Cited by 269Gastrointestinal motility and disordersInflammatory Bowel DiseaseGut microbiota and health

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Pathophysiological Mechanisms of Stress-Induced Intestina Damage

Gareau, Melanie, Silva, Manuel, Perdue, Mary·2008·Current Molecular Medicine

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Abstract

Stress has been shown to have both central and peripheral effects, promoting psychological illness (such as anxiety and depression), as well influencing peripheral disease in the intestine. Stress in humans can exacerbate symptoms of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), lowering visceral pain thresholds and decreasing mucosal barrier function. Studies in rodents have revealed that both acute and chronic exposure to stressors can lead to pathophysiology of the small and large intestine, including altered ion secretion and increased epithelial permeability (by both transcellular and paracellular pathways). Prolonged exposure to stress can induce low-grade inflammation, cause ultrastructural epithelial abnormalities, and alter bacterial-host interactions allowing greater microbial translocation. In this review, we discuss the stress response and the effects of both acute and chronic stress to induce pathophysiological damage to the gut. We present the potential pathways involved, and the proposed mechanisms of action mediating the effects. Furthermore, we explore the impact of early life stress on colonic physiology in neonatal rodents and the implications for gut dysfunction in adulthood.

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“Chronic stress is thought to be associated with activation of cellular immunity, increased production of pro-inflammatory cytokines, release of corticotropin-releasing factor (CRF), acute hyperactivity of the HPA axis followed by a chronic blunted HPA response and glucocorticoid hyposensitivity [35].”
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Background
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“[2–4] A recent clinical trial with the mast cell stabilizer and histamine-1-receptor (H1R) antagonist ketotifen confirmed the possible relevance of this cell type.”
Method
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“Based on the clinical evidence that both IBD and IBS have intestinal inflammation and dysmotility in different extent, the differential diagnosis for distinguishing IBD and IBS based on clinical signs and symptoms are difficult, and approximately 60~80% of IBD patients suffer from IBS [40], how to ameliorate both inte…”
ResultInfluential
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Authors: Gareau, M., Silva, M., & Perdue, M.
Affiliations: McMaster University (CA)
ORCID: Silva, Manuel
Venue: Current Molecular Medicine
Publisher: Bentham Science Publishers Ltd.
Published: 2008-06-01
Volume: 8
Issue: 4
Pages: 274-281
ISSN: 1566-5240 (ISSN-L)
DOI: 10.2174/156652408784533760
OpenAlex: W2144967252
Cited by: 268
References: 0
Citations by year: 2026: 6 · 2025: 13 · 2024: 13 · 2023: 26 · 2022: 15 · 2021: 17 · 2020: 17 · 2019: 20 · 2018: 16 · 2017: 10 · 2016: 15 · 2015: 9 · 2014: 16 · 2013: 15 · 2012: 11
FWCI: 15.93
Type: journal article
Language: en
Open access: closed
Locations: Current Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: psychological stress, intestinal injury, irritable bowel syndrome, inflammatory bowel disease, visceral pain, mucosal barrier function, epithelial permeability, ion secretion, low-grade inflammation, epithelial ultrastructure, gut microbiota, microbial translocation, early life stress, colonic physiology, stress response
MeSH terms: Acute Disease, Animals, Animals, Newborn, Chronic Disease, Disease Models, Animal, Humans, Intestinal Mucosa, Intestine, Large, Intestine, Small, Maternal Deprivation, Permeability, Rodentia, Stress, Physiological, Stress, Psychological, Inflammatory Bowel Diseases, Irritable Bowel Syndrome

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Pathophysiological Mechanisms of Stress-Induced Intestina Damage

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