The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.
DNA Transposons: Nature and Applications in Genomics
Open accessAbstract
Repeated DNA makes up a large fraction of a typical mammalian genome, and some repetitive elements are able to move within the genome (transposons and retrotransposons). DNA transposons move from one genomic location to another by a cut-and-paste mechanism. They are powerful forces of genetic change and have played a significant role in the evolution of many genomes. As genetic tools, DNA transposons can be used to introduce a piece of foreign DNA into a genome. Indeed, they have been used for transgenesis and insertional mutagenesis in different organisms, since these elements are not generally dependent on host factors to mediate their mobility. Thus, DNA transposons are useful tools to analyze the regulatory genome, study embryonic development, identify genes and pathways implicated in disease or pathogenesis of pathogens, and even contribute to gene therapy. In this review, we will describe the nature of these elements and discuss recent advances in this field of research, as well as our evolving knowledge of the DNA transposons most widely used in these studies.
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Lee, C. S., Bishop, E. S., Zhang, R., Yu, X., Farina, E. M., Yan, S., Zhao, C., Zeng, Z., Shu, Y., Wu, X., et al. (2017) · Genes & Diseases · doi:10.1016/j.gendis.2017.04.001 · Cited by 691
Transposable Elements, Inflammation, and Neurological Disease
Saleh, A., Macia, A., & Muotri, A. R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00894 · Cited by 149
Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression
Grundman, J., Spencer, B., Sarsoza, F., & Rissman, R. A. (2021) · PLOS ONE · doi:10.1371/journal.pone.0251611 · Cited by 27
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Metadata
- Authors
- Munoz-Lopez, M., & Garcia-Perez, J.
- Venue
- Current Genomics
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2010-04-01
- Volume
- 11
- Issue
- 2
- Pages
- 115-128
- ISSN
- 1389-2029 (ISSN-L)
- OpenAlex
- W2055058281
- Cited by
- 447
- References
- 151
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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