The DOI matches its Crossref record; 219 of the 219 references it cites were found in a registry or an index.
Cytokine Signaling Modulates Blood-Brain Barrier Function
Open accessAbstract
The blood-brain barrier (BBB) provides a vast interface for cytokines to affect CNS function. The BBB is a target for therapeutic intervention. It is essential, therefore, to understand how cytokines interact with each other at the level of the BBB and how secondary signals modulate CNS functions beyond the BBB. The interactions between cytokines and lipids, however, have not been fully addressed at the level of the BBB. Here, we summarize current understanding of the localization of cytokine receptors and transporters in specific membrane microdomains, particularly lipid rafts, on the luminal (apical) surface of the microvascular endothelial cells composing the BBB. We then illustrate the clinical context of cytokine effects on the BBB by neuroendocrine regulation and amplification of inflammatory signals. Two unusual aspects discussed are signaling crosstalk by different classes of cytokines and genetic regulation of drug efflux transporters. We also introduce a novel area of focus on how cytokines may act through nuclear hormone receptors to modulate efflux transporters and other targets. A specific example discussed is the ATP-binding cassette transporter-1 (ABCA-1) that regulates lipid metabolism. Overall, cytokine signaling at the level of the BBB is a crucial feature of the dynamic regulation that can rapidly change BBB function and affect brain health and disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The BBB is disrupted under inflammatory conditions [29, 30].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Structure and function of the blood–brain barrier
Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185
THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE
Endicott, J. A., & Ling, V. (1989) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.58.070189.001033 · Cited by 2,071
Transport of brain-derived neurotrophic factor across the blood–brain barrier
Pan, W., Banks, W. A., Fasold, M. B., Bluth, J., & Kastin, A. J. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00141-5 · Cited by 1,354
Self-citationRevitalizing membrane rafts: new tools and insights
Simons, K., & Gerl, M. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2977 · Cited by 1,268
Leptin enters the brain by a saturable system independent of insulin
Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B., & Maness, L. M. (1996) · Peptides · doi:10.1016/0196-9781(96)00025-3 · Cited by 1,222
Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
Guglielmo, G. M. D., Roy, C. L., Goodfellow, A. F., & Wrana, J. L. (2003) · Nature Cell Biology · doi:10.1038/ncb975 · Cited by 1,152
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.
Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics · doi:10.1038/ng0996-95 · Cited by 1,086
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.
Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033
Bunone, G., Briand, P.-A., Miksicek, R. J., & Picard, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00571.x · Cited by 985
Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions
Persidsky, Y., Ramirez, S. H., Haorah, J., & Kanmogne, G. D. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9025-3 · Cited by 922
Research works printed but not linked: 6
- [21]Pan W Xiang S Tu H Kastin AJ Dermietzel R Spray DC Nedergaard M In Blood-Brain Barrier Interfaces: From Ontogeny to Artificial Barriers 2006 247 64 Wiley-VCH Weinheim, Germany
- [76]Yu Y Kastin AJ Pan W Reciprocal interactions of insulin and IGF-1 in receptor-mediated transport across the BBB. Endocrinol 2006 147 2611 5 16497794
- [90]Tu H Kastin AJ Pan W CRH-R1 and CRH-R2 are both trafficking and signaling receptors for urocortin. Mol Endocrinol 2007 21 700 11 17170072
- [135]Tu H Kastin AJ Pan W CRH-R1 and CRH-R2 are both trafficking and signaling receptors for urocortin. Mol Endocrinol 2007 21 700 11 17170072
- [171]Tu H Kastin AJ Bjorbaek C Pan W Urocortin trafficking in cerebral microvessel endothelial cells. J Mol Neurosci 2007 31 171 82 17478891
- [189]Barger PM Browning AC Garner AN Kelly DP p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. J Biol Chem 2001 276 48 44495 501 11577087
Cited by
Sorted by citations
Blood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease
Erickson, M. A., & Banks, W. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.135 · Cited by 572
Rheumatoid arthritis and depression: an inflammatory perspective
Nerurkar, L., Siebert, S., McInnes, I. B., & Cavanagh, J. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30255-4 · Cited by 426
Brown, J. A., Pensabene, V., Markov, D. A., Allwardt, V., Neely, M. D., Shi, M., Britt, C. M., Hoilett, O. S., Yang, Q. K., Brewer, B. M., et al. (2015) · Biomicrofluidics · doi:10.1063/1.4934713 · Cited by 414
Skvarc, D., Berk, M., Byrne, L. K., Dean, O. M., Dodd, S., Lewis, M., Marriott, A., Moore, E. M., Morris, G., Page, R. S., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.011 · Cited by 318
Harris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279
Metadata
- Authors
- Pan, W., P. Stone, K., Hsuchou, H., K. Manda, V., Zhang, Y., & J. Kastin, A.
- Affiliations
- Pennington Biomedical Research Center (US)
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-11-01
- Volume
- 17
- Issue
- 33
- Pages
- 3729-3740
- ISSN
- 1381-6128 (ISSN-L)
- PMC
- PMC3939622
- OpenAlex
- W2042991023
- Cited by
- 241
- References
- 210
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 19 · 2023: 23 · 2022: 24 · 2021: 25 · 2020: 29 · 2019: 20 · 2018: 22 · 2017: 12 · 2016: 8 · 2015: 16 · 2014: 6 · 2013: 4 · 2012: 2
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DK54880)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-54880, R01DK054880, R56DK054880)
- National Institute of Neurological Disorders and Stroke (NS62291, R01NS062291)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- blood-brain barrier, cytokine signaling, lipid rafts, cytokine receptors, efflux pumps, ABCA1, nuclear receptors, neuroinflammation, neuroendocrine regulation, signaling crosstalk, microvascular endothelial cells, lipid metabolism
- MeSH terms
- Animals, Blood-Brain Barrier, Carrier Proteins, Pharmaceutical Preparations, Humans, Inflammation, Ligands, Neuropeptides, Signal Transduction, Cytokines, Receptors, Cytoplasmic and Nuclear
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
