The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis
Open accessAbstract
Tumor cell migration and invasion play fundamental roles in cancer metastasis. The mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously expressed serine/threonine (Ser/Thr) kinase, is a central regulator of cell growth, proliferation, differentiation and survival. Recent studies have shown that mTOR also plays a critical role in the regulation of tumor cell motility, invasion and cancer metastasis. Current knowledge indicates that mTOR functions as two distinct complexes, mTORC1 and mTORC2. mTORC1 phosphorylates p70 S6 kinase (S6K1) and eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1), and regulates cell growth, proliferation, survival and motility. mTORC2 phosphorylates Akt, protein kinase C α (PKCα) and the focal adhesion proteins, and controls the activities of the small GTPases (RhoA, Cdc42 and Rac1), and regulates cell survival and the actin cytoskeleton. Here we briefly review recent knowledge of mTOR complexes and the role of mTOR signaling in tumor cell migration and invasion. We also discuss recent efforts about the mechanism by which rapamycin, a specific inhibitor of mTOR, inhibits cell migration, invasion and cancer metastasis.
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Cites
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Cited by
Rapamycin passes the torch: a new generation of mTOR inhibitors
Benjamin, D., Colombi, M., Moroni, C., & Hall, M. N. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3531 · Cited by 989
The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics
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mTOR: Role in cancer, metastasis and drug resistance
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The role of Pdcd4 in tumour suppression and protein translation
Wang, Q., & Yang, H. (2018) · Biology of the Cell · doi:10.1111/boc.201800014 · Cited by 113
Regulation of mTOR Activity in Snell Dwarf and GH Receptor Gene-Disrupted Mice
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Metadata
- Authors
- Huang, S., & Zhou, H.
- Venue
- Current Protein & Peptide Science
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2011-02-01
- Volume
- 12
- Issue
- 1
- Pages
- 30-42
- ISSN
- 1389-2037 (ISSN-L)
- OpenAlex
- W1996983679
- Cited by
- 270
- References
- 173
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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