Role of Drug Delivery System in Improving the Bioavailability of Resveratrol
Abstract
Resveratrol (RSV) is known as a natural polyphenolic compound that is known for its therapeutic activities but has limited bioavailability. The aim of our study was to explore various drug-delivering methods that are being employed to achieve target-oriented delivery and therapeutic performance of RSV. To improve the bioavailability and pharmacokinetic properties of RSV, efforts are being made by producing efficient formulations accompanying efficient drug delivery strategies. Several clinical trial studies have been conducted on RSV isomers, and the majority of studies indicated that trans-RSV had better clinical potential and therapeutic effectiveness in various types of complications such as colorectal cancer, metabolic syndrome, hypertension, obesity, neurodegenerative diseases, diabetes, hepatic disease, cardiac disorders, and breast cancer. However, multiple research studies enable us to understand various strategies that can enhance the systemic availability and efficacy of topical RSV formulations. In this article, we emphasize the hurdles of RSV delivery processes. We summarized that for delivering liquid and solid microparticles of RSV, the micro-particulate system works efficiently. Another technique in which particles are enclosed by a coating is called microencapsulation. This technique reduces the degradation of pharmaceutical compounds. Similarly, the cyclodextrin system is mainly used for poorly soluble drugs. On the other hand, the vesicular system is another micro-particulate system that can encapsulate hydrophilic and hydrophobic drugs. However, the RSV nanosponge formulations have advanced nanodrug delivery systems also make it possible to use RSV for its antioxidant potential.
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Advanced drug delivery platforms can improve solubility, stability, bioavailability, and site-specific targeting, increasing treatment efficacy while minimizing systemic exposure.
“More broadly, advanced drug delivery platforms can improve solubility [22], stability [23], bioavailability [24], and site‐specific targeting [25], ultimately increasing treatment efficacy while minimizing systemic exposure.”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [24]
Cites
Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995) · Pharmaceutical Research · doi:10.1023/a:1016212804288 · Cited by 5,430 · see citing works
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958 · see citing works
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Loftsson, Þ., & Brewster, M. E. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js950534b · Cited by 2,179 · see citing works
HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS
Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., & Walle, U. K. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.104.000885 · Cited by 1,893 · see citing works
Biological effects of resveratrol
Frémont, L. (2000) · Life Sciences · doi:10.1016/s0024-3205(99)00410-5 · Cited by 1,663 · see citing works
Bioavailability of resveratrol
Walle, T. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05842.x · Cited by 1,051 · see citing works
Solid lipid nanoparticles: A modern formulation approach in drug delivery system
Mukherjee, S., Ray, S., & Thakur, R. S. (2009) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.57282 · Cited by 1,001 · see citing works
The therapeutic potential of resveratrol: a review of clinical trials
Berman, A. Y., Motechin, R. A., Wiesenfeld, M. Y., & Holz, M. K. (2017) · npj Precision Oncology · doi:10.1038/s41698-017-0038-6 · Cited by 895 · see citing works
Boocock, D. J., Faust, G. E. S., Patel, K. R., Schinas, A. M., Brown, V. A., Ducharme, M. P., Booth, T. D., Crowell, J. A., Perloff, M., Gescher, A. J., et al. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-0022 · Cited by 827 · see citing works
A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
Turner, R. S., Thomas, R. G., Craft, S., van Dyck, C. H., Mintzer, J. E., Reynolds, B., Brewer, J. B., Rissman, R. A., Raman, R., Aisen, P. S. S., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000002035 · Cited by 753 · see citing works
Absorption of three wine-related polyphenols in three different matrices by healthy subjects
Goldberg, D. M., Yan, J., & Soleas, G. J. (2003) · Clinical Biochemistry · doi:10.1016/s0009-9120(02)00397-1 · Cited by 685 · see citing works
Metabolism and bioavailability oftrans-resveratrol
Wenzel, E., & Somoza, V. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200500010 · Cited by 677 · see citing works
Administration of resveratrol: What formulation solutions to bioavailability limitations?
Amri, A., Chaumeil, J. C., Sfar, S., & Charrueau, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.083 · Cited by 631 · see citing works
Antioxidant effects of resveratrol in the cardiovascular system
Xia, N., Daiber, A., Förstermann, U., & Li, H. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13492 · Cited by 576 · see citing works
Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials
Bishayee, A. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0160 · Cited by 530 · see citing works
Cardiovascular Protective Effects of Resveratrol
Bradamante, S., Barenghi, L., & Villa, A. M. (2004) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2004.tb00139.x · Cited by 528 · see citing works
Antibacterial and antifungal properties of resveratrol
Vestergaard, M., & Ingmer, H. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.02.015 · Cited by 482 · see citing works
Resveratrol and Cardiovascular Diseases
Bonnefont‐Rousselot, D. (2016) · Nutrients · doi:10.3390/nu8050250 · Cited by 447 · see citing works
Almeida, L., Vaz‐da‐Silva, M., Falcão, A. C., Soares, E., Costa, R., Loureiro, A. I., Fernandes‐Lopes, C., Rocha, J., Nunes, T., Wright, L. C., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800177 · Cited by 427 · see citing works
Pigments of rat liver microsomes
Klingenberg, M. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00621-5 · Cited by 412 · see citing works
Jain, S. K., Jain, P. K., Umamaheshwari, R. B., et al. (2003) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120025458 · Cited by 408 · see citing works
Ansari, K. A., Vavia, P. R., Trotta, F., & Cavalli, R. (2011) · AAPS PharmSciTech · doi:10.1208/s12249-011-9584-3 · Cited by 382 · see citing works
Enhancing the bioavailability of resveratrol by combining it with piperine
Johnson, J. J., Nihal, M., Siddiqui, I. A., Scarlett, C. O., Bailey, H. H., Mukhtar, H., & Ahmad, N. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100117 · Cited by 340 · see citing works
Human, Rat, and Mouse Metabolism of Resveratrol
Yu, C., Shin, Y. G., Chow, A. W., Li, Y., Kosmeder, J. W., Lee, Y. S., Hirschelman, W. H., Pezzuto, J. M., Mehta, R. G., & van Breemen, R. B. (2002) · Pharmaceutical Research · doi:10.1023/a:1021414129280 · Cited by 322 · see citing works
The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol
Teskač, K., & Kristl, J. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.10.011 · Cited by 288 · see citing works
Nanosponges: A Novel Class of Drug Delivery System - Review
Selvamuthukumar, S., Singireddy, A., Krishnamoorthy, K., & Manavalan, R. (2012) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3k308 · Cited by 274 · see citing works
Cyclodextrin complexes: Perspective from drug delivery and formulation
Jacob, S., & Nair, A. B. (2018) · Drug Development Research · doi:10.1002/ddr.21452 · Cited by 263 · see citing works
Resveratrol and derivatives for the prevention and treatment of cancer
Fulda, S. (2010) · Drug Discovery Today · doi:10.1016/j.drudis.2010.07.005 · Cited by 258 · see citing works
Resveratrol: review on therapeutic potential and recent advances in drug delivery
Pangeni, R., Sahni, J. K., Ali, J., Sharma, S., & Baboota, S. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.919253 · Cited by 255 · see citing works
Resveratrol: An overview of its anti-cancer mechanisms
Elshaer, M., Chen, Y., Wang, X. J., & Tang, X. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.06.028 · Cited by 247 · see citing works
Ye, F., Guo, H.-F., Zhang, H., et al. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.12.014 · Cited by 245 · see citing works
Neuroprotective effects of resveratrol in Alzheimer disease pathology
Rege, S. D., Geetha, T., Griffin, G. D., Broderick, T. L., & Babu, J. R. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00218 · Cited by 243 · see citing works
Effect of resveratrol incorporated in liposomes on proliferation and UV-B protection of cells
Caddeo, C., Teskač, K., Sinico, C., & Kristl, J. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.07.024 · Cited by 218 · see citing works
Complexation of resveratrol with cyclodextrins: Solubility and antioxidant activity
Lu, Z., Cheng, B., Hu, Y., Zhang, Y., & Zou, G. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.04.042 · Cited by 204 · see citing works
The Impact of Aqueous Solubility and Dose on the Pharmacokinetic Profiles of Resveratrol
Das, S., Lin, H., Ho, P. C., & Ng, K. (2008) · Pharmaceutical Research · doi:10.1007/s11095-008-9677-1 · Cited by 202 · see citing works
Resveratrol transport and metabolism by human intestinal Caco-2 cells
Kaldas, M. I., Walle, U. K., & Walle, T. (2003) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235702612 · Cited by 189 · see citing works
Micro/Nanorobot: A Promising Targeted Drug Delivery System
Hu, M., Ge, X., Chen, X., Mao, W., Qian, X., & Yuan, W. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070665 · Cited by 186 · see citing works
Resveratrol and diabetes: A critical review of clinical studies
Öztürk, E., Arslan, A. K. K., Yerer, M. B., & Bishayee, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.070 · Cited by 184 · see citing works
Burkon, A., & Somoza, V. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700290 · Cited by 180 · see citing works
Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol
Basly, J. P., Marre-Fournier, F., Bail, J.-C. L., Habrioux, G., & Chulia, A. J. (2000) · Life Sciences · doi:10.1016/s0024-3205(99)00650-5 · Cited by 179 · see citing works
Resveratrol: From Basic Science to the Clinic
Cucciolla, V., Borriello, A., Oliva, A., Galletti, P., Zappia, V., & Ragione, F. D. (2007) · Cell Cycle · doi:10.4161/cc.6.20.4815 · Cited by 174 · see citing works
Rotchés-Ribalta, M., Andrés‐Lacueva, C., Estruch, R., Escribano, E., & Urpí-Sardà, M. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.08.001 · Cited by 173 · see citing works
Hoseini, A., Namazi, G., Farrokhian, A., Reiner, Ž., Aghadavod, E., Bahmani, F., & Asemi, Z. (2019) · Food & Function · doi:10.1039/c9fo01075k · Cited by 171 · see citing works
Lançon, A., Delma, D., Osman‐Ponchet, H., Thenot, J. P., & Latruffe, N. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.164 · Cited by 167 · see citing works
Cyclodextrins as resveratrol carrier system
Lucas-Abellán, C., Fortea, M. I., López-Nicolás, M., & Núñez‐Delicado, E. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2006.10.068 · Cited by 156 · see citing works
Fogacci, F., Tocci, G., Presta, V., Fratter, A., Borghi, C., & Cicero, A. F. G. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1422480 · Cited by 143 · see citing works
Santi, C. D., Pietrabissa, A., Spisni, R., Mosca, F., & Pacifici, G. M. (2000) · Xenobiotica · doi:10.1080/004982500433282 · Cited by 141 · see citing works
Agarwal, B., Campen, M. J., Channell, M. M., Wherry, S. J., Varamini, B., Davis, J. G., Baur, J. A., & Smoliga, J. M. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.09.027 · Cited by 137 · see citing works
The Effects of Resveratrol in the Treatment of Metabolic Syndrome
Hou, C., Tain, Y., Yu, H., & Huang, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030535 · Cited by 137 · see citing works
Efficiency of resveratrol-loaded sericin nanoparticles: Promising bionanocarriers for drug delivery
Suktham, K., Koobkokkruad, T., Wutikhun, T., & Surassmo, S. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.12.015 · Cited by 136 · see citing works
Using Liposomes as Carriers for Polyphenolic Compounds: The Case of Trans-Resveratrol
Bonechi, C., Martini, S., Ciani, L., Lamponi, S., Rebmann, H., Rossi, C., & Ristori, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041438 · Cited by 133 · see citing works
Das, S., Chaudhury, A., & Ng, K. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.12.015 · Cited by 127 · see citing works
Absorption of trans-resveratrol in rats
Soleas, G. J., Angelini, M., Grass, L., Diamandis, E. P., & Goldberg, D. M. (2001) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(01)35239-4 · Cited by 125 · see citing works
Nanosponges – a completely new nano-horizon: pharmaceutical applications and recent advances
Ahmed, R. Z., Patil, G., & Zaheer, Z. (2012) · Drug Development and Industrial Pharmacy · doi:10.3109/03639045.2012.694610 · Cited by 116 · see citing works
Santi, C. D., Pietrabissa, A., Spisni, R., Mosca, F., & Pacifici, G. M. (2000) · Xenobiotica · doi:10.1080/004982500406435 · Cited by 115 · see citing works
Improvements of cellular stress response on resveratrol in liposomes
Kristl, J., Teskač, K., Caddeo, C., Abramović, Z., & Šentjurc, M. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2009.06.006 · Cited by 106 · see citing works
Rius, C., Abu-Taha, M. I., Hermenegildo, C., Piqueras, L., Cerdá‐Nicolás, M., Issekutz, A. C., Estañ, L., Cortijo, J., Morcillo, E. J., Orallo, F., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001043 · Cited by 96 · see citing works
Nanosponges: a potential nanocarrier for novel drug delivery-a review
Shringirishi, M., Prajapati, S. K., Mahor, A., et al. (2014) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(14)60667-8 · Cited by 96 · see citing works
Sun, W., Wang, W., Kim, J., et al. (2008) · Springer eBooks · doi:10.1007/978-0-387-74911-2_21 · Cited by 94 · see citing works
Anticancer activity of resveratrol on implanted human primary gastric carcinoma cells in nude mice
Zhou, H. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i2.280 · Cited by 93 · see citing works
Mendes, J. B. E., Riekes, M. K., de Oliveira, V. M., Michél, M. D., Stulzer, H. K., Khalil, N. M., Zawadzki, S. F., Mainardes, R. M., & Farago, P. V. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/542937 · Cited by 91 · see citing works
Chen, X., He, H., Wang, G., Yang, B., Ren, W., Ma, L., & Yu, Q. (2007) · Biomedical Chromatography · doi:10.1002/bmc.747 · Cited by 91 · see citing works
Annunziata, G., Jiménez‐García, M., Capó, X., Moranta, D., Arnone, A., Tenore, G. C., Sureda, A., & Tejada, S. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111248 · Cited by 86 · see citing works
Antimicrobial Activity of Resveratrol Analogues
Chalal, M., Klinguer, A., Echairi, A., et al. (2014) · Molecules · doi:10.3390/molecules19067679 · Cited by 83 · see citing works
López-Nicolás, M., Núñez‐Delicado, E., Perez-Lopez, A. J., Carbonell-Barrachina, Á. A., & Cuadra‐Crespo, P. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.09.013 · Cited by 82 · see citing works
Resveratrol: A potential challenger against gastric cancer
Zulueta, A. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i37.10636 · Cited by 82 · see citing works
Feijén, J., Hennink, W. E., & Zhong, Z. (2013) · Nanomedicine · doi:10.2217/nnm.12.197 · Cited by 82 · see citing works
Antioxidant Activity of the Stilbene Astringin, Newly Extracted from Vitis vinifera Cell Cultures
Mérillon, J., Fauconneau, B., Téguo, P. W., et al. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.6.1092 · Cited by 77 · see citing works
A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy
Abedini, E., Khodadadi, E., Zeinalzadeh, E., Moaddab, S. R., Asgharzadeh, M., Mehramouz, B., Dao, S., & Kafil, H. S. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/8866311 · Cited by 77 · see citing works
Augustin, M. A., Abeywardena, M. Y., Patten, G. S., Head, R. J., Lockett, T. J., Luca, A. D., & Sanguansri, L. (2011) · Journal of Functional Foods · doi:10.1016/j.jff.2011.01.003 · Cited by 74 · see citing works
Haghighatdoost, F., & Hariri, M. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0253-4 · Cited by 69 · see citing works
Chen, W., SHAW, L.-H., Chang, P., et al. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3077 · Cited by 64 · see citing works
Shah, A., Reyes, L. M., Morton, J. S., Fung, D., Schneider, J., & Davidge, S. T. (2015) · The Journal of Physiology · doi:10.1113/jp271133 · Cited by 61 · see citing works
Liu, Q., Guan, J., Sun, Z., et al. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118562 · Cited by 53 · see citing works
Enhancement of in vivo human skin penetration of resveratrol by chitosan-coated lipid microparticles
Scalia, S., Trotta, V., Iannuccelli, V., & Bianchi, A. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.07.043 · Cited by 51 · see citing works
Washington, K. E., Kularatne, R. N., Biewer, M. C., & Stefan, M. C. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00972 · Cited by 49 · see citing works
Tosato, M. G., Girón, J. V. M., Martin, A. A., Tippavajhala, V. K., de Mele, M. F. L., & Dicelio, L. E. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.04.073 · Cited by 49 · see citing works
Wen, Q., Zhang, Y., Luo, J., Xiong, K., Lü, Y., Wu, Z., Wang, B. Q., Wu, J., Chen, Y., & Fu, S. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119334 · Cited by 49 · see citing works
Das, S., Ng, K., & Ho, P. C. (2010) · Journal of drug targeting · doi:10.3109/1061186x.2010.504272 · Cited by 45 · see citing works
Singh, G., & Pai, R. S. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12232 · Cited by 43 · see citing works
Pharmacokinetic Study of trans-Resveratrol in Adult Pigs
Azorín‐Ortuño, M., Yáñez-Gascón, M. J., Pallarés, F. J., Vallejo, F., Larrosa, M., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102799m · Cited by 42 · see citing works
The main potentialities of resveratrol for drug delivery systems
Ruivo, J., Francisco, C., Oliveira, R., & Figueiras, A. (2015) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s1984-82502015000300002 · Cited by 36 · see citing works
Rafiee, S., Mohammadi, H., Ghavami, A., Sadeghi, E., Safari, Z., & Askari, G. (2020) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2020.101281 · Cited by 36 · see citing works
Das, S., & Ng, K. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22212 · Cited by 33 · see citing works
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“More broadly, advanced drug delivery platforms can improve solubility [22], stability [23], bioavailability [24], and site-specific targeting [25], ultimately increasing treatment efficacy while minimizing systemic exposure.”
- Authors
- Saleem, Z., Rehman, K., & Hamid Akash, M. S.
- Affiliations
- Government College University, Faisalabad (PK)
- The Women University Multan (PK)
- Department of Pharmaceutical Chemistry, Government College University, Faisalabad, Pakistan
- Venue
- Current Pharmaceutical Design
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2022-06
- Volume
- 28
- Issue
- 20
- Pages
- 1632-1642
- ISSN
- 1381-6128 (ISSN-L)
- OpenAlex
- W4283822886
- Cited by
- 34
- References
- 84
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 12 · 2023: 6 · 2022: 2
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Pharmaceutical Design (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- resveratrol, bioavailability, drug delivery systems, trans-resveratrol, microencapsulation, cyclodextrins, vesicular systems, nanosponges, polyphenols, topical formulation, pharmacokinetics, poorly water-soluble drugs
- MeSH terms
- Resveratrol, Antioxidants, Biological Availability, Drug Compounding, Pharmaceutical Preparations, Humans
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