The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.
Fatty Acids - Induced Lipotoxicity and Inflammation
Abstract
Fatty acids are known to serve as energetic substrates, key components of membrane lipids, and as substrates for the synthesis of signaling molecules and complex lipids. They are also known to be ligands either of membrane receptors involved in cell signaling or of nuclear receptors mediating gene regulation. Accumulation of fatty acids due to altered metabolism and/or unbalanced diet has been described to be toxic for several tissues, especially liver. In numerous cell types, cell death, cytokine secretion and activation of inflammatory processes appear to be a consequence of fatty acid accumulation. This review presents the different classes of fatty acids known to trigger toxic effects and inflammation, the cellular and subcellular targets of these fatty acids in the context of non-alcoholic fatty liver disease (NAFLD), and the mechanisms by which these effects are mediated.
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“Besides them, cholesterol oxide derivatives and other long chain derivatives of fatty acids including prostaglandins, leukotrienes and neuroprotectins are present [63, 64].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [64]
Citations
Cites
1 retracted
Comparative toxicity of oleic and linoleic acid on human lymphocytes
Cury‐Boaventura, M. F., Gorjão, R., de Lima, T. M., Newsholme, P., & Curi, R. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.07.038 · Cited by 137
RetractedObesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,687
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650
Cited by
Sorted by citations
Identification of ACSL4 as a biomarker and contributor of ferroptosis
Yuan, H., Li, X., Zhang, X., Kang, R., & Tang, D. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.08.124 · Cited by 1,071
Decoding cell death signals in liver inflammation
Brenner, C., Galluzzi, L., Kepp, O., & Kroemer, G. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.033 · Cited by 1,022
Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
Khan, S., Barve, K. H., & Kumar, M. S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200528142429 · Cited by 820
“Besides them, cholesterol oxide derivatives and other long chain derivatives of fatty acids including prostaglandins, leukotrienes and neuroprotectins are present [63, 64].”
BackgroundUnderstanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
Rada, P., González‐Rodríguez, Á., García‐Monzón, C., & Valverde, Á. M. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03003-w · Cited by 544
Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum
Andreis, D. T., & Singer, M. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4249-z · Cited by 185
Metadata
- Authors
- Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., & Lizard, G.
- Venue
- Current Drug Metabolism
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2012-10-01
- Volume
- 13
- Issue
- 10
- Pages
- 1358-1370
- ISSN
- 1389-2002 (ISSN-L)
- OpenAlex
- W2028509006
- Cited by
- 111
- References
- 175
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 13 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 1
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- fatty acids, lipotoxicity, inflammation, non-alcoholic fatty liver disease, fatty acid accumulation, cell death, cytokine production, nuclear receptors, cell surface receptors, hepatotoxicity, lipid metabolism
- MeSH terms
- Animals, Fatty Acids, Fatty Liver, Humans, Inflammation, Oxidative Stress, Hepatocytes, Non-alcoholic Fatty Liver Disease
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