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Fatty Acids - Induced Lipotoxicity and Inflammation
Abstract
Fatty acids are known to serve as energetic substrates, key components of membrane lipids, and as substrates for the synthesis of signaling molecules and complex lipids. They are also known to be ligands either of membrane receptors involved in cell signaling or of nuclear receptors mediating gene regulation. Accumulation of fatty acids due to altered metabolism and/or unbalanced diet has been described to be toxic for several tissues, especially liver. In numerous cell types, cell death, cytokine secretion and activation of inflammatory processes appear to be a consequence of fatty acid accumulation. This review presents the different classes of fatty acids known to trigger toxic effects and inflammation, the cellular and subcellular targets of these fatty acids in the context of non-alcoholic fatty liver disease (NAFLD), and the mechanisms by which these effects are mediated.
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“Besides them, cholesterol oxide derivatives and other long chain derivatives of fatty acids including prostaglandins, leukotrienes and neuroprotectins are present [63, 64].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [64]
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Broadley, D., Riche, A. L., Guénin, S., Jimenez, F., Vinocur, L., Edelkamp, J., & Bertolini, M. (2025) · International Journal of Cosmetic Science · doi:10.1111/ics.70035 · Cited by 2
Ganamurali, N., Devarajan, M., & Sabarathinam, S. (2025) · Lipids · doi:10.1002/lipd.70030 · Cited by 2
Zu, B., Zhang, Y., Yu, Z., Li, B., Cheng, S., Du, M., Li, R., Liu, C., & Zhou, B. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c00486 · Cited by 2
(2014) · Inflammation and Cell Signaling · doi:10.14800/ics.200 · Cited by 2
Animal Models Used for Studying the Benefits of Probiotics in Metabolic Disorders
Garg, A., Kumar, A., Pottoo, F. H., & Chawla, P. A. (2022) · Springer eBooks · doi:10.1007/978-981-16-8444-9_13 · Cited by 3
Li, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15793-6.00003-2 · Cited by 2
Zarrouk, A. (2013) · theses.fr (ABES) · doi:10.70675/0ca0afb8z8b2cz4b48zb97az382f4a6003ba · Cited by 2
Lee, D., Shim, S. H., & Kang, K. S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0328486 · Cited by 1
Metadata
- Authors
- Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., & Lizard, G.
- Venue
- Current Drug Metabolism
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-10-01
- Volume
- 13
- Issue
- 10
- Pages
- 1358-1370
- ISSN
- 1389-2002 (ISSN-L)
- OpenAlex
- W2028509006
- Cited by
- 111
- References
- 175
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 13 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 1
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- fatty acids, lipotoxicity, inflammation, non-alcoholic fatty liver disease, fatty acid accumulation, cell death, cytokine production, nuclear receptors, cell surface receptors, hepatotoxicity, lipid metabolism
- MeSH terms
- Animals, Fatty Acids, Fatty Liver, Humans, Inflammation, Oxidative Stress, Hepatocytes, Non-alcoholic Fatty Liver Disease
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