Cited by 269Gastrointestinal motility and disordersInflammatory Bowel DiseaseGut microbiota and health

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Pathophysiological Mechanisms of Stress-Induced Intestina Damage

Gareau, Melanie, Silva, Manuel, Perdue, Mary·2008·Current Molecular Medicine

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Abstract

Stress has been shown to have both central and peripheral effects, promoting psychological illness (such as anxiety and depression), as well influencing peripheral disease in the intestine. Stress in humans can exacerbate symptoms of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), lowering visceral pain thresholds and decreasing mucosal barrier function. Studies in rodents have revealed that both acute and chronic exposure to stressors can lead to pathophysiology of the small and large intestine, including altered ion secretion and increased epithelial permeability (by both transcellular and paracellular pathways). Prolonged exposure to stress can induce low-grade inflammation, cause ultrastructural epithelial abnormalities, and alter bacterial-host interactions allowing greater microbial translocation. In this review, we discuss the stress response and the effects of both acute and chronic stress to induce pathophysiological damage to the gut. We present the potential pathways involved, and the proposed mechanisms of action mediating the effects. Furthermore, we explore the impact of early life stress on colonic physiology in neonatal rodents and the implications for gut dysfunction in adulthood.

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“Of 11 longitudinal studies of the effects of stress [ , , , , , , , , , , ,”
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Background
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Need for a comprehensive medical approach to the neuro-immuno-gastroenterology of irritable bowel syndrome.
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Background
Development of an ex Vivo Method for Multi-unit Recording of Microbiota-Colonic-Neural Signaling in Real Time
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Background
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Moreno, J. L. G.-C., Torronteras, A. R., González, M. D. R., et al. (2016) · European Journal of Pediatrics · doi:10.1007/s00431-016-2724-8 · Cited by 19
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Anton-Păduraru, D.-T., Trofin, F., Năstase, E. V., Miftode, R.-Ş., Miftode, I.-L., Trandafirescu, M. F., Cojocaru, E., Țarcă, E., Mîndru, D. E., & Dorneanu, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010041 · Cited by 21
“Stress has been recognized to heighten intestinal permeability, thereby providing an avenue for bacteria to translocate across the intestinal mucosa and directly interact with both immune cells and neuronal cells of the enteric nervous system [36].”
Background
Engineering Human Microbiota: Influencing Cellular and Community Dynamics for Therapeutic Applications
Woloszynek, S., Pastor, S. J., Mell, J. C., Nandi, N., Sokhansanj, B. A., & ROSEN, G. L. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.01.003 · Cited by 20
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Ramalho, J. B., Spiazzi, C. C., Bicca, D. F., Rodrigues, J. F., Sehn, C. P., da Silva, W. P., & Cibin, F. W. S. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113847 · Cited by 19
Perinatal maternal probiotic intervention impacts immune responses and ileal mucin gene expression in a rat model of irritable bowel syndrome
Barouei, J., Moussavi, M., & Hodgson, D. M. (2015) · Beneficial Microbes · doi:10.3920/bm2013.0011 · Cited by 18
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Background
“Gut–brain axis”: Review of the role of the probiotics in anxiety and depressive disorders
Gambaro, E., Gramaglia, C. M., Baldon, G., Chirico, E., Martelli, M. I., Renolfi, A., & Zeppegno, P. (2020) · Brain and Behavior · doi:10.1002/brb3.1803 · Cited by 21
Dexamethasone Immunosuppression Resulting in Turkey Clostridial Dermatitis: A Retrospective Analysis of Seven Studies, 1998–2009
Huff, G. R., HUFF, W. E., & Rath, N. C. (2013) · Avian Diseases · doi:10.1637/10522-030113-reg.1 · Cited by 18
Gut feelings: bacteria and the brain.
Foster, J. A. (2013) · Europe PMC (PubMed Central) · Cited by 21
Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases
Atanasova, K., Knödler, L.-L., Reindl, W., Ebert, M. P. A., & Thomann, A. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-025-01036-x · Cited by 19
“Stress is known to increase intestinal permeability, making it possible for bacteria to translocate across the intestinal mucosa and directly access both immune and neuronal cells of the enteric nervous system [51, 52].”
Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood
Shin, S. H., & Kim, Y. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_6 · Cited by 19
Sanguinarine-based isoquinoline alkaloids modulated the gut-brain axis and enhanced growth performance and gut integrity in natural heat stress broiler chickens
Khongthong, S., Faroongsarng, D., Roekngam, N., Nopparat, J., Kraitavin, W., Pastor, A., Steiner, T., & Theapparat, Y. (2023) · Livestock Science · doi:10.1016/j.livsci.2023.105297 · Cited by 17
Chronic stress and intestinal barrier function: Implications for infection and inflammation in intensive salmon aquaculture
Sundh, H. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 17
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Ulvestad, E. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-071-7_2 · Cited by 17
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DuPont, H. L. (2010) · doi:10.1002/9781444314403.ch19 · Cited by 16
A high-grain diet alters the omasal epithelial structure and expression of tight junction proteins in a goat model
Liu, J., Xu, T., Zhu, W., et al. (2014) · The Veterinary Journal · doi:10.1016/j.tvjl.2014.03.025 · Cited by 15
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“The connection between the severe psychobiological and physiological stress and gastric damage has long been recognized (33).”
Background
A Probiotic Mixture Induces Anxiolytic- and Antidepressive-Like Effects in Fischer and Maternally Deprived Long Evans Rats
Daugé, V., Philippe, C., Mariadassou, M., Rué, O., Martin, J., Rossignol, M., Dourmap, N., Svilar, L., Tourniaire, F., Monnoye, M., et al. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.581296 · Cited by 15
Interactions between the gut microbiome and the central nervous system and their role in schizophrenia, bipolar disorder and depression
Chrobak, A. A., Nowakowski, J., & Dudek, D. (2016) · Archives of Psychiatry and Psychotherapy · doi:10.12740/app/62962 · Cited by 15
“receptor 2), thus modulating stress-induced gut permeability, motility, immune and inflammatory response [22,23].”
Background
Irritable bowel syndrome and inflammatory bowel disease: infectious gastroenteritis-related disorders?
Ishihara, S., Aziz, M., Oshima, N., Mishima, Y., Imaoka, H., Moriyama, I., & Kinoshita, Y. (2009) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-008-0051-y · Cited by 14
“A variety of mechanisms underlying the pathogenesis of IBS has been reported, including genetic factors (with candidate genes proposed) [38–40], disturbances of intestinal motility [6– 12], visceral hypersensitivity [41, 42], and stress responses [43, 44 ].”
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“66”
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Authors: Gareau, M., Silva, M., & Perdue, M.
Affiliations: McMaster University (CA)
ORCID: Silva, Manuel
Venue: Current Molecular Medicine
Publisher: Bentham Science Publishers Ltd.
Published: 2008-06-01
Volume: 8
Issue: 4
Pages: 274-281
ISSN: 1566-5240 (ISSN-L)
DOI: 10.2174/156652408784533760
OpenAlex: W2144967252
Cited by: 268
References: 0
Citations by year: 2026: 6 · 2025: 13 · 2024: 13 · 2023: 26 · 2022: 15 · 2021: 17 · 2020: 17 · 2019: 20 · 2018: 16 · 2017: 10 · 2016: 15 · 2015: 9 · 2014: 16 · 2013: 15 · 2012: 11
FWCI: 15.93
Type: journal article
Language: en
Open access: closed
Locations: Current Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: psychological stress, intestinal injury, irritable bowel syndrome, inflammatory bowel disease, visceral pain, mucosal barrier function, epithelial permeability, ion secretion, low-grade inflammation, epithelial ultrastructure, gut microbiota, microbial translocation, early life stress, colonic physiology, stress response
MeSH terms: Acute Disease, Animals, Animals, Newborn, Chronic Disease, Disease Models, Animal, Humans, Intestinal Mucosa, Intestine, Large, Intestine, Small, Maternal Deprivation, Permeability, Rodentia, Stress, Physiological, Stress, Psychological, Inflammatory Bowel Diseases, Irritable Bowel Syndrome

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Pathophysiological Mechanisms of Stress-Induced Intestina Damage

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