Peptide Vaccine Therapy in Colorectal Cancer
Open accessAbstract
Colorectal cancer is the third most common cause of cancer-related deaths and the second most prevalent (after breast cancer) in the western world. High metastatic relapse rates and severe side effects associated with the adjuvant treatment have urged oncologists and clinicians to find a novel, less toxic therapeutic strategy. Considering the limited success of the past clinical trials involving peptide vaccine therapy to treat colorectal cancer, it is necessary to revise our knowledge of the immune system and its potential use in tackling cancer. This review presents the efforts of the scientific community in the development of peptide vaccine therapy for colorectal cancer. We review recent clinical trials and the strategies for immunologic monitoring of responses to peptide vaccine therapy. We also discuss the mechanisms underlying the therapy and potential molecular targets in colon cancer.
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The main drawback of peptide vaccines is their HLA-type restricted nature; only patients who carry the required HLA allele will be able to respond to the therapy, which substantially limits its application.
“The main drawback is the human leukocyte antigen (HLA)-type restricted nature of the therapy. This is because HLA molecules are expressed in a variety of super-types and only a particular HLA-super-type can recognize a specific antigen. In the clinical setting, this means that only those patients who carry the required HLA allele will be able to respond to the therapy, which substantially limits”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [152]
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Setiono, S. B. V., Turalaki, G. L. A., & Tallei, T. E. (2026) · Heca Journal of Applied Sciences · doi:10.60084/hjas.v4i1.372
- Authors
- Bartnik, A., Nirmal, A. J., & Yang, S.-Y.
- Affiliations
- The Royal Free Hospital (GB)
- Research Department of General Surgery, Division of Surgery and Interventional Science, UCL Medical School, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
- Venue
- Vaccines
- Publisher
- MDPI AG
- Published
- 2012-08-24
- Volume
- 1
- Issue
- 1
- Pages
- 1-16
- ISSN
- 2076-393X (ISSN-L)
- PMC
- PMC4552199
- OpenAlex
- W2106399572
- Cited by
- 39
- References
- 58
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 5 · 2013: 2
- FWCI
- 0.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Vaccines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- colorectal cancer, cancer immunotherapy, tumor antigens, molecular targets, immune monitoring, clinical trials, adjuvant therapy, metastatic relapse
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