Skin Protection Against UVA-Induced Iron Damage by Multiantioxidants and Iron Chelating Drugs/Prodrugs
Abstract
In humans, prolonged sunlight exposure is associated with various pathological states. The continuing drive to develop improved skin protection involves not only approaches to reduce DNA damage by solar ultraviolet B (UVB) but also the development of methodologies to provide protection against ultraviolet A (UVA), the oxidising component of sunlight. Furthermore identification of specific cellular events following ultraviolet (UV) irradiation is likely to provide clues as to the mechanism of the development of resulting pathologies and therefore strategies for protection. Our discovery that UVA radiation, leads to an immediate measurable increase in 'labile' iron in human skin fibroblasts and keratinocytes provides a new insight into UVA-induced skin damage, since iron is a catalyst of biological oxidations. The main purpose of this overview is to bring together some of the new findings related to mechanisms underlying UVA-induced iron release and to discuss novel approaches based on the use of multiantioxidants and light-activated caged-iron chelators for efficient protection of skin cells against UVA-induced iron damage.
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Ultraviolet radiation and iron content in women's post-menopausal skin cells increase rapidly, reduce the skin's antioxidant capacity, and lead to aging.
“Studies have shown that ultraviolet radiation and iron content in women’s post-menopausal skin cells increase rapidly, reduce the skin’s antioxidant capacity, and lead to aging [64,65].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [64]
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- Authors
- Reelfs, O., M. Eggleston, I., & Pourzand, C.
- Affiliations
- University of Bath (GB)
- Venue
- Current Drug Metabolism
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-03-01
- Volume
- 11
- Issue
- 3
- Pages
- 242-249
- ISSN
- 1389-2002 (ISSN-L)
- OpenAlex
- W2126333107
- Cited by
- 34
- References
- 0
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 5
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (067653/Z/02/Z)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- UVA, skin protection, labile iron, iron chelators, dermal fibroblasts, keratinocytes, oxidative stress, photoprotection, iron release
- MeSH terms
- Animals, Antioxidants, DNA Damage, Humans, Iron, Iron Chelating Agents, Prodrugs, Skin, Sunlight, Ultraviolet Rays, Skin Aging, Oxidative Stress
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