Down syndrome biobank consortium: a perspective
Open accessAbstract
Individuals with Down syndrome (DS) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early‐onset Alzheimer's disease (AD)‐type dementia by early midlife. Despite ongoing clinical trials to treat late‐onset AD, individuals with DS are often excluded. Furthermore, timely diagnosis or management is often not available. Of the genetic causes of AD, people with DS represent the largest cohort. Currently, there is a knowledge gap regarding the underlying neurobiological mechanisms of DS‐related AD (DS‐AD), partly due to limited access to well‐characterized brain tissue and biomaterials for research. To address this challenge, we created an international consortium of brain banks focused on collecting and disseminating brain tissue from persons with DS throughout their lifespan, named the Down Syndrome Biobank Consortium (DSBC) consisting of 11 biobanking sites located in Europe, India, and the USA. This perspective describes the DSBC harmonized protocols and tissue dissemination goals.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
All cases underwent neuropathological assessment by a board-certified neuropathologist according to a modified National Institute on Aging-Alzheimer's Association protocol.
“All cases underwent neuropathological assessment by a board‐certified neuropathologist according to a modified National Institute on Aging—Alzheimer's Association protocol. 4”
From Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations (2026) · cites this paper as [4]
The Methods section, “Tissue and biofluid processing” (page not provided), says tissue sections are stained according to NIA–AA protocols and describes stains used for neuropathological examination. It does not say that all cases were assessed by a board-certified neuropathologist or that the protocol was modified. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nichols, E., Steinmetz, J. D., Vollset, S. E., Fukutaki, K., Chalek, J., Abd-Allah, F., Abdoli, A., Abualhasan, A., Abu-Gharbieh, E., Akram, T. T., et al. (2022) · The Lancet Public Health · doi:10.1016/s2468-2667(21)00249-8 · Cited by 5,575 · see citing works
Staging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357 · see citing works
Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159 · see citing works
Antonarakis, S. E., Skotko, B. G., Rafii, M. S., Strydom, A., Pape, S. E., Bianchi, D. W., Sherman, S. L., & Reeves, R. H. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0143-7 · Cited by 964 · see citing works
Jack, C. R., Knopman, D. S., Weigand, S. D., Wiste, H. J., Vemuri, P., Lowe, V., Kantarci, K., Gunter, J. L., Senjem, M. L., Ivnik, R. J., et al. (2012) · Annals of Neurology · doi:10.1002/ana.22628 · Cited by 602 · see citing works
Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set
Besser, L. M., Kukull, W. A., Knopman, D. S., Chui, H. C., Galasko, D., Weıntraub, S., Jicha, G. A., Carlsson, C. M., Burns, J. M., Quinn, J. F., et al. (2018) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000279 · Cited by 511 · see citing works
Mann, D. M. A., & Esiri, M. M. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90019-1 · Cited by 471 · see citing works
Alzheimer's disease in Down's syndrome: Clinicopathologic studies
Wisniewski, K. E., Dalton, A. J., McLachlan, D. R. C., Wen, G. Y., & Wisniewski, H. M. (1985) · Neurology · doi:10.1212/wnl.35.7.957 · Cited by 417 · see citing works
Dementia in Down syndrome: unique insights for Alzheimer disease research
Lott, I. T., & Head, E. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0132-6 · Cited by 383 · see citing works
Self-citationTrisomy 21 consistently activates the interferon response
Sullivan, K. D., Lewis, H. C., Hill, A. A., Pandey, A., Jackson, L. P., Cabral, J. M., Smith, K. P., Liggett, L. A., Gomez, E. B., Galbraith, M. D., et al. (2016) · eLife · doi:10.7554/elife.16220 · Cited by 362 · see citing works
Alzheimer's disease associated with Down syndrome: a genetic form of dementia
Fortea, J., Zaman, S. H., Hartley, S., Rafii, M. S., Head, E., & Carmona-Iragui, M. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00245-3 · Cited by 357 · see citing works
Self-citationFortea, J., Vilaplana, E., Carmona-Iragui, M., Benejam, B., Videla, L., Barroeta, I., Fernández, S., Altuna, M., Pegueroles, J., Montal, V., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30689-9 · Cited by 340 · see citing works
Self-citationDown syndrome and Alzheimer's disease: common pathways, common goals
Hartley, D., Blumenthal, T., Carrillo, M., DiPaolo, G., Esralew, L., Gardiner, K., Granholm, A.-C., Iqbal, K., Krams, M., Lemere, C., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.10.007 · Cited by 290 · see citing works
Self-citationAging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology
Head, E., T. Lott, I., M. Wilcock, D., & A. Lemere, C. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666151020114607 · Cited by 289 · see citing works
Self-citationAtypical aging in down syndrome
Zigman, W. B. (2013) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.1128 · Cited by 262 · see citing works
Molecular pathology of neurodegenerative diseases: principles and practice
Kovács, G. G. (2019) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2019-205952 · Cited by 243 · see citing works
Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome
Iulita, M. F., Garzón Chavez, D., Klitgaard Christensen, M., Valle Tamayo, N., Plana-Ripoll, O., Rasmussen, S. A., Roqué Figuls, M., Alcolea, D., Videla, L., Barroeta, I., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.12910 · Cited by 195 · see citing works
Self-citationStoltzner, S. E., Grenfell, T. J., Mori, C., Wisniewski, K. E., Wisniewski, T. M., Selkoe, D. J., & Lemere, C. A. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64753-0 · Cited by 187 · see citing works
Evolution of neuroinflammation across the lifespan of individuals with Down syndrome
Flores-Aguilar, L., Iulita, M. F., Kovecses, O., Torres, M. D., Levi, S. M., Zhang, Y., Askenazi, M., Wisniewski, T., Busciglio, J., & Cuello, A. C. (2020) · Brain · doi:10.1093/brain/awaa326 · Cited by 138 · see citing works
Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome
Hamlett, E. D., Goetzl, E. J., Ledreux, A., Vasilevko, V., Boger, H. A., LaRosa, A., Clark, D., Carroll, S. L., Carmona‐Iragui, M., Fortea, J., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.08.012 · Cited by 129 · see citing works
Self-citationMiyoshi, E., Morabito, S., Henningfield, C. M., Das, S., Rahimzadeh, N., Shabestari, S. K., Michael, N., Emerson, N., Reese, F., Shi, Z., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01961-x · Cited by 115 · see citing works
Self-citationMultisite assessment of NIA‐AA guidelines for the neuropathologic evaluation of Alzheimer's disease
Montine, T. J., Monsell, S. E., Beach, T. G., Bigio, E. H., Bu, Y., Cairns, N. J., Frosch, M., Henriksen, J., Kofler, J., Kukull, W. A., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.07.492 · Cited by 113 · see citing works
Wilcock, D. M., Hurban, J., Helman, A. M., Sudduth, T. L., McCarty, K. L., Beckett, T. L., Ferrell, J. C., Murphy, M. P., Abner, E. L., Schmitt, F. A., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.05.016 · Cited by 110 · see citing works
Self-citationDiagnosis and Management of Down Syndrome
Gupta, N., & Kabra, M. (2013) · The Indian Journal of Pediatrics · doi:10.1007/s12098-013-1249-7 · Cited by 106 · see citing works
Cerebrovascular pathology in Down syndrome and Alzheimer disease
Head, E., Phelan, M. J., Doran, E., Kim, R. C., Poon, W. W., Schmitt, F. A., & Lott, I. T. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0499-4 · Cited by 105 · see citing works
Self-citationFurther understanding the connection between Alzheimer's disease and Down syndrome
Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., et al. (2020) · Alzheimer's & Dementia · doi:10.1002/alz.12112 · Cited by 105 · see citing works
Self-citationOpportunities, barriers, and recommendations in Down syndrome research
Hendrix, J. A., Amon, A., Abbeduto, L., Agiovlasitis, S., Alsaied, T., Anderson, H. A., Bain, L. J., Baumer, N., Bhattacharyya, A., Bogunovic, D., et al. (2021) · Translational Science of Rare Diseases · doi:10.3233/trd-200090 · Cited by 100 · see citing works
Self-citationThe triple challenges associated with age‐related comorbidities in D own syndrome
Glasson, E. J., Dye, D. E., & Bittles, A. H. (2013) · Journal of Intellectual Disability Research · doi:10.1111/jir.12026 · Cited by 95 · see citing works
Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal‐dominant Alzheimer's disease
Carmona‐Iragui, M., Balasa, M., Benejam, B., Alcolea, D. A., Fernández, S., Videla, L., Sala, I., Sánchez‐Saudinós, M. B., Morenas‐Rodríguez, E., Nogué, R. R., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.03.007 · Cited by 88 · see citing works
Self-citationOxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome
Head, E., Garzon-Rodriguez, W., Johnson, J. K., Lott, I. T., Cotman, C. W., & Glabe, C. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0431 · Cited by 75 · see citing works
Self-citationAging with Down Syndrome—Where Are We Now and Where Are We Going?
Alldred, M. J., Martini, A. C., Patterson, D., Hendrix, J. A., & Granholm, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10204687 · Cited by 70 · see citing works
Self-citationBenejam, B., Videla, L., Vilaplana, E., Barroeta, I., Carmona‐Iragui, M., Altuna, M., Valldeneu, S., Fernández, S., Giménez, S., Iulita, M. F., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12047 · Cited by 63 · see citing works
Self-citationAssessing general cognitive and adaptive abilities in adults with Down syndrome: a systematic review
Hamburg, S., Lowe, B., Startin, C. M., Padilla, C., Coppus, A. M. W., Silverman, W. P., Fortea, J., Zaman, S. H., Head, E., Handen, B. L., et al. (2019) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-019-9279-8 · Cited by 58 · see citing works
Self-citationDisturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism
Barone, E., Arena, A., Head, E., Butterfield, D. A., & Marzia Perluigi, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.07.009 · Cited by 53 · see citing works
Self-citationLongitudinal Clinical and Cognitive Changes Along the Alzheimer Disease Continuum in Down Syndrome
Videla, L., Benejam, B., Pegueroles, J., Carmona‐Iragui, M., Padilla, C., Fernández, S., Barroeta, I., Altuna, M., Valldeneu, S., Garzón, D., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.25573 · Cited by 48 · see citing works
Self-citationPerez, S. E., Miguel, J. C., He, B., Malek‐Ahmadi, M. H., Abrahamson, E. E., Ikonomović, M. D., Lott, I. T., Doran, E. W., Alldred, M. J., Ginsberg, S. D., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01965-6 · Cited by 47 · see citing works
Self-citationNeuropathological correlates of amyloid PET imaging in Down syndrome
Abrahamson, E. E., Head, E., Lott, I. T., Handen, B. L., Mufson, E. J., Christian, B. T., Klunk, W. E., & Ikonomović, M. D. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22713 · Cited by 45 · see citing works
Self-citationMiyoshi, E., Morabito, S., Henningfield, C. M., et al. (2023) · bioRxiv · doi:10.1101/2023.07.24.550282 · Cited by 45 · see citing works
Sleep Disorders in Adults with Down Syndrome
Giménez, S., Altuna, M., Blessing, E., Osorio, R. M., & Fortea, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143012 · Cited by 39 · see citing works
Self-citationCooper, S., Ademola, T., CASLAKE, M. J., Douglas, E. A., Evans, J. J., Greenlaw, N., Haig, C. E., Hassiotis, A., Jahoda, A. J., McConnachie, A., et al. (2016) · Trials · doi:10.1186/s13063-016-1370-9 · Cited by 27 · see citing works
Wegiel, J., Flory, M., Kuchna, I., Nowicki, K., Wegiel, J., Ma, S. Y., Zhong, N., Bobrowicz, T., de Leon, M. D., Lai, F., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01300-9 · Cited by 27 · see citing works
Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue
Lemoine, L., Ledreux, A., Mufson, E. J., Perez, S. E., Šimić, G., Doran, E. W., Lott, I. T., Carroll, S. L., Bharani, K., Thomas, S., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00414-3 · Cited by 26 · see citing works
Self-citationPatterns of Mixed Pathologies in Down Syndrome
Ichimata, S., Yoshida, K., Visanji, N. P., Lang, A. E., Nishida, N., & Kovacs, G. G. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215675 · Cited by 25 · see citing works
Neurogenesis and neuronal differentiation in the postnatal frontal cortex in Down syndrome
Utagawa, E. C., Moreno, D. G., Schafernak, K. T., Arva, N. C., Malek‐Ahmadi, M. H., Mufson, E. J., & Perez, S. E. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01385-w · Cited by 24 · see citing works
Self-citationLedreux, A., Thomas, S., Hamlett, E. D., Trautman, C. W., Gilmore, A., Hager, E. R., Paredes, D., Margittai, M., Fortea, J., & Granholm, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173931 · Cited by 22 · see citing works
Self-citationNeural correlates of episodic memory in adults with Down syndrome and Alzheimer’s disease
Benejam, B., Aranha, M. R., Videla, L., Padilla, C., Valldeneu, S., Fernández, S., Altuna, M., Carmona‐Iragui, M., Barroeta, I., Iulita, M. F., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01064-x · Cited by 22 · see citing works
Self-citationEXOSOME RELEASE AND CARGO IN DOWN SYNDROME
Hamlett, E., Larosa, A. C., Mufson, E., Fortea, J., Ledreux, A., & Granholm, A. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22712 · Cited by 21 · see citing works
Self-citationExploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome
Andrews, E. J., Martini, A. C., & Head, E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.954999 · Cited by 20 · see citing works
Self-citationMiguel, J. C., Perez, S. E., Malek‐Ahmadi, M. H., & Mufson, E. J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.645334 · Cited by 17 · see citing works
Self-citationCare of Adults With Intellectual and Developmental Disabilities: Down Syndrome.
Wilson, B., Jones, K. B., Weedon, D., & Bilder, D. A. (2015) · PubMed · Cited by 16 · see citing works
Control tissue in brain banking: the importance of thorough neuropathological assessment
Nolan, M., Troakes, C., King, A., Bódi, I., & Al‐Sarraj, S. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1376-6 · Cited by 14 · see citing works
Postnatal Cytoarchitecture and neurochemical hippocampal dysfunction in Down Syndrome
Moreno, D. G., Utagawa, E. C., Arva, N. C., Schafernak, K. T., Mufson, E. J., & Perez, S. E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10153414 · Cited by 7 · see citing works
Self-citationEditorial: Down Syndrome, Neurodegeneration and Dementia
Mufson, E. J., Ginsberg, S. D., Ma, T., Ledreux, A., & Perez, S. E. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.791044 · Cited by 7 · see citing works
Self-citationAging in Down Syndrome: Latest Clinical Advances and Prospects
Martini, A. C., Alldred, M. J., & Granholm, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215037 · Cited by 5 · see citing works
Self-citationElectrophysiologic effects of ethanol in human brain xenografts in oculo: antagonism by Ro15-4513.
Palmer, M. R., Eriksdotter-Nilsson, M., Bygdeman, M., Stieg, P. E., Strömberg, I., Olson, L., Seiger, Å., Hoffer, B. J., & Granholm, A.-C. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12717-1 · Cited by 4 · see citing works
Self-citationBiomarkers show value of studying dementia in Down syndrome
Granholm, A., & Ledreux, A. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00558-w · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [43]Mufson EJ, Ginsberg SD, Ma T, Ledreux A, Perez SE. Editorial: Down syndrome. Front Aging Neurosci. 2021; 13: 791044. 34975462 PMC8715919
Cited by
Sorted by citations
The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome
Granholm, A., & Hamlett, E. D. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051338 · Cited by 18 · see citing works
Self-citationVidela, L., Benejam, B., Barroeta, I., Fernández, S., Altuna, M., Arranz, J., Rodríguez‐Baz, Í., Arriola‐Infante, J. E., Maure‐Blesa, L., Soriano, L. D. H., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70259 · Cited by 14 · see citing works
Self-citationMartá-Ariza, M., Leitner, D. F., Kanshin, E., Suazo, J., Giusti Pedrosa, A., Thierry, M., Lee, E. B., Devinsky, O., Drummond, E., Fortea, J., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02844-z · Cited by 15 · see citing works
Self-citationCell-specific copper dyshomeostasis mechanism in Alzheimer’s disease
Okafor, M., Faller, P., & Vitale, N. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00504-6 · Cited by 11 · see citing works
Granholm, A., Englund, E. M., Gilmore, A., Head, E., Yong, W. H., Perez, S. E., Guzman, S. J., Hamlett, E. D., & Mufson, E. J. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02743-9 · Cited by 9 · see citing works
Self-citationAlldred, M. J., Ibrahim, K. W., Pidikiti, H., Chiosis, G., Mufson, E. J., Stutzmann, G. E., & Ginsberg, S. D. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01891-z · Cited by 7 · see citing works
Self-citationAlldred, M. J., Pidikiti, H., Ibrahim, K. W., Lee, S. H., Heguy, A., Hoffman, G. E., Roussos, P., Wısnıewskı, T., Węgiel, J., Stutzmann, G. E., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02768-0 · Cited by 7 · see citing works
Self-citationVertebrate and Invertebrate Animal Models for the Study of Down Syndrome
Granholm, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168092 · Cited by 3 · see citing works
Self-citationCholinotrophic basal forebrain connectome dysfunction in Down syndrome with and without dementia
Moreno-Rodríguez, M., Perez, S. E., Nadeem, M., Head, E., & Mufson, E. J. (2025) · iScience · doi:10.1016/j.isci.2025.113041 · Cited by 1 · see citing works
Self-citationAguilar, L. F., Zaikos, T. D., Rivera, I., Wright, S. T., Lou, J., Gawronski, B., Gonzalez, L., Berry, J. V., Rouanet, J. P., Edwards, N. C., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03028-z · Cited by 1 · see citing works
Self-citationNordbeck, A. J., Martá‐Ariza, M., Ek Olofsson, H., Kanshin, E., Ueberheide, B., Jones, K., Sanford, B., Hamlett, E. D., Head, E., Mufson, E. J., et al. (2026) · Alzheimer's & Dementia · doi:10.1002/alz.71776
Self-citationPolyamine biosynthesis dysregulation in Alzheimer’s disease and Down syndrome cellular modelsPreprint
Sola, A., Sandberg, A., Pham, C., Revier, A., Hebinck, M., Penney, A. L., Caviedes, P. A., Kumar, S., Granholm, A., Linseman, D. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.31.635912
Self-citationA review of clinical trials in Down Syndrome
Denne, E., Channell, M. M., White, N., Fidler, D., Baumer, N., Wu, J., Tapia, I. E., Froehlich, T., Hartley, S., & Esbensen, A. J. (2025) · International review of research in developmental disabilities · doi:10.1016/bs.irrdd.2025.09.002
Avilés-Granados, C., Gea‐González, A., Sáez-Leyva, J., Perez, S. E., Mufson, E. J., Granholm, A., Carmona‐Iragui, M., Zetterberg, H., Blennow, K., Fortea, J., et al. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02289-9
Self-citationDomenico, F. D., Marzia Perluigi, A., Tramutola, A., Bacalini, M. G., Victorino, D. B., Barroeta, I., Bartesaghi, R., Carfì, A., Carmona‐Iragui, M., Cohen, A. D., et al. (2026) · NeuroMolecular Medicine · doi:10.1007/s12017-026-08921-0
Self-citationPainous, C., Martínez, A., Cámara, A., Fernandez, M., Martı́, M. J., Muñoz, E., Sánchez‐Gómez, A., Pérez‐Soriano, A., Garrido, A., Brenlla, C., et al. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01387-8
Self-citationMultiomics and proteomic insights into Alzheimer’s disease biology in Down syndrome
Martá-Ariza, M., & Wisniewski, T. R. (2026) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2026.2695187
Self-citationHo, S. G., Shen, Z., Lewis, A., Patel, M., Zheng, A., Proscino, G., Ho, T., Wang, J., Albert, M., & Moghekar, A. (2026) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.70524
- Authors
- Aldecoa, I., Barroeta, I., Carroll, S. L., Fortea, J., Gilmore, A., Ginsberg, S. D., Guzman, S. J., Hamlett, E. D., Head, E., Perez, S. E., Potter, H., Molina‐Porcel, L., Raha‐Chowdhury, R., Wisniewski, T., Yong, W. H., Zaman, S., Ghosh, S., Mufson, E. J., & Granholm, A.
- Affiliations
- Pathology Department Hospital Clinic de Barcelona‐University of Barcelona Barcelona Spain
- Hospital de Sant Pau (ES)
- Medical University of South Carolina (US)
- University of Colorado Anschutz (US)
- Nathan Kline Institute for Psychiatric Research (US)
- University of California, Irvine (US)
- Barrow Neurological Institute (US)
- Hospital Clínic de Barcelona (ES)
- University of Cambridge (GB)
- Center for Cognitive Neurology, Departments of Neurology, Pathology and Psychiatry New York University Grossman School of Medicine New York New York USA
- University of Calcutta (IN)
- Corresponding author
- Granholm, Ann‐Charlotte
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2024-01-25
- Volume
- 20
- Issue
- 3
- Pages
- 2262-2272
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC10984425
- OpenAlex
- W4391223168
- Cited by
- 19
- References
- 56
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 5
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Greater South Information System
- Funders
- National Institutes of Health (R01AG071228, R01AG070153, R01AG061566, P01AG060882, P30AG066512)
- Barrow Neurological Foundation
- BrightFocus Foundation (CA2018010)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Down syndrome
- MeSH terms
- Alzheimer Disease, Brain, Down Syndrome, Europe, Humans, Biological Specimen Banks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
