded Photosensitizers as Light-Triggered Antimicrobial Agents
Hilgers, F., Bitzenhofer, N. L., Ackermann, Y. S., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184608 · Cited by 33 · see citing works
Antimicrobial photodynamic therapy with Bixa orellana extract and blue LED in the reduction of halitosis—A randomized, controlled clinical trial
Gonçalves, M. L. L., da Mota, A. C. C., Deana, A. M., Cavalcante, L. A. D. S., Horliana, A. C. R. T., Pavani, C., Motta, L. J., Fernandes, K. P. S., Mesquita‐Ferrari, R. A., da Silva, D. D. F. T., et al. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101751 · Cited by 32 · see citing works
Learning from Nature: Bioinspired Chlorin-Based Photosensitizers Immobilized on Carbon Materials for Combined Photodynamic and Photothermal Therapy
Dias, L. D., & Mfouo-Tynga, I. S. (2020) · Biomimetics · doi:10.3390/biomimetics5040053 · Cited by 32 · see citing works
Aloe-emodin-mediated antimicrobial photodynamic therapy against multidrug-resistant Acinetobacter baumannii: An in vivo study
Wang, Y., Li, J., Geng, S., et al. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102311 · Cited by 32 · see citing works
Serum albumins are efficient delivery systems for the photosensitizer hypericin in photosensitization-based treatments against Staphylococcus aureus
Pezzuoli, D., Cozzolino, M., Montali, C., et al. (2018) · Food Control · doi:10.1016/j.foodcont.2018.07.027 · Cited by 31 · see citing works
Preliminary evaluation of the positively and negatively charge effects of tetra-substituted porphyrins on photoinactivation of rapidly growing mycobacteria
Guterres, K. B., Rossi, G. G., Menezes, L. B., et al. (2019) · Tuberculosis · doi:10.1016/j.tube.2019.06.001 · Cited by 31 · see citing works
Natural anthraquinones as novel photosentizers for antiparasitic photodynamic inactivation
Dimmer, J. A., Cabral, F. V., Sabino, C. P., et al. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.152894 · Cited by 30 · see citing works
Antimicrobial Photodynamic Inactivation Affects the Antibiotic Susceptibility of Enterococcus spp. Clinical Isolates in Biofilm and Planktonic Cultures
Woźniak, A., Kruszewska-Naczk, B., Pierański, M. K., Rychłowski, M., & Grinholc, M. (2021) · Biomolecules · doi:10.3390/biom11050693 · Cited by 30 · see citing works
Exploring the Galleria mellonella model to study antifungal photodynamic therapy
Figueiredo-Godoi, L. M. A., de Menezes, R. T., Carvalho, J. S., et al. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.05.010 · Cited by 29 · see citing works
Antimicrobial photodynamic therapy efficacy against specific pathogenic periodontitis bacterial species
Park, D., Kim, M. G., Choi, J. W., Baek, J., Lee, S. H., & Baek, K. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101688 · Cited by 29 · see citing works
The in vitro Photoinactivation of Helicobacter pylori by a Novel LED-Based Device
Morici, P., Battisti, A., Tortora, G., Menciassi, A., Checcucci, G., Ghetti, F., & Sgarbossa, A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00283 · Cited by 29 · see citing works
Host-guest complexes - boosting the performance of photosensitizers.
Sowa, A., & Voskuhl, J. (2020) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2020.119595 · Cited by 29 · see citing works
Synthesis of chlorins, bacteriochlorins and their tetraaza analogues
Dudkin, S. V., Makarova, E. A., & Lukyanets, E. A. (2015) · Russian Chemical Reviews · doi:10.1070/rcr4565 · Cited by 28 · see citing works
Photodynamic antimicrobial activity of new porphyrin derivatives against methicillin resistant Staphylococcus aureus
Taşlı, H., Akbıyık, A., Topaloğlu, N., Alptüzün, V., & Parlar, S. (2018) · The Journal of Microbiology · doi:10.1007/s12275-018-8244-7 · Cited by 28 · see citing works
Enhanced photodynamic inactivation for Gram-negative bacteria by branched polyethylenimine-containing nanoparticles under visible light irradiation
Wang, Q., Zhang, D., Feng, J., et al. (2020) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2020.09.106 · Cited by 28 · see citing works
The effect of combined curcumin-mediated photodynamic therapy and artificial skin on Staphylococcus aureus–infected wounds in rats
Paolillo, F. R., Rodrigues, P. G. S., Bagnato, V. S., et al. (2020) · Lasers in Medical Science · doi:10.1007/s10103-020-03160-6 · Cited by 28 · see citing works
Urinary tract infection caused by methicillin-resistant Staphylococcus pseudintermedius in a dog.
Rubin, J. E., & Gaunt, M. C. (2011) · PubMed · Cited by 27 · see citing works
Photodynamic antimicrobial effects of bis-indole alkaloid indigo from Indigofera truxillensis Kunth (Leguminosae)
Andreazza, N. L., de Lourenço, C. C., Stefanello, M. É. A., et al. (2015) · Lasers in Medical Science · doi:10.1007/s10103-015-1735-4 · Cited by 27 · see citing works
Antimicrobial Photodynamic Therapy mediated by Photodithazine® in the treatment of denture stomatitis: A case report
Alves, F., Alonso, G. C., Carmello, J. C., et al. (2017) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2017.11.018 · Cited by 27 · see citing works
Toward better microbial safety of wheat sprouts: chlorophyllin-based photosensitization of seeds
Žudyté, B., & Lukšiené, Ž. (2019) · Photochemical & Photobiological Sciences · doi:10.1039/c9pp00157c · Cited by 27 · see citing works
Optimization of optical parameters for improved photodynamic therapy of Staphylococcus aureus using endogenous coproporphyrin III
Walter, A. B., Simpson, J., Jenkins, J. L., Skaar, E. P., & Jansen, D. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.101624 · Cited by 27 · see citing works
Inactivation of microbes on fruit surfaces using photodynamic therapy and its influence on the postharvest shelf-life of fruits
Zhang, X., Wu, J., Xu, C., et al. (2020) · Food Science and Technology International · doi:10.1177/1082013220921330 · Cited by 27 · see citing works
Assessment and Characterization of Some New Photosensitizers for Antimicrobial Photodynamic Therapy (aPDT)
Dascalu, L. M., Moldovan, M., Prodan, D., Ciotlaus, I., Popescu, V., Bâldea, I., Carpa, R., Sava, S., Chifor, R., & Badea, M. E. (2020) · Materials · doi:10.3390/ma13133012 · Cited by 27 · see citing works
Inactivation of specific spoilage organism (Pseudomonas) of sturgeon by curcumin-mediated photodynamic inactivation
Chen, G., Li, Y., Gao, R., et al. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101827 · Cited by 26 · see citing works
Antimicrobial and immunomodulatory responses of photodynamic therapy in Galleria mellonella model
Huang, X., Xu, M., Pan, W., et al. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01882-9 · Cited by 26 · see citing works
Antimicrobial Photoinactivation Using Visible Light Plus Water-Filtered Infrared-A (VIS + wIRA) and Hypericum Perforatum Modifies In Situ Oral Biofilms
Vollmer, A., Al‐Ahmad, A., Argyropoulou, A., Thurnheer, T., Hellwig, E., Attin, T., Vach, K., Wittmer, A., Ferguson, K., Skaltsounis, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56925-7 · Cited by 25 · see citing works
Antimicrobial activity of amphiphilic nanomicelles loaded with curcumin against Pseudomonas aeruginosa alone and activated by blue laser light
Rupel, K., Zupin, L., Brich, S., Mardirossian, M., Ottaviani, G., Gobbo, M., Lenarda, R. D., Pricl, S., Crovella, S., Zacchigna, S., et al. (2020) · Journal of Biophotonics · doi:10.1002/jbio.202000350 · Cited by 25 · see citing works
Clinical Analysis of Five Methods Used to Treat Condylomata Acuminata
Shi, H., Zhang, X., Ma, C., et al. (2013) · Dermatology · doi:10.1159/000355351 · Cited by 24 · see citing works
Natural photosensitizers from Tripterygium wilfordii and their antimicrobial photodynamic therapeutic effects in a Caenorhabditis elegans model
Alam, S. T., Hwang, H., Son, J. D., et al. (2021) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2021.112184 · Cited by 24 · see citing works
Toxicological evaluation of the topoisomerase inhibitor, etoposide, in the model animal Caenorhabditis elegans and 3T3‐L1 normal murine cells
Lee, S. Y., Kim, J. Y., Jung, Y., & Kang, K. (2017) · Environmental Toxicology · doi:10.1002/tox.22406 · Cited by 23 · see citing works
Self-citation
Antifungal photosensitive activity of Porophyllum obscurum (Spreng.) DC.: Correlation of the chemical composition of the hexane extract with the bioactivity
Postigo, A., Funes, M. D., Petenatti, E. M., Bottai, H., Pacciaroni, A. D. V., & Sortino, M. A. (2017) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2017.10.023 · Cited by 23 · see citing works
Synergistic effects of ultrasound and photodynamic therapy leading to biofilm eradication on polyurethane catheter surfaces modified with hypericin nanoformulations
Vögeling, H., Plenagl, N., Seitz, B. S., et al. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109749 · Cited by 23 · see citing works
A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen
Ruiz‐González, R., White, J. H., Agut, M., et al. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c2pp25126d · Cited by 22 · see citing works
Effect of photodynamic inactivation of Escherichia coli by hypericin
Zhang, J.-N., Zhang, F., Tang, Q., et al. (2018) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-018-2464-1 · Cited by 22 · see citing works
New Flu Antiviral Candidate May Thwart Drug Resistance
Hampton, T. (2020) · JAMA · doi:10.1001/jama.2019.20225 · Cited by 22 · see citing works
Evolution of surviving Streptoccocus pyogenes from pharyngotonsillitis patients submit to multiple cycles of antimicrobial photodynamic therapy
Soares, J. M., Inada, N. M., Bagnato, V. S., et al. (2020) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2020.111985 · Cited by 21 · see citing works
Antimicrobial photodynamic effect of extracts and oxoaporphine alkaloid isomoschatoline from Guatteria blepharophylla
Andreazza, N. L., de Lourenço, C. C., Tasco, A. J. H., Pinheiro, M. L. B., Stefanello, M. É. A., Costa, E. V., & Salvador, M. J. (2016) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2016.04.010 · Cited by 20 · see citing works
The Impact of Photosensitizer Selection on Bactericidal Efficacy Of PDT against Cariogenic Biofilms: A Systematic Review and Meta-Analysis
Teófilo, M. Í. S., Russi, T. M. A. Z. D. C., Silva, P. G. D. B., Balhaddad, A. A., Melo, M. A. S., & Rolim, J. P. M. L. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.102046 · Cited by 20 · see citing works
Photodynamic therapry with curcumin in the reduction of enterococcus faecalis biofilm in bone cavity: rMicrobiological and spectral fluorescense analysis
Rocha, M. P., Santos, M. S., Rodrigues, P. L. F., et al. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.102084 · Cited by 20 · see citing works
Photodynamic activity of Tagetes minuta extracts against superficial fungal infections
Giacone, L., Cordisco, E., Garrido, M. C., Petenatti, E. M., & Sortino, M. A. (2019) · Medical Mycology · doi:10.1093/mmy/myz114 · Cited by 19 · see citing works
Antibacterial photodynamic activity of photosensitizer-embedded alginate-pectin-carboxymethyl cellulose composite biopolymer films
Sharma, M., Dube, A., & Majumder, S. K. (2020) · Lasers in Medical Science · doi:10.1007/s10103-020-03083-2 · Cited by 19 · see citing works
Sn(IV) N-confused porphyrins as photosensitizer dyes for photodynamic therapy in the near IR region.
Babu, B., Mack, J., & Nyokong, T. (2020) · Dalton Transactions · doi:10.1039/d0dt03296d · Cited by 19 · see citing works
Combinatory Effect of ALA‐PDT and Itraconazole Treatment for Trichosporon asahii
Lan, Y., Lu, S., Zheng, B., et al. (2020) · Lasers in Surgery and Medicine · doi:10.1002/lsm.23343 · Cited by 19 · see citing works
Measuring the Effect of Chemicals on the Growth and Reproduction of Caenorhabditis elegans
Lee, S. Y., & Kang, K. (2017) · Journal of Visualized Experiments · doi:10.3791/56437 · Cited by 18 · see citing works
Self-citation
Photodynamic therapy with Bixa orellana extract and LED for the reduction of halitosis: study protocol for a randomized, microbiological and clinical trial
Gonçalves, M. L. L., da Mota, A. C. C., Deana, A. M., et al. (2018) · Trials · doi:10.1186/s13063-018-2913-z · Cited by 18 · see citing works
Photosensitizing proteins for antibacterial photodynamic inactivation
Hally, C., Delcanale, P., Nonell, S., Viappiani, C., & Abbruzzetti, S. (2020) · Translational Biophotonics · doi:10.1002/tbio.201900031 · Cited by 18 · see citing works
Photoantimicrobials—An update
Maisch, T. (2020) · Translational Biophotonics · doi:10.1002/tbio.201900033 · Cited by 18 · see citing works
In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections
Raschpichler, M., Agel, M. R., Pinnapireddy, S. R., et al. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c8pp00267c · Cited by 16 · see citing works
Identification of carbonylated proteins in a bactericidal process induced by curcumin with blue light irradiation on imipenem‐resistant Acinetobacter baumannii
Chang, K., Cheng, Y., Lai, M., et al. (2019) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.8548 · Cited by 16 · see citing works
Effect of photosensitisers on growth and morphology of Phytophthora citrophthora coupled with leaf bioassays in pear seedlings
Zambounis, A. G., Sytar, O., Valasiadis, D., et al. (2020) · Plant Protection Science · doi:10.17221/102/2019-pps · Cited by 16 · see citing works
Photodynamic inactivation for in vitro decontamination of Staphylococcus aureus in whole blood
Corrêa, T. Q., Blanco, K. C., Soares, J. M., et al. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.08.013 · Cited by 15 · see citing works
Total mouth photodynamic therapy mediated by blue led and curcumin in individuals with AIDS
da Silva, F. C., Rosa, L. P., Santos, G. P. D. O., et al. (2020) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2020.1756774 · Cited by 14 · see citing works
Side effects of intra-gastric photodynamic therapy: an in vitro study
Faraoni, P., Gnerucci, A., Ranaldi, F., et al. (2018) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2018.07.010 · Cited by 13 · see citing works
Dye extract of calyces of Hibiscus sabdariffa has photodynamic antibacterial activity: A prospect for sunlight‐driven fresh produce sanitation
Majiya, H., & Galstyan, A. (2020) · Food Science & Nutrition · doi:10.1002/fsn3.1580 · Cited by 13 · see citing works
Effect of antibacterial photodynamic therapy on Streptococcus mutans plaque biofilm in vitro
Liang, X., Zou, Z., Zou, Z., et al. (2020) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545820500224 · Cited by 13 · see citing works
Hypericin-glucamine antimicrobial photodynamic therapy in the progression of experimentally induced periodontal disease in rats
Macedo, P. D., Corbi, S. C. T., de Oliveira, G. J. P. L., et al. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.11.003 · Cited by 12 · see citing works
Plant Photodynamic Stress: What's New?
Issawi, M., Sol, V., & Riou, C. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00681 · Cited by 11 · see citing works
Anti-Early Stage of Bacterial Recolonization Effect of Curcuma longa Extract as Photodynamic Adjunctive Treatment
Hormdee, D., Rinsathorn, W., Puasiri, S., & Jitprasertwong, P. (2020) · International Journal of Dentistry · doi:10.1155/2020/8823708 · Cited by 10 · see citing works
Use of nanostructured materials in drug delivery
Vázquez-Hernández, F., Granada-Ramírez, D. A., Arias-Cerón, J. S., et al. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100716-7.00020-9 · Cited by 9 · see citing works
Photodynamic inactivation of Pseudomonas aeruginosa bacterial biofilms using photosensitizers based on octacationic derivatives of phthalocyanines and bacteriochlorins
Meerovich, G. A., Akhlyustina, E. V., Глебовна, Т. И., et al. (2020) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1439/1/012036 · Cited by 9 · see citing works
The ineffectiveness of antimicrobial photodynamic therapy in the absence of preincubation of the microorganisms in the photosensitizer
Galo, Í. D. C., Carvalho, J. A., Santos, J. L. M. C., Braoios, A., & Prado, R. P. (2020) · Fisioterapia em Movimento · doi:10.1590/1980-5918.033.ao04 · Cited by 9 · see citing works
COMBINED EFFECT OF EUCALYPTUS MICROCORYS AQUEOUS EXTRACT AND LIGHT ON PATHOGENIC ESCHERICHIA COLI SURVIVAL IN AQUATIC MICROCOSM
Arfao, A. T., Ewoti, O. V. N., Onana, M. F., et al. (2020) · Journal of Microbiology Biotechnology and Food Sciences · doi:10.15414/jmbfs.2020.9.5.1003-1008 · Cited by 9 · see citing works
The Potential Role of Photosensitizers in Fight against Mosquitoes: Phototoxicity of Rose Bengal against Culex Pipiens Larvae
younis, M., Khater, H. F., Hussein, A., et al. (2020) · Benha Medical Journal · doi:10.21608/bmfj.2020.119556 · Cited by 9 · see citing works
A dual enhanced anti-bacterial strategy based on high chlorin e6-loaded polyethyleneimine functionalized graphene
Wang, J., Yang, Y., Xu, Y., et al. (2020) · RSC Advances · doi:10.1039/d0ra07976f · Cited by 9 · see citing works
Chlorophyll derivatives for pest and disease control: Are they safe?
Azizullah, A., & Murad, W. (2014) · Environmental Impact Assessment Review · doi:10.1016/j.eiar.2014.09.011 · Cited by 7 · see citing works
Sonophotodynamic Therapy for the inactivation of Staphylococcus aureus biofilm
Alves, F., Inada, N. M., Bagnato, V. S., et al. (2019) · International Photodynamic Association World Congress · doi:10.1117/12.2528214 · Cited by 7 · see citing works
Immobilization of alkyl-pterin photosensitizer on silicon surfaces through in situ S 2 reaction as suitable approach for photodynamic inactivation of Staphylococcus aureus
Urrutia, M. N., Sosa, M. J., Pissinis, D. E., et al. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111456 · Cited by 7 · see citing works
Measuring the Effects of Bacteria and Chemicals on the Intestinal Permeability of Caenorhabditis elegans
Le, T. A. N., Selvaraj, B., Lee, J. W., & Kang, K. (2019) · Journal of Visualized Experiments · doi:10.3791/60419 · Cited by 6 · see citing works
Self-citation
Morpho-molecular mechanisms study of photodynamic therapy and curcumin larvicide action on wild mosquitoes larvae of genus AedesPreprint
Araújo, B., Silva, E., Rosa, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.13.200295 · Cited by 5 · see citing works
Tweaking the Pigments of Life: Conversion of Porphyrins to Pyrrole-Modified Porphyrins
Brücknera, C. (2018) · Current Organic Synthesis · doi:10.2174/157017941506180829101807 · Cited by 1 · see citing works

Flagged first, then by citations

Sorted by citations

Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp.
Abreu, A. P., Martins, R., & Nunes, J. (2023) · Bioengineering · doi:10.3390/bioengineering10080955 · Cited by 119 · see citing works

Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsionsPreprint
Sletten, E. M., Day, R. A., Estabrook, D. A., et al. (2017) · ChemRxiv · doi:10.26434/chemrxiv.5382781.v1 · Cited by 4 · see citing works
Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsionsPreprint
Sletten, E. M., Day, R. A., Estabrook, D. A., et al. (2017) · ChemRxiv · doi:10.26434/chemrxiv.5382781
Fluorous photosensitizers enhance photodynamic therapy with perfluorocarbon nanoemulsions
Day, R. A., Estabrook, D. A., Logan, J. K., & Sletten, E. M. (2017) · Chemical Communications · doi:10.1039/c7cc07038a · Cited by 76 · see citing works
Perfluorocarbon nanoparticles enhance reactive oxygen levels and tumour growth inhibition in photodynamic therapy
Cheng, Y., Cheng, H., Jiang, C., Qiu, X., Wang, K., Huan, W., Yuan, A., Wu, J., & Hu, Y. (2015) · Nature Communications · doi:10.1038/ncomms9785 · Cited by 941 · see citing works
Research advances in action mechanisms of photodynamic therapy and photosensitizer
Shi, S., Wang, Y., Wan, G., et al. (2016) · Guoji shengwu yixue gongcheng zazhi · doi:10.3760/cma.j.issn.1673-4181.2016.05.010

Authors: Polat, E., & Kang, K.
Affiliations: Korea Institute of Science and Technology (KR)
Corresponding author: Kang, Kyungsu
ORCID: Polat, Ece
Kang, Kyungsu
Venue: Biomedicines
Publisher: MDPI AG
Published: 2021-05-21
Volume: 9
Issue: 6
Pages: 584
ISSN: 2227-9059 (ISSN-L)
DOI: 10.3390/biomedicines9060584
PMC: PMC8224061
OpenAlex: W3163507051
Cited by: 235
References: 180
Citations by year: 2026: 32 · 2025: 56 · 2024: 70 · 2023: 33 · 2022: 33 · 2021: 11
FWCI: 5.95
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomedicines (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Korea Institute of Science and Technology (2E31311)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: antimicrobial photodynamic therapy, natural photosensitizers, reactive oxygen species, antimicrobial resistance, Gram-negative bacteria, natural extracts, photosensitizer solubility, cell surface engineering, sonodynamic therapy, nanotechnology, computer simulation, in vivo models

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks