Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

Williams, Robert J.; Spencer, Jeremy P.E.

doi:10.1016/j.freeradbiomed.2011.09.010

Cited by 456Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionDementia and Cognitive Impairment Research

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

Williams, Robert J., Spencer, Jeremy P.E.·2012·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2011.09.010

Open this paper in CoChat — free account

Abstract

There is increasing evidence that the consumption of flavonoid-rich foods can beneficially influence normal cognitive function. In addition, a growing number of flavonoids have been shown to inhibit the development of Alzheimer disease (AD)-like pathology and to reverse deficits in cognition in rodent models, suggestive of potential therapeutic utility in dementia. The actions of flavonoid-rich foods (e.g., green tea, blueberry, and cocoa) seem to be mediated by the direct interactions of absorbed flavonoids and their metabolites with a number of cellular and molecular targets. For example, their specific interactions within the ERK and PI3-kinase/Akt signaling pathways, at the level of receptors or kinases, have been shown to increase the expression of neuroprotective and neuromodulatory proteins and increase the number of, and strength of, connections between neurons. Concurrently, their effects on the vascular system may also lead to enhancements in cognitive performance through increased brain blood flow and an ability to initiate neurogenesis in the hippocampus. Additional mechanisms have been suggested for the ability of flavonoids to delay the initiation of and/or slow the progression of AD-like pathology and related neurodegenerative disorders, including a potential to inhibit neuronal apoptosis triggered by neurotoxic species (e.g., oxidative stress and neuroinflammation) or disrupt amyloid β aggregation and effects on amyloid precursor protein processing through the inhibition of β-secretase (BACE-1) and/or activation of α-secretase (ADAM10). Together, these processes act to maintain the number and quality of synaptic connections in key brain regions and thus flavonoids have the potential to prevent the progression of neurodegenerative pathologies and to promote cognitive performance.

Integrity signals

Registry

Crossref · 10.1016/j.freeradbiomed.2011.09.010

Cites

221 of 221 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

BACE performs proteolysis by generating soluble APPβ and CTFβ; CTFβ undergoes γ-secretase proteolysis to generate toxic Aβ neuropeptides with 40-43 amino acids, finally causing the amyloid plaques characteristic of Alzheimer's disease.
“This protein known as the BACE performs proteolysis by generating a soluble fragment in the extracellular space known as “soluble APPβ” and an additional fragment bound to the plasma membrane, CTFβ peptide that undergoes proteolysis yet again by γ-secretase to generate toxic neuropeptides Aβ with 40–43 amino acids, finally causing the amyloid plaques characteristic of AD [165,166,167].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [167]

1 retracted

RETRACTED: Psychological assessment of the effects of treatment with phytoestrogens on postmenopausal women: a randomized, double-blind, crossover, placebo-controlled study
Casini, M. L., Marelli, G., Papaleo, E., Ferrari, A. G., D’Ambrosio, F., & Unfer, V. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.09.048 · Cited by 141 · see citing works
Retracted
Polyphenols: Food sources and bioavailability
Manach, C., Scalbert, A., Morand, C., Rémésy, C., & Jiménez, L. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.5.727 · Cited by 8,175 · see citing works
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · see citing works
Mammalian neural stem cells.
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 3,949 · see citing works
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,248 · see citing works
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Flavonoids: antioxidants or signalling molecules?
Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016 · see citing works
Neural plasticity in the ageing brain
Burke, S. N., & Barnes, C. A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1809 · Cited by 1,600 · see citing works
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers
Ehrnhoefer, D. E., Bieschke, J., Boeddrich, A., Herbst, M., Masino, L., Lurz, R., Engemann, S., Pastore, A., & Wanker, E. (2008) · Nature Structural &Molecular Biology · doi:10.1038/nsmb.1437 · Cited by 1,424 · see citing works
Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
Williamson, G., & Manach, C. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.243s · Cited by 1,340 · see citing works
Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine
Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211 · see citing works
Experience-Induced Neurogenesis in the Senescent Dentate Gyrus
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03206.1998 · Cited by 1,150 · see citing works
(–)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
Schroeter, H., Heiss, C., Balzer, J., Kleinbongard, P., Keen, C. L., Hollenberg, N. K., Sies, H., Kwik-Uribe, C., Schmitz, H. H., & Kelm, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510168103 · Cited by 1,052 · see citing works
Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function.
Harris, K., & Kater, S. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002013 · Cited by 1,032 · see citing works
EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
Bieschke, J., Russ, J., Friedrich, R., Ehrnhoefer, D. E., Wobst, H. J., Neugebauer, K., & Wanker, E. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0910723107 · Cited by 986 · see citing works
Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation
Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08114.1999 · Cited by 980 · see citing works
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila
Yin, J. C. P., Wallach, J. S., Del Vecchio, M., Wilder, E. L., Zhou, H., Quinn, W. G., & Tully, T. (1994) · Cell · doi:10.1016/0092-8674(94)90399-9 · Cited by 959 · see citing works
CREB: A Major Mediator of Neuronal Neurotrophin Responses
Finkbeiner, S. M., Tavazoie, S. F., Maloratsky, A., Jacobs, K. M., Harris, K. M., & Greenberg, M. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80395-5 · Cited by 950 · see citing works
Neurogenesis may relate to some but not all types of hippocampal‐dependent learning
Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y., & Gould, E. (2002) · Hippocampus · doi:10.1002/hipo.10103 · Cited by 853 · see citing works
Basic biochemical mechanisms behind the health benefits of polyphenols
Fraga, C. G., Galleano, M., Verstraeten, S. V., & Oteiza, P. I. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.006 · Cited by 748 · see citing works
Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study
Ruitenberg, A., den Heijer, T., Bakker, S. L. M., van Swieten, J. C., Koudstaal, P. J., Hofman, A., & Breteler, M. M. B. (2005) · Annals of Neurology · doi:10.1002/ana.20493 · Cited by 733 · see citing works
Green tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice
Rezai-Zadeh, K., Shytle, D., Sun, N., Mori, T., Hou, H., Jeanniton, D., Ehrhart, J., Townsend, K., Zeng, J., Morgan, D., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1521-05.2005 · Cited by 713 · see citing works
Dietary patterns and risk of dementia: The Three-City cohort study
Barberger-Gateau, P., Raffaitin, C., Letenneur, L., Berr, C., Tzourio, C., Dartigues, J. F., & Alpérovitch, A. (2007) · Neurology · doi:10.1212/01.wnl.0000278116.37320.52 · Cited by 700 · see citing works
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
Jang, S., Liu, X., Yepes, M., Shepherd, K. R., Miller, G. W., Liu, Y., Wilson, W. D., Xiao, G., Blanchi, B., Sun, Y. E., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913572107 · Cited by 689 · see citing works
Expression of Concern: Potent anti‐amyloidogenic and fibril‐destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease
Ono, K., Yoshiike, Y., Takashima, A., Hasegawa, K., Naiki, H., & Yamada, M. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01976.x · Cited by 681 · see citing works
Vascular risk factors for Alzheimer’s disease:
Breteler, M. M. B. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00110-4 · Cited by 664 · see citing works
Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis
Drapeau, E., Mayo, W., Aurousseau, C., Moal, M. L., Piazza, P., & Abrous, D. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2334169100 · Cited by 657 · see citing works
Intake of flavonoids and risk of dementia
Commenges, D., Scotet, V., Renaud, S., Jacqmin‐Gadda, H., Barberger‐Gateau, P., & Dartigues, J. (2000) · European Journal of Epidemiology · doi:10.1023/a:1007614613771 · Cited by 647 · see citing works
CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila
Yin, J. C. P., Del Vecchio, M., Zhou, H., & Tully, T. (1995) · Cell · doi:10.1016/0092-8674(95)90375-5 · Cited by 642 · see citing works
A computational theory of hippocampal function, and empirical tests of the theory
Rolls, E. T., & Kesner, R. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.04.005 · Cited by 608 · see citing works
Flavonoid permeability across an in situ model of the blood–brain barrier
Youdim, K. A., Qaiser, M. Z., Begley, D. J., Rice-Evans, C. A., & Abbott, N. J. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.11.023 · Cited by 605 · see citing works
Blueberry supplementation improves memory in older adults
Krikorian, R., Shidler, M. D., Nash, T. A., Kalt, W., Vinqvist-Tymchuk, M. R., Shukitt-Hale, B., & Joseph, J. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9029332 · Cited by 582 · see citing works
Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study
Tzounis, X., Rodriguez‐Mateos, A., Vulevic, J., Gibson, G. R., Kwik-Uribe, C. L., & Spencer, J. P. E. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.000075 · Cited by 582 · see citing works
Interaction between flavonoids and the blood–brain barrier: <i>in vitro</i> studies
Youdim, K. A., Dobbie, M. S., Kuhnle, G., Proteggente, A. R., Abbott, N. J., & Rice‐Evans, C. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01652.x · Cited by 578 · see citing works
Green tea polyphenol (–)‐epigallocatechin‐3‐gallate prevents N ‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced dopaminergic neurodegeneration
Levites, Y., Weinreb, O., Maor, G., Youdim, M. B. H., & Mandel, S. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00490.x · Cited by 567 · see citing works
Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory
Andrés‐Lacueva, C., Shukitt‐Hale, B., Galli, R. L., Jáuregui, O., Lamuela-Raventós, R. M., & Joseph, J. A. (2005) · Nutritional Neuroscience · doi:10.1080/10284150500078117 · Cited by 564 · see citing works
Bioavailability of dietary flavonoids and phenolic compounds
Crozier, A., Rio, D. D., & Clifford, M. N. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.007 · Cited by 550 · see citing works
Cocoa Reduces Blood Pressure and Insulin Resistance and Improves Endothelium-Dependent Vasodilation in Hypertensives
Grassi, D., Necozione, S., Lippi, C., Croce, G., Valeri, L., Pasqualetti, P., Desideri, G., Blumberg, J. B., & Ferri, C. (2005) · Hypertension · doi:10.1161/01.hyp.0000174990.46027.70 · Cited by 546 · see citing works
Regulation of Endothelial Nitric Oxide Synthase: Location, Location, Location
Shaul, P. W. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.155952 · Cited by 541 · see citing works
Inhibition of Heparin-induced Tau Filament Formation by Phenothiazines, Polyphenols, and Porphyrins
Taniguchi, S., Suzuki, N., Masuda, M., Hisanaga, S., Iwatsubo, T., Goedert, M., & Hasegawa, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408714200 · Cited by 540 · see citing works
Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition
Agullo, G., Gamet‐Payrastre, L., Manenti, S., Viala, C., Rémésy, C., Chap, H., & Payrastre, B. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)82453-7 · Cited by 535 · see citing works
Wide distribution of [3H](-)-epigallocatechin gallate, a cancer preventive tea polyphenol, in mouse tissue
Suganuma, M. (1998) · Carcinogenesis · doi:10.1093/carcin/19.10.1771 · Cited by 527 · see citing works
Fruit and Vegetable Juices and Alzheimer’s Disease: The Kame Project
Dai, Q., Borenstein, A. R., Wu, Y., Jackson, J. C., & Larson, E. B. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.03.045 · Cited by 524 · see citing works
Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning
Impey, S., Smith, D. M., Obrietan, K. H., Donahue, R. J., Wade, C. B., & Storm, D. R. (1998) · Nature Neuroscience · doi:10.1038/2830 · Cited by 520 · see citing works
Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
Weinreb, O., Mandel, S. A., Amit, T., & Youdim, M. B. H. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.05.002 · Cited by 506 · see citing works
Flavonoid Intake and Cognitive Decline over a 10-Year Period
Letenneur, L., Proust‐Lima, C., Gouge, A. L., Dartigues, J. F., & Barberger‐Gateau, P. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm036 · Cited by 484 · see citing works
Blood Pressure Is Reduced and Insulin Sensitivity Increased in Glucose-Intolerant, Hypertensive Subjects after 15 Days of Consuming High-Polyphenol Dark Chocolate13
Grassi, D., Desideri, G., Necozione, S., Lippi, C., Casale, R., Properzi, G., Blumberg, J. B., & Ferri, C. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.9.1671 · Cited by 481 · see citing works
Effects of Low Habitual Cocoa Intake on Blood Pressure and Bioactive Nitric Oxide: A Randomized Controlled Trial
Taubert, D., Roesen, R., Lehmann, C., Jung, N., & Schömig, E. (2007) · JAMA · doi:10.1001/jama.298.1.49 · Cited by 476 · see citing works
Flavonoid-Rich Dark Chocolate Improves Endothelial Function and Increases Plasma Epicatechin Concentrations in Healthy Adults
Engler, M. B., Engler, M. M., Chen, C. Y., Malloy, M. J., Browne, A., Chiu, E. Y., Kwak, H., Milbury, P. E., Paul, S. M., Blumberg, J. B., et al. (2004) · Journal of the American College of Nutrition · doi:10.1080/07315724.2004.10719361 · Cited by 465 · see citing works
Colonic metabolites of berry polyphenols: the missing link to biological activity?
Williamson, G., & Clifford, M. N. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003946 · Cited by 463 · see citing works
Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
Rezai-Zadeh, K., Arendash, G. W., Hou, H., Fernandez, F., Jensen, M., Runfeldt, M., Shytle, R. D., & Tan, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.107 · Cited by 459 · see citing works
Protein kinase C inhibition by plant flavonoids
Ferriola, P. C., Cody, V., & Middleton, E. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90309-2 · Cited by 454 · see citing works
Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases
Mandel, S. A., & Youdim, M. B. H. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.04.012 · Cited by 443 · see citing works
Effect of Soy Protein Containing Isoflavones on Cognitive Function, Bone Mineral Density, and Plasma Lipids in Postmenopausal Women: A Randomized Controlled Trial
Kreijkamp-Kaspers, S., Kok, L., Grobbee, D. E., de Haan, E. H. F., Aleman, A., Lampe, J. W., & van der Schouw, Y. T. (2004) · JAMA · doi:10.1001/jama.292.1.65 · Cited by 438 · see citing works
Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits
Joseph, J. A., Shukitt‐Hale, B., Denisova, N. A., Prior, R. L., Cao, G., Martín, A., Taglialatela, G., & Bickford, P. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08047.1998 · Cited by 432 · see citing works
Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels
Williams, C. M., Mohsen, M. A. E., Vauzour, D., Rendeiro, C., Butler, L. T., Ellis, J. A., Whiteman, M., & Spencer, J. P. E. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.008 · Cited by 426 · see citing works
Involvement of Protein Kinase C Activation and Cell Survival/ Cell Cycle Genes in Green Tea Polyphenol (−)-Epigallocatechin 3-Gallate Neuroprotective Action
Levites, Y., Amit, T., Youdim, M. B. H., & Mandel, S. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202832200 · Cited by 417 · see citing works
CREB and the formation of long-term memory
Yin, J. C. P., & Tully, T. P. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80082-1 · Cited by 399 · see citing works
Nitric Oxide and Angiogenesis
Ziche, M., & Morbidelli, L. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006431309841 · Cited by 391 · see citing works
Flavonoids: modulators of brain function?
Spencer, J. P. E. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508965776 · Cited by 385 · see citing works
Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (‐)‐epigallocatechin‐3‐gallate: implications for neurodegenerative diseases
Mandel, S. A., Weinreb, O., Amit, T., & Youdim, M. B. H. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02291.x · Cited by 379 · see citing works
Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function
Murphy, K. J., Chronopoulos, A., Singh, I., Francis, M., Moriarty, H., Pike, M. J., Turner, A., Mann, N. J., & Sinclair, A. J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.6.1466 · Cited by 374 · see citing works
Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3
Schroeter, H., Spencer, J. P. E., Rice-Evans, C. A., & WILLIAMS, R. J. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3580547 · Cited by 373 · see citing works
Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species
Spencer, J. P. E., Jenner, P., Daniel, S. E., Lees, A. J., Marsden, D. C., & Halliwell, B. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71052112.x · Cited by 373 · see citing works
Parkinson's Disease Risks Associated with Cigarette Smoking, Alcohol Consumption, and Caffeine Intake
Checkoway, H., Powers, K. M., Smith‐Weller, T., Franklin, G. M., Longstreth, W. T., & Swanson, P. D. (2002) · American Journal of Epidemiology · doi:10.1093/aje/155.8.732 · Cited by 370 · see citing works
Uptake and metabolism of epicatechin and its access to the brain after oral ingestion
Mohsen, M. M. A. E., Kuhnle, G., Rechner, A. R., Schroeter, H., Rose, S., Jenner, P. G., & Rice-Evans, C. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01137-1 · Cited by 369 · see citing works
Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1
Jang, S., Kelley, K. W., & Johnson, R. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802865105 · Cited by 365 · see citing works
Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model
Joseph, J. A., Arendash, G. W., Gordon, M. N., Diamond, D. M., Shukitt‐Hale, B., Morgan, D., & Denisova, N. A. (2003) · Nutritional Neuroscience · doi:10.1080/1028415031000111282 · Cited by 361 · see citing works
The impact of fruit flavonoids on memory and cognition
Spencer, J. P. E. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003934 · Cited by 359 · see citing works
Grape-Derived Polyphenolics Prevent A Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease
Wang, J., Ho, L., Zhao, W., Ono, K., Rosensweig, C., Chen, L., Humala, N., Teplow, D. B., & Pasinetti, G. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0364-08.2008 · Cited by 358 · see citing works
Pomegranate juice decreases amyloid load and improves behavior in a mouse model of Alzheimer's disease
Hartman, R. E., Shah, A., Fagan, A. M., Schwetye, K. E., Parsadanian, M., Schulman, R. N., Finn, M. B., & Holtzman, D. M. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.08.006 · Cited by 358 · see citing works
Targeting the CREB pathway for memory enhancers
Tully, T., Bourtchouladze, R., Scott, R., & Tallman, J. F. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1061 · Cited by 355 · see citing works
Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment
Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., & Joseph, J. A. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509992364 · Cited by 353 · see citing works
Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability
Spencer, J. P. E., Rice-Evans, C. A., & Williams, R. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305063200 · Cited by 350 · see citing works
Multifunctional Activities of Green Tea Catechins in Neuroprotection
Mandel, S. A., Avramovich‐Tirosh, Y., Reznichenko, L., Zheng, H., Weinreb, O., Amit, T., & Youdim, M. B. H. (2005) · Neurosignals · doi:10.1159/000085385 · Cited by 347 · see citing works
MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide
Schroeter, H., BOYD, C., SPENCER, J., WILLIAMS, R., Cadenas, E., & Rice-Evans, C. A. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00075-1 · Cited by 338 · see citing works
Identification of Anthocyanins in the Liver, Eye, and Brain of Blueberry-Fed Pigs
Kalt, W., Blumberg, J. B., McDonald, J. E., Vinqvist, M. R., Fillmore, S. A. E., Graf, B. A., O’Leary, J. M., & Milbury, P. E. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071998l · Cited by 336 · see citing works
Anthocyanin Metabolism in Rats and Their Distribution to Digestive Area, Kidney, and Brain
Talavéra, S., Felgines, C., Texier, O., Besson, C., Gil‐Izquierdo, Á., Lamaison, J., & Rémésy, C. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050145v · Cited by 334 · see citing works
The Effect of Flavanol-rich Cocoa on the fMRI Response to a Cognitive Task in Healthy Young People
Francis, S., Head, K., Morris, P. G., & Macdonald, I. A. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200606001-00018 · Cited by 314 · see citing works
A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4
Bourtchouladze, R., Lidge, R., Catapano, R., Stanley, J., Gossweiler, S., Romashko, D., Scott, R., & Tully, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834280100 · Cited by 313 · see citing works
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
Maher, P. A., Akaishi, T., & Abe, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607822103 · Cited by 307 · see citing works
Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-term Blueberry Supplementation in Aged Rats
Casadesús, G., Shukitt‐Hale, B., Stellwagen, H. M., Zhu, X., Lee, H., Smith, M. A., & Joseph, J. A. (2004) · Nutritional Neuroscience · doi:10.1080/10284150400020482 · Cited by 304 · see citing works
Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
van Praag, H., Lucero, M. J., Yeo, G. W., Stecker, K., Heivand, N., Zhao, C., Yip, E., Afanador, M., Schroeter, H., Hammerstone, J., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0914-07.2007 · Cited by 303 · see citing works
Neuroinflammatory processes in Parkinson's disease
Hirsch, É. C., Hunot, S., & Hartmann, A. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.10.013 · Cited by 298 · see citing works
Green tea catechins as brain‐permeable, natural iron chelators‐antioxidants for the treatment of neurodegenerative disorders
Mandel, S. A., Amit, T., Reznichenko, L., Weinreb, O., & Youdim, M. B. H. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500156 · Cited by 293 · see citing works
Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-κB) activation and cell death by tea extracts in neuronal cultures11Abbreviations: BT, Black Tea; EMSA, Electromobility Shift Assay; EGCG, (-)-Epigallocatechin-3-gallate; GT, Green Tea; NB SH-SY5Y cells, Human neuroblastoma SH-SY5Y cells; 6-OHDA, 6-hydroxydopamine; IL, Interleukin; LDH, Lactate Dehydrogenase; MPTP, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NF-κB, nuclear factor-κB; OS, Oxidative Stress; PD, Parkinson’s Disease; ROS, Reactive Oxygen Species; SNPC, Substantia Nigra Pars Compacta; TBARS, thiobarbituric acid reactive substances.
Levites, Y., Youdim, M. B. H., Maor, G., & Mandel, S. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00813-9 · Cited by 291 · see citing works
Consumption of cocoa flavanols results in acute improvements in mood and cognitive performance during sustained mental effort
Scholey, A. B., French, S., Morris, P. J., Kennedy, D. O., Milne, A., & Haskell‐Ramsay, C. F. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881109106923 · Cited by 284 · see citing works
Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging
Small, S. A., Chawla, M. K., Buonocore, M. H., Rapp, P. R., & Barnes, C. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400285101 · Cited by 281 · see citing works
Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia
Lee, H., Kim, Y. O., Kim, H., Kim, S. Y., Noh, H. S., Kang, S. S., Cho, G. J., Choi, W. S., & Suk, K. (2003) · The FASEB Journal · doi:10.1096/fj.03-0057fje · Cited by 278 · see citing works
GABAA Receptor Channel Pharmacology
Johnston, G. A. R. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612054021024 · Cited by 274 · see citing works
Signal transduction events elicited by natural products: Role of MAPK and caspase pathways in homeostatic response and induction of apoptosis
Kong, A. T., Yu, R., Chen, C., Mandlekar, S., & Primiano, T. (2000) · Archives of Pharmacal Research · doi:10.1007/bf02976458 · Cited by 270 · see citing works
The interactions of flavonoids within neuronal signalling pathways
Spencer, J. P. E. (2007) · Genes & Nutrition · doi:10.1007/s12263-007-0056-z · Cited by 268 · see citing works
Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IκB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia
Chen, J.-C., Ho, F., Chao, P.-D. L., Chen, C., Jeng, K.-C. G., Hsu, H.-B., Lee, S. T., Wu, W. T., & Lin, W. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.08.005 · Cited by 266 · see citing works
NO and angiogenesis
Cooke, J. P. (2003) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(03)00034-5 · Cited by 266 · see citing works
Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats
Pu, F., Mishima, K., Irie, K., Motohashi, K., Tanaka, Y., Orito, K., Egawa, T., Kitamura, Y., Egashira, N., Iwasaki, K., et al. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0070247 · Cited by 261 · see citing works
Intake of Flavonoid-Rich Wine, Tea, and Chocolate by Elderly Men and Women Is Associated with Better Cognitive Test Performance
Nurk, E., Refsum, H., Drevon, C. A., Tell, G. S., Nygaard, H. A., Engedal, K., & Smith, A. D. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.095182 · Cited by 261 · see citing works
Arg3.1/Arc mRNA Induction by Ca2+and cAMP Requires Protein Kinase A and Mitogen-Activated Protein Kinase/Extracellular Regulated Kinase Activation
Waltereit, R., Dammermann, B., Wulff, P., Scafidi, J., Staubli, U. V., Kauselmann, G., Bundman, M. C., & Kuhl, D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05484.2001 · Cited by 259 · see citing works
Dietary flavonoids: Role of (−)-epicatechin and related procyanidins in cell signaling
Fraga, C. G., & Oteiza, P. I. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.002 · Cited by 257 · see citing works
Flavonoids and the inhibition of PKC and PI 3-kinase
Gamet‐Payrastre, L., Manenti, S., Gratacap, M., Tulliez, J. E., Chap, H., & Payrastre, B. (1999) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(98)00220-1 · Cited by 255 · see citing works
Activation of pro‐survival Akt and ERK1/2 signalling pathways underlie the anti‐apoptotic effects of flavanones in cortical neurons
Vauzour, D., Vafeiadou, K., Rice-Evans, C. A., Williams, R. J., & Spencer, J. P. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04841.x · Cited by 254 · see citing works
Bioavailability of Gallic Acid and Catechins from Grape Seed Polyphenol Extract is Improved by Repeated Dosing in Rats: Implications for Treatment in Alzheimer's Disease
Ferruzzi, M. G., Lobo, J., Janle, E. M., Cooper, B. R., Simon, J. E., Wu, Q., Welch, C., Ho, L., Weaver, C. M., & Pasinetti, G. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1135 · Cited by 250 · see citing works
Protective effects of the green tea polyphenol (−)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils
Lee, S., Suh, S., & Kim, S.-P. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01159-9 · Cited by 245 · see citing works
Neuroprotective molecular mechanisms of (−)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties
Weinreb, O., Amit, T., Mandel, S. A., & Youdim, M. B. H. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0143-4 · Cited by 244 · see citing works
Eating soya improves human memory
File, S. E., Jarrett, N., Fluck, E., Duffy, R., Casey, K., & Wiseman, H. (2001) · Psychopharmacology · doi:10.1007/s002130100845 · Cited by 241 · see citing works
Flavonoid modulation of GABA A receptors
Hanrahan, J. R., Chebib, M., & Johnston, G. A. R. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01228.x · Cited by 241 · see citing works
ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease
Maher, P. A., Dargusch, R., Bodai, L., Gerard, P. E., Purcell, J. M., & Marsh, J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq460 · Cited by 237 · see citing works
Epigallocatechin Gallate, a Green Tea Polyphenol, Mediates NO-dependent Vasodilation Using Signaling Pathways in Vascular Endothelium Requiring Reactive Oxygen Species and Fyn
Kim, J., Formoso, G., Li, Y., Potenza, M. A., Marasciulo, F. L., Montagnani, M., & Quon, M. J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609725200 · Cited by 236 · see citing works
Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2
Eggler, A. L., Gay, K. A., & Mesecar, A. D. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700249 · Cited by 234 · see citing works
Flavonols and flavones as BACE-1 inhibitors: Structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features
Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T., & Sugimoto, H. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.01.017 · Cited by 234 · see citing works
Chocolate consumption in relation to blood pressure and risk of cardiovascular disease in German adults
Buijsse, B., Weikert, C., Drogan, D., Bergmann, M. M., & Boeing, H. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq068 · Cited by 227 · see citing works
The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury
Vafeiadou, K., Vauzour, D., Lee, H. Y., Rodriguez‐Mateos, A., Williams, R. J., & Spencer, J. P. E. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2009.01.016 · Cited by 224 · see citing works
Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease
Datla, K. P., Christidou, M., Widmer, W. W., ROOPRAI, H. K., & Dexter, D. T. (2001) · Neuroreport · doi:10.1097/00001756-200112040-00053 · Cited by 224 · see citing works
Long-Term Administration of Green Tea Catechins Improves Spatial Cognition Learning Ability in Rats
Haque, A. M., Hashimoto, M., Katakura, M., Tanabe, Y., Hara, Y., & Shido, O. (2006) · Journal of Nutrition · doi:10.1093/jn/136.4.1043 · Cited by 224 · see citing works
Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide‐activated BV2 microglia
Lau, F. C., Bielinski, D. F., & Joseph, J. A. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21205 · Cited by 221 · see citing works
Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and Aβ Pathology in a Transgenic Mouse Model of Alzheimer’s Disease
Onozuka, H., Nakajima, A., Matsuzaki, K., Shin, R., Ogino, K., Saigusa, D., Tetsu, N., Yokosuka, A., Sashida, Y., Mimaki, Y., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.140293 · Cited by 220 · see citing works
The impact of flavonoids on memory: physiological and molecular considerations
Spencer, J. P. E. (2009) · Chemical Society Reviews · doi:10.1039/b800422f · Cited by 219 · see citing works
Estrogen-containing hormone therapy and Alzheimer’s disease risk: Understanding discrepant inferences from observational and experimental research
Henderson, V. W. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.017 · Cited by 215 · see citing works
Blueberry Supplemented Diet: Effects on Object Recognition Memory and Nuclear Factor-kappa B Levels in Aged Rats
Goyarzu, P., Malin, D. H., Lau, F. C., Taglialatela, G., Moon, W. D., Jennings, R., Moy, E., Moy, D. M., Lippold, S., Shukitt‐Hale, B., et al. (2004) · Nutritional Neuroscience · doi:10.1080/10284150410001710410 · Cited by 213 · see citing works
Pharmacokinetics of (−)-Epigallocatechin-3-gallate in Conscious and Freely Moving Rats and Its Brain Regional Distribution
Lin, L.-C., Wang, M.-N., Tseng, T.-Y., Sung, & Tsai, T. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062816a · Cited by 211 · see citing works
Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study
Kritz‐Silverstein, D. C., hlen, D. V. M., Barrett-Connor, E. L., & Bressel, M. (2003) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200310030-00004 · Cited by 210 · see citing works
ADAM10 Activation Is Required for Green Tea (–)-Epigallocatechin-3-gallate-induced α-Secretase Cleavage of Amyloid Precursor Protein
Obregon, D. F., Rezai-Zadeh, K. P., Bai, Y., Sun, N., Hou, H., Ehrhart, J. C., Zeng, J., Mori, T., Arendash, G. W., Shytle, D., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600617200 · Cited by 210 · see citing works
Sustained Increase in Flow-Mediated Dilation After Daily Intake of High-Flavanol Cocoa Drink Over 1 Week
Heiß, C., Finis, D., Kleinbongard, P., Hoffmann, A., Rassaf, T., Kelm, M., & Sies, H. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31802d0001 · Cited by 207 · see citing works
(−)‐Epigallocatechin gallate inhibits lipopolysaccharide‐induced microglial activation and protects against inflammation‐mediated dopaminergic neuronal injury
Li, R., Huang, Y., Du, F., & Le, W. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20315 · Cited by 205 · see citing works
Imaging hippocampal function across the human life span: Is memory decline normal or not?
Small, S. A., Tsai, W. Y., DeLaPaz, R., Mayeux, R., & Stern, Y. (2002) · Annals of Neurology · doi:10.1002/ana.10105 · Cited by 205 · see citing works
Improvement of Endothelial Function With Dietary Flavanols Is Associated With Mobilization of Circulating Angiogenic Cells in Patients With Coronary Artery Disease
Heiss, C., Jahn, S., Taylor, M., Real, W. M., Angeli, F. S., Wong, M. L., Amabile, N., Prasad, M., Rassaf, T., Ottaviani, J. I., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.039 · Cited by 202 · see citing works
The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs
Matter, W. F., Brown, R. F., & Vlahos, C. J. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90792-j · Cited by 200 · see citing works
Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones
Duffy, R., Wiseman, H., & File, S. E. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00116-3 · Cited by 199 · see citing works
Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies
Macready, A. L., Kennedy, O. B., Ellis, J. A., Williams, C. M., Spencer, J. P. E., & Butler, L. T. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0135-4 · Cited by 198 · see citing works
Effects of Concord grape juice on cognitive and motor deficits in aging
Shukitt‐Hale, B., Carey, A. N., Simon, L., Mark, D. A., & Joseph, J. A. (2006) · Nutrition · doi:10.1016/j.nut.2005.07.016 · Cited by 197 · see citing works
Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity*
Ono, K., Condron, M. M., Ho, L., Wang, J., Zhao, W., Pasinetti, G. M., & Teplow, D. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806154200 · Cited by 190 · see citing works
Fast Access of Some Grape Pigments to the Brain
Passamonti, S., Vrhovšek, U., Vanzo, A., & Mattivi, F. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050565k · Cited by 186 · see citing works
Red wine polyphenols‐induced, endothelium‐dependent NO‐mediated relaxation is due to the redox‐sensitive PI3‐kinase/Akt‐dependent phosphorylation of endothelial NO‐synthase in the isolated porcine coronary artery
Ndiaye, M., Chataigneau, M., Lobysheva, I. I., Chataigneau, T., & Schini‐Kerth, V. B. (2004) · The FASEB Journal · doi:10.1096/fj.04-2146fje · Cited by 185 · see citing works
Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein
Schroeter, H., Williams, R. J., Matin, R., Iversen, L. L., & Rice-Evans, C. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00415-9 · Cited by 184 · see citing works
Impact of diet on adult hippocampal neurogenesis
Stangl, D., & Thuret, S. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0134-5 · Cited by 182 · see citing works
Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression
Mann, G. E., Rowlands, D. J., Li, F., deWinter, P., & Siow, R. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.004 · Cited by 181 · see citing works
p38 MAPK-mediated Transcriptional Activation of Inducible Nitric-oxide Synthase in Glial Cells
Bhat, N. R., Feinstein, D. L., Shen, Q., & Bhat, A. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204994200 · Cited by 179 · see citing works
Cell Signaling Pathways and Iron Chelation in the Neurorestorative Activity of Green Tea Polyphenols: Special Reference to Epigallocatechin Gallate (EGCG)
Mandel, S. A., Amit, T., Kalfon, L., Reznichenko, L., Weinreb, O., & Youdim, M. B. H. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15207 · Cited by 173 · see citing works
The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function
Pearson, D. A., Paglieroni, T. G., Rein, D., Wun, T., Schramm, D. D., Wang, J. F., Holt, R. R., Gosselin, R. C., Schmitz, H. H., & Keen, C. L. (2002) · Thrombosis Research · doi:10.1016/s0049-3848(02)00128-7 · Cited by 173 · see citing works
(‐)Epicatechin stimulates ERK‐dependent cyclic AMP response element activity and up‐regulates GluR2 in cortical neurons
Schroeter, H., Bahia, P. K., Spencer, J. P. E., Sheppard, O., Rattray, M., Cadenas, E., Rice-Evans, C. A., & Williams, R. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04434.x · Cited by 173 · see citing works
CRE-Mediated Gene Transcription in Neocortical Neuronal Plasticity during the Developmental Critical Period
Pham, T. A., Impey, S., Storm, D. R., & Stryker, M. P. (1999) · Neuron · doi:10.1016/s0896-6273(00)80679-0 · Cited by 173 · see citing works
Xenobiotic Metabolism and Berry Flavonoid Transport across the Blood−Brain Barrier
Milbury, P. E., & Kalt, W. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903529m · Cited by 171 · see citing works
Iron and α-Synuclein in the Substantia Nigra of MPTP-Treated Mice: Effect of Neuroprotective Drugs R-Apomorphine and Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate
Mandel, S. A., Maor, G., & Youdim, M. B. H. (2004) · Journal of Molecular Neuroscience · doi:10.1385/jmn:24:3:401 · Cited by 171 · see citing works
Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats
Mohsen, M. A. E., Marks, J., Kuhnle, G., Moore, K. P., Debnam, E. S., Srai, S. K., Rice-Evans, C. A., & Spencer, J. P. E. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051596 · Cited by 170 · see citing works
A double-blind, placebo-controlled, randomized trial of the effects of dark chocolate and cocoa on variables associated with neuropsychological functioning and cardiovascular health: clinical findings from a sample of healthy, cognitively intact older adults
Crews, W. D., Harrison, D. W., & Wright, J. W. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.872 · Cited by 169 · see citing works
Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity
Zheng, L. T., Ock, J., Kwon, B., & Suk, K. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2007.12.012 · Cited by 168 · see citing works
The Anti-Amyloidogenic Effect Is Exerted against Alzheimer's β-Amyloid Fibrils in Vitro by Preferential and Reversible Binding of Flavonoids to the Amyloid Fibril Structure
Hirohata, M., Hasegawa, K., Tsutsumi, S., Ohhashi, Y., Ookoshi, T., Ono, K., Yamada, M., & Naiki, H. (2007) · Biochemistry · doi:10.1021/bi061540x · Cited by 167 · see citing works
Cell death mechanisms in neurodegeneration
Jellinger, K. A. (2001) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2001.tb00134.x · Cited by 166 · see citing works
Effects of blackberries on motor and cognitive function in aged rats
Shukitt‐Hale, B., Cheng, V., & Joseph, J. A. (2009) · Nutritional Neuroscience · doi:10.1179/147683009x423292 · Cited by 166 · see citing works
Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity
Vauzour, D., Corona, G., & Spencer, J. P. E. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.03.016 · Cited by 166 · see citing works
Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Aβ1-42 oligomers and upregulating synaptic plasticity–related proteins in the hippocampus
Li, Q., Zhao, H., Zhang, Z. F., Liu, Z. G., Pei, X., Wang, J. B., & Li, Y. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.014 · Cited by 165 · see citing works
Spatial and temporal expression of short, long/medium, or both opsins in human fetal cones
Xiao, M., & Hendrickson, A. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001002)425:4 · Cited by 165 · see citing works
Iron dysregulation in Alzheimer's disease: Multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents
Mandel, S., Amit, T., Bar-Am, O., & Youdim, M. B. H. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.001 · Cited by 164 · see citing works
Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain
Spencer, J. P. E. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110000054 · Cited by 163 · see citing works
Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease
Barzilai, A., & Melamed, E. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00020-0 · Cited by 156 · see citing works
Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts
Spencer, J. P. E., Schroeter, H., Crossthwaithe, A. J., Kuhnle, G., Williams, R. J., & Rice-Evans, C. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00704-3 · Cited by 154 · see citing works
Alzheimer’s disease, cerebrovascular dysfunction and the benefits of exercise: From vessels to neurons
Lange‐Asschenfeldt, C., & Kojda, G. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.04.002 · Cited by 153 · see citing works
Behavioral and genoprotective effects of Vaccinium berries intake in mice
Barros, D. M., Amaral, O. B., Izquierdo, I., Geracitano, L. A., Raseira, M. D. C. B., Henriques, A. T., & Ramirez, M. R. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.05.001 · Cited by 149 · see citing works
Understanding the Broad-Spectrum Neuroprotective Action Profile of Green Tea Polyphenols in Aging and Neurodegenerative Diseases
Mandel, S. A., Amit, T., Weinreb, O., & Youdim, M. B. H. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101803 · Cited by 143 · see citing works
Activation of Endothelial Nitric-oxide Synthase by the p38 MAPK in Response to Black Tea Polyphenols
Anter, E., Thomas, S. R., Schulz, E., Shapira, O. M., Vita, J. A., & Keaney, J. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405547200 · Cited by 142 · see citing works
Is There a Role for Estrogen Replacement Therapy in the Prevention and Treatment of Dementia?
Birge, S. J. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb03749.x · Cited by 140 · see citing works
Influence of the Severity of Cognitive Impairment on the Effect of the Ginkgo biloba Extract EGb 761® in Alzheimer’s Disease
Bars, P. L. L., Velasco, F. M., Ferguson, J. M., Dessain, E. C., Kieser, M., & Hoerr, R. (2002) · Neuropsychobiology · doi:10.1159/000048668 · Cited by 132 · see citing works
Effect of lyophilised berries on memory, anxiety and locomotion in adult rats
RAMIREZ, M., Izquierdo, I., Raseira, M. D. C. B., Zuanazzi, J. Â. S., Barros, D. M., & Henriques, A. T. (2005) · Pharmacological Research · doi:10.1016/j.phrs.2005.07.003 · Cited by 130 · see citing works
Flavonoid transport across RBE4 cells: A blood-brain barrier model
Faria, A., Pestana, D., Teixeira, D., Azevedo, J., de Freitas, V. A. P., Mateus, N. F. D. C. B., & Calhau, C. (2010) · Cellular & Molecular Biology Letters · doi:10.2478/s11658-010-0006-4 · Cited by 130 · see citing works
Potential Therapeutic Effects of Exercise to the Brain
Ang, E., Gomez-Pinilla, F., Ang, E., & Gomez-Pinilla, F. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707782023280 · Cited by 129 · see citing works
Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators
Amit, T., Avramovich‐Tirosh, Y., Youdim, M. B. H., & Mandel, S. (2008) · The FASEB Journal · doi:10.1096/fj.07-8627rev · Cited by 126 · see citing works
Effect of Estradiol and Soy Phytoestrogens on Choline Acetyltransferase and Nerve Growth Factor mRNAs in the Frontal Cortex and Hippocampus of Female Rats
Pan, Y., Anthony, M. S., & Clarkson, T. B. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-64.x · Cited by 122 · see citing works
Grape Derived Polyphenols Attenuate Tau Neuropathology in a Mouse Model of Alzheimer's Disease
Wang, J., Santa‐María, I., Ho, L., Ksiȩżak-Reding, H., Ono, K., Teplow, D. B., & Pasinetti, G. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-101074 · Cited by 121 · see citing works
Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs
Schroeter, H., Heiß, C., Spencer, J. P. E., Keen, C. L., Lupton, J. R., & Schmitz, H. H. (2010) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2010.09.008 · Cited by 120 · see citing works
Corrigendum to Flavonoid permeability across an in situ model of the blood–brain barrier. Free Radic. Biol. Med. 36: 592–604; 2004.
Youdim, K. A., Qaiser, M. Z., Begley, D. J., Rice-Evans, C. A., & Abbott, N. J. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.03.003 · Cited by 118 · see citing works
Cocoa Flavanols and Brain Perfusion
Fisher, N. D. L., Sorond, F. A., & Hollenberg, N. K. (2006) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200606001-00017 · Cited by 117 · see citing works
An examination of the effects of the antioxidant Pycnogenol® on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population
Ryan, J. L., Croft, K. D., Mori, T. A., Wesnes, K. A., Spong, J., Downey, L. A., Kure, C., Lloyd, J., & Stough, C. K. K. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108091584 · Cited by 117 · see citing works
Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation
Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T., & Sugimoto, H. (2008) · Neuroreport · doi:10.1097/wnr.0b013e32830b8ae1 · Cited by 115 · see citing works
5‐S‐Cysteinyl‐conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase‐3 activity in neurons
Spencer, J. P. E., Whiteman, M., Jenner, P. G., & Halliwell, B. B. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00808.x · Cited by 113 · see citing works
Determination of naringenin and its glucuronide conjugate in rat plasma and brain tissue by high-performance liquid chromatography
Peng, H., Cheng, F. C., Huang, Y., Chen, C. F., & Tsai, T. (1998) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(98)00204-7 · Cited by 112 · see citing works
Plasma Levels and Distribution of Flavonoids in Rat Brain after Single and Repeated Doses of StandardizedGinkgo bilobaExtract EGb 761®
Rangel-Ordóñez, L., Nöldner, M., Schubert‐Zsilavecz, M., & Wurglics, M. (2010) · Planta Medica · doi:10.1055/s-0030-1249962 · Cited by 109 · see citing works
The Effects of an Extract of Ginkgo biloba, EGb 761, on Cognitive Behavior and Longevity in the Rat
Winter, J. C. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00464-2 · Cited by 108 · see citing works
The in vivo synaptic plasticity mechanism of EGb 761‐induced enhancement of spatial learning and memory in aged rats
Wang, Y., Wang, L., Wu, J., & Cai, J. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706720 · Cited by 108 · see citing works
Evidence for up-regulation of brain-derived neurotrophic factor mRNA by soy phytoestrogens in the frontal cortex of retired breeder female rats
Pan, Y., Anthony, M. S., & Clarkson, T. B. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00994-x · Cited by 105 · see citing works
Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease
Spires‐Jones, T. L., & Hannan, A. J. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04677.x · Cited by 102 · see citing works
Cocoa flavanols: effects on vascular nitric oxide and blood pressure
Fraga, C. G., Litterio, M. C., Prince, P. D., Calabró, V., Piotrkowski, B., & Galleano, M. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-010fr · Cited by 101 · see citing works
Recent advances in berry supplementation and age-related cognitive decline
Willis, L., Shukitt‐Hale, B., & Joseph, J. A. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32831b9c6e · Cited by 100 · see citing works
An Examination of the Efficacy of Ginkgo biloba Extract EGb 761 on the Neuropsychologic Functioning of Cognitively Intact Older Adults
Mix, J. A., & Crews, W. D. (2000) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2000.6.219 · Cited by 100 · see citing works
Nutritional intervention in brain aging: reducing the effects of inflammation and oxidative stress.
Lau, F. C., Shukitt‐Hale, B., & Joseph, J. A. (2007) · PubMed · Cited by 100 · see citing works
Modulation of TNF‐α Secretion in Peripheral Blood Mononuclear Cells by Cocoa Flavanols and Procyanidins
Mao, T. K., de Water, J. V., Keen, C. L., Schmitz, H. H., & Gershwin, M. E. (2002) · Journal of Immunology Research · doi:10.1080/1044667031000137601 · Cited by 98 · see citing works
(−)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain
Tomonaga, N., Tomonaga, S., Tachibana, T., Denbow, D. M., & Furuse, M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.12.024 · Cited by 97 · see citing works
Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: Implications for Parkinson’s disease and protection by polyphenols
Vauzour, D., Ravaioli, G. M., Vafeiadou, K., Rodriguez‐Mateos, A., Angeloni, C., & Spencer, J. P. E. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.011 · Cited by 96 · see citing works
Activation of glutathione peroxidase via Nrf1 mediates genistein’s protection against oxidative endothelial cell injury
Hernandez-Montes, E., Pollard, S. E., Vauzour, D., Jofre‐Monseny, L., Rota, C., Rimbach, G. H., Weinberg, P. D., & Spencer, J. P. E. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.197 · Cited by 96 · see citing works
Nutritional Intervention in Brain Aging
Lau, F. C., Shukitt‐Hale, B., & Joseph, J. A. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/1-4020-5688-5_14 · Cited by 94 · see citing works
Effects of soy isoflavone supplementation on cognitive function in Chinese postmenopausal women
Ho, S. C., Chan, A. S.-Y., Ho, Y. P., So, E. K. F., Sham, A., Zee, B. C.-Y., & Woo, J. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31802c4f4f · Cited by 93 · see citing works
Interactions of Flavones and Other Phytochemicals with Adenosine Receptors
Jacobson, K. A., Moro, S., Manthey, J. A., West, P. L., & Ji, X. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-5235-9_15 · Cited by 86 · see citing works
Dietary flavonoid (−)epicatechin stimulates phosphatidylinositol 3‐kinase‐dependent anti‐oxidant response element activity and up‐regulates glutathione in cortical astrocytes
Bahia, P. K., Rattray, M., & Williams, R. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05542.x · Cited by 86 · see citing works
Epigallocatechin gallate (EGCG) suppresses β-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3β activation
Lin, C., Chen, T., Chiu, M., Way, T., & Lin, J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.012 · Cited by 86 · see citing works
Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin
Maher, P. A. (2009) · Genes & Nutrition · doi:10.1007/s12263-009-0142-5 · Cited by 85 · see citing works
EGCG functions through estrogen receptor‐mediated activation of ADAM10 in the promotion of non‐amyloidogenic processing of APP
Fernandez, J. W., Rezai-Zadeh, K. P., Obregon, D. F., & Tan, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.09.022 · Cited by 83 · see citing works
Grape Seed Polyphenolic Extract as a Potential Novel Therapeutic Agent in Tauopathies
Ho, L., Yemul, S., Wang, J., & Pasinetti, G. M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0969 · Cited by 82 · see citing works
The effects of soy milk and isoflavone supplements on cognitive performance in healthy, postmenopausal women.
Fournier, L. R., Ryan-Borchers, T., Robison, L. M., Wiediger, M. D., Park, J. S., Chew, B. P., McGuire, S., Sclar, D. A., Skaer, T. L., & Beerman, K. A. (2007) · PubMed · Cited by 81 · see citing works
CREB and the discovery of cognitive enhancers
Scott, R. H., Bourtchuladze, R., Gossweiler, S., Dubnau, J., & Tully, T. (2002) · Journal of Molecular Neuroscience · doi:10.1007/s12031-002-0029-z · Cited by 79 · see citing works
Flavonoids as Opioid Receptor Ligands: Identification and Preliminary Structure−Activity Relationships
Katavic, P. L., Lamb, K. R., Navarro, H. A., & Prisinzano, T. E. (2007) · Journal of Natural Products · doi:10.1021/np070194x · Cited by 77 · see citing works
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols
Ksiȩżak-Reding, H., Ho, L., Santa‐María, I., Díaz-Ruiz, C., Wang, J., & Pasinetti, G. M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.006 · Cited by 72 · see citing works

Flagged first, then by citations

1 of the 222 references couldn’t be matched to a known paper.

Sorted by citations

Role of Phenolic Compounds in Human Disease: Current Knowledge and Future Prospects
Rahman, M. M., Rahaman, M. S., Islam, M. R., Rahman, F., Mithi, F. M., Alqahtani, T., Almikhlafi, M. A., Alghamdi, S. Q., Alruwaili, A. S., Hossain, M. S., et al. (2021) · Molecules · doi:10.3390/molecules27010233 · Cited by 900 · see citing works
Flavones: An important scaffold for medicinal chemistry
Singh, M., Kaur, M., & Silakari, O. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.07.013 · Cited by 542 · see citing works
Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects
Vauzour, D. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/914273 · Cited by 431 · see citing works
Astrocyte Heterogeneity: Impact to Brain Aging and Disease
Matias, I., Morgado, J., & Gomes, F. C. A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00059 · Cited by 387 · see citing works
Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders
Ayaz, M., Sadiq, A., Junaid, M., Ullah, F., Ovais, M., Ullah, I., Ahmed, J., & Shahid, M. M. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00155 · Cited by 348 · see citing works
Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
Mastroiacovo, D., Kwik-Uribe, C. L., Grassi, D., Necozione, S., Raffaele, A., Pistacchio, L., Righetti, R., Bocale, R., Lechiara, M. C., Marini, C., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092189 · Cited by 344 · see citing works
The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?
Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works
Neuroprotective Effects of Citrus Flavonoids
Hwang, S.-L., Shih, P., & Yen, G. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf204452y · Cited by 320 · see citing works
Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)
Singh, N. A., Mandal, A. K. A., & Khan, Z. A. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0179-4 · Cited by 319 · see citing works
Benefits in Cognitive Function, Blood Pressure, and Insulin Resistance Through Cocoa Flavanol Consumption in Elderly Subjects With Mild Cognitive Impairment: The Cocoa, Cognition, and Aging (CoCoA) Study
Desideri, G., Kwik-Uribe, C., Grassi, D., Necozione, S., Ghiadoni, L., Mastroiacovo, D., Raffaele, A., Ferri, L., Bocale, R., Lechiara, M. C., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.193060 · Cited by 311 · see citing works
Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions
Andrieu, S., Coley, N., Lovestone, S., Aisen, P. S., & Vellas, B. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00153-2 · Cited by 293 · see citing works
Recent Research on Flavonoids and their Biomedical Applications
Wen, K., Fang, X., Yang, J., Yao, Y., Nandakumar, K. S., Salem, M. L., & Cheng, K. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200713184138 · Cited by 267 · see citing works
Current evidence on the effect of dietary polyphenols intake on chronic diseases
Costa, C., Tsatsakis, A. M., Mamoulakis, C., Teodoro, M., Briguglio, G., Caruso, E., Tsoukalas, D., Margina, D. M., Dardiotis, E., Kouretas, D., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.023 · Cited by 262 · see citing works
The neuroprotective effects of cocoa flavanol and its influence on cognitive performance
Nehlig, A. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04378.x · Cited by 249 · see citing works
Nutrition for the ageing brain: Towards evidence for an optimal diet
Vauzour, D., Camprubi-Robles, M., Miquel-Kergoat, S., Andres-Lacueva, C., Bánáti, D., Barberger-Gateau, P., Bowman, G. L., Caberlotto, L., Clarke, R., Hogervorst, E., et al. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.010 · Cited by 241 · see citing works
Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases
Rodríguez-Morató, J., Xicota, L., Fitó, M., Farré, M., Dierssen, M., & de la Torre, R. (2015) · Molecules · doi:10.3390/molecules20034655 · Cited by 242 · see citing works
Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues
Sato, M., Murakami, K., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K., Masuda, Y., Takegoshi, K., & Irie, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.464222 · Cited by 232 · see citing works
Curcumin as a MicroRNA Regulator in Cancer: A Review
Momtazi‐Borojeni, A. A., Shahabipour, F., Khatibi, S., Johnston, T. P., Pirro, M., & Sahebkar, A. (2016) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2016_3 · Cited by 230 · see citing works
Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease
Goyal, D., Shuaib, S., Mann, S., & Goyal, B. (2017) · ACS Combinatorial Science · doi:10.1021/acscombsci.6b00116 · Cited by 229 · see citing works
miRNA as molecular target of polyphenols underlying their biological effects
Milenković, D., Jude, B., & Morand, C. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.046 · Cited by 218 · see citing works
Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mild-to-moderate dementia
Kent, K., Charlton, K., Roodenrys, S., Batterham, M., Potter, J., Traynor, V., Gilbert, H., Morgan, O., & Richards, R. (2017) · European Journal of Nutrition · doi:10.1007/s00394-015-1083-y · Cited by 214 · see citing works
“The ability of flavonoids to modulate Alzheimer’s disease progression is still poorly understood (17).”
Background
Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks
Domingues, C., Silva, O. A. B. D. C. E., & Henriques, A. G. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170317113606 · Cited by 212 · see citing works
The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function
Rees, A., Dodd, G. F., & Spencer, J. P. E. (2018) · Nutrients · doi:10.3390/nu10121852 · Cited by 196 · see citing works
The Neuroprotective Potentiality of Flavonoids on Alzheimer’s Disease
Calderaro, A., Patanè, G. T., Tellone, E., Barreca, D., Ficarra, S., Misiti, F., & Laganà, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314835 · Cited by 199 · see citing works
Characterization of antioxidant polyphenols from Myrciaria jaboticaba peel and their effects on glucose metabolism and antioxidant status: A pilot clinical study
Plaza, M., Batista, Â. G., Cazarin, C. B. B., Sandahl, M., Turner, C., Östman, E. M., & Maróstica, M. R. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.04.142 · Cited by 190 · see citing works
Role of microRNAs in the Therapeutic Effects of Curcumin in Non-Cancer Diseases
Momtazi‐Borojeni, A. A., Derosa, G., Maffioli, P., Banach, M., & Sahebkar, A. (2016) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-016-0202-7 · Cited by 179 · see citing works
The mechanisms of action of flavonoids in the brain: Direct versus indirect effects
Rendeiro, C., Rhodes, J. S., & Spencer, J. P. E. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.002 · Cited by 182 · see citing works
Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behavior
Sokolov, A. N., Pavlova, M. A., Klosterhalfen, S., & Enck, P. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.013 · Cited by 178 · see citing works
Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer’s disease
Moreno, L. C. G. E. A. I., Puerta, E., Suárez-Santiago, J. E., Santos-Magalhães, N. S., Ramírez, M. J., & Irache, J. M. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.11.061 · Cited by 170 · see citing works
Enhancing Human Cognition with Cocoa Flavonoids
Socci, V., Tempesta, D., Desideri, G., de Gennaro, L., & Ferrara, M. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00019 · Cited by 141 · see citing works
Neuroprotective Effect of Chlorogenic Acid on Mitochondrial Dysfunction-Mediated Apoptotic Death of DA Neurons in a Parkinsonian Mouse Model
Singh, S. S., Nand, S., Birla, H., Zahra, W., Rathore, A. S., Dilnashin, H., Singh, R., & Singh, S. P. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6571484 · Cited by 160 · see citing works
Neuroinflammation in Alzheimer's Disease
Sawikr, Y., Yarla, N. S., Peluso, I., Kamal, M. A., Aliev, G. M., & Bishayee, A. (2017) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2017.02.001 · Cited by 159 · see citing works
Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System
Lee, J., Jo, D., Park, D., Chung, H. Y., & Mattson, M. P. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007757 · Cited by 154 · see citing works
Recent progress in multifunctional metal chelators as potential drugs for Alzheimer's disease
Santos, M. A., Chand, K., & Chaves, S. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2016.04.013 · Cited by 149 · see citing works
Long-term dietary flavonoid intake and risk of Alzheimer disease and related dementias in the Framingham Offspring Cohort
Shishtar, E., Rogers, G. T., Blumberg, J. B., Au, R., & Jacques, P. F. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa079 · Cited by 153 · see citing works
Low-density lipoprotein receptor-related protein 1: A physiological Aβ homeostatic mechanism with multiple therapeutic opportunities
Sagare, A. P., Deane, R., & Zloković, B. V. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.07.008 · Cited by 144 · see citing works
The genetic aspects of berries: from field to health
Mazzoni, L., Pérez-López, P., Giampieri, F., Álvarez-Suárez, J. M., Gasparrini, M., Forbes-Hernández, T. Y., Quiles, J. L., Mezzetti, B., & Battino, M. A. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7216 · Cited by 139 · see citing works
Nutraceuticals in cognitive impairment and Alzheimer’s disease
Mecocci, P., Tinarelli, C., Schulz, R. J., & Polidori, M. C. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00147 · Cited by 144 · see citing works
Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology
Vauzour, D. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6473 · Cited by 136 · see citing works
Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease
Uddin, M. S., Kabir, M. T., Niaz, K., Jeandet, P., Clément, C., Mathew, B., Rauf, A., Rengasamy, K. R. R., Sobarzo‐Sánchez, E., Ashraf, G. M., et al. (2020) · Molecules · doi:10.3390/molecules25061267 · Cited by 134 · see citing works
Zea mays lea silk extract mediated synthesis of nickel oxide nanoparticles as positive electrode material for asymmetric supercabattery
Nwanya, A. C., Ndipingwi, M. M., Ikpo, C. O., Obodo, R. M., Nwanya, S. C., Botha, S. S., Ezema, F. I., Iwuoha, E. I., & Mâaza, M. (2019) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2019.153581 · Cited by 131 · see citing works
The biological activities of butyrylcholinesterase inhibitors
Zhou, S., & Huang, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112556 · Cited by 132 · see citing works
Beneficial Effects of Dietary EGCG and Voluntary Exercise on Behavior in an Alzheimer's Disease Mouse Model
Walker, J. M., Klakotskaia, D., Ajit, D., Weisman, G. A., Wood, W. G., Sun, G. Y., Serfözö, P. D., Simonyi, Á., & Schachtman, T. R. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-140981 · Cited by 128 · see citing works
A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
Whyte, A. R., Cheng, N., Fromentin, E., & Williams, C. M. (2018) · Nutrients · doi:10.3390/nu10060660 · Cited by 132 · see citing works
RETRACTED ARTICLE: Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice
Khan, M. S., Ali, T., Kim, M. W., Jo, M. H., Chung, J. I., & Kim, M. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1101-1 · Cited by 129 · see citing works
Retracted
Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress
Haider, S., Liaquat, L., Ahmad, S., Batool, Z., Siddiqui, R. A., Tabassum, S., Shahzad, S., Rafiq, S., & Naz, N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227631 · Cited by 127 · see citing works
A Review of the Cognitive Effects Observed in Humans Following Acute Supplementation with Flavonoids, and Their Associated Mechanisms of Action
Bell, L., Lamport, D. J., Butler, L. T., & Williams, C. M. (2015) · Nutrients · doi:10.3390/nu7125538 · Cited by 124 · see citing works
Anthocyanins protect against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration in the adult mouse cortex
Khan, M. S., Ali, T., Kim, M. W., Jo, M. H., Jo, M. G., Badshah, H., & Kim, M. O. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.005 · Cited by 124 · see citing works
Amentoflavone protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through PI3K/Akt and ERK signaling pathways
Cao, Q. C., Qin, L., Huang, F., Wang, X., Liu, Y., Shi, H., Wu, H., Zhang, B., Chen, Z., & Wu, X. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.01.019 · Cited by 125 · see citing works
Flavonoids: Potential Candidates for the Treatment of Neurodegenerative Disorders
Devi, S., Kumar, V., Singh, S. K., Dubey, A. K., & Kim, J.-J. (2021) · Biomedicines · doi:10.3390/biomedicines9020099 · Cited by 124 · see citing works
Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
Polyphenols and the Human Brain: Plant “Secondary Metabolite” Ecologic Roles and Endogenous Signaling Functions Drive Benefits
Kennedy, D. O. (2014) · Advances in Nutrition · doi:10.3945/an.114.006320 · Cited by 125 · see citing works
Rutin activates the MAPK pathway and BDNF gene expression on beta-amyloid induced neurotoxicity in rats
Moghbelinejad, S., Nassiri‐Asl, M., Farivar, T. N., Abbasi, E., Sheikhi, M., Taghiloo, M., Farsad, F., Samimi, A., & Hajiali, F. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.10.010 · Cited by 118 · see citing works
Polyphenols in dementia: From molecular basis to clinical trials
Molino, S., Dossena, M., Buonocore, D., Ferrari, F., Venturini, L., Ricevuti, G., & Verri, M. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.07.021 · Cited by 119 · see citing works
Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery
Lungare, S., Hallam, K., & Badhan, R. K. S. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.09.042 · Cited by 116 · see citing works
Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration
Flanagan, E. C., Müller, M. M., Hornberger, M., & Vauzour, D. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0226-1 · Cited by 115 · see citing works
Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities
Cho, N., Lee, K. Y., Huh, J., Choi, J. H., Yang, H., Jeong, E. J., Kim, H. P., & Sung, S. H. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.05.007 · Cited by 115 · see citing works
Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders
Nash, K. M., & Shah, Z. A. (2015) · Integrative Medicine Insights · doi:10.4137/imi.s25054 · Cited by 111 · see citing works
Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model
Dabbagh-Bazarbachi, H., Clergeaud, G., Quesada, I., Ortiz, M., O’Sullivan, C. K., & Fernández-Larrea, J. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5014633 · Cited by 109 · see citing works
Inflammation and Alzheimer’s Disease: Mechanisms and Therapeutic Implications by Natural Products
Rather, M. A., Khan, A., Alshahrani, S., Rashid, H., Qadri, M. M., Rashid, S., Alsaffar, R. M., Kamal, M. A., & Rehman, M. U. (2021) · Mediators of Inflammation · doi:10.1155/2021/9982954 · Cited by 112 · see citing works
Bioavailability of Epigallocatechin Gallate Administered with Different Nutritional Strategies in Healthy Volunteers
Andreu-Férnández, V., Almeida-Toledano, L., Pizarro, N., Navarro‐Tapia, E., Gómez‐Roig, M. D., de la Torre, R., & García‐Algar, Ó. (2020) · Antioxidants · doi:10.3390/antiox9050440 · Cited by 112 · see citing works
Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults
Haskell‐Ramsay, C. F., Stuart, R. C., Okello, E. J., & Watson, A. W. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1454-7 · Cited by 106 · see citing works
Cinnamon, a promising prospect towards Alzheimer’s disease
Momtaz, S., Hassani, S., Khan, F., Ziaee, M., & Abdollahi, M. R. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.011 · Cited by 106 · see citing works
Recommendations on reporting requirements for flavonoids in research
Balentine, D. A., Dwyer, J. T., Erdman, J. W., Ferruzzi, M. G., Gaine, P. C., Harnly, J. M., & Kwik-Uribe, C. L. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.071274 · Cited by 104 · see citing works
Vitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway
Hu, M. C., Li, F., & Wang, W. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s156920 · Cited by 104 · see citing works
Effects of Tea Catechins on Alzheimer’s Disease: Recent Updates and Perspectives
Ide, K., Matsuoka, N., Yamada, H., Furushima, D., & Kawakami, K. (2018) · Molecules · doi:10.3390/molecules23092357 · Cited by 103 · see citing works
Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands
Iraji, A., Khoshneviszadeh, M., Firuzi, O., Khoshneviszadeh, M., & Edraki, N. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103649 · Cited by 102 · see citing works
Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation
Carregosa, D., Carecho, R., Figueira, I., & dos Santos, C. N. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02155 · Cited by 98 · see citing works
The acute and sub-chronic effects of cocoa flavanols on mood, cognitive and cardiovascular health in young healthy adults: a randomized, controlled trial
Massee, L. A., Ried, K., Pase, M. P., Travica, N., Yoganathan, J., Scholey, A. B., Macpherson, H., Kennedy, G., Sali, A., & Pipingas, A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00093 · Cited by 93 · see citing works
Cognitive impairments in type 2 diabetes, risk factors and preventive strategies
Sharma, G., Parihar, A., Talaiya, T., Dubey, K., Porwal, B., & Parihar, M. S. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0105 · Cited by 91 · see citing works
Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing
Cox, C. J., Choudhry, F., Peacey, E., Perkinton, M. S., Richardson, J. C., Howlett, D. R., Lichtenthaler, S. F., Francis, P. T., & Williams, R. J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.032 · Cited by 87 · see citing works
Effects of cocoa extract and a multivitamin on cognitive function: a randomized clinical trial
Baker, L. D., Manson, J. E., Rapp, S. R., Sesso, H. D., Gaussoin, S. A., Shumaker, S. A., & Espeland, M. A. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.12767 · Cited by 88 · see citing works
Role of Flavonoids in Neurodegenerative Diseases: Limitations and Future Perspectives
Maan, G., Sikdar, B., Kumar, A., Shukla, R., & Mishra, A. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200416085330 · Cited by 85 · see citing works
Mitochondrial Dysfunction
Leuner, K., Stockburger, C., Denzer, I., Eckert, G. P., & Müller, W. E. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394625-6.00007-6 · Cited by 84 · see citing works
Nutritional compositions and antioxidative capacity of the silk obtained from immature and mature corn
Rahman, N. A., & Ishak, W. R. W. (2013) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2013.11.002 · Cited by 86 · see citing works
Chocolate intake is associated with better cognitive function: The Maine-Syracuse Longitudinal Study
Crichton, G. E., Elias, M. F., & Alkerwi, A. (2016) · Appetite · doi:10.1016/j.appet.2016.02.010 · Cited by 81 · see citing works
Cocoa powder triggers neuroprotective and preventive effects in a human Alzheimer's disease model by modulating BDNF signaling pathway
Cimini, A., Gentile, R., D’Angelo, B., Benedetti, E., Cristiano, L., Avantaggiati, M. L., Giordano, A., Ferri, C., & Desideri, G. (2013) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24548 · Cited by 80 · see citing works
In Vitro Modulation of TrkB Receptor Signaling upon Sequential Delivery of Curcumin-DHA Loaded Carriers Towards Promoting Neuronal Survival
Guerzoni, L. P. B., Nicolas, V., & Angelova, A. (2016) · Pharmaceutical Research · doi:10.1007/s11095-016-2080-4 · Cited by 78 · see citing works
Potential Role of (-)-Epigallocatechin-3-Gallate (EGCG) in the Secondary Prevention of Alzheimer Disease
Xicota, L., Rodríguez-Morató, J., Dierssen, M., & de la Torre, R. (2015) · Current Drug Targets · doi:10.2174/1389450116666150825113655 · Cited by 76 · see citing works
Evaluation of the antidepressant activity of Moringa oleifera alone and in combination with fluoxetine
Kaur, G., Invally, M., Sanzagiri, R., & Buttar, H. S. (2015) · Journal of Ayurveda and Integrative Medicine · doi:10.4103/0975-9476.172384 · Cited by 76 · see citing works
Flavonoids as an Intervention for Alzheimer’s Disease: Progress and Hurdles Towards Defining a Mechanism of Action
Hole, K. L., & Williams, R. J. (2020) · Brain Plasticity · doi:10.3233/bpl-200098 · Cited by 78 · see citing works
Naringenin: A prospective therapeutic agent for Alzheimer's and Parkinson's disease
Goyal, A., Verma, A., Dubey, N., Raghav, J., & Agrawal, A. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14415 · Cited by 76 · see citing works
Naringenin-induced enhanced antioxidant defence system meliorates cholinergic neurotransmission and consolidates memory in male rats
Liaquat, L., Batool, Z., Sadir, S., Rafiq, S., Shahzad, S., Perveen, T., & Haider, S. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.12.034 · Cited by 73 · see citing works
Functions of flavonoids in the central nervous system: Astrocytes as targets for natural compounds
Matias, I. C. P., Buosi, A. S., & Gomes, F. C. A. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.01.009 · Cited by 70 · see citing works
Cognitive Function and Consumption of Fruit and Vegetable Polyphenols in a Young Population: Is There a Relationship?
Carrillo, J. Á., Zafrilla, P., & Marhuenda, J. (2019) · Foods · doi:10.3390/foods8100507 · Cited by 72 · see citing works
Catechin attenuates behavioral neurotoxicity induced by 6-OHDA in rats
Teixeira, M. D. A., Souza, C. M. D. A., Menezes, A. P. F., do Carmo, M. R. S., Fonteles, A. A., Gurgel, J. P., Lima, F. A. V., Viana, G. S. B., & Andrade, G. M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.05.012 · Cited by 71 · see citing works
Polyphenols, antioxidants, and antimutagenic effects of Copaifera langsdorffii fruit
Batista, Â. G., Ferrari, A. S., da Cunha, D. C., da Silva-Maia, J. K., Cazarin, C. B. B., Corrêa, L. C., Prado, M. A., de Carvalho-Silva, L. B., Esteves, E. A., & Maróstica, M. R. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.11.093 · Cited by 70 · see citing works
The Impact of Epicatechin on Human Cognition: The Role of Cerebral Blood Flow
Haskell‐Ramsay, C. F., Schmitt, J. A. J., & Actis‐Goretta, L. (2018) · Nutrients · doi:10.3390/nu10080986 · Cited by 70 · see citing works
Botanicals and phytochemicals active on cognitive decline: The clinical evidence
Cicero, A. F. G., Fogacci, F., & Banach, M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.029 · Cited by 70 · see citing works
Flavanol-rich chocolate acutely improves arterial function and working memory performance counteracting the effects of sleep deprivation in healthy individuals
Grassi, D., Socci, V., Tempesta, D., Ferri, C., Gennaro, L. D., Desideri, G., & Ferrara, M. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000926 · Cited by 67 · see citing works
Jaboticaba berry peel intake prevents insulin‐resistance‐induced tau phosphorylation in mice
Batista, Â. G., Soares, E. S., Mendonça, M. C. P., da Silva-Maia, J. K., Dionísio, A. P., Sartori, C. R., da Cruz‐Höfling, M. A., & Maróstica, M. R. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600952 · Cited by 69 · see citing works
Food‐based anthocyanin intake and cognitive outcomes in human intervention trials: a systematic review
Kent, K., Charlton, K. E., Netzel, M. E., & Fanning, K. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12431 · Cited by 67 · see citing works
Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective
Priglinger, E., Urmann, C., Steffenhagen, C., Bieler, L., Brunner, D., Furtner, T., Humpel, C., Bäumer, B. E., Bandtlow, C. E., Couillard‐Després, S., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.06.005 · Cited by 65 · see citing works
The science of matcha: Bioactive compounds, analytical techniques and biological properties
Devkota, H. P., Gaire, B. P., Hori, K., Subedi, L., Adhikari‐Devkota, A., Belwal, T., Paudel, K. R., Jha, N. K., Singh, S. K., Chellappan, D. K., et al. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.10.021 · Cited by 67 · see citing works
The Bad, the Good, and the Ugly about Oxidative Stress
Jiménez-Del-Río, M., & Velez‐Pardo, C. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/163913 · Cited by 64 · see citing works
Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1
Matias, I. C. P., Diniz, L. P., Buosi, A. S., Neves, G. A., Stipursky, J., & Gomes, F. C. A. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00184 · Cited by 64 · see citing works
A flavonoid agonist of the TrkB receptor for BDNF improves hippocampal neurogenesis and hippocampus-dependent memory in the Ts65Dn mouse model of DS
Stagni, F., Giacomini, A., Guidi, S., Emili, M., Uguagliati, B., Salvalai, M. E., Bortolotto, V., Grilli, M., Rimondini, R., & Bartesaghi, R. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.08.018 · Cited by 63 · see citing works
Apigenin Ameliorates Scopolamine-Induced Cognitive Dysfunction and Neuronal Damage in Mice
Kim, Y., Kim, J.-H., He, M., Lee, A., & Cho, E. J. (2021) · Molecules · doi:10.3390/molecules26175192 · Cited by 63 · see citing works
Up‐regulation of β‐amyloidogenesis in neuron‐like human cells by both 24‐ and 27‐hydroxycholesterol: protective effect of N‐acetyl‐cysteine
Gamba, P., Guglielmotto, M., Testa, G., Monteleone, D., Zerbinati, C., Gargiulo, S., Biasi, F., Iuliano, L., Giaccone, G., Mauro, A., et al. (2014) · Aging Cell · doi:10.1111/acel.12206 · Cited by 63 · see citing works
Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?
Almeida, S., Alves, M. G., Sousa, M., Oliveira, P. F., & Silva, B. M. (2016) · Neurotoxicity Research · doi:10.1007/s12640-015-9590-4 · Cited by 64 · see citing works

Flavonoids as Prospective Neuroprotectants and Their Therapeutic Propensity in Aging Associated Neurological Disorders
Ayaz, M., Sadiq, A., Junaid, M., Ullah, F., Ovais, M., Ullah, I., Ahmed, J., & Shahid, M. M. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00155 · Cited by 348 · see citing works
Role of BDNF Signaling in the Neuroprotective and Memory-enhancing Effects of Flavonoids in Alzheimer’s Disease
Amidfar, M., Garcez, M. L., Askari, G., Bagherniya, M., Khorvash, F., Golpour-Hamedani, S., & de Oliveira, J. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527323666230912090856 · Cited by 17 · see citing works
Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer’s Disease
Minocha, T., Birla, H., Obaid, A. A., Rai, V., Pradeep, S., Shivamallu, C., Moustafa, M., Al-Shehri, M., Al‐Emam, A., Tikhonova, M. A., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6038996 · Cited by 151 · see citing works
Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology
Vauzour, D. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6473 · Cited by 136 · see citing works
Alzheimer’s Disease: Analysis of Flavonoids with Mechanism Focusing Upon Targeting Aβ- Deposition and BDNF/Trkb Along with Other Signalling Pathway
Ayush Bajpai, A. S. (2023) · Journal of chemical health risks

Authors: Williams, R. J., & Spencer, J. P. E.
Affiliations: University of Bath (GB)
University of Reading (GB)
Corresponding author: Spencer, Jeremy P.E.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2012-01
Volume: 52
Issue: 1
Pages: 35-45
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2011.09.010
OpenAlex: W2000424893
Cited by: 448
References: 222
Citations by year: 2026: 11 · 2025: 17 · 2024: 28 · 2023: 16 · 2022: 36 · 2021: 34 · 2020: 36 · 2019: 38 · 2018: 34 · 2017: 42 · 2016: 34 · 2015: 37 · 2014: 36 · 2013: 33 · 2012: 15
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Alzheimer's Society
Biotechnology and Biological Sciences Research Council (BB/G005702/1, BB/E023185/1, BB/F008953/1)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: flavonoids, Alzheimer's disease, dementia, flavonoid-rich foods, green tea, blueberry, Theobroma cacao, flavonoid metabolites, ERK signaling, PI3K/Akt signaling, neuroprotection, neurogenesis, hippocampus, cerebral blood flow, neuronal apoptosis, oxidative stress, neuroinflammation, amyloid-beta aggregation, APP processing, BACE1, ADAM10, synaptic connectivity, cognitive function, neurodegeneration
MeSH terms: Alzheimer Disease, Animals, Brain, Cognition, Enzyme Activation, Flavonoids, Humans, Neurons, Signal Transduction, Gene Expression, Amyloid beta-Peptides, Phosphatidylinositol 3-Kinases, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Proto-Oncogene Proteins c-akt, Mice, Rats, Amyloid Precursor Protein Secretases, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks