The DOI matches its Crossref record; 241 of the 241 references it cites were found in a registry or an index.
Flavonoids: modulators of brain function?
Open accessAbstract
Emerging evidence suggests that dietary phytochemicals, in particular flavonoids, may exert beneficial effects on the central nervous system by protecting neurons against stress-induced injury, by suppressing neuroinflammation and by improving cognitive function. It is likely that flavonoids exert such effects, through selective actions on different components of a number of protein kinase and lipid kinase signalling cascades, such as the phosphatidylinositol-3 kinase (PI3K)/Akt, protein kinase C and mitogen-activated protein kinase (MAPK) pathways. This review explores the potential inhibitory or stimulatory actions of flavonoids within these pathways, and describes how such interactions are likely to underlie neurological effects through their ability to affect the activation state of target molecules and/or by modulating gene expression. Future research directions are outlined in relation to the precise site(s) of action of flavonoids within signalling pathways and the sequence of events that allow them to regulate neuronal function.
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Cites
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Cited by
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Self-citationPolyphenols and Human Health: Prevention of Disease and Mechanisms of Action
Vauzour, D., Rodriguez-Mateos, A., Corona, G., Oruna-Concha, M. J., & Spencer, J. P. E. (2010) · Nutrients · doi:10.3390/nu2111106 · Cited by 855
Self-citationWilliams, R. J., & Spencer, J. P. E. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.010 · Cited by 448
Cocoa and Chocolate in Human Health and Disease
Katz, D. L., Doughty, K., & Ali, A. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3697 · Cited by 441
Habitual intake of dietary flavonoids and risk of Parkinson disease
Gao, X., Cassidy, A., Schwarzschild, M. A., Rimm, E. B., & Ascherio, A. (2012) · Neurology · doi:10.1212/wnl.0b013e31824f7fc4 · Cited by 332
Metadata
- Authors
- Spencer, J. P. E.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008-05
- Volume
- 99
- Issue
- E-S1
- Pages
- ES60-ES77
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2130409253
- Cited by
- 384
- References
- 241
- FWCI
- 12.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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