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Fungal ATP-Binding Cassette (ABC) Transporters in Drug Resistance & Detoxification
Abstract
Pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi. PDR shares several similarities with processes in bacteria and higher eukaryotes. In mammalian cells, multidrug resistance (MDR) develops from an initial single drug resistance, eventually leading to a broad cross-resistance to many structurally and functionally unrelated compounds. Notably, a number of membrane-embedded energy-consuming ATP-binding cassette (ABC) transporters have been implicated in the development of PDR/MDR phenotypes. The yeast Saccharomyces cerevisiae genome harbors some 30 genes encoding ABC proteins, several of which mediate PDR. Therefore, yeast served as an important model organism to study the functions of evolutionary conserved ABC genes, including those mediating clinical antifungal resistance in fungal pathogens. Moreover, yeast cells lacking endogenous ABC pumps are hypersensitive to many antifungal drugs, making them suitable for functional studies and cloning of ABC transporters from fungal pathogens such as Candida albicans. This review discusses drug resistance phenomena mediated by ABC transporters in the model system S. cerevisiae and certain fungal pathogens.
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“The Pleiotropic Drug Resistance (PDR) network is central to the drug response in fungi, and its overactivation is associated with drug resistance.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [4]
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Metadata
- Authors
- Sipos, G., & Kuchler, K.
- Affiliations
- Max Perutz Labs (AT)
- Corresponding author
- Kuchler, Karl
- ORCID
- Kuchler, Karl
- Venue
- Current Drug Targets
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2006-04-01
- Volume
- 7
- Issue
- 4
- Pages
- 471-481
- ISSN
- 1389-4501 (ISSN-L)
- OpenAlex
- W2006747148
- Cited by
- 123
- References
- 0
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 10 · 2023: 15 · 2022: 9 · 2021: 6 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 7 · 2012: 8
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Drug Targets (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vienna Science and Technology Fund
- Herzfelder'sche Familienstiftung
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- ABC transporters, pleiotropic drug resistance, multidrug resistance, antifungal resistance, detoxification, Saccharomyces cerevisiae, Candida albicans, fungal pathogens, cross-resistance
- MeSH terms
- Animals, Fungi, Humans, Mycoses, Phenotype, Substrate Specificity, ATP-Binding Cassette Transporters, Drug Resistance, Fungal
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