The DOI matches its Crossref record; 174 of the 174 references it cites were found in a registry or an index.
Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease
Abstract
Alzheimer's disease (AD) is an irrevocable chronic brain disorder featured by neuronal loss, microglial accumulation, and progressive cognitive impairment. The proper pathophysiology of this life-threatening disorder is not completely understood and no exact remedies have been found yet. Over the last few decades, research on AD has mainly highlighted pathomechanisms linked to a couple of the major pathological hallmarks, including extracellular senile plaques made of amyloid-β (Aβ) peptides, and intracellular neurofibrillary tangles (NFTs) made of tau proteins. Aβ can induce apoptosis, trigger an inflammatory response, and inhibit the synaptic plasticity of the hippocampus, which ultimately contributes to reducing cognitive functions and memory impairment. Recently, a third disease hallmark, the neuroinflammatory reaction that is mediated by cerebral innate immune cells, has become a spotlight in the current research area, assured by pre-clinical, clinical, and genetic investigations. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a cytokine producer, is significantly associated with physiological inflammatory proceedings and thus shows a promising candidate for inflammation- based AD therapy. Recent data reveal that phytochemicals, mainly polyphenol compounds, exhibit potential neuroprotective functions and these may be considered as a vital resource for discovering several drug candidates against AD. Interestingly, phytochemicals can easily interfere with the signaling pathway of NF-κB. This review represents the anti-neuroinflammatory potential of polyphenols as inhibitors of NF-κB to combat AD pathogenesis.
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“the presence of anti-inflammatory and antioxidant properties is another crucial feature of natural compounds contributing to their therapeutic potential (Uddin et al., 2021)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Uddin et al., 2021
Citations
Cites
NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791
Global prevalence of dementia: a Delphi consensus study
Ferri, C. P., Prince, M. J., Brayne, C., Brodaty, H., Fratiglioni, L., Ganguli, M., Hall, K. S., Hasegawa, K., Hendrie, H. C., Huang, Y., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67889-0 · Cited by 5,336
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580
Crosstalk of reactive oxygen species and NF-κB signaling
Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505
The neuropathological diagnosis of Alzheimer's disease
DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329
Signaling to NF-κB by Toll-like receptors
Kawai, T., & Akira, S. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.09.002 · Cited by 2,468
Lycopene as the most efficient biological carotenoid singlet oxygen quencher
Mascio, P. D., Kaiser, S., & Sies, H. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90467-0 · Cited by 2,238
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208
Research works printed but not linked: 13
- Uddin M.S.; Kabir M.T.; Jakaria M.; Exploring the potential of neuroproteomics in Alzheimer’s disease. Curr Top Med Chem 2020,20,2263-2278 · DOI
- Dementia cases set to triple by 2050 but still largely ignoredAvailable from: WHO
- Uddin M.S.; Kabir M.T.; Al Mamun A.; Exploring potential of alkaloidal phytochemicals targeting neuroinflammatory signaling of Alzheimer’s disease. Curr Pharm Des 2020,26 · DOI
- Kumar R; Harilal S; Parambi DGT; Fascinating chemo preventive story of wogonin: A chance to hit on the head in cancer treatment Curr Pharm Des 2020; 26 Online ahead of print PMID: 32338206
- Norden DM; Muccigrosso MM; Godbout JP; Norden DM, Muccigrosso MM, Godbout JP Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease Neuropharmacology 2015; 96(Pt A): 29-41 http://dxdoiorg/101016/jneuropharm201410028 PMID: 25445485
- Meraz-Ríos M.A.; Toral-Rios D.; Franco-Bocanegra D.; Villeda-Hernández J.; Campos-Peña V.; Inflammatory process in Alzheimer’s disease. Front Integr Nuerosci 2013,7,59
- Beg A; Ruben S. R.S.-G.; 1992,10,1899-1913
- Chen G; Zhang S; Shi J; Ai J; Qi M; Neurology CH-E; Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of tlr4/NF-ΚB pathway. 2009,216(398),406
- Farrar W.L.; Kilian P.; Hill J.M.; Ruff M.R.; Pert C.B.; Visualization of cytokine and virus receptors common to the immune and central nervous system. Lymphokine Res 1987,6(1),29-34
- Carter BD; Kaltschmidt C; Kaltschmidt B; Selective activation of NF-κB by nerve growth factor through the neurotrophin receptor P75. Science (80- ) 1996; 272: 542-5.
- Kuršvietienė L; Stanevičienė I; Mongirdienė A; Bernatonienė J; Multiplicity of effects and health benefits of resveratrol Medicina (Lithuania) 2016; 52: 148-55
- Kapoor L.D.; Handbook of ayurverdic medicinal plants 1990
- Ambegaokar S.S.; Wu L.; Alamshahi K.; Curcumin inhibits dose-dependently and time-dependently neuroglial cell proliferation and growth. Neuroendocrinol Lett 2003,24(6),469-473
Cited by
Sorted by citations
Shi, M., Chu, F., Zhu, F., & Zhu, J. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.870517 · Cited by 275
Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73
Metadata
- Authors
- Uddin, M. S., Hasana, S., Ahmad, J., Hossain, M. F., Rahman, M. M., Behl, T., Rauf, A., Ahmad, A., Hafeez, A., Perveen, A., & Ashraf, G. M.
- Affiliations
- Southeast University (BD)
- The University of Agriculture, Peshawar (PK)
- Pharmakon Neuroscience Research Network, Dhaka,Bangladesh
- Chitkara University (IN)
- University of Swabi (PK)
- Amity University (IN)
- Glocal University (IN)
- King Abdulaziz University (SA)
- Corresponding author
- Uddin, Md. Sahab
- Ashraf, Ghulam Md
- ORCID
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2021-01
- Volume
- 27
- Issue
- 3
- Pages
- 402-414
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W3101281606
- Cited by
- 49
- References
- 174
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 12 · 2021: 10
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Alzheimer's disease, polyphenols, NF-κB inhibition, neuroinflammation, neuroprotection, amyloid-beta, neurofibrillary tangles, microglia, phytochemicals, anti-inflammatory drug candidates, innate immune response
- MeSH terms
- Alzheimer Disease, Humans, Amyloid beta-Peptides, NF-kappa B, Microglia, Polyphenols
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- CoChat. (2026). Citation check: Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease. https://app.cochat.ai/papers/10.2174/1381612826666201118092422
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- Uddin, M. S., Hasana, S., Ahmad, J., Hossain, M. F., Rahman, M. M., Behl, T., Rauf, A., Ahmad, A., Hafeez, A., Perveen, A., & Ashraf, G. M. (2021). Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease. Current Pharmaceutical Design. https://doi.org/10.2174/1381612826666201118092422
