Cited by 111Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesisFatty Acid Research and Health

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Fatty Acids - Induced Lipotoxicity and Inflammation

Savary, Stephane, Trompier, Doriane, Andreoletti, Pierre, Le Borgne, Francoise, Demarquoy, Jean, Lizard, Gerard·2012·Current Drug Metabolism

DOI 10.2174/138920012803762729

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Abstract

Fatty acids are known to serve as energetic substrates, key components of membrane lipids, and as substrates for the synthesis of signaling molecules and complex lipids. They are also known to be ligands either of membrane receptors involved in cell signaling or of nuclear receptors mediating gene regulation. Accumulation of fatty acids due to altered metabolism and/or unbalanced diet has been described to be toxic for several tissues, especially liver. In numerous cell types, cell death, cytokine secretion and activation of inflammatory processes appear to be a consequence of fatty acid accumulation. This review presents the different classes of fatty acids known to trigger toxic effects and inflammation, the cellular and subcellular targets of these fatty acids in the context of non-alcoholic fatty liver disease (NAFLD), and the mechanisms by which these effects are mediated.

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Authors: Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., & Lizard, G.
ORCID: Trompier, Doriane
Andreoletti, Pierre
Demarquoy, Jean
Venue: Current Drug Metabolism
Publisher: Bentham Science Publishers Ltd.
Published: 2012-10-01
Volume: 13
Issue: 10
Pages: 1358-1370
ISSN: 1389-2002 (ISSN-L)
DOI: 10.2174/138920012803762729
OpenAlex: W2028509006
Cited by: 111
References: 175
Citations by year: 2026: 7 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 13 · 2019: 9 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 1
FWCI: 5.96
Type: journal article
Language: en
Open access: closed
Locations: Current Drug Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords: fatty acids, lipotoxicity, inflammation, non-alcoholic fatty liver disease, fatty acid accumulation, cell death, cytokine production, nuclear receptors, cell surface receptors, hepatotoxicity, lipid metabolism
MeSH terms: Animals, Fatty Acids, Fatty Liver, Humans, Inflammation, Oxidative Stress, Hepatocytes, Non-alcoholic Fatty Liver Disease

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Fatty Acids - Induced Lipotoxicity and Inflammation

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