Safety of Lumbar Puncture Procedures in Patients with Alzheimers Disease
Open accessAbstract
Changes in cerebrospinal fluid (CSF) biomarkers are representative of biochemical changes in the brain. Collection of CSF by lumbar puncture (LP) is essential for biomarker analysis, which is important for research in neurodegenerative disorders. However, LP for research purposes has been controversial due to a reported high incidence of severe LP headache when using standard 18g or 20g Quincke needles with a beveled cutting tip. A procedural safety analysis was performed using the database of a multicenter, 13-week study of CSF cholinesterase activity. A 24g Sprotte atraumatic needle was used to collect CSF at baseline and at Week 13 from 63 older patients with mild to moderate Alzheimer's disease. There was a < 2% LP headache incidence, and a favorable safety profile was reported. In conclusion, LP performed with a 24g Sprotte atraumatic needle (blunt, "bullet" tip) was a well tolerated procedure, with good acceptability.
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CSF collection followed a standardized protocol across all studies.
“CSF in all studies was collected in a standardized manner12,64–67.”
From A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease (2017) · cites this paper as [64]
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- Authors
- Peskind, E., Nordberg, A., Darreh-Shori, T., & Soininen, H.
- Affiliations
- University of Washington (US)
- Karolinska University Hospital (SE)
- University of Eastern Finland (FI)
- Corresponding author
- Peskind, E.
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2009-06-01
- Volume
- 6
- Issue
- 3
- Pages
- 290-292
- ISSN
- 1567-2050 (ISSN-L)
- PMC
- PMC4035477
- OpenAlex
- W2128244416
- Cited by
- 66
- References
- 7
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Alzheimer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Novartis Pharmaceuticals Corporation
- National Institute on Aging (P50AG005136)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Neurology › Neurosurgical Procedures and Complications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- lumbar puncture, Alzheimer's disease, post-dural puncture headache, cerebrospinal fluid collection, atraumatic needles, Sprotte needle, Quincke needle, procedural safety, older adults
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Male, Middle Aged, Spinal Puncture, Cohort Studies, Post-Dural Puncture Headache
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