Role of Cellular Biomolecules in Screening, Diagnosis and Treatment of Colorectal Cancer
Abstract
Background: Prevention is the primary strategy to avoid the occurrence and mortality of colorectal cancer. Generally, the concentrations of tumor markers tested during the diagnosis and believed to assist the detection of disease in the early stages of cancer. Some of the biomarkers are also important during treatment and real-time monitoring of the progress of treatment. Methods: We considered a rationale search of key references from the database of peer-reviewed research and review literatures of colorectal cancer. The topic of search was focused on the novel methods and modern techniques of Screening, Diagnosis, and Treatment of colorectal cancer. The screened publications were critically analysed using a deductive content analysis and the matter was put in separate headings and sub headings. Results: It was found that endoscopic examination, early detection, and surgery are some of the common strategies to manage colorectal cancer because late stages are difficult to treat due to the high-cost requirement and fewer chances of survival. As far as chemotherapy is concerned, systemic chemotherapy has been shown to offer the maximum benefit to patients with cancer metastasis. Among different chemotherapy measures, primary colorectal cancer prevention agents involve pharmaceuticals, phytochemicals, and dietary supplements are some of the standard options. Conclusion: In this review article, we have provided a comprehensive analysis of different biomarkers for the detection of colorectal cancer as well as different formulations developed for efficient treatment of the disease. The use of dietary supplements, the combinatorial approach, and nanotechnology-based strategies for colorectal cancer diagnosis and treatment are some of the recent and modern methods of cancer management.
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Colorectal cancer patients have obvious anxiety and depression, and the severity of the disease is increasing.
“According to related studies, colorectal cancer patients have obvious anxiety and depression, and the severity of the disease is increasing [9].”
From Mindfulness intervention, homogeneous medical concept, and concentrated solution nursing for colorectal cancer patients: a retrospective study (2024) · cites this paper as [9]
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Flagged first, then by citations
Cited by
Sorted by citations
Ghafar, M. T. A., Gharib, F., Abd-Elsalam, S. M., Elkhouly, R. A., Elshora, A. A., Shalaby, K. H., El-Guindy, D. M., El-Rashidy, M. A., Soliman, N. A., Abu-Elenin, M. M., et al. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05334-5 · Cited by 64 · see citing works
“1 3 new noninvasive methods for CRC screening other than colonoscopy and colonic biopsy which is not applicable for screening due to its invasive nature [18].”
MethodGhafar, M. T. A., Morad, M. A., El-Zamarany, E. A., Ziada, D. H., Soliman, H. H., Abd-Elsalam, S. M., & Salama, M. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106375 · Cited by 45 · see citing works
Feng, Y., Wang, K., Fan, J., Wu, X., Li, T., & Yang, Z. (2024) · BMC Cancer · doi:10.1186/s12885-024-12508-y · Cited by 26 · see citing works
“According to related studies, colorectal cancer patients have obvious anxiety and depression, and the severity of the disease is increasing [9].”
Han, B., Wang, X., & Yin, X. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-06859-w · Cited by 15 · see citing works
Ai, L., Luo, X., Yan, X., & Jiang, S. (2021) · Bioengineered · doi:10.1080/21655979.2021.1951930 · Cited by 14 · see citing works
Comprehensive analysis of Syk gene methylation in colorectal cancer
Bu, F., Zhu, X., Liu, S., Kang, L., Zhu, J., & Huang, J. (2021) · Immunity Inflammation and Disease · doi:10.1002/iid3.449 · Cited by 9 · see citing works
“The currently preferred treatment modality for CRC is surgery, but surgical treatment for metastatic CRC patients remains poor.(3) According to statistics from the American Cancer Society, the 5‐year survival rate of CRC confined to the intestinal wall (Stage I and II) after surgical resection is close to 90%, and onc…”
BackgroundZhao, R., Yin, F., Fredimoses, M., Zhao, J., Fu, X., Xu, B., Liang, M., Chen, H., Liu, K., Lei, M., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155612 · Cited by 9 · see citing works
- Authors
- Mei, X.-L., & Zheng, Q.-F.
- Affiliations
- Department of Pathology, The Second Hospital of Jilin University, Changchun, Jilin, China
- Department of Endoscopy Center, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China
- ORCID
- Zheng, Qing-Fan
- Venue
- Current Drug Metabolism
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2019-12-30
- Volume
- 20
- Issue
- 11
- Pages
- 880-888
- ISSN
- 1389-2002 (ISSN-L)
- OpenAlex
- W2982705936
- Cited by
- 7
- References
- 99
- Citations by year
- 2024: 2 · 2021: 3 · 2020: 2
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Keywords
- colorectal cancer, tumor markers, cancer screening, cancer diagnosis, chemotherapy, colorectal cancer prevention, dietary supplements, phytochemicals, nanotechnology-based drug delivery, early detection, endoscopy, metastasis
- MeSH terms
- Humans, Biomarkers, Tumor, Colorectal Neoplasms, Early Detection of Cancer
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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