Perinatal maternal probiotic intervention impacts immune responses and ileal mucin gene expression in a rat model of irritable bowel syndrome
Abstract
Alterations in immune responses and intestinal secretory state are among features commonly observed in the maternal separation (MS) rat model of Irritable Bowel Syndrome. This study examined whether perinatal maternal introduction of probiotics influences plasma immune markers and ileal mucin-2 (MUC2) gene expression in rat offspring exposed to neonatal maternal separation (MS, 3 h/day, postnatal days (PND) 2-14) and/or subsequently to acute restraint stress in adulthood (AS, 30 min/day, PND 83-85). Data analysis indicated that stress protocols did not affect plasma tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ) and interleukin (IL)-6 levels in young offspring (PND 24) born to the vehicle-treated dams. Maternal probiotic intervention was associated with significantly decreased IFN-γ levels in young offspring compared with non-probiotic offspring (P≤0.05). It also induced a significant increase in IL-6 levels in MS pups (P≤0.05). Exposure of both non-MS and MS offspring to AS induced a significant increase in haptoglobin levels compared to controls (P≤0.05), whereas all offspring born to the probiotic-treated dams, irrespective of stress treatment conditions, exhibited significantly decreased haptoglobin levels to well below the control levels (P≤0.05). MS and/or AS did not affect ileal expression of MUC2 in offspring born to the non-probiotic treated dams. While maternal probiotic intake significantly downregulated ileal gene expression of MUC2 in MS male young offspring, it was associated with significantly upregulated MUC2 mRNA expression in MS or AS adult male offspring. These findings suggest that maternal probiotic intervention may exert long-lasting anti-inflammatory effects and impact gut outcomes in offspring at increased risk of dysfunctional gut.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Maternal probiotic intervention increased the gene expression of ileal mucin-2 (MUC2).
“maternal probiotic intervention also increased the gene expression of ileal mucin-2 (MUC2) [230]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [230]
Cites
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890 · see citing works
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579 · see citing works
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
Lai, S. K., Wang, Y.-Y., & Hanes, J. S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.11.002 · Cited by 1,827 · see citing works
Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers
Ensign, L. M., Cone, R. A., & Hanes, J. S. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.12.009 · Cited by 1,646 · see citing works
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
Mucin dynamics and enteric pathogens
McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428 · see citing works
Dynamic DNA methylation programs persistent adverse effects of early-life stress
Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · see citing works
O'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works
Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works
Stress Hormones, Th1/Th2 patterns, Pro/Anti-inflammatory Cytokines and Susceptibility to Disease
Elenkov, I. J., & Chrousos, G. P. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(99)00188-5 · Cited by 804 · see citing works
Mack, D. R., Ahrné, S., Hyde, L., Wei, S. H., & Hollingsworth, M. A. (2003) · Gut · doi:10.1136/gut.52.6.827 · Cited by 666 · see citing works
Heterogeneity of mucin gene expression in normal and neoplastic tissues.
Ho, S. B., Niehans, G. A., Lyftogt, C. T., Yan, P., Cherwitz, D. L., Gum, E. T., Dahiya, R., & Kim, Y. S. (1993) · PubMed · Cited by 665 · see citing works
Immune Activation in Patients With Irritable Bowel Syndrome
Liebregts, T., Adam, B., Bredack, C., Röth, A., Heinzel, S., Lester, S., Downie–Doyle, S., Smith, E., Drew, P., Talley, N. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.046 · Cited by 660 · see citing works
Dinan, T. G., Quigley, E. M. M., Ahmed, S. M. M., Scully, P., O’Brien, S., O’Mahony, L., O’Mahony, S., Shanahan, F., & Keeling, P. W. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.033 · Cited by 636 · see citing works
Rautava, S., Kalliomäki, M. A., & Isolauri, E. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.120273 · Cited by 566 · see citing works
Mack, D., Michail, S., Wei, S., McDougall, L., & Hollingsworth, M. (1999) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g941 · Cited by 544 · see citing works
The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
Caballero‐Franco, C., Keller, K., Simone, C. D., & Chadee, K. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00265.2006 · Cited by 493 · see citing works
Gareau, M. G., Jury, J., MacQueen, G., Sherman, P. M., & Perdue, M. H. (2007) · Gut · doi:10.1136/gut.2006.117176 · Cited by 472 · see citing works
Audie, J. P., Janin, A., Porchet, N., Copin, M., Gosselin, B. H., & Aubert, J. (1993) · Journal of Histochemistry & Cytochemistry · doi:10.1177/41.10.8245407 · Cited by 458 · see citing works
Coutinho, S. V., Plotsky, P. M., Sablad, M., Miller, J. C., Zhou, H., Bayati, A. I., McRoberts, J. A., & Mayer, E. A. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00240.2001 · Cited by 456 · see citing works
Bacterial translocation from the gastrointestinal tract
Berg, R. D. (1995) · Trends in Microbiology · doi:10.1016/s0966-842x(00)88906-4 · Cited by 443 · see citing works
Maternal separation as a model of brain-gut axis dysfunction
O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415 · see citing works
Bode, J. G., Albrecht, U., Häussinger, D., Heinrich, P. C., & Schaper, F. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2011.09.008 · Cited by 379 · see citing works
KAJANDER, K., MYLLYLUOMA, E., RAJILIĆ‐STOJANOVIĆ, M., KYRÖNPALO, S., RASMUSSEN, M., JÄRVENPÄÄ, S., ZOETENDAL, E. G., DE VOS, W. M., VAPAATALO, H., & KORPELA, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03542.x · Cited by 367 · see citing works
Evolving pathophysiologic models of functional gastrointestinal disorders
Mayer, E. A., & Collins, S. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33584 · Cited by 326 · see citing works
Benjamini, E., & Leskowitz, S. S. (1988) · Andalas University Repository (Andalas University) · Cited by 315 · see citing works
Krebs, N. F., Westcott, J., Butler, N. N., Robinson, C. C., Bell, M. L., & Hambidge, K. M. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000189346.25172.fd · Cited by 315 · see citing works
Chang, S.-K., Dohrman, A., Basbaum, C. B., Ho, S. B., Tsuda, T., Toribara, N. W., Gum, J. R., & Kim, Y. S. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90057-4 · Cited by 280 · see citing works
Pathophysiological Mechanisms of Stress-Induced Intestina Damage
Gareau, M., Silva, M., & Perdue, M. (2008) · Current Molecular Medicine · doi:10.2174/156652408784533760 · Cited by 268 · cited 1× · see citing works
“This concept has been applied to the ontogeny of a variety of disorders later in life including functional gastro-intestinal disorders (FGIDs) such as irritable bowel syndrome (IBS) (Gareau et al., 2008; O’Mahony et al., 2011).”
BackgroundCorticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat
Santos, J., Saunders, P. R., Hanssen, N. P. M., Yang, P., Yates, D. A., Groot, J. A., & Perdue, M. H. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.2.g391 · Cited by 251 · see citing works
Söderholm, J. D., Yates, D. A., Gareau, M. G., Yang, P.-C., MacQueen, G., & Perdue, M. H. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00314.2002 · Cited by 243 · see citing works
Barreau, F., Ferrier, L., Fioramonti, J., & Bueno, L. P. (2004) · Gut · doi:10.1136/gut.2003.024174 · Cited by 240 · see citing works
Interleukin‐4 and Interferon‐γ: The Quintessence of a Mutual Antagonistic Relationship
Paludan (1998) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1998.00435.x · Cited by 219 · see citing works
Immunology: Understanding The Immune System
Elgert, K. D. (1996) · Cited by 205 · see citing works
Irritable bowel syndrome: towards biomarker identification
Clarke, G. A., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.08.001 · Cited by 180 · see citing works
Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity
Scully, P., McKernan, D. P., Keohane, J., Groeger, D., Shanahan, F., Dinan, T. G., & Quigley, E. M. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.159 · Cited by 176 · see citing works
Barreau, F., Cartier, C., Ferrier, L., Fioramonti, J., & Bueno, L. P. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.019 · Cited by 171 · see citing works
SIMRÉN, M., ÖHMAN, L., OLSSON, J., SVENSSON, U., OHLSON, K., POSSERUD, I., & STRID, H. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04183.x · Cited by 169 · see citing works
Blümer, N., Sel, S., Virna, S., Patrascan, C. C., Zimmermann, S., Herz, U., Renz, H. E., & Garn, H. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02671.x · Cited by 168 · see citing works
Administration of Oral Probiotic Bacteria to Pregnant Women Causes Temporary Infantile Colonization
Schultz, M., Göttl, C., Young, R. J., Iwen, P. C., & Vanderhoof, J. A. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200403000-00012 · Cited by 166 · see citing works
Barreau, F., Ferrier, L., Fioramonti, J., & Bueno, L. P. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180db2949 · Cited by 156 · see citing works
Walker, A. K., Nakamura, T., Byrne, R. J., Naicker, S., Tynan, R. J., Hunter, M., & Hodgson, D. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.010 · Cited by 150 · see citing works
Self-citationBarreau, F., Cartier, C., Leveque, M., Ferrier, L., Moriez, R., Laroute, V., Rosztoczy, A. I., Fioramonti, J., & Bueno, L. P. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120907 · Cited by 144 · see citing works
Interferon γ Gene Expression in Sensory Neurons: Evidence for Autocrine Gene Regulation
Neumann, H., Schmidt, H., Wilharm, E., Behrens, L., & Wekerle, H. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.12.2023 · Cited by 128 · see citing works
Cain, K. C., Jarrett, M. E., Burr, R. L., Rosen, S., Hertig, V. L., & Heitkemper, M. M. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0516-3 · Cited by 126 · see citing works
O’Malley, D., Julio‐Pieper, M., Gibney, S. M., Dinan, T. G., & Cryan, J. F. (2009) · Stress · doi:10.3109/10253890903067418 · Cited by 122 · see citing works
García‐Ródenas, C. L., Bergonzelli, G. E., Nutten, S., Schumann, A., Cherbut, C., Turini, M., Ornstein, K., Rochat, F., & Corthésy‐Theulaz, I. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000226376.95623.9f · Cited by 114 · see citing works
Giffen, P. S., Turton, J. A., Andrews, C. M., Barrett, P., Clarke, C. J., Fung, K.-W., Munday, M. R., Roman, I., Smyth, R., Walshe, K., et al. (2003) · Archives of Toxicology · doi:10.1007/s00204-003-0458-7 · Cited by 112 · see citing works
Barouei, J., Moussavi, M., & Hodgson, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046051 · Cited by 99 · see citing works
Self-citationColonic mucus: secretion and turnover in relation to dietary fibre intake
Brownlee, I. A., Havler, M. E., Dettmar, P. W., Allen, A., & Pearson, J. P. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2003206 · Cited by 93 · see citing works
Gastrointestinal expression and partial cDNA cloning of murine Muc2
van Klinken, B. J., Einerhand, A. W. C., Duits, L. A., Makkink, M. K., Tytgat, K. M. A. J., Renes, I. B., Verburg, M., Büller, H. A., & Dekker, J. P. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.1.g115 · Cited by 93 · see citing works
Rosztoczy, A. I., Fioramonti, J., Jármay, K., Barreau, F., Wittmann, T., & Bueno, L. P. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1350-1925.2003.00451.x · Cited by 91 · see citing works
Influence of Short-Chain Fatty Acids on Iron Absorption by Proximal Colon
Bouglé, D. L., Vaghefi, N., Roland, N., Bouvard, G., Arhan, P., Bureau, F., Neuville, D., & Maubois, J. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202320378176 · Cited by 87 · see citing works
The effect of gastro-intestinal mucus on drug absorption
MacAdam, A. (1993) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(93)90010-2 · Cited by 83 · see citing works
Moussavi, M., & Adams, M. C. (2009) · Current Microbiology · doi:10.1007/s00284-009-9545-1 · Cited by 53 · see citing works
Self-citationAssessment of visceral sensitivity using radio telemetry in a rat model of maternal separation
Welting, O., van den Wijngaard, R. M., de Jonge, W. J., Holman, R., & Boeckxstaens, G. E. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00677.x · Cited by 53 · see citing works
Julio‐Pieper, M., O’Mahony, C. M., Clarke, G. A., Bravo, J. A., Dinan, T. G., & Cryan, J. F. (2011) · Stress · doi:10.3109/10253890.2011.607524 · Cited by 50 · see citing works
Estienne, M., Claustre, J., Clain-Gardechaux, G., Paquet, A., Taché, Y., Fioramonti, J., & Plaisancié, P. (2010) · Gut · doi:10.1136/gut.2009.190728 · Cited by 50 · see citing works
Maternal-to-Infant Transmission of Probiotics: Concept Validation in Mice, Rats, and Pigs
Buddington, R. K., Williams, C. H., Kostek, B. M., Buddington, K. K., & Kullen, M. J. (2009) · Neonatology · doi:10.1159/000253756 · Cited by 46 · see citing works
Hyland, N. P., Julio‐Pieper, M., O’Mahony, S. M., Bulmer, D. C., Lee, K., Quigley, E. M. M., Dinan, T. G., & Cryan, J. F. (2009) · Gut · doi:10.1136/gut.2008.167882 · Cited by 34 · see citing works
Fåk, F., Ahrné, S., Molin, G., Jeppsson, B. W., & Weström, B. R. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114507883036 · Cited by 33 · see citing works
Immunological consequences of maternal separation in infant primates
Coe, C. L., Lubach, G. R., & Ershler, W. B. (1989) · New Directions for Child and Adolescent Development · doi:10.1002/cd.23219894507 · Cited by 31 · see citing works
Israeli, E., Hershcovici, T., Berenshtein, E., Zannineli, G., Wengrower, D., Weiss, O., Chevion, M., & Goldin, E. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9827-z · Cited by 29 · see citing works
Colonization of an Infant with the Probiotic, Lactobacillus GG, by Maternal Transmission
Vanderhoof, J. A., Iwen, P. C., Hinrichs, S. H., Bilyeu, D., & Young, R. J. (1999) · Pediatric Research · doi:10.1203/00006450-199904020-00702 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies
Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2219 · Cited by 320 · see citing works
Moya-Pérez, Á., Pérez‐Villalba, A., Benítez‐Páez, A., Campillo, I., & Sanz, Y. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.05.011 · Cited by 177 · see citing works
Early-life stress and inflammation: A systematic review of a key experimental approach in rodents
Dutcher, E. G., Pama, E. A. C., Lynall, M.-E., Khan, S. A., Clatworthy, M. R., Robbins, T. W., Bullmore, E. T., & Dalley, J. W. (2020) · Brain and Neuroscience Advances · doi:10.1177/2398212820978049 · Cited by 93 · see citing works
Agusti, A., Moya-Pérez, A., Campillo, I., Montserrat-de la Paz, S., Cerrudo, V., Perez-Villalba, A., & Sanz, Y. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0768-z · Cited by 85 · see citing works
Probiotics in early life: a preventative and treatment approach
Hashemi, A., Villa, C., & Comelli, E. M. (2016) · Food & Function · doi:10.1039/c5fo01148e · Cited by 56 · see citing works
Biodetoxification and Protective Properties of Probiotics
Pop, O. L., Suharoschi, R., & Gabbianelli, R. (2022) · Microorganisms · doi:10.3390/microorganisms10071278 · Cited by 54 · see citing works
Maternal separation in rodents: a journey from gut to brain and nutritional perspectives
Rincel, M., & Darnaudéry, M. (2019) · Proceedings of The Nutrition Society · doi:10.1017/s0029665119000958 · Cited by 50 · see citing works
Darbaky, Y., Evrard, B., Patrier, S., Falenta, J., Garcin, S., Tridon, A., Dapoigny, M. C., Silberberg, C., Nivoliez, A., & Diop, L. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13320 · Cited by 34 · see citing works
Chen, Z., Ceballos‐Francisco, D., Guardiola, F. A., & Esteban, M. Á. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.02.022 · Cited by 32 · see citing works
Homage to the ‘H’ in developmental origins of health and disease
Rosenfeld, C. S. (2016) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174416000465 · Cited by 28 · see citing works
Joseph, J., & Law, C. A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.010 · Cited by 26 · see citing works
Ruiz‐Malagón, A. J., Rodríguez, M. J., Rodríguez‐Sojo, M. J., Vezza, T., Pischel, I., Algieri, F., Rodríguez‐Cabezas, M. E., Rodríguez‐Nogales, A., & Gálvez, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.967644 · Cited by 17 · see citing works
Rodríguez‐Nogales, A., Algieri, F., Vezza, T., Garrido‐Mesa, J., Molina‐Tijeras, J. A., Rodríguez‐Cabezas, M. E., Utrilla, M. P., Pischel, I., & Gálvez, J. (2019) · Nutrients · doi:10.3390/nu11010140 · Cited by 12 · see citing works
Esfand, S. M., Querdasi, F. R., Gancz, N. N., Savoca, P. W., Nussbaum, S. G., Somers, J. A., Ditzer, J., Figueroa, M. B., Chu, K. A., Towner, E., et al. (2024) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2024.100880 · Cited by 2 · see citing works
Immunity in Rodent Models of Stress
Hachenberg, S., Russo, S. J., & Cathomas, F. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.11.007 · Cited by 2 · see citing works
Moussavi, M., Cuskelly, A., Jung, Y., Hodgson, D. M., & Barouei, J. (2022) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbac199 · Cited by 2 · see citing works
Self-citationRole of the gut-brain axis in early stress-induced emotional vulnerability
Rincel, M. (2017) · theses.fr (ABES) · doi:10.70675/5e8a972cz9ad1z42aezb89cze6474124ef90
Pocheron, A.-L. (2019) · theses.fr (ABES) · doi:10.70675/29969b86z2649z4b67zb315za23a1106f4ef
- Authors
- Barouei, J., Moussavi, M., & Hodgson, D. M.
- Affiliations
- University of Newcastle Australia (AU)
- Venue
- Beneficial Microbes
- Publisher
- Walter de Gruyter GmbH
- Published
- 2015-01-01
- Volume
- 6
- Issue
- 1
- Pages
- 83-96
- ISSN
- 1876-2883 (ISSN-L)
- 1876-2891
- OpenAlex
- W2151284068
- Cited by
- 18
- References
- 65
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 4
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Beneficial Microbes (publishedVersion)
- PubMed (publishedVersion)
- NOVA (University of Newcastle Australia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- irritable bowel syndrome, maternal separation, restraint stress, immune response, interferon-gamma, interleukin-6, TNF-α, haptoglobin, anti-inflammatory activity
- MeSH terms
- Animals, Disease Models, Animal, Immunologic Factors, Intestinal Mucosa, Mucins, Gene Expression, Cytokines, Probiotics, Irritable Bowel Syndrome, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
