Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Inflammation and Alzheimer’s disease

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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Hearing loss and cognitive decline in older adults

Lin, F. R., Yaffe, K., Xia, J., Xue, Q.-L., Harris, T. B., Purchase-Helzner, E., Satterfield, S., Ayonayon, H. N., Ferrucci, L., Simonsick, E. M., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.1868 · Cited by 4,017

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

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A Review of Biomarkers for Alzheimer’s Disease in Down Syndrome

Lee, N., Chien, Y., & Hwu, W. (2017) · Neurology and Therapy · doi:10.1007/s40120-017-0071-y · Cited by 23

Current viral-mediated gene transfer research for treatment of Alzheimer’s disease

Sasmita, A. O. (2018) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2018.1523521 · Cited by 26

Tau PET Imaging for Staging of Alzheimer's Disease in Down Syndrome

Rafii, M. S. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22658 · Cited by 23

Restoring microglial and astroglial homeostasis using DNA immunization in a down Syndrome mouse model.

Illouz, T., Madar, R., Biragyn, A., & Okun, E. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.10.004 · Cited by 22

Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation

Haertle, L., Müller, T., Lardenoije, R., Maierhofer, A., Dittrich, M. T., Riemens, R. J. M., Stora, S., Roche, M., Leber, M., Riedel-Heller, S. G., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0787-x · Cited by 22

Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain

Ledreux, A., Thomas, S., Hamlett, E. D., Trautman, C. W., Gilmore, A., Hager, E. R., Paredes, D., Margittai, M., Fortea, J., & Granholm, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173931 · Cited by 23

Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome

Chen, X., Xing, Z., Chen, Q.-D., Salvi, R., Zhang, X., Tycko, B., Mobley, W. C., & Yu, Y. E. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.700280 · Cited by 26

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose

Chen, X., Zuo, X., Becker, A., Head, E., & Mobley, W. C. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12835 · Cited by 23

Glucagon-Like Peptide-1 Cleavage Product Improves Cognitive Function in a Mouse Model of Down Syndrome

Day, S. M., Yang, W., Wang, X., Stern, J. E., Zhou, X., Macauley, S. L., & Ma, T. (2019) · eNeuro · doi:10.1523/eneuro.0031-19.2019 · Cited by 21

Exosome release and cargo in Down syndrome

Hamlett, E. D., LaRosa, A., Mufson, E. J., Fortea, J., Ledreux, A., & Granholm, A. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22712 · Cited by 21

Comparison of longitudinal Aβ in nondemented elderly and Down syndrome

Tudorascu, D., Anderson, S., Minhas, D. S., Yu, Z., COMER, D. M., Lao, P. J., Hartley, S. L., Laymon, C. M., Snitz, B. E., Lopresti, B. J., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.030 · Cited by 22

Increased non-protein bound iron in Down syndrome: contribution to lipid peroxidation and cognitive decline

Manna, C., Officioso, A., Trojsi, F., Tedeschi, G., Leoncini, S., Signorini, C., Ciccoli, L., & Felice, C. D. (2016) · Free Radical Research · doi:10.1080/10715762.2016.1253833 · Cited by 20

Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis

Head, E., Powell, D. K., & Schmitt, F. A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00191 · Cited by 20

Future horizons in Alzheimer's disease research

Wısnıewskı, T., & Drummond, E. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.08.001 · Cited by 20

microRNAs expression correlates with levels of APP, DYRK1A, hyperphosphorylated Tau and BDNF in the hippocampus of a mouse model for Down syndrome during ageing

Chaves, J. C. S., Machado, F. T., de Almeida, M. F., Bacovsky, T. B., & Ferrari, M. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.134541 · Cited by 21

Down syndrome biobank consortium: a perspective

Aldecoa, I., Barroeta, I., Carroll, S. L., Fortea, J., Gilmore, A., Ginsberg, S. D., Guzman, S. J., Hamlett, E. D., Head, E., Perez, S. E., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13692 · Cited by 19

Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome

Grigorova, M., Mak, E., Brown, S. S. G., Beresford‐Webb, J., Hong, Y. T., Fryer, T. D., Coles, J., Aigbirhio, F. I., Tudorascu, D., Cohen, A. D., et al. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.07.003 · Cited by 20

The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome

Granholm, A., & Hamlett, E. D. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051338 · Cited by 23

Blood circulating miR-28-5p and let-7d-5p associate with premature ageing in Down syndrome

Morsiani, C., Bacalini, M. G., Collura, S., Moreno‐Villanueva, M., Breusing, N., Bürkle, A., Grune, T., Franceschi, C., de Eguileor, M., & Capri, M. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111691 · Cited by 18

Down syndrome: Distribution of brain amyloid in mild cognitive impairment

Keator, D., Phelan, M. J., Taylor, L., Doran, E., Krinsky-McHale, S., Price, J., Ballard, E., Kreisl, W., Hom, C., Nguyen, D. D., et al. (2020) · Alzheimer's & Dementia · doi:10.1002/dad2.12013 · Cited by 19

Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down syndrome

Wang, X., Yang, Q., Zhou, X., Keene, C. D., Ryazanov, A. G., & Ma, T. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13916 · Cited by 17

Identifying dementia in Down syndrome with the Severe Impairment Battery, Brief Praxis Test and Dementia Scale for People with Learning Disabilities

Wallace, E. R., Harp, J. P., Pelt, K. L. V., Koehl, L., Caban‐Holt, A., Anderson-Mooney, A. J., Jicha, G. A., Lightner, D. D., Robertson, W. C., Head, E., et al. (2021) · Journal of Intellectual Disability Research · doi:10.1111/jir.12901 · Cited by 17

Adapting prescribing criteria for amyloid‐targeted antibodies for adults with Down syndrome

Hillerstrom, H., Fisher, R. A., Janicki, M. P., Chicoine, B. A., Christian, B. T., Esbensen, A. J., Esralew, L., Fortea, J., Hartley, S. L., Hassenstab, J. J., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13778 · Cited by 17

Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome

Kaur, G., Gauthier, S. A., Pérez‐González, R., Pawlik, M., Singh, A. B., Cosby, B., Mohan, P. S., Smiley, J. F., & Levy, E. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.08.025 · Cited by 17

The Role of Oxidative Stress in Trisomy 21 Phenotype

Buczyńska, A., Sidorkiewicz, I., Kretowski, A. J., & Zbucka-Krętowska, M. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01417-6 · Cited by 21

Age exacerbates abnormal protein expression in a mouse model of Down syndrome

Ahmed, M. M., Block, A., Tong, S., Davisson, M. T., & Gardiner, K. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.05.002 · Cited by 16

Comparison of the amyloid plaque proteome in Down syndrome, early‐onset Alzheimer's disease, and late‐onset Alzheimer's disease

Martá-Ariza, M., Leitner, D. F., Kanshin, E., Suazo, J., Giusti Pedrosa, A., Thierry, M., Lee, E. B., Devinsky, O., Drummond, E., Fortea, J., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02844-z · Cited by 15

Resistance and resilience to Alzheimer's disease in Down syndrome

Boyle, R. T., Koops, E. A., Ances, B. M., Andrews, E. J., Arenaza‐Urquijo, E. M., Bejanin, A., Brickman, A. M., Buckley, R. F., Clas, G. S., Costello, E., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70151 · Cited by 14

From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome

Watson, L. A., & Meharena, H. S. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1198129 · Cited by 13

Amyloid-β peptide signature associated with cerebral amyloid angiopathy in familial Alzheimer’s disease with APPdup and Down syndrome

Kasri, A., Camporesi, E., Gkanatsiou, E., Boluda, S., Brinkmalm, G., Stimmer, L., Ge, J., Hanrieder, J., Villain, N., Duyckaerts, C. J., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02756-4 · Cited by 16

Clinical and research application of fluid biomarkers in autosomal dominant Alzheimer's disease and Down syndrome

Carmona‐Iragui, M., O’Connor, A., Llibre‐Guerra, J. J., Lao, P. J., Ashton, N. J., Fortea, J., & Sánchez‐Valle, R. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105327 · Cited by 13

Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early‐onset Alzheimer's disease

Dekker, A. D., Vermeiren, Y., Carmona‐Iragui, M., Benejam, B., Videla, L., Gelpí, E., Aerts, T., Dam, D. V., Fernández, S., Lleó, A., et al. (2017) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2017.11.001 · Cited by 15

Comparative analysis of the DYRK1A-SRSF6-TNNT2 pathway in myocardial tissue from individuals with and without Down syndrome

Quiñones‐Lombraña, A., & Blanco, J. G. (2019) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2019.104268 · Cited by 12

Untangle the mystery behind DS-associated AD – Is APP the main protagonist?

Elangovan, A., Babu, H. W. S., Iyer, M., Gopalakrishnan, A. V., & Vellingiri, B. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101930 · Cited by 12

The history of Down syndrome–associated Alzheimer's disease; past, present, and future

Maure‐Blesa, L., Carmona‐Iragui, M., Lott, I. T., Head, E., Wısnıewskı, T., Rafii, M. S., Espinosa, J. M., Flórez, J., Mobley, W. C., Holland, A. J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70158 · Cited by 12

Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease

Ma, W., Chen, A.-F., Xie, X., & Huang, Y. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108342 · Cited by 12

Neuro-Ophthalmological Manifestations in Children with Down Syndrome: Current Perspectives

Postolache, L., Monier, A., & Lhoir, S. (2021) · Eye and Brain · doi:10.2147/eb.s319817 · Cited by 13

Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants

Meineck, M., Schuck, F., Abdelfatah, S., Efferth, T., & Endres, K. (2016) · Medicines · doi:10.3390/medicines3040030 · Cited by 12

DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients

Moreau, M., Carmona‐Iragui, M., Altuna, M., Dalzon, L., Barroeta, I., Vilaire-Meunier, M., Durand, S., Fortea, J., Rebillat, A., & Janel, N. (2022) · Biomedicines · doi:10.3390/biomedicines10061380 · Cited by 12

The Global Deterioration Scale for Down Syndrome Population (GDS-DS): A Rating Scale to Assess the Progression of Alzheimer’s Disease

Rodriguez, E., García‐Alba, J., Novell, R., & Esteba‐Castillo, S. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20065096 · Cited by 11

Balance and Gait

da Conceição, A. D. S. G. G., Ana, L., Mattar, G. P., da Silva, M. D. F. R., Ramos, A. R., de Oliveira, A. M., Carvalho, C. L., Ribeiro, O. G., Varotto, B. L. R., Martinez, L. D., et al. (2023) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000580 · Cited by 11

Partial trisomy of chromosome 21 without the Down syndrome phenotype

Su, M., Kuan, L.-C., Chou, Y., Tan, S.-Y., Kuo, T., & Kuo, P. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4796 · Cited by 11

Dementia in People with Intellectual Disabilities

Deb, S. S., Strydom, A., Hithersay, R., Gomiero, T., Vreese, L. P. D., Janicki, M. P., Jokinen, N. S., & Service, K. P. (2022) · Springer eBooks · doi:10.1007/978-3-319-95720-3_28 · Cited by 10

Medial temporal lobe atrophy in Down syndrome along the Alzheimer’s disease continuum

Buehner, B. J., Morcillo-Nieto, A. O., Zsadanyi, S. E., Aranha, M. R., Arriola‐Infante, J. E., Vaqué‐Alcázar, L., Arranz, J., Rodríguez‐Baz, Í., Maure‐Blesa, L., Videla, L., et al. (2025) · Brain · doi:10.1093/brain/awaf133 · Cited by 12

Enhancing protein O-GlcNAcylation in down syndrome mice mitigates memory dysfunctions through the rescue of mitochondrial bioenergetics, stress responses and pathological markers

Lanzillotta, C., Prestia, F., Greco, V., Iavarone, F., Cordella, F., Sette, C., Forte, E., Tramutola, A., Lanzillotta, S., Cassano, T., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103769 · Cited by 10

Autosomal Reciprocal Translocations

Gardner, R. J. M., & Amor, D. J. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780199329007.003.0005 · Cited by 10

A Retrospective, Longitudinal, Claims-Based Comparison of Concomitant Diagnoses Between Individuals with and Without Down Syndrome

Kong, A. M., Hurley, D., Evans, K. A., Brixner, D. I., Csoboth, C. T., & Visootsak, J. (2017) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2017.23.7.761 · Cited by 10

Assessment of dementia in a clinical sample of persons with intellectual disability

Rösner, P., Berger, J., Tarasova, D., Birkner, J., Kaiser, H., Diefenbacher, A., & Sappok, T. (2021) · Journal of Applied Research in Intellectual Disabilities · doi:10.1111/jar.12913 · Cited by 10

Cognitive and Functional Differences in Aging with and without Intellectual Disabilities: Observational Study

Tena-Bernal, O., Sánchez-Peña, M., Gómez‐Cabello, A., Salavera, C., Supervía, P. U., & Calatayud, E. (2021) · Sustainability · doi:10.3390/su131910515 · Cited by 9

Single-Nucleus Profiling Identifies Accelerated Oligodendrocyte Precursor Cell Senescence in a Mouse Model of Down Syndrome

Rusu, B., Kukreja, B., Wu, T., Dan, S. J., Feng, M. Y., & Kalish, B. T. (2023) · eNeuro · doi:10.1523/eneuro.0147-23.2023 · Cited by 9

Origin, toxicity and characteristics of two amyloid oligomer polymorphs

Niyangoda, C., Barton, J., Bushra, N., Karunarathne, K., Strauss, G. L., Fakhre, F., Koria, P., & Muschol, M. (2021) · RSC Chemical Biology · doi:10.1039/d1cb00081k · Cited by 9

Acquired mild cognitive impairment in adults with Down syndrome: Age‐related prevalence derived from single point assessment data normed by degree of intellectual disability

Oliver, C., Adams, D., Holland, A. J., Brown, S. S. G., Ball, S. L., Dodd, K., & Carr, J. (2021) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5674 · Cited by 9

Neuropathological findings in Down syndrome, Alzheimer’s disease and control patients with and without SARS-COV-2: preliminary findings

Granholm, A., Englund, E. M., Gilmore, A., Head, E., Yong, W. H., Perez, S. E., Guzman, S. J., Hamlett, E. D., & Mufson, E. J. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02743-9 · Cited by 11

Analysis of Heteroplasmic Variants in the Cardiac Mitochondrial Genome of Individuals with Down Syndrome

Hefti, E., Bard, J., & Blanco, J. G. (2016) · Human Mutation · doi:10.1002/humu.23071 · Cited by 8

Comparative genome-wide DNA methylation analysis in myocardial tissue from donors with and without Down syndrome

Cejas, R. B., Wang, J., Blair, R. H., Liu, S., & Blanco, J. G. (2020) · Gene · doi:10.1016/j.gene.2020.145099 · Cited by 8

Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome

Campbell, N. B., Patel, Y., Moore, T. L., Medalla, M., & Zeldich, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043477 · Cited by 8

Organizational Events

Kinney, H. C., & Volpe, J. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42876-7.00007-7 · Cited by 8

Chromosome Instability Syndromes

Gardner, R. J. M., & Amor, D. J. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780199329007.003.0016 · Cited by 9

Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model

Araya, P., Niemeyer, B., Schade, K., Dunn, L. N., Waugh, K., Busquet, N., Brindley, C., Brown, C., Winkler, C., Lyford, H. R., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113130 · Cited by 7

Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals

Alldred, M. J., Ibrahim, K. W., Pidikiti, H., Chiosis, G., Mufson, E. J., Stutzmann, G. E., & Ginsberg, S. D. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01891-z · Cited by 7

Analysis of microisolated frontal cortex excitatory layer III and V pyramidal neurons reveals a neurodegenerative phenotype in individuals with Down syndrome

Alldred, M. J., Pidikiti, H., Ibrahim, K. W., Lee, S. H., Heguy, A., Hoffman, G. E., Roussos, P., Wısnıewskı, T., Węgiel, J., Stutzmann, G. E., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02768-0 · Cited by 8

Alzheimer’s Disease-related Biomarkers in Aging Adults with Down Syndrome: Systematic Review

Bram, J. M. D. F., Talib, L. L., Joaquim, H. P. G., Carvalho, C. L., Gattaz, W. F., & Forlenza, O. V. (2019) · Current Psychiatry Research and Reviews · doi:10.2174/1573400515666190122152855 · Cited by 7

Magnetic resonance imaging biomarkers for cognitive decline in Down syndrome

DiProspero, N. D., Kim, S., & Yassa, M. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818845-3.00014-1 · Cited by 11

Using Machine Learning Classifiers to Identify the Critical Proteins in Down Syndrome

Kulan, H., & Dağ, T. (2018) · International Conference on Computational Biology and Bioinformatics (ICCBB) · doi:10.1145/3290818.3290831 · Cited by 7

Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome

Dohl, J., Treadwell, Z., Norris, C. M., & Head, E. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70034 · Cited by 6

In silico identification of critical proteins associated with learning process and immune system for Down syndrome

Kulan, H., & Dağ, T. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210954 · Cited by 6

Modified cued recall test in the French population with Down syndrome: A retrospective medical records analysis

Sacco, S., Falquero, S., Bouis, C., Akkaya, M., Gallard, J., Pichot, A., Radice, G., Bazin, F., Montestruc, F., Hiance‐Delahaye, A., et al. (2022) · Journal of Intellectual Disability Research · doi:10.1111/jir.12957 · Cited by 6

Postmortem Neocortical 3H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer’s Disease

Pivtoraiko, V. N., Racic, T., Abrahamson, E. E., Villemagne, V. L., Handen, B. L., Lott, I. T., Head, E., & Ikonomović, M. D. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.728739 · Cited by 6

AD-Syn-Net: systematic identification of Alzheimer’s disease-associated mutation and co-mutation vulnerabilities via deep learning

Pan, X., Coban‐Akdemir, Z., Gao, R., Jiang, X., Sheynkman, G., Wu, E., Huang, J. H., Sahni, N., & Yi, S. S. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad030 · Cited by 6

Cognitive and Behavioral Domains That Reliably Differentiate Normal Aging and Dementia in Down Syndrome

Harp, J. P., Koehl, L., Pelt, K. L. V., Hom, C. L., Doran, E. W., Head, E., Lott, I. T., & Schmitt, F. A. (2021) · Brain Sciences · doi:10.3390/brainsci11091128 · Cited by 6

Trends and predictions for survival and mortality in individuals with Down syndrome in Brazil: A 21‐year analysis

Gomes, F. D. C., Neto, J. S. D. M., Goloni‐Bertollo, E. M., & Pavarino, É. C. (2020) · Journal of Intellectual Disability Research · doi:10.1111/jir.12735 · Cited by 6

Premature Aging in Aneuploid Yeast is Caused in Part by Aneuploidy-Induced Defects in Ribosome Quality ControlPreprint

Escalante, L. E., Hose, J., Howe, H., Paulsen, N., Place, M., & Gasch, A. P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.22.600216 · Cited by 6

Development of Alzheimer’s disease in Down syndrome

García, O. A., Domínguez-de-la-Cruz, E., Luna-Martínez, I. G., Garnett-Carbajal, J. A., & Villegas-Piña, J. A. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.1006104 · Cited by 4

PET‐measured amyloid beta accumulates at an accelerated rate in Down syndrome compared to neurotypical populations

McVea, A. K., DiFilippo, A. H., McLachlan, M., Betcher, B., Zammit, M. D., Betthauser, T. J., Converse, A. K., Murali, D., Stone, C. K., Hartley, S. L., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70357 · Cited by 5

Can Green Tea Polyphenols Improve Phenotypes Associated With Down Syndrome?

Roper, R. J., & Goodlett, C. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813008-7.00035-7 · Cited by 5

Can early physical therapy positively affect the onset of independent walking in infants with Down syndrome? A retrospective cohort study

CORRADO, B., SOMMELLA, N., Ciardi, G., RAIANO, E., Scala, I., Strisciuglio, P., & IAMMARRONE, C. S. (2022) · Minerva Pediatrics · doi:10.23736/s2724-5276.18.05041-7 · Cited by 5

Aging with Intellectual Disability: Dementia and Cognitive Decline

Sheerin, F. K., McCallion, P., McGlinchey, E., O’Dwyer, M., Reilly, E., & McCarron, M. (2020) · Autism and child psychopathology series · doi:10.1007/978-3-030-46835-4_19 · Cited by 5

Pro-inflammatory Cytokine GM-CSF Improves Learning/Memory and Brain Pathology in Dp16 Down Syndrome Mice and Improves Learning/Memory in Wild-Type MicePreprint

Ahmed, M. M., Wang, A. C.-J., Elos, M. T., Chial, H. J., Sillau, S. H., Solano, D., Coughlan, C. M., Aghili, L., Anton, P., Markham, N., et al. (2021) · bioRxiv · doi:10.1101/2021.07.04.451073 · Cited by 2

A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s DiseasePreprint

Jin, M., Ma, Z., Dang, R., Zhang, H., Kim, R., Xue, H., Pascual, J. R., Finkbeiner, S., Head, E., Liu, Y., et al. (2024) · bioRxiv · doi:10.1101/2024.03.12.584646 · Cited by 5

What Can We Learn About Alzheimer’s Disease from People with Down Syndrome?

Maure‐Blesa, L., Rodríguez‐Baz, Í., Carmona‐Iragui, M., & Fortea, J. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_546 · Cited by 5

Joint spatial associations of amyloid beta and tau pathology in Down syndrome and preclinical Alzheimer's disease: Cross‐sectional associations with early cognitive impairments

Fu, J. F., Garimella, A. H., Lapointe, A., Aye, W. W. T., Chen, C. D., Lee, J. H., Krinsky‐McHale, S. J., Zaman, S. H., Lott, I. T., Hom, C. L., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70424 · Cited by 3

Age and sex are associated with Alzheimer's disease neuropathology in Down syndrome

Andrews, E. J., Ngo, P. T., Pascual, J. R., Gonzalez, F., Phelan, M. J., Wright, S. T., Harp, J. P., Schmitt, F. A., Lai, F., Lao, P. J., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70408 · Cited by 4

Early Chronic Fluoxetine Treatment of Ts65Dn Mice Rescues Synaptic Vesicular Deficits and Prevents Aberrant Proteomic Alterations

Fatemi, S. H., Otte, E. D., Folsom, T. D., Eschenlauer, A. C., Roper, R. J., Aman, J. W., & THURAS, P. D. (2024) · Genes · doi:10.3390/genes15040452 · Cited by 4

Is heart disease a risk factor for low dementia test battery scores in older persons with Down syndrome? Exploratory, pilot study, and commentary

Percy, M. E., & Lukiw, W. J. (2017) · International Journal of Developmental Disabilities · doi:10.1080/20473869.2017.1301023 · Cited by 4

Dementia and Intellectual Disability: Prevalence, Assessment and Post-Diagnostic Support

McGlinchey, E., Reilly, E., McCallion, P., Dunne, P., Mulryan, N., Carroll, R. E., & McCarron, M. (2019) · Autism and child psychopathology series · doi:10.1007/978-3-030-20843-1_51 · Cited by 4

Autosomal Ring Chromosomes

Gardner, R. J. M., & Amor, D. J. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780199329007.003.0011 · Cited by 4

Vertebrate and Invertebrate Animal Models for the Study of Down Syndrome

Granholm, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168092 · Cited by 6

Pro‑inflammatory insulin‑resistant lipid phenotype in down syndrome identified by 1H‑NMR metabolomics in obesity-matched African‑American children and young adults

Qu, H., Connolly, J. J., Eister, G., Mentch, F. D., Glessner, J., & Hakonarson, H. H. (2025) · Scientific Reports · doi:10.1038/s41598-025-26217-4 · Cited by 3

Amyloid β Peptide Modifies Membrane Architecture and Surface Electrostatic Properties of Human Red Blood Cells

Staneva, G., Yordanova, V., Danailova, A., Marinovska, A.-M., Dér, A., & Taneva, S. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311361 · Cited by 3

Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis

Huang, T., Lam, X.-J., Lim, C.-T., Jusoh, N., Fakurazi, S., Cheah, P.-S., & Ling, K. (2024) · Journal of Intellectual Disabilities · doi:10.1177/17446295241299160 · Cited by 3

U1‐70K and U1A and tau pathogenesis in demented and non‐demented individuals with Down syndrome

Perez, S. E., Miguel, J. C., Nadeem, M., Malek‐Ahmadi, M. H., Hales, C. M., Head, E., & Mufson, E. J. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70474 · Cited by 2

Chromosome Disorders

Haldeman‐Englert, C. R., Saitta, S. C., & Zackai, E. H. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-40139-5.00020-6 · Cited by 3

A pathway linking pulse pressure to dementia in adults with Down syndrome

Rizvi, B. M., Lao, P. J., Sathishkumar, M. T., Taylor, L., Queder, N., McMillan, L. C., Edwards, N. C., Keator, D. B., Doran, E. W., Hom, C. L., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae157 · Cited by 3

Chromosome Abnormalities Detected at Prenatal Diagnosis

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Rita Levi-Montalcini, NGF Metabolism in Health and in the Alzheimer’s Pathology

Cuello, A. C. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-74046-7_9 · Cited by 3

The Origins and Consequences of Chromosome Pathology

Gardner, R. J. M., & Amor, D. J. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780199329007.003.0003 · Cited by 3

Elements of Medical Cytogenetics

Gardner, R. J. M., & Amor, D. J. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780199329007.003.0001 · Cited by 3

Down Syndrome and Alzheimer’s Disease: Issues and Implications for Social Work Practice

Fredericksen, J., & Fabbre, V. D. (2017) · Journal of Gerontological Social Work · doi:10.1080/01634372.2017.1393480 · Cited by 3

The dependence of basal forebrain cholinergic neurons on NGF: The case in Alzheimer pathology

Cuello, A. C., & Carmo, S. D. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19088-9.00010-x · Cited by 2

When Two Worlds Collide: The Contribution and Association Between Genetics (APOEε4) and Neuroinflammation (IL-1β) in Alzheimer’s Neuropathogenesis

Jagadeesh, N., Liu, L., Balasubramaniam, M., Ayyadevara, S., & Griffin, W. S. T. (2025) · Cells · doi:10.3390/cells14151216 · Cited by 2

Brain Aging and Alzheimer’s Disease in Down Syndrome

Helman, A. M., Pelt, K. L. V., Schmitt, F. A., & Head, E. (2022) · doi:10.1093/oxfordhb/9780190645441.013.22 · Cited by 1

Down syndrome and Alzheimer's disease: A link between development and aging

Lott, I. T., & Head, E. (2001) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.1025 · Cited by 161

F3–01–02: Alzheimer's disease and Down syndrome

Lemere, C. A. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.04.223

Dementia in Down syndrome: unique insights for Alzheimer disease research

Lott, I. T., & Head, E. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0132-6 · Cited by 383

Down syndrome: a model for the study of Alzheimer’s disease and aging

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