The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Essential Fatty Acids - A Review
Abstract
Essential fatty acids (EFAs): cis-linoleic acid (LA) and alpha-linolenic acid (ALA) are essential for humans and their deficiency is rare in humans due to their easy availability in diet. EFAs are metabolized to their respective long-chain metabolites: dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA) from LA; and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from ALA. Some of these long-chain metabolites form precursors to respective prostaglandins (PGs), thromboxanes (TXs), and leukotrienes (LTs), lipoxins (LXs) and resolvins. EFAs and their metabolites may function as endogenous angiotensin converting enzyme and HMG-CoA reductase inhibitors, nitric oxide enhancers, anti-hypertensives, and anti-atherosclerotic molecules. EFAs react with nitric oxide (NO) to yield respective nitroalkene derivatives that have cell-signaling actions via ligation and activation of peroxisome proliferator-activated receptors (PPARs). In several diseases such as obesity, hypertension, diabetes mellitus, coronary heart disease, alcoholism, schizophrenia, Alzheimer's disease, atherosclerosis, and cancer the metabolism of EFAs is altered. Thus, EFAs and their derivatives have significant clinical implications.
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Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet
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Self-citationAtherosclerosis: An intracellular deficiency in essential fatty acids
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Cited by
Fatty acid requirements in ontogeny of marine and freshwater fish
Tocher, D. R. (2010) · Aquaculture Research · doi:10.1111/j.1365-2109.2008.02150.x · Cited by 1,075
Balić, A., Vlašić, D., Žužul, K., Marinović, B., & Bukvić Mokos, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030741 · Cited by 400
Fotuhi, M., Mohassel, P., & Yaffe, K. (2009) · Nature Reviews Neurology · doi:10.1038/ncpneuro1044 · Cited by 344
Are all n-3 polyunsaturated fatty acids created equal?
Anderson, B. M., & Ma, D. W. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-33 · Cited by 334
Johnson, G. H., & Fritsche, K. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.03.029 · Cited by 268
Metadata
- Authors
- Das, U.
- Venue
- Current Pharmaceutical Biotechnology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2006-12-01
- Volume
- 7
- Issue
- 6
- Pages
- 467-482
- ISSN
- 1389-2010 (ISSN-L)
- OpenAlex
- W2061658502
- Cited by
- 425
- References
- 12
- FWCI
- 9.97
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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