Kuchler, Karl

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

Sanglard, D., Kuchler, K., Ischer, F., Pagani, J. L., Monod, M., & Bille, J. (1995) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityDrug Transport and Resistance Mechanisms

Cited by 815

The Facultative Intracellular Pathogen Candida glabrata Subverts Macrophage Cytokine Production and Phagolysosome Maturation

Seider, K., Brunke, S., Schild, L., Jablonowski, N., Wilson, D., Majer, O., Barz, D., Haas, A., Kuchler, K., Schaller, M., et al. (2011) · The Journal of Immunology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 220

The yeast protein kinase C cell integrity pathway mediates tolerance to the antifungal drug caspofungin through activation of Slt2p mitogen-activated protein kinase signaling.

Reinoso-Martín, C., Schüller, C., Schuetzer-Muehlbauer, M., & Kuchler, K. (2003) · Eukaryotic Cell

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 193

Systematic Phenotyping of a Large-Scale Candida glabrata Deletion Collection Reveals Novel Antifungal Tolerance Genes

Schwarzmüller, T., Ma, B., Hiller, E., Istel, F., Tscherner, M., Brunke, S., Ames, L., Firon, A., Green, B., Cabral, V., et al. (2014) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 191

Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections

Majer, O., Bourgeois, C., Zwolanek, F., Lassnig, C., Kerjaschki, D., Mack, M., Müller, M., & Kuchler, K. (2012) · PLoS Pathogens

Antifungal resistance and susceptibilityinterferon and immune responses

Cited by 156

A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5

Ernst, R., Kueppers, P., Klein, C. M., Schwarzmueller, T., Kuchler, K., & Schmitt, L. (2008) · Proceedings of the National Academy of Sciences

Drug Transport and Resistance MechanismsATP Synthase and ATPases Research

Cited by 146

The yeast zinc finger regulators Pdr1p and Pdr3p control pleiotropic drug resistance (PDR) as homo‐ and heterodimers in vivo

Mamnun, Y. M., Pandjaitan, R., Mahé, Y., Delahodde, A., & Kuchler, K. (2002) · Molecular Microbiology

Fungal and yeast genetics researchDrug Transport and Resistance Mechanisms

Cited by 125

The Set3/Hos2 Histone Deacetylase Complex Attenuates cAMP/PKA Signaling to Regulate Morphogenesis and Virulence of Candida albicans

Hnisz, D., Majer, O., Frohner, I. E., Komnenovic, V., & Kuchler, K. (2010) · PLoS Pathogens

Fungal and yeast genetics researchAntifungal resistance and susceptibility

Cited by 124

Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2/4 orthologous transcription factors

Roetzer, A., Gregori, C., Jennings, A. M., Quintin, J., Ferrandon, D., Butler, G., Kuchler, K., Ammerer, G., & Schüller, C. (2008) · Molecular Microbiology

Fungal and yeast genetics researchBacterial Genetics and Biotechnology

Cited by 124

Fungal ATP-Binding Cassette (ABC) Transporters in Drug Resistance & Detoxification

Sipos, G., & Kuchler, K. (2006) · Current Drug Targets

Drug Transport and Resistance MechanismsAntifungal resistance and susceptibility

Cited by 123

The ATP‐binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3

Mahé, Y., Parle‐McDermott, A., Nourani, A., Delahodde, A., Lamprecht, A., & Kuchler, K. (1996) · Molecular Microbiology

Drug Transport and Resistance MechanismsFungal and yeast genetics research

Cited by 117

Conventional Dendritic Cells Mount a Type I IFN Response against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-β Signaling

Bourgeois, C., Majer, O., Frohner, I. E., Lesiak-Markowicz, I., Hildering, K.-S., Glaser, W., Stockinger, S., Decker, T., Akira, S., Müller, M., et al. (2011) · The Journal of Immunology

Immune Response and Inflammationinterferon and immune responses

Cited by 116

Inhibition of CBLB protects from lethal Candida albicans sepsis

Wirnsberger, G., Zwolanek, F., Asaoka, T., Kozieradzki, I., Tortola, L., Wimmer, R. A., Kavirayani, A., Fresser, F., Baier, G., Langdon, W. Y., et al. (2016) · Nature Medicine

Immune Response and InflammationAntifungal resistance and susceptibility

Cited by 113

A Histone Deacetylase Adjusts Transcription Kinetics at Coding Sequences during Candida albicans Morphogenesis

Hnisz, D., Bardet, A. F., Nobile, C. J., Petryshyn, A., Glaser, W., Schöck, U., Stark, A., & Kuchler, K. (2012) · PLoS Genetics

Fungal and yeast genetics researchGenomics and Chromatin Dynamics

Cited by 100

The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators

Wolfger, H., Mahé, Y., Parle-McDermott, A., Delahodde, A., & Kuchler, K. (1997) · FEBS Letters

Fungal and yeast genetics researchDrug Transport and Resistance Mechanisms

Cited by 97

Immune evasion, stress resistance, and efficient nutrient acquisition are crucial for intracellular survival of Candida glabrata within macrophages

Seider, K., Gerwien, F., Kasper, L., Allert, S., Brunke, S., Jablonowski, N., Schwarzmüller, T., Barz, D., Rupp, S., Kuchler, K., et al. (2014) · Eukaryotic Cell

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 91

A Histone Deacetylase Complex Mediates Biofilm Dispersal and Drug Resistance in Candida albicans

Nobile, C. J., Fox, E. P., Hartooni, N., Mitchell, K. F., Hnisz, D., Andes, D. R., Kuchler, K., & Johnson, A. D. (2014) · mBio

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 87

Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response

Charlet, R., Pruvost, Y., Tumba, G., Istel, F., Poulain, D., Kuchler, K., Sendid, B., & Jawhara, S. (2018) · Scientific Reports

Gut microbiota and healthAntifungal resistance and susceptibility

Cited by 74

Positions and Numbers of FKS Mutations in Candida albicans Selectively Influence In Vitro and In Vivo Susceptibilities to Echinocandin Treatment

Lackner, M., Tscherner, M., Schaller, M., Kuchler, K., Mair, C., Sartori, B., Istel, F., Arendrup, M. C., & Lass-Flörl, C. (2014) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 67

Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection

Riedelberger, M., Penninger, P., Tscherner, M., Seifert, M., Jenull, S., Brunnhofer, C., Scheidl, B., Tsymala, I., Bourgeois, C., Petryshyn, A., et al. (2020) · Cell Host & Microbe

Antifungal resistance and susceptibilityIron Metabolism and Disorders

Cited by 64

Identification of Candida glabrata Genes Involved in pH Modulation and Modification of the Phagosomal Environment in Macrophages

Kasper, L., Seider, K., Gerwien, F., Allert, S., Brunke, S., Schwarzmüller, T., Ames, L., Zubiria-Barrera, C., Mansour, M. K., Becken, U., et al. (2014) · PLoS ONE

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 59

The two-component response regulator Ssk1 and the mitogen-activated protein kinase Hog1 control antifungal drug resistance and cell wall architecture of Candida auris

Shivarathri, R., Jenull, S., Stoiber, A., Chauhan, M., Mazumdar, R., Singh, A., Nogueira, F., Kuchler, K., Chowdhary, A., & Chauhan, N. (2020) · mSphere

Antifungal resistance and susceptibilityFungal and yeast genetics research

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The Fungal Histone Acetyl Transferase Gcn5 Controls Virulence of the Human Pathogen Candida albicans through Multiple Pathways

Shivarathri, R., Tscherner, M., Zwolanek, F., Singh, N. K., Chauhan, N., & Kuchler, K. (2019) · Scientific Reports

Fungal and yeast genetics researchAntifungal resistance and susceptibility

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The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways

Tscherner, M., Zwolanek, F., Jenull, S., Sedlazeck, F. J., Petryshyn, A., Frohner, I. E., Mavrianos, J., Chauhan, N., von Haeseler, A., & Kuchler, K. (2015) · PLOS Pathogens

Fungal and yeast genetics researchGenomics and Chromatin Dynamics

Cited by 57