The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
GABAA Receptor Channel Pharmacology
Abstract
GABA(A) receptor channels are ubiquitous in the mammalian central nervous system mediating fast inhibitory neurotransmission by becoming permeant to chloride ions in response to GABA. The emphasis of this review is on the rich chemical diversity of ligands that influence GABA(A) receptor function. Such diversity provides many avenues for the design and development of new chemical entities acting on GABA(A) receptors. There is also a significant diversity of GABA(A) receptor subtypes composed of different protein subunits. The discovery of subtype specific agents is a major challenge in the continuing development of GABA(A) receptor pharmacology. Leads for the discovery of new chemical entities that influence GABA(A) receptors come from using recombinant GABA(A) receptors of known subunit composition as has been elegantly demonstrated by the refining of benzodiazepine actions with alpha1 subunit preferring agents showing sedative properties but not anxiolytic properties. The most recent advances in the therapeutic use of agents acting on GABA(A) receptors concern the promotion of sound sleep. Many herbal medicines are used to promote sleep and many of their active ingredients include flavonoids and terpenoids known to modulate GABA(A) receptor function.
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1 retracted
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RetractedFlavonoid antioxidants: chemistry, metabolism and structure-activity relationships
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The biochemistry and medical significance of the flavonoids
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Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
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Structure and gating mechanism of the acetylcholine receptor pore
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Which GABAA-receptor subtypes really occur in the brain?
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Cited by
Olsen, R. W., & Sieghart, W. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00505 · Cited by 1,064
The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives
Wanka, L., Iqbal, K., & Schreiner, P. R. (2013) · Chemical Reviews · doi:10.1021/cr100264t · Cited by 696
Williams, R. J., & Spencer, J. P. E. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.010 · Cited by 448
Ashcroft, F. M. (2006) · Nature · doi:10.1038/nature04707 · Cited by 403
Flavonoids: modulators of brain function?
Spencer, J. P. E. (2008) · British Journal of Nutrition · doi:10.1017/s0007114508965776 · Cited by 384
Metadata
- Authors
- Johnston, G.
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2005-06-01
- Volume
- 11
- Issue
- 15
- Pages
- 1867-1885
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W1989578288
- Cited by
- 274
- References
- 173
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
