The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.
Cytokine Signaling Modulates Blood-Brain Barrier Function
Open accessAbstract
The blood-brain barrier (BBB) provides a vast interface for cytokines to affect CNS function. The BBB is a target for therapeutic intervention. It is essential, therefore, to understand how cytokines interact with each other at the level of the BBB and how secondary signals modulate CNS functions beyond the BBB. The interactions between cytokines and lipids, however, have not been fully addressed at the level of the BBB. Here, we summarize current understanding of the localization of cytokine receptors and transporters in specific membrane microdomains, particularly lipid rafts, on the luminal (apical) surface of the microvascular endothelial cells composing the BBB. We then illustrate the clinical context of cytokine effects on the BBB by neuroendocrine regulation and amplification of inflammatory signals. Two unusual aspects discussed are signaling crosstalk by different classes of cytokines and genetic regulation of drug efflux transporters. We also introduce a novel area of focus on how cytokines may act through nuclear hormone receptors to modulate efflux transporters and other targets. A specific example discussed is the ATP-binding cassette transporter-1 (ABCA-1) that regulates lipid metabolism. Overall, cytokine signaling at the level of the BBB is a crucial feature of the dynamic regulation that can rapidly change BBB function and affect brain health and disease.
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“The BBB is disrupted under inflammatory conditions [29, 30].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [30]
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Items 201–219 of 219
Banks, W. A., & Kastin, A. J. (1988) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198805000-00008 · Cited by 31
Unexpected Amplification of Leptin-Induced Stat3 Signaling by Urocortin: Implications for Obesity
Pan, W., Tu, H., Hsuchou, H., Daniel, J., & Kastin, A. J. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0071-y · Cited by 30
Self-citationDifferent mechanisms influencing permeation of PDGF‐AA and PDGF‐BB across the blood–brain barrier
Kastin, A. J., Akerstrom, V. L., Hackler, L., & Pan, W. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01933.x · Cited by 26
Self-citationTNFα trafficking in cerebral vascular endothelial cells
Pan, W., Kastin, A. J., DANIEL, J., et al. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.01.005 · Cited by 26
Self-citationOpposing effects of proteasomes and lysosomes on LIFR: Modulation by TNF
Yu, C., Kastin, A. J., Tu, H., & Pan, W. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0017-4 · Cited by 25
Self-citationLiver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury
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TNF reduces LIF endocytosis despite increasing NFκB‐mediated gp130 expression
Yu, C., Kastin, A. J., & Pan, W. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21105 · Cited by 23
Self-citationUrocortin trafficking in cerebral microvessel endothelial cells
Tu, H., Kastin, A. J., Bjørbæk, C., & Pan, W. (2007) · Journal of Molecular Neuroscience · doi:10.1385/jmn/31:02:171 · Cited by 21
Self-citationSubtil, A., Rocca, A., & Dautry‐Varsat, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29424 · Cited by 20
Pretreatment with glucose increases entry of urocortin into mouse brain
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The Cdk5/p35 Kinases Modulate Leptin-Induced STAT3 Signaling
He, Y., Kastin, A. J., Hsuchou, H., & Pan, W. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-008-9174-3 · Cited by 15
Self-citationDifferential Role of TNF Receptors in Cellular Trafficking of Intact TNF
Pan, W., Tu, H., Yu, C., Hsuchou, H., Yang, Y., & Kastin, A. J. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000107539 · Cited by 15
Self-citationThe somatotrophic axis in brain function
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Flagged first, then by citations
Research works printed but not linked: 6
- [21]Pan W Xiang S Tu H Kastin AJ Dermietzel R Spray DC Nedergaard M In Blood-Brain Barrier Interfaces: From Ontogeny to Artificial Barriers 2006 247 64 Wiley-VCH Weinheim, Germany
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- [90]Tu H Kastin AJ Pan W CRH-R1 and CRH-R2 are both trafficking and signaling receptors for urocortin. Mol Endocrinol 2007 21 700 11 17170072
- [135]Tu H Kastin AJ Pan W CRH-R1 and CRH-R2 are both trafficking and signaling receptors for urocortin. Mol Endocrinol 2007 21 700 11 17170072
- [171]Tu H Kastin AJ Bjorbaek C Pan W Urocortin trafficking in cerebral microvessel endothelial cells. J Mol Neurosci 2007 31 171 82 17478891
- [189]Barger PM Browning AC Garner AN Kelly DP p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. J Biol Chem 2001 276 48 44495 501 11577087
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Sorted by citations
Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease
Erickson, M. A., & Banks, W. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.135 · Cited by 572
Rheumatoid arthritis and depression: an inflammatory perspective
Nerurkar, L., Siebert, S., McInnes, I. B., & Cavanagh, J. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30255-4 · Cited by 426
Brown, J. A., Pensabene, V., Markov, D. A., Allwardt, V., Neely, M. D., Shi, M., Britt, C. M., Hoilett, O. S., Yang, Q. K., Brewer, B. M., et al. (2015) · Biomicrofluidics · doi:10.1063/1.4934713 · Cited by 414
Skvarc, D., Berk, M., Byrne, L. K., Dean, O. M., Dodd, S., Lewis, M., Marriott, A., Moore, E. M., Morris, G., Page, R. S., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.011 · Cited by 318
Harris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279
Metadata
- Authors
- Pan, W., P. Stone, K., Hsuchou, H., K. Manda, V., Zhang, Y., & J. Kastin, A.
- Affiliations
- Pennington Biomedical Research Center (US)
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-11-01
- Volume
- 17
- Issue
- 33
- Pages
- 3729-3740
- ISSN
- 1381-6128 (ISSN-L)
- PMC
- PMC3939622
- OpenAlex
- W2042991023
- Cited by
- 241
- References
- 210
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 19 · 2023: 23 · 2022: 24 · 2021: 25 · 2020: 29 · 2019: 20 · 2018: 22 · 2017: 12 · 2016: 8 · 2015: 16 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DK54880)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-54880, R01DK054880, R56DK054880)
- National Institute of Neurological Disorders and Stroke (NS62291, R01NS062291)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- blood-brain barrier, cytokine signaling, lipid rafts, cytokine receptors, efflux pumps, ABCA1, nuclear receptors, neuroinflammation, neuroendocrine regulation, signaling crosstalk, microvascular endothelial cells, lipid metabolism
- MeSH terms
- Animals, Blood-Brain Barrier, Carrier Proteins, Pharmaceutical Preparations, Humans, Inflammation, Ligands, Neuropeptides, Signal Transduction, Cytokines, Receptors, Cytoplasmic and Nuclear
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